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Extracellular matrix remodelling in dental pulp tissue of carious human teeth through the prism of single-cell RNA sequencing

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International Journal of Oral Science 2023年第3期15卷 450-461页

作者： Anamaria Balic Dilara Perver Pierfrancesco Pagella hubert rehrauer Bernd Stadlinger Andreas E.Moor Viola Vogel Thimios A.Mitsiadis Orofacial Development and Regeneration Institute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurichSwitzerland Department of Health Sciences and Technology Institute of Translational MedicineETH ZurichZurichSwitzerland Functional Genomics Center Zurich ETH Zurich and University of ZurichZurichSwitzerland Clinic of Cranio-Maxillofacial and Oral Surgery University of ZurichZurichSwitzerland Department of Biosystems Science and Engineering ETH ZurichBaselSwitzerland

Carious lesions are bacteria-caused destructions of the mineralised dental tissues,marked by the simultaneous activation of immune responses and regenerative events within the soft dental pulp *** major molecular players in tooth decay have been uncovered during the past years,a detailed map of the molecular and cellular landscape of the diseased pulp is still *** this study we used single-cell RNA sequencing analysis,supplemented with immunostaining,to generate a comprehensive single-cell atlas of the pulp of carious human *** data demonstrated modifications in the various cell clusters within the pulp of carious teeth,such as immune cells,mesenchymal stem cells(MSC)and fibroblasts,when compared to the pulp of healthy human *** immune response in the carious pulp tissue is accompanied by specific changes in the fibroblast and MSC *** changes include the upregulation of genes encoding extracellular matrix(ECM)components,including COL1A1 and Fibronectin(FN1),and the enrichment of the fibroblast cluster with *** incremental changes in the ECM composition of carious pulp tissues were further confirmed by immunostaining *** of the Fibronectin fibres under mechanical strain conditions showed a significant tension reduction in carious pulp tissues,compared to the healthy *** present data demonstrate molecular,cellular and biomechanical alterations in the pulp of human carious teeth,indicative of extensive ECM remodelling,reminiscent of fibrosis observed in other *** comprehensive atlas of carious human teeth can facilitate future studies of dental pathologies and enable comparative analyses across diseased organs.

关键词： organs pulp matrix

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