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ThyroidNet:A Deep Learning Network for Localization and Classification of Thyroid Nodules

Computer Modeling in Engineering & Sciences 2024年第4期139卷 361-382页

作者： Lu chen huaqiang chen Zhikai Pan Sheng Xu Guangsheng Lai Shuwen chen Shuihua Wang Xiaodong Gu Yudong Zhang Ultrasonic Department Zhongda Hospital Affiliated to Southeast UniversityNanjing210009China School of Physics and Information Engineering Jiangsu Second Normal UniversityNanjing211200China School of Computing and Mathematical Sciences University of LeicesterLeicesterLE17RHUK Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia State Key Laboratory of MillimeterWaves Southeast UniversityNanjing210096China Jiangsu Province Engineering Research Center of Basic Education Big Data Application Jiangsu Second Normal UniversityNanjing211200China School of Software Engineering Quanzhou Normal UniversityQuanzhou362000China Department of Biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou215123China

Aim:This study aims to establish an artificial intelligence model,ThyroidNet,to diagnose thyroid nodules using deep learning techniques ***:A novel method,ThyroidNet,is introduced and evaluated based on deep learning for the localization and classification of thyroid ***,we propose the multitask TransUnet,which combines the TransUnet encoder and decoder with multitask ***,we propose the DualLoss function,tailored to the thyroid nodule localization and classification *** balances the learning of the localization and classification tasks to help improve the model’s generalization ***,we introduce strategies for augmenting the ***,we submit a novel deep learning model,ThyroidNet,to accurately detect thyroid ***:ThyroidNet was evaluated on private datasets and was comparable to other existing methods,including U-Net and *** results show that ThyroidNet outperformed these methods in localizing and classifying thyroid *** achieved improved accuracy of 3.9%and 1.5%,***:ThyroidNet significantly improves the clinical diagnosis of thyroid nodules and supports medical image analysis *** research directions include optimization of the model structure,expansion of the dataset size,reduction of computational complexity and memory requirements,and exploration of additional applications of ThyroidNet in medical image analysis.

关键词： ThyroidNet deep learning TransUnet multitask learning medical image analysis

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某老旧通信机房节能改造

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通信与信息技术 2024年第2期 71-73页

作者：陈华强中通服咨询设计研究院有限公司江苏南京210019

针对某高耗能老旧机房,通过实地摸排和问题诊断,找出耗能主因。采用定制化方案,从重整机房空间布局,优化气流组织,升级空调设备等方面进行升级改造,实现机房节能。改造完成后机房PUE可降低至1.5以下,并消除了热点隐患,提升了利用率。

关键词：老旧机房节能改造定制化方案 PUE

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PEG-rhG-CSF预防小细胞肺癌化疗后中性粒细胞减少症的效果分析

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中国医学创新 2024年第23期21卷 15-18页

作者：刘社清宋现书陈华强北京市朝阳区桓兴肿瘤医院综合三科北京100040

目的:探讨聚乙二醇化重组人粒细胞刺激因子(PEG-rhG-CSF)预防小细胞肺癌化疗后中性粒细胞减少症的效果。方法:选取2020年1月—2023年3月北京市朝阳区桓兴肿瘤医院收治的小细胞肺癌化疗患者200例,按照信封法分为两组。对照组(n=98)化疗... 详细信息

目的:探讨聚乙二醇化重组人粒细胞刺激因子(PEG-rhG-CSF)预防小细胞肺癌化疗后中性粒细胞减少症的效果。方法:选取2020年1月—2023年3月北京市朝阳区桓兴肿瘤医院收治的小细胞肺癌化疗患者200例,按照信封法分为两组。对照组(n=98)化疗后应用重组人粒细胞刺激因子(rhGCSF),观察组(n=102)化疗后应用PEG-rhG-CSF。比较两组中性粒细胞减少症发生率、免疫功能、血清肿瘤标志物水平及不良反应发生情况。结果:观察组中性粒细胞减少症发生率低于对照组,差异有统计学意义(P0.05)。结论:小细胞肺癌化疗后应用PEG-rhG-CSF能有效预防中性粒细胞减少症的发生,改善机体免疫功能,抑制血清肿瘤标志物水平,且安全性良好。

关键词：小细胞肺癌化疗聚乙二醇化重组人粒细胞刺激因子中性粒细胞减少症

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Tuning the release rate of volatile molecules by pore surface engineering in metal-organic frameworks

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Chinese Chemical Letters 2021年第6期32卷 1988-1992页

作者： Hongwen chen huaqiang chen Bo Zhang Liming Jiang Youqing Shen Engang Fu Dan Zhao Zhuxian Zhou Key Laboratory of Biomass Chemical Engineering of Ministry of Education and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Chemical&Biomolecular Engineering National University of SingaporeSingapore 117585Singapore

Encapsulation and controlled release of volatile molecules such as fragrances in a designed manner is important but challenging for the flavor and fragrance ***,we report the tuning release of volatile molecules by postsynthetic modification of an amine-terminated metal-organic framework(MOF)MIL-101-NH_(2).By amidation,we obtained three MIL-101 MOFs,the trimethylacetamideterminated TC-MIL-101,the benzamide-terminated BC-MIL-101,and the oxalic acid monoamideterminated *** the MOFs can efficiently encapsulate volatile ***,we demonstrate that the release profile of volatiles can be widely tuned to sustain the release in several days to months and even over a year using different modified MIL-101 *** show that the release profiles are correlated with the binding energies between the guest volatiles and pores in *** pore diffusion and the synergistic transport are the rate-limiting step of the guest molecules from the modified MOFs.

关键词： Metal-organic frameworks(MOFs) Postsynthetic modification Encapsulation and sustained-release Fragrances Host-guest interaction

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慢就业现象下高校就业教育路径调整研究

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晋城职业技术学院学报 2024年第1期17卷 81-85页

作者：欧阳超群陈华强林楚宸李光明泉州医学高等专科学校福建泉州362000 闽南师范大学福建漳州363000 仰恩大学福建泉州362000 香港中文大学(深圳) 深圳518172 福建理工大学福州350000

当下,高校毕业生慢就业现象特别突出。高校就业教育工作要根据当前国内和国际形势的新变化、思想政治教育环境的新特点,以进一步强化爱国主义教育为工作主线,以全方位调动思政教育资源为有效手段,以提高学生责任和担当意识为重要内容,... 详细信息

当下,高校毕业生慢就业现象特别突出。高校就业教育工作要根据当前国内和国际形势的新变化、思想政治教育环境的新特点,以进一步强化爱国主义教育为工作主线,以全方位调动思政教育资源为有效手段,以提高学生责任和担当意识为重要内容,提升高校就业教育的生动性、实效性和针对性,履行好高校为党育人、为国育才的重要使命。

关键词：慢就业现象高校就业教育路径调整

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Heme oxygenase 1 linked to inactivation of subchondral osteoclasts in osteoarthritis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 513-528页

作者： Miao CHU Guangdong chen Kai chen Pengfei ZHU Zhen WANG Zhonglai QIAN huaqiang TAO Yaozeng XU Dechun GENG Department of Orthopedics the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Orthopedics Yixing People’s HospitalYixing 214200China Department of Orthopedics Hai’an People’s HospitalHai’an 226600China Department of Orthopedics Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedicineSuzhou 215028China

Osteoarthritis(OA)is a chronic progressive osteoarthropathy in the *** activation plays a crucial role in the occurrence of subchondral bone loss in early ***,the specific mechanism of osteoclast differentiation in OA remains *** our study,gene expression profiles related to OA disease progression and osteoclast activation were screened from the Gene Expression Omnibus(GEO)***2R and Funrich analysis tools were employed to find differentially expressed genes(DEGs).Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses demonstrated that chemical carcinogenesis,reactive oxygen species(ROS),and response to oxidative stress were mainly involved in osteoclast differentiation in OA subchondral ***,fourteen DEGs that are associated with oxidative stress were *** first ranked differential gene,heme oxygenase 1(HMOX1),was selected for further *** results showed that osteoclast activation in the pathogenesis of OA subchondral bone is accompanied by the downregulation of *** was revealed to inhibit osteoclastogenesis by targeting HMOX1 and upregulating the expression of antioxidant protein in ***,carnosol was found to alleviate the severity of OA by inhibiting the activation of subchondral osteoclasts in *** research indicated that the activation of osteoclasts due to subchondral bone redox dysplasia may serve as a significant pathway for the advancement of *** HMOX1 in subchondral osteoclasts may offer novel insights for the treatment of early OA.

关键词： Osteoclast Oxidative stress Osteoarthritis(OA) Heme oxygenase 1(HMOX1) Carnosol

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Metal ion metabolism and osteoporosis:possible implications for pharmaceutical biotechnology and tissue engineering

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Science China(Life Sciences) 2024年第8期67卷 1763-1765页

作者： huaqiang Tao Qiufei Wang Kai chen Pengfei Zhu Ye Gu Dechun Geng Department of Orthopedics The First Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Orthopedics Changshu Hospital Affiliated to Soochow UniversityFirst People’s Hospital of Changshu CityChangshu 215506China Department of Orthopedics Hai’an People’s HospitalHai’an 226600China

Osteoporosis(OP)is a systemic metabolic bone disease characterized by low bone mass,damage to bone microstructure and increased bone *** imbalance of functional coupling between osteoblasts and osteoclasts contributes to the pathological progression of the disease(Rachner et al.,2011).The pathogenesis of OP is precisely controlled by the complex regulatory network of the bone *** elements,although present in small amounts in the body,are essential for their influence on the physiological activities of *** ions act as effective catalysts and have applications in all stages of cell biochemical evolution(Qian et al.,2021).Bone tissue contains various metal elements,and metal ions play indispensable roles in bone metabolism at the molecular and cellular levels(Luo et al.,2023).However,it is important to note that these metal ions can also contribute to the progression of OP by influencing multiple cellular pathways either directly or indirectly.

关键词： metabolism biotechnology indispensable

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无造孔剂模压烧结制备多孔Cu_(60)Zn_(40)合金的工艺及组织调控

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材料研究与应用 2024年第2期18卷 280-286页

作者：骆仁智王吉应苏利川叶墨稼陈华强沈伟吴彩霞浙江省冶金研究院有限公司浙江杭州310011

金属多孔材料在制备过程中通常需要掺杂造孔剂以调控孔隙结构,但去除造孔剂需要较长时间,且残留造孔剂会对母材造成污染或腐蚀。以水雾化Cu_(60)Zn_(40)合金粉末为原材料,在未掺杂造孔剂条件下,采用单轴限位模压和烧结工艺制备了多孔Cu_... 详细信息

金属多孔材料在制备过程中通常需要掺杂造孔剂以调控孔隙结构,但去除造孔剂需要较长时间,且残留造孔剂会对母材造成污染或腐蚀。以水雾化Cu_(60)Zn_(40)合金粉末为原材料,在未掺杂造孔剂条件下,采用单轴限位模压和烧结工艺制备了多孔Cu_(60)Zn_(40)合金,深入研究了高度压缩比和烧结时间对其孔隙结构的影响。研究结果表明,在未掺杂造孔剂的情况下,粉末冶金制备的多孔Cu_(60)Zn_(40)合金的孔隙结构主要受压制条件和烧结工艺控制。随着压坯高度压缩比从1.6增加至2.0,多孔Cu_(60)Zn_(40)合金的孔隙率降低了48.15%,同时最大孔径、平均孔径和最小孔径分别减小了45.51%、46.72%和66.43%。尽管孔隙形貌未发生明显变化,但该调控方式有效改变了合金的孔隙尺寸。随着烧结时间延长,多孔Cu_(60)Zn_(40)合金的孔隙形状明显趋于球形化,而孔隙率和孔隙尺寸变化幅度较小。因此,采用模压烧结法制备的多孔Cu_(60)Zn_(40)合金,可通过调整高度压缩比灵活调控开孔隙率和孔隙尺寸,可通过调控烧结时间优化孔隙形貌。此外,在多孔Cu_(60)Zn_(40)合金的烧结过程中,锌的挥发量与高度压缩比成反比,与烧结时间成正比。本研究为无掺杂造孔剂调控金属多孔材料孔隙结构提供了可靠的理论和技术支持,对粉末冶金制备金属多孔材料具有重要理论和实际意义。

关键词：模压成型多孔材料 Cu_(60)Zn_(40) 高度压缩比烧结时间孔隙结构粉末冶金烧结造孔剂锌挥发

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Modification of short-range repulsive interactions in ReaxFF reactive force field for Fe–Ni–Al alloy

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Chinese Physics B 2021年第8期30卷 113-119页

作者： huaqiang chen Lin Lang Shuaiyu Yi Jinlong Du Guangdong Liu Lixia Liu Yufei Wang Yuehui Wang Huiqiu Deng Engang Fu State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Department of Applied Physics School of Physics and ElectronicsHunan UniversityChangsha 410082China Department of Chemistry and Biology University of Electronic Science and Technology of China Zhongshan InstituteZhongshan 528402China

The short-range repulsive interactions of any force field must be modified to be applicable for high energy atomic collisions because of extremely far from equilibrium state when used in molecular dynamics(MD)*** this work,the short-range repulsive interaction of a reactive force field(ReaxFF),describing Fe-Ni-Al alloy system,is well modified by adding a tabulated function form based on Ziegler-Biersack-Littmark(ZBL)*** modified interaction covers three ranges,including short range,smooth range,and primordial *** short range is totally predominated by ZBL *** primordial range means the interactions in this range is the as-is ReaxFF with no *** smooth range links the short-range ZBL and primordial-range ReaxFF potentials with a taper *** energies and forces are guaranteed to be continuous,and qualified to the consistent requirement in *** modified force field is applicable for simulations of energetic particle bombardments and reproducing point defects'booming and recombination effectively.

关键词： molecular dynamics force field modification Fe–Ni–Al alloy irradiation

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构建澳门特别行政区新宪制秩序——以宪法之花的丰硕成果为视角

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行政管理改革 2019年第10期10卷 11-16页

作者：陈华强澳门特别行政区立法会澳门法制研究会

澳门特别行政区在回归祖国20年来,充分演绎宪法与基本法的“母子”关系,让宪法的精神和基本原则在澳门开花结果。在“一国两制”方针下,通过“高度自治”、“澳人治澳”等先行先试政策,宪法结出丰硕成果。实践证明,澳门回归后的管治模... 详细信息

澳门特别行政区在回归祖国20年来,充分演绎宪法与基本法的“母子”关系,让宪法的精神和基本原则在澳门开花结果。在“一国两制”方针下,通过“高度自治”、“澳人治澳”等先行先试政策,宪法结出丰硕成果。实践证明,澳门回归后的管治模式是改革开放精神的成功案例,也是实现国家统一、人民幸福和民族复兴的正确路径。

关键词：澳门回归20年宪法澳门基本法宪制秩序

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