Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrinα2β1
作者机构：Guangdong Provincial Key Laboratory of Molecular Target&Clinical PharmacologySchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical University511436 GuangzhouGuangdongP.R.China Institute of Respiratory and Occupational DiseasesCollaborative Innovation Center for CancerMedical CollegeShanxi Datong University037009 DatongP.R.China School of Chinese MedicineHong Kong Baptist UniversityHong KongP.R.China College of Public HealthGuangzhou Medical University511436 GuangzhouGuangdongP.R.China Cancer Center of Datongthe Second People’s Hospital of Datong037005 ShanxiP.R.China GZMU-GIBH School of Life SciencesGuangzhou Medical University511436 GuangzhouGuangdongP.R.China Xinjiang Institute of Materia Medica830004 UrumqiP.R.China Department of PathologyShanxi Provincial People’s Hospital030012 TaiyuanP.R.China Key Laboratory of Tropical Translational Medicine of Ministry of EducationHainan Medical University571199 HaikouP.R.China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2020年第5卷第1期
页 面：2006-2018页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the National Natural Science Foundation of China(81773888,U1903126,81902152,81473320) the Fund of Guangdong Science and Technology Department(2016A020226024) the Fund of Guangzhou Science and Technology Program(201707010048) the Fund of Construction of High Level Universities in Guangzhou Medical University(Nanshan Scholars Program and Academic Backbone Program)
摘 要：Exosomes play critical roles in regulating various physiological and pathological processes,including immune stimulation,immune suppression,cardiovascular diseases,and *** studies show that exosomes that transport specific microRNAs(miRNAs)are involved in tumor ***,the molecular mechanism by which tumor invasion and migration are regulated by exosomes from non-small cell lung cancer(NSCLC)is not well ***,we show that exosomes shuttling low levels of miR-34c-3p are involved in NSCLC *** results showed that exosomes derived from NSCLC cells carrying low levels of miR-34c-3p could be transported into the cytoplasm of NSCLC cells and accelerate NSCLC invasion and migration by upregulating integrinα2β1.A luciferase assay revealed that integrinα2β1 was the direct target of miR-34c-3p,and overexpression of integrinα2β1 could promote the invasion and migration of NSCLC *** analysis of exosomes derived from clinical serum samples indicated that the expression of miR-34c-3p was significantly downregulated in exosomes from NSCLC patients compared with that of normal controls.A549-derived exosomes promoted NSCLC cells lung metastases in *** shuttling low levels of miR-34c-3p were associated with the progression of NSCLC in vitro and in *** data demonstrate that exosomes shuttling low levels of miR-34c-3p can accelerate the invasion and migration of NSCLC by upregulating integrinα2β***-34c-3p can be a diagnostic and prognostic marker for *** expression of integrinα2β1 is positively related to the migration and metastasis of NSCLC cells.
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