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Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation

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Animal Nutrition 2022年第1期8卷 350-360页

作者： Muhammad Akhtar Yan Chen Ziyu Ma Xiaolong Zhang Deshi Shi Jawaria AKhan huazhen liu Department of Basic Veterinary Medicine College of Animal Science and Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China Department of Preventive Veterinary Medicine College of Animal Science and Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China Department of Veterinary Medicine Faculty of Veterinary ScienceUniversity of Veterinary and Animal SciencesLahore54000Pakistan

Gut inflammation is a challenging concern in humans and animals,which disturbs normal growth and leads to severe bowel *** chain fatty acids(SCFA)are the gut microbiota metabolites produced from fermentation of non-digestible carbohydrates,and have been reported to modulate gut *** have been implicated as the potential therapeutic bioactive molecules for gut inflammatory diseases,and could be an alternative to antibiotic growth promoters(AGP).In this review,the existing knowledge about the types of SCFA,the related gut microbes producing SCFA,the roles of SCFA in maintaining gut homeostasis,and how SCFA modulate gut inflammation is *** therapeutic application of SCFA in the treatment of inflammatory bowel disease(IBD)is also highlighted

关键词： Gut microbiota Short chain fatty acid Gut inflammation Gut homeostasis Inflammatory bowel disease

Ablative fractional CO_(2)laser surgery improving sleep quality,pain and pruritus in adult hypertrophic scar patients:a prospective cohort study

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Burns & Trauma 2021年第1期9卷 372-382页

作者： Kaiyang Lv huazhen liu Haiting Xu Caixia Wang Shihui Zhu Xiaozhen Lou Pengfei Luo Shichu Xiao Zhaofan Xia Department of Plastic Surgery Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092People’s Republic of China Department of Burn Surgery the First affiliated Hospital to Naval Medical UniversityShanghai 200433People’s Republic of China Department of Burn and Plastic Surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandong 250021People’s Republic of China Department of Plastic Surgery The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000People’s Republic of China Shanghai Institute of Laser Technology Shanghai 200233People’s Republic of China

Background:Poor sleep quality is associated with a decrease in quality of life in patients with major burn scars,combined with pruritus and *** interventions have been reported to improve the sleep quality of patients with *** the current prospective cohort study,we investigated the efficacy of CO_(2)-ablative fractional laser(AFL)surgery vs conventional surgery in post-burn patients with hypertrophic scars with sleep quality as the primary study ***:In total 68 consecutive patients undergoing scar surgical treatment were recruited,including a CO_(2)-AFL surgery cohort(n=35)and a conventional surgery cohort(n=33).A subgroup from the AFL cohort was *** quality,pain and pruritus were *** linear regression analyses were performed to reveal the effect of CO_(2)-AFL ***:The CO_(2)-AFL surgery cohort had significantly lower Pittsburgh sleep quality index(PSQI)global scores than the conventional surgery cohort after the last surgical *** the subgroup of patients receiving hardware sleep monitoring,CO_(2)-AFL markedly increased deep sleep time,deep sleep efficiency and reduced initial sleep *** to the conventional surgery cohort,the CO_(2)-AFL cohort presented significantly lower pain and pruritus *** analysis showed pain and pruritus were significantly associated with PSQI scores,and there were also significant correlations between pain and pruritus *** linear regression analysis showed that surgery method was negatively linearly correlated with visual analog scale(VAS)pain score,brief pain inventory(BPI)total,VAS pruritus score,5-D itch scale total,four-item itch questionnaire(FIIQ)total and PSQI ***:CO_(2)-AFL surgery significantly improved sleep quality and reduced pain and pruritus of hypertrophic scar *** alleviation of sleep disorder was associated with improvement of deep sleep quality including deep sleep time and deep sleep deficiency

关键词： Burn scar Ablative CO_(2)fractional laser Cardiopulmonary coupling Sleep quality Pain Pruritus

Clarifying sleep characteristics and analyzing risk factors of sleep disorders to promote a predictive, preventive, and personalized medicine in patients with burn scars

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Clarifying sleep characteristics and analyzing risk factors ...

Problems of Agricultural Technological Innovation in China and Countermeasures

中国睡眠研究会第十五届全国学术年会

作者： huazhen liu Shanghai Changhai Hospital

Purpose This study assessed sleep quality in patients with burn scars and investigated risk factors of sleep disorders to guide clinical *** the strategy of predictive, preventive, and personalized medicine(PPPM/3PM), we proposed that risk assessment based on clinical indicators could prompt primary prediction, targeted prevention, and personalized interventions to improve the management of sleep disorders present in patients with burn *** This retrospective study recruited patients with burn scars and healthy volunteers from the Shanghai Burn Treatment *** information and data, including demographic characteristics, scar evaluation,and sleep quality, were obtained through the hospital information system, classical scar scale, and self-report *** quality was assessed using the Pittsburgh Sleep Quality Index(PSQI) and monitored using a cardiopulmonary-coupled *** and pruritus were assessed using the visual analog scale(VAS).Scar appearance was assessed using the modified Vancouver scar scale(mVSS).Results The sample was comprised of 128 hypertrophic scar(HS) patients, with 61.7% males, a mean age of 41.1 ± 11.6 years, and burn area of 46.2 ± 27.9% total body surface area(TBSA).Patients with PSQI ≥ 7 accounted for 76.6%, and the global PSQI score was 9.4 ± *** sleep data showed that initial enter deep sleep time, light sleep time, awakening time, light sleep efficiency, and sleep apnea index were higher but deep sleep time, sleep efficiency, and deep sleep efficiency were lower in HS patients than that in healthy *** univariate analysis showed that age, hyperplasia time of scar, narrow airway, microstomia, VAS for pain and pruritus, and mVSS total(comprised of pigmentation, vascularity, height and pliability) were associated with the PSQI score(p < 0.1).Multivariable linear regression showed narrow airway, VAS for pain and pruritus, and mVSS specifically height, were the ris

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Asian Agricultural Research 2013年第3期5卷 7-10页

作者： Hongbo liu Ren liu huazhen liu Zhongkai University of Agriculture and Engineering Guangzhou University of Chinese Medicine

Major problems of agricultural technological innovation in China were summarized as below: first,poor agricultural science and technology system; second,deficient technological promotion system; third,shortage of agricultural professionals; fourth,serious shortage of science and technology input. In view of these problems,the following suggestions were given to improve the innovation of agricultural technology in China. ( 1) Restructuring agricultural research institutes,establishing cooperative innovation centers,improving agricultural technological innovation system; ( 2) Specifying the direction of research projects,improving scientific research level of technicians,so as to improve the agricultural technological innovation capacity; ( 3) Improving promotion and service stations in towns,organizing technological service teams of agricultural universities and colleges,establishing agricultural technological promotion systems; ( 4) Increasing input in agricultural technological innovation by attracting government input,enterprise investment and other financial support; ( 5) Cultivating more talents of agricultural technology,training leading agricultural technicians,grassroots agricultural service staff and practical talents.

关键词： Technological innovation Scientific research capac

The five major autoimmune diseases increase the risk of cancer:epidemiological data froma large-scale cohort study in China

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Cancer Communications 2022年第5期42卷 435-446页

作者： Ziyue Zhou huazhen liu Yiying Yang Jingya Zhou Lidan Zhao Hua Chen Yunyun Fei Wen Zhang Mengtao Li Yan Zhao Xiaofeng Zeng Fengchun Zhang Huaxia Yang Xuan Zhang Department of Rheumatology and Clinical Immunology National Clinical Research Center for Dermatologic and Immunologic Diseasesthe Ministry of Education Key LaboratoryPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730P.R.China Clinical Immunology Center Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730P.R.China Department of Medical Records Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730P.R.China State Key Laboratory of Difficult Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730P.R.China Department of Rheumatology National Center of GerontologyInstitute of Geriatric MedicineBeijing HospitalPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730P.R.China

Background:Cancer incidence and mortality have received critical attention during the long-term management of morbidities in patients with autoimmune diseases(AIDs).This study aimed to investigate and compare the risk of cancer associated with five major AIDs in a large-scale Chinese ***:A total of 8,120 AID patients consecutively admitted to a national tertiary referral center in China were included and followed-up for 38,726.55 patient-years,including those with systemic lupus erythematosus(SLE),rheumatoid arthritis(RA),Sjoren’s syndrome(SS),systemic scleroderma(SSc),and idiopathic inflammatory myositis(IIM).Demographic data,cancer incidence,predilecting sites and cancer onset time were recorded and compared among the five ***:Four hundred and thirty(5.3%)patients developed *** median agewas 57.5 years and AID durationwas 79.8 *** estimated total standardized incidence ratio(SIR)of cancer in AIDs patients was 3.37,with the highest SIR observed in IIM(4.31),followed by RA(3.99),SSc(3.77),SS(2.88)and SLE(2.58).The increased SIR of cancers in AID patients showed a female predominance(female ***:3.59 vs.2.77)and younger patient involvement(age<50 vs.≥50 years:4.88 vs.3.04).Patientswith SLE had increased SIRs for developing hematologic malignancies and solid tumors located in the urinary bladder,corpus uteri and cervix *** with SS had a significantly high SIR for developing non-Hodgkin’s *** 3 years of IIM diagnosis,74.6%of the patients developed cancer and they had a high risk of ovarian *** was associated with a wide distribution of scancers,including non-Hodgkin’s lymphoma,gynecologic,urinary tract,thyroid gland and lung *** patients had increased SIRs for developing cervical uterine,lung,and breast ***:Patients with five major AIDs in China had an increased risk of developing cancer,with a predominance in women and younger patients,although cancer incidence,predilection site

关键词： autoimmune disease cancer risk standardized incidence ratio lupus erythematosus rheumatoid arthritis Sjoren’s syndrome systemic scleroderma idiopathic inflammatory myositis epidemiology

PSORI-CM02 suppress allograft rejection via induction of CD8+CD122+PD-1+ regulatory T cells

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PSORI-CM02 suppress allograft rejection via induction of CD8...

The distribution and developmental changing of IL-21 in silkie immune organs

第十二届全国免疫学学术大会

作者： liu huazhen Qiu Feifei Liang Chunling Chen Yuchao Dai Zhenhua Joint Immunology Program Section of ImmunologyGuangdong Provincial Academy of Chinese Medical Sciences

Achieving long-term allograft survival without continuously global immunosuppression is highly desirable as longterm immunosuppression causes various side ***,it is compelling to search for alternative *** medicine PSORI-CM01,a formula with seven herbs,has been used to treat patients with autoimmune psoriasis for *** we investigated anoptimized formula,PSORI-CM02 consisting of five natural *** found that similar to cyclosporine,PSORI-CM02 significantly inhibited skin allograft *** also suppressed T cell proliferationin vitro and reduced their phosphorylation of mTOR signaling,P70 S6 ***,PSORI-CM02 increased CD8CD122PD-1 Treg frequencies with CD4FoxP3 Tregs remaining intact in recipients,whereas cyclosporine reduced CD4FoxP3 Treg numbers,implying that PSORI-CM02 is a better immunosuppressant than ***,omission of any single herbal component rendered the whole formula ineffective in both suppression and Treg induction,indicating that these herbs exert their effects cooperatively,not simply through several independent molecular *** of CD122 T cells abolished the extension of allograft survival induced by ***,UFLC fingerprinting ruled out that PSORI-CM02 containscyclosporineand rapamycin while PSORICM02 did not cause any illness and toxic injury in ***,for the first time,we discovered that herbal formula PSORI-CM02 alone suppresses allograft rejection.

关键词： PSORI-CM02 allograft CD8+CD122+PD-1+ Treg

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The distribution and developmental changing of IL-21 in silk...

黄河流域七大城市群绿色发展效率测度及特征分析

中国畜牧兽医学会动物解剖学及组织胚胎学分会第十七次学术研讨会

作者： liu Zhiwei Peng Kemei Song Hui liu huazhen Chen Min Lu Zhiqiang liu Yinxue College of Animal Science and Veterinary Medicine Huazhong Agricultural University

To investigate IL-21 distribution characteristics and development changes in silkie immune organs,in order to breeding and provide the theoretical basis for disease control and *** paraffin section,immunohistochemical techniques were used in the present *** results showed that:(1) In the thymus of silkie,IL-21 is mainly distributed in medulla with a small amount in cortex. Around the thymus corpuscle in medulla,there are many positive cells which are brown,round,similar in size and with no obvious *** nuclei can be clearly seen in the positive cells contained in the thymus of silkies that are 112 days *** with the increase of day age,the amount of IL-21 in the cortex becomes less and *** the thymus of 63-day-old silkies,the amount of IL-21 in medulla is most close to that in *** are few positive cells in the thymus of 112-day-old silkies.(2) In silkies’ spleen,IL-21 is mainly distributed in white pulp with a small number in red *** positive cells can be seen around the spleen summary in the white *** spleen summaries insilkies that are 7 and 14 days old are not as clear as those in 21-day old and older *** cells can also be observed near the marginal zone and ellipsoids of the white *** round or nearly round positive cells are brownish-yellowwith a smaller diameter than those in the thymus and no obvious nucleus.(3) In silkies’ Fabricius bursa,IL-21 is mainlydistributed in mucosal epithelium,epithelial plexus and medulla with a small amount in cortex and some in lamina *** brownish-yellow positive cells differ in diameter and have no clear ***-21 is a kind of cell factor that plays an important role in silkies’ immune system and has a wide distribution in the immune *** amount of IL-21 varies in different immune organs and in silkies of different day ages.

关键词： IL-21 Silkie Immune organ Distribution characteristics Developmental changing

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干旱区地理 2023年第5期46卷 846-856页

作者：孟望生刘华桢张扬甘肃政法大学商学院甘肃兰州730070 甘肃政法大学经济学院甘肃兰州730070 陕西师范大学国际商学院陕西西安710119

黄河流域城市群绿色发展对于全流域生态保护与绿色高质量发展至关重要。采用超效率SBM模型测度黄河流域七大城市群所辖城市2007—2019年的绿色发展效率,对其时空演化特征进行刻画,并分别采用引力模型和均衡函数分析七大城市群间绿色发... 详细信息

黄河流域城市群绿色发展对于全流域生态保护与绿色高质量发展至关重要。采用超效率SBM模型测度黄河流域七大城市群所辖城市2007—2019年的绿色发展效率,对其时空演化特征进行刻画,并分别采用引力模型和均衡函数分析七大城市群间绿色发展的关联特征和城市群内部的均衡特征。结果表明:(1)从时序特征来看,城市群的绿色发展效率以2014年为界呈现先下降后上升的变化趋势。(2)从空间分布来看,城市群所辖城市的绿色发展效率在空间格局上呈现低效率空间集聚现象。(3)从关联特征来看,不同城市群间绿色发展的关联强度存在较大差异,其关联关系主要有单向溢出关联、双向溢出关联和无关联。(4)从均衡特征来看,城市群的绿色发展效率与其均衡度之间存在负相关关系,且各城市群在绿色发展效率和均衡度的关系上主要呈现低效率-高均衡度、低效率-低均衡度和高效率-低均衡度3种类型。

关键词：绿色发展效率城市群关联特征均衡特征黄河流域

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点阵激光治疗瘢痕的机制研究进展

中华烧伤杂志 2021年第4期37卷 386-390页

作者：刘华振吕开阳上海交通大学医学院附属新华医院整形外科 200092

瘢痕是皮肤组织创伤异常修复的结果。近年来点阵激光被越来越广泛地应用于瘢痕治疗中,但其治疗机制尚不明确。目前研究表明点阵激光能够在靶组织中形成多个微热损伤区,诱导皮肤创伤修复反应,影响表皮层和真皮层细胞的功能,诱导血管和胶... 详细信息

瘢痕是皮肤组织创伤异常修复的结果。近年来点阵激光被越来越广泛地应用于瘢痕治疗中,但其治疗机制尚不明确。目前研究表明点阵激光能够在靶组织中形成多个微热损伤区,诱导皮肤创伤修复反应,影响表皮层和真皮层细胞的功能,诱导血管和胶原蛋白变化,改变热休克蛋白、微小RNA、基质金属蛋白酶和转化生长因子β、碱性成纤维细胞生长因子等细胞因子的表达,促进药物运输,达到治疗瘢痕的效果。本文从细胞及组织学机制、分子机制及药物运输3个方面对点阵激光治疗瘢痕的机制进行综述。

关键词：瘢痕细胞因子类点阵激光分子机制