Engineered Vasculature for Organ-on-a-Chip Systems

作     者：Abdellah Aazmi Hongzhao Zhou Yuting Li Mengfei Yu Xiaobin Xu Yutong Wu Liang Ma Bin Zhang Huayong Yang Abdellah Aazmi;Hongzhao Zhou;Yuting Li;Mengfei Yu;Xiaobin Xu;Yutong Wu;Liang Ma;Bin Zhang;Huayong Yang

作者机构：State Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhou 310058China School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China The Affiliated Stomatologic HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China School of Materials Science and EngineeringTongji UniversityShanghai 201804China 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2022年第8卷第2期

页      面：131-147页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 080903[工学-微电子学与固体电子学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：National Key Research and Development Program of China (2018YFA0703000) the National Natural Science Foundation of China (51875518) the Key Research and Development Projects of Zhejiang Province (2017C01054) the Fundamental Research Funds for the Central Universities(2020QNA4001 and 2019XZZX003-02) for their support 

主　　题：Organ-on-a-chip Vasculature Bioprinting Tumor-on-a-chip 

摘      要：Organ-on-a-chip technology,a promising three-dimensional(3D)dynamic culture method,ensures accu-rate and efficient cell culture and has great potential for replacing animal models in preclinical *** circulatory system,the most abundant organ in the human body,plays a crucial role in oxygen exchange and mass transfer,which is the determining factor for the survival of tissues and ***,it is essential to integrate the circulatory system into an organ-on-a-chip to recreate tissue and organ microenvironments and physiological *** review discusses the synergy between the vasculature and the emerging organ-on-a-chip technology,which offers even better possibilities of dupli-cating physiology and disease *** addition,we review the different steps of a vascularized organ-on-a-chip fabrication process,including structure fabrication and tissue construction using differ-ent biofabrication ***,we outline the applicability of this technology in the fascinating and fast-developing field of organ and tumor culture.