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Design of a High Precision Multichannel 3D Bioprinter

Chinese Journal of Mechanical Engineering 2023年第6期36卷 127-146页

作者： Jintao Li Bin Zhang Yichen Luo huayong yang State Key Laboratory of Fluid Power Transmission and Control School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China

Three-dimensional(3D)printing technology is expected to solve the organ shortage ***,owing to the accuracy limitations,it is difficult for the current bioprinting technology to achieve an accurate control of the spatial position and distribution of a single cell or single component *** this study,to accurately achieve the directional deposition of different cells and biological materials in the spatial position for the construction of large transplantable tissues and organs,a high-precision multichannel 3D bioprinter with submicron-level motion accuracy is designed,and concurrent and synergistic printing methods are *** on the high-precision motion characteristics of the gantry structure and the requirements of concurrent and synergistic printing,a 3D bioprint-ing system with a set of 6 channels is designed to achieve six-in-one *** on the Visual C++environ-ment,a control system software that integrates the programmable multi-axis controller(PMAC)motion,pneumatic,and temperature control subsystems was developed and ***,based on measurements and experiments,the 3D bioprinter and its control system was verified to fulfil the requirements of multichannel,concurrent,and syn-ergistic printing with submicron-level motion accuracy,significantly shortening the printing time and improving the printing *** study not only provides an equipment basis for printing complex heterogeneous tissue structures,but also improves the flexibility and functionality of bioprinting,and ultimately makes the construction of complex multicellular tissues or organs possible.

关键词： 3D bioprinting High precision Concurrent and synergistic printing Multichannel Control system Six-in-one printing

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Deep multimodal learning for municipal solid waste sorting

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Science China(Technological Sciences) 2022年第2期65卷 324-335页

作者： LU Gang WANG YuanBin XU HuXiu yang huayong ZOU Jun State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

Automated waste sorting can dramatically increase waste sorting efficiency and reduce its regulation cost. Most of the current methods only use a single modality such as image data or acoustic data for waste classification, which makes it difficult to classify mixed and confusable wastes. In these complex situations, using multiple modalities becomes necessary to achieve a high classification accuracy. Traditionally, the fusion of multiple modalities has been limited by fixed handcrafted features. In this study, the deep-learning approach was applied to the multimodal fusion at the feature level for municipal solid-waste *** specifically, the pre-trained VGG16 and one-dimensional convolutional neural networks(1 D CNNs) were utilized to extract features from visual data and acoustic data, respectively. These deeply learned features were then fused in the fully connected layers for classification. The results of comparative experiments proved that the proposed method was superior to the single-modality methods. Additionally, the feature-based fusion strategy performed better than the decision-based strategy with deeply learned features.

关键词： deep multimodal learning municipal waste sorting multimodal fusion convolutional neural networks

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海底原位分层声学测量模拟装置的设计与实验

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广东海洋大学学报 2024年第1期44卷 111-117页

作者：李跃金邹大鹏杨华勇崔小明吴磊李赶先广东工业大学机电工程学院广东广州510006 南方海洋科学与工程广东省实验室(广州) 广东广州511458 中国科学院边缘海与大洋地质重点实验室中国科学院南海海洋研究所广东广州510301

【目的】为研究原位测量装置的测量特性和不同环境下海底沉积物声学特性的变化机制,设计一种海底原位分层声学测量模拟装置。【方法】装置主要由分层运动控制单元、声学测量单元和计算机控制单元三部分组成,通过电动缸对声学测量探杆进... 详细信息

【目的】为研究原位测量装置的测量特性和不同环境下海底沉积物声学特性的变化机制,设计一种海底原位分层声学测量模拟装置。【方法】装置主要由分层运动控制单元、声学测量单元和计算机控制单元三部分组成,通过电动缸对声学测量探杆进行定位运动与连续运动控制,实现对声学测量探杆运动精度分析。通过在水中进行测量标定,获得装置声学测量探杆的校正距离差和扩散衰减系数。通过模拟原位分层声学测量实验,实现不同类型海底沉积物的声学特性测量。【结果与结论】声学测量探杆的校正距离差为77.14 mm,此装置发射声波的平均扩散衰减系数为(34.30±0.46)dB/m。声学测量探杆运动控制精度高,能准确运动到不同层中进行声学特性分层测量,定位测量和连续测量两种测量方式都能获得稳定的实验数据。

关键词：分层测量海底沉积物声学特性系统标定环境影响

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Biomanufacturing in Japan:frontier research from 2018 to 2023

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Bio-Design and Manufacturing 2023年第6期6卷 617-645页

作者： Qing Cao yangqianhui Zhang Runyi Deng Kai Ren huayong yang Dong Han State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310058China School of Mechanical Engineering Zhejiang UniversityHangzhou 310058China

Biomanufacturing(BM)is a multidisciplinary area incorporating the characteristics of living organisms and engineering principles to create valuable products for various sectors,including medicine,energy,and the *** has undergone a remarkable transformation in the last two decades,entering the era of BM4.0 and becoming a pivotal driver of the sustainable ***,Japan has made significant advances in BM,contributing to its development through the creation of innovative materials,advanced processes,and interdisciplinary ***,because of certain development policies,this research has not been widely recognized on an international *** paper provides a comprehensive summary of the research progress made by renowned Japanese laboratories and researchers in biomedical materials,bio-three-dimensional(3D)printing,and biomedical applications in the last five *** unique contributions are introduced and analyzed,illuminating the distinctive approaches and breakthroughs within each ***,this review highlights the current challenges and prospects of *** viewpoints presented in this paper are intended to serve as a valuable reference for scholars studying BM in Japan.

关键词： Biomanufacturing(BM) Japan Biomedical materials Bio-3D printing Biomedical applications

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Self-sensing actuators with programmable actuation performances for soft robots

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Science China(Technological Sciences) 2023年第11期66卷 3070-3079页

作者： JIAO ZhongDong YE ZhiQiu ZHU PingAn TANG Wei yang huayong ZOU Jun State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310058China

Designing soft robots that are able to perceive unstructured,dynamic environments and their deformations has been a long-term *** reported self-sensing soft actuators were mostly constructed via integrating separate actuators and *** actuation performances and the sensing reliability are affected owing to the unmatched materials and weak *** a seamless integration of soft actuators and sensors remains a grand ***,we report a fabrication strategy to endow soft actuators with sensing capability and programmable actuation *** foam inside the actuator functions as actuator and sensor simultaneously,effectively addressing the conformability and connection reliability issues that existed in current self-sensing *** actuators are lightweight(a decrease of 58%in weight),powerful(lifting a load of 433 times of its own weight),and versatile(coupling twisting and contraction motions).Furthermore,the actuators are able to detect multiple physical stimuli with high reliability,demonstrating their exteroception and proprioception *** self-sensing soft robotic prototypes,including a bionic bicep and a bionic neck,are constructed to illustrate their *** study opens up new possibilities for the design of soft actuators and has promising potential in a variety of applications,ranging from human-robot interaction,soft orthotics,to wearable robotics.

关键词： soft robot twisting actuator self-sensing actuator artificial muscle soft actuator soft sensor

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Laser direct writing of Ga_(2)O_(3)/liquid metal-based flexible humidity sensors

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光电进展(英文) 2023年第7期6卷 30-39页

作者： Songya Cui Yuyao Lu Depeng Kong Huayu Luo Liang Peng Geng yang huayong yang Kaichen Xu State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310030China School of Information and Electrical Engineering Hangzhou City UniversityHangzhou 310015China

Flexible and wearable humidity sensors play a vital role in daily point-of-care diagnosis and noncontact human-machine ***,achieving a facile and high-speed fabrication approach to realizing flexible humidity sensors remains a *** this work,a wearable capacitive-type Ga_(2)O_(3)/liquid metal-based humidity sensor is demonstrated by a one-step laser direct writing *** to the photothermal effect of laser,the Ga_(2)O_(3)-wrapped liquid metal particles can be selectively sintered and converted from insulative to conductive traces with a resistivity of 0.19Ω·cm,while the untreated regions serve as active sensing layers in response to moisture *** 95%relative humidity,the humidity sensor displays a highly stable performance along with rapid response and recover *** these superior properties,the Ga_(2)O_(3)/liquid metal-based humidity sensor is able to monitor human respiration rate,as well as skin moisture of the palm under different physiological states for healthcare monitoring.

关键词： laser direct writing liquid metal humidity sensors flexible electronics wearable sensors

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Enhanced mixing efficiency for a novel 3D Tesla micromixer for Newtonian and non-Newtonian fluids

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第12期24卷 1065-1078页

作者： Abdellah AAZMI Zixian GUO Haoran YU Weikang LV Zengchen JI huayong yang Liang MA State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310058China School of Mechanical Engineering Zhejiang UniversityHangzhou 310058China

The fabrication of constructs with gradients for chemical,mechanical,or electrical composition is becoming critical to achieving more complex structures,particularly in 3D printing and *** need is underscored by the complexity of in vivo tissues,which exhibit heterogeneous structures comprised of diverse cells and *** inspiration from the classical Tesla valve,our study introduces a new concept of micromixers to address this *** innovative micromixer design is tailored to enhance the re-creation of in vivo tissue structures and demonstrates an advanced capability to efficiently mix both Newtonian and non-Newtonian ***,our 3D Tesla valve micromixer achieves higher mixing efficiency with fewer cycles,which represents a significant improvement over the traditional mixing *** advance is pivotal for the field of 3D printing and bioprinting,and offers a robust tool that could facilitate the development of gradient hydrogel-based constructs that could also accurately mimic the intricate heterogeneity of natural tissues.

关键词： Micromixing 3D printing Non-Newtonian fluids Computational fluid dynamics

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Phase-transforming mechanical metamaterials with dynamically controllable shape-locking performance

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National Science Review 2023年第9期10卷 270-285页

作者： Yiding Zhong Wei Tang Huxiu Xu Kecheng Qin Dong Yan Xujun Fan yang Qu Zhaoyang Li Zhongdong Jiao huayong yang Jun Zou State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University School of Mechanical Engineering Zhejiang University Institute of Process Equipment College of Energy EngineeringZhejiang University

Active mechanical metamaterials with customizable structures and deformations,active reversible deformation,dynamically controllable shape-lo cking performance and stretchability are highly suitable for applications in soft robotics and flexible electronics,yet it is challenging to integrate them due to their mutual ***,we introduce a class of phase-transforming mechanical metamaterials(PMMs) that integrate the above *** arranging basic actuating units according to the designed pattern configuration and positional relationship,PMMs can customize complex and diverse structures and ***-vapor phase transformation provides active reversible large deformation while a silicone matrix offers *** contained carbonyl iron powder endows PMMs with dynamically controllable shape-lo cking performance,thereby achieving magnetically assisted shape locking and energy storing in different working *** build a theoretical model and finite element simulation to guide the design process of PMMs,so as to develop a variety of PMMs with different functions suitable for different applications,such as a programmed PMM,reconfigurable antenna,soft lens,soft mechanical memory,biomimetic hand,biomime tic flytrap and self-contained soft *** are applicable to achieve various 2D deformations and 2D-to-3D deformations,and integrate multiple properties,including customizable structures and deformations,active reversible deformation,rapid reversible shape locking,adjustable energy storing and stretchability,which could open a new application avenue in soft robotics and flexible ele ctronics.

关键词： active mechanical metamaterials shape locking energy storage liquid–vapor phase transform soft robotics

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Suspension printing of liquid metal in yield-stress fluid for resilient 3D constructs with electromagnetic functions

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npj Flexible Electronics 2022年第1期6卷 507-517页

作者： Qian Wu Fengbo Zhu Ziliang Wu Yu Xie Jin Qian Jun Yin huayong yang The State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310028China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310028China College of Materials Science&Engineering Taiyuan University of TechnologyTaiyuan 030024China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China

Liquid metal is an ideal conductive material for soft electronics because of its high conductivity and fluidity at room ***,the large surface tension and high mass density of liquid metal make forming three-dimensional(3D)dangling structures a challenging *** here is a suspension printing strategy for direct deposition of galinstan-based liquid metal into 3D dangling structures with high shape fidelity and spatial resolution(~150μm).Acrylamide/nanoclay suspension served as a yieldstress fluid support bath,with selected hydrogen peroxide to immediately oxidize the gallium skin and strengthen the extruded liquid metal,thus continuous liquid metal filaments were deposited *** subsequent photo-curing of acrylamide/nanoclay works as a resilient outer packaging,giving rise to a~500%tensile deformation for liquid metal-hydrogel *** suspension printing strategy should broaden the opportunity of using 3D and functional liquid metal constructs for soft yet resilient electromagnetic devices.

关键词： stress deformation liquid

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Engineered Vasculature for Organ-on-a-Chip Systems

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Engineering 2022年第2期8卷 131-147页

作者： Abdellah Aazmi Hongzhao Zhou Yuting Li Mengfei Yu Xiaobin Xu Yutong Wu Liang Ma Bin Zhang huayong yang State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310058China School of Mechanical Engineering Zhejiang UniversityHangzhou 310058China The Affiliated Stomatologic Hospital School of MedicineZhejiang UniversityHangzhou 310003China School of Materials Science and Engineering Tongji UniversityShanghai 201804China

Organ-on-a-chip technology,a promising three-dimensional(3D)dynamic culture method,ensures accu-rate and efficient cell culture and has great potential for replacing animal models in preclinical *** circulatory system,the most abundant organ in the human body,plays a crucial role in oxygen exchange and mass transfer,which is the determining factor for the survival of tissues and ***,it is essential to integrate the circulatory system into an organ-on-a-chip to recreate tissue and organ microenvironments and physiological *** review discusses the synergy between the vasculature and the emerging organ-on-a-chip technology,which offers even better possibilities of dupli-cating physiology and disease *** addition,we review the different steps of a vascularized organ-on-a-chip fabrication process,including structure fabrication and tissue construction using differ-ent biofabrication ***,we outline the applicability of this technology in the fascinating and fast-developing field of organ and tumor culture.

关键词： Organ-on-a-chip Vasculature Bioprinting Tumor-on-a-chip

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