检索结果-南通市图书馆

电子技术应用 2010年第3期36卷 123-123页

作者： huber+SUHNER公司 huber+SUHNER公司

huber＋SUHNER在光纤应用的开发和生产上有着数十年的丰富经验，不断进行各种科技创新，并在自己所涉及的三个主要市场：通信、工业和交通领域里均取得了又一次巨大的成功。根据市场需求，huber＋SUHNER推出LC-HQ推拉式连接器。

关键词：连接器推拉式市场需求科技创新交通领域

In situ characterization of particle formation in spray flame synthesis using wide-angle light scattering

在线全文

学校读者我要写书评

暂无评论

Particuology 2024年第3期86卷 304-312页

作者： Simon Aβmann Franz J.T.huber Stefan Will Lehrstuhl für Technische Thermodynamik(LTT) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91058Germany Erlangen Graduate Schoolin Advanced Optical Technologies(SAOT) Friedrich-Alexander-Universitat Erlangen-Nurnberg(FAU)Erlangen91052Germany Competence Unit Engineering of Advanced Materials(EAM) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91052Germany

Wide-angle light scattering(WALS)was used for in situ measurements of droplet and nanoparticle size distributions during the synthesis of titania and iron oxide particles from liquid precursor solutions in the standardized SpraySyn burner for spray flame *** was synthesized from titanium tetraisopropoxide(TTIP)and iron oxide from iron(II)nitrate nonahydrate(INN)using ethanol(EtOH)as *** images were taken at heights up to 120 mm above the burner surface and classified into droplet and particle *** size distributions were derived from a sequential analysis of scattering data containing the oscillating Mie pattern,the lognormal size distribution parameters for spherical and fractal particle fractions from a multivariate approach on averaged particle scattering *** results show that the precursor addition leads to altered evaporation behavior and even droplet disruption probably induced by puffing or micro-explosions compared to pure *** the case of TTIP(a hygroscopic alkoxide),the synthesis of a large fraction of spheres was observed,while the nitrate INN leads to the formation of mostly fractal aggregates.

关键词： Spray flame synthesis Metal oxide particles Elastic light scattering Droplet size distribution Nanoparticle morphology Particle size distribution

Methyltransferase-like 3(METTL3)inhibition potentiates anti-tumor immunity:a novel strategy for improving anti-PD1 therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第1期9卷 10-11页

作者： Anna Brichkina Roman Suezov Magdalena huber Institute of Systems Immunology Member of the German Center for Lung Research(DZL)Philipps University of Marburg35043 MarburgGermany

In a recent article published in Cancer Discovery,Guirguis et *** that enzymatic inhibitors of the m6 A methyltransferase METTL3 induced a formation of immunostimulatory doublestranded mRNAs(dsRNAs)in cancer cells,which triggered a profound tumor-cell-intrinsic interferon response leading to an enhanced antigen presentation and thereby increased killing of tumor cells by cytotoxic CD8+*** inhibition of METTL3 synergized with anti-PD1 immunotherapy,highlighting its potential for improving cancer treatment.

关键词： PD1 immunity

No evidence of contagious yawning in the red-footed tortoise Geochelone carbonaria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2011年第4期57卷 477-484页

作者： Anna WILKINSON Natalie SEBANZ Isabella MANDL Ludwig huber Department of Cognitive Biology University of Vienna Althanstrasse 14 Vienna 1090 Austria Department of Biological Sciences University of Lincoln Lincoln LN2 2LG UK Donders Institute for Brain Cognition and Behavior Centre for Cognition Radboud University Nijmegen P.O. Box 9104 6500 HE Nijmegen The Netherlands

Three hypotheses have attempted to explain the phenomenon of contagious yawning. It has been hypothesized that it is a fixed action pattern for which the releasing stimulus is the observation of another yawn, that it is the result of non-conscious mimicry emerging through close links between perception and action or that it is the result of empathy, involving the ability to engage in mental state attribution. This set of experiments sought to distinguish between these hypotheses by examining contagious yawning in a species that is unlikely to show nonconscious mimicry and empathy but does respond to social stimuli： the red-footed tortoise Geochelone carbonaria. A demonstrator tortoise was conditioned to yawn when presented with a red square-shaped stimulus. Observer tortoises were exposed to three conditions： observation of conditioned yawn, non demonstration control, and stimulus only control. We measured the number of yawns for each observer animal in each condition. There was no difference between conditions. Experiment 2 therefore increased the number of conditioned yawns presented. Again, there was no significant difference between conditions. It seemed plausible that the tortoises did not view the conditioned yawn as a real yawn and therefore a final experiment was run using video recorded stimuli. The observer tortoises were presented with three conditions： real yawn, conditioned yawns and empty background. Again there was no significant difference between conditions. We therefore conclude that the red-footed tortoise does not yawn in response to observing a conspecific yawn. This suggests that contagious yawning is not the result of a fixed action pattern but may involve more complex social processes [Current Zoology 57 （4）： 477-484, 2011].

关键词： Reptile Contagious yawn Empathy Nonconscious mimicry Fixed action pattern

Crosslinking-mediated activation of the FcεRI:Does it need antigen for success?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2022年第5期46卷 1125-1129页

作者： MICHAEL huber SANDRO CAPELLMANN Institute of Biochemistry and Molecular Immunology Medical FacultyRWTH Aachen UniversityAachen52074Germany

Mast cells(MCs),hematopoietic cells of the myeloid lineage,are well-known for their pro-inflammatory nature contributing to the development of various allergic and autoimmune *** of the characteristic receptors on MCs,the high-affinity receptor for IgE(FcεRI),is activated in its IgE-bound state via binding and crosslinking by polyvalent *** results in its phosphorylation by the SRC family kinase LYN,initiating differential signaling pathways,eventually triggering immunological effector functions,such as degranulation and cytokine *** publications have reported on FcεRI-dependent but antigen-independent MC activation by antibody-mediated crosslinking of membrane molecules(e.g.,transmembrane proteins and glycosphingolipids)that are both localized in membrane rafts and in close vicinity to the Fcε*** this Viewpoint we will briefly introduce FcεRI-mediated MC stimulation,cite examples of FcεRI-proximal molecules,the crosslinking of which can cause FcεRI-dependent MC activation,and discuss the potential of certain viruses as well as auto-antibodies to act as indirect FcεRI-crosslinking *** latter cases,antigen-independent FcεRI-mediated pro-inflammatory MC activation could contribute to the development of detrimental cytokine storms.

关键词： Mast cell FcεRI Rafts Transmembrane proteins Virus receptor

Anatomy of a eustatic event during the Turonian (Late Cretaceous) hot greenhouse climate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2017年第1期60卷 20-29页

作者： Bilal U. HAQ Brian T. huber Department of Paleobiology MRC-121Smithsonian InstitutionWashington D C 20013USA Sorbonne ISTEP Pierre&Marie Curie UniversityParis 75005France

Sequence stratigraphic studies consider relative change in sea level(as regulated by eustasy,local tectonics and sediment supply)as the main builder of the stratigraphic *** has generally been considered as a consequence of the growth and decay of continental ice sheets that would explain large,rapid changes in sea level,even during periods of relative global climatic ***,such a mechanism has become increasingly difficult to envision during times of extreme global warmth such as the Turonian,when the equator-to-pole temperature gradient was very low and the presence of polar ice seems *** paper investigates the timing and extent of sea level falls during the late Cenomanian through Turonian,especially the largest of those events,sequence boundary KTu4,which occurred during the middle to late Turonian peak of the Cretaceous hot greenhouse *** conclude that the amplitude of the widespread third-order sea level fall in the middle Turonian that is centered at^91.8 Ma varies at different locations depending on the influence of dynamic topography on local tectonics and regional climatic *** volume variations seem unlikely as a mechanism for controlling sea level at this ***,this causal factor cannot be ruled out completely since Antarctic highlands(if they existed in the Late Cretaceous)could sequester enough water as ice to cause eustatic *** ascertain this requires detailed tomographic imaging of Antarctica,followed by geodynamic modeling,to determine whether high plateaus could have existed to accumulate ephemeral ice *** mechanisms for sea level change,such as transference between ground water(a small amplitude shorter time scale effect)and the ocean and entrainment and release of water from the mantle to the oceanic reservoir(a potentially large amplitude and longer time scale process),are intriguing and need to be explored further to prove their efficacy at third-order time scales.

关键词： Eustatic event Turonian Hot greenhouse climate

Pathogenic and therapeutic role of exosomes in neurodegenerative disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第1期19卷 75-79页

作者： Christa C.huber Hongmin Wang Division of Basic Biomedical Sciences Sanford School of MedicineUniversity of South DakotaVermillionSDUSA

Neurodegenerative disorders affect millions of people worldwide,and the prevalence of these disorders is only projected to rise as the number of people over 65 will drastically increase in the coming *** therapies exist to aid in symptomatic relief,effective treatments that can stop or reve rse the progress of each neurodegenerative disease are ***,research on the role of extracellular vesicles as disease markers and therapeutics has been intensively ***,30-150 nm in diameter,are one type of extracellular vesicles facilitating cell-to-cell *** are thought to play a role in disease propagation in a variety of neurodegenerative diseases,such as Alzheimer's disease,Parkinson s disease,and amyotrophic lateral ***,the exosomes derived from the patients are an invaluable source of disease *** the other hand,exosomes,especially those derived from stem cells,could serve as a therapeutic for these disorders,as seen by a rapid increase in clinical trials investigating the therapeutic efficacy of exosomes in different neurological *** review summarizes the pathological burden and therapeutic approach of exosomes in neurodegenerative *** also highlight how heat shock increases the yield of exosomes while still maintaining their therapeutic ***,this review concludes with outstanding questions that remain to be addressed in exosomal research.

关键词： aging Alzheimer's disease biomarker drug exosome extracellular vesicle neurodegenerative disease Parkinson's disease therapy

A machine learning approach to model solute grain boundary segregation

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2018年第1期4卷 130-137页

作者： Liam huber Raheleh Hadian Blazej Grabowski Jörg Neugebauer Max-Planck-Institut für Eisenforschung GmbH D-40237 DüsseldorfGermany

Even minute amounts of one solute atom per one million bulk atoms may give rise to qualitative changes in the mechanical response and fracture resistance of modern structural *** changes are commonly related to enrichment by several orders of magnitude of the solutes at structural defects in the host *** underlying concept—segregation—is thus fundamental in materials *** include it in modern strategies of materials design,accurate and realistic computational modelling tools are ***,the enormous number of defect configurations as well as sites solutes can occupy requires models which rely on severe *** the present study we combine a high-throughput study containing more than 1 million data points with machine learning to derive a computationally highly efficient framework which opens the opportunity to model this important mechanism on a routine basis.

关键词： grain solute boundary

Numerical Modelling of Seismic Site Effects Incorporating Non-linearity and Groundwater Level Changes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Earth Science 2010年第6期21卷 931-940页

作者： Dominik Ehret Joachim Rohn Dieter Hannich Carlos Grandas Gerhard huber Department of Applied Geology University of Erlangen-Nuremberg Department of Applied Geology University (TH) of Karlsruhe Institute of Soil and Rock Mechanics University (TH) of Karlsruhe

In the past decades, the necessity for detailed earthquake microzonation studies was recognized worldwide. Therefore, different approaches were established and applied. Unfortunately, the majority of these approaches are not based on pre-existing field data but require extensive seismic measurements and investigations. Furthermore, these approaches incorporate non-linearity inadequately and cannot take groundwater level changes into account. For this purpose, notably numerical models are most suitable. These models require a good knowledge of the local geological conditions （especially of the uppermost unconsolidated units）, information about the geotechnical parameters of these units, and a hydrogeological model of the investigated area. Most of this information can be obtained from geotechnical investigations and surveys that have already been carried out in most densely populated areas. In a case study for Bucharest City, non-linear analyses were performed using software that is based on the visco-hypoplastic constitutive law. The results indicate that groundwater level changes have an important influence on duration and amplitude of ground response and thus should be considered for seismic microzonation studies. This approach ean be used to display site effects and to identify different microzones taking different earthquake magnitudes and groundwater levels into account.

关键词： microzonation site effect visco-hypoplasticity non-linearity Bucharest Romania.

Effects of Direction of Bridging of Thiocyanato on the Dimension of Coordination Polymers: Synthesis, Characterization and Single-crystal X-ray Structure Determination of [Cd(4,4'-dm-2,2'-bpy)(NCS)_2]_n and [Cd(4,4'-dmo-2,2'-bpy)(NCS)_2]_n Coordination Pol

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Structural Chemistry 2015年第7期34卷 1135-1144页

作者： HOSSEIN Shirdel FARZIN Marandi ABBAS Jalilzadeh SEBASTIAN huber ARNO Pfitzner Department of Food Industry Maku Branch Islamic Azad University Department of Chemistry Payame Noor University Institut für Anorganische Chemie Universitaet Regensburg 93040Regensburg Germany

Two new cadmium（II）-thiocyanato coordination polymers with 4,4＇-dimethyl-2,2＇-bipyridine（4,4＇-dm-2,2＇-bpy） and 4,4＇-dimethoxy-2,2＇-bipyridine（4,4＇-dmo-2,2＇-bpy） as chelating ligands were synthesized and characterized by elemental analysis, IR and 1H NMR spectroscopy and X-ray crystallography. Thermal properties were also studied as well. These complexes have formed as [Cd（4,4＇-dm-2,2＇-bpy）（NCS）2]n（1） and [Cd（4,4＇-dmo-2,2＇-bpy）（NCS）2]n（2）. The coordination numbers of CdII in 1 and 2 are six（Cd N4S2）. Direction of bridging of thiocyanato anions in 1 and 2 created one- and two-dimensional coordination polymers, respectively. The supramolecular features in these complexes were guided and controlled by weak directional intermolecular interactions.

关键词： 2 2’-bipyridine cadmium(II) coordination polymer weak interactions