检索结果-南通市图书馆

Inefficiency of C3H/HeN Mice to Control Chlamydial Lung Infection Correlates with Downregulation of Neutrophil Activation during the Late Stage of Infection

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2009年第4期6卷 253-260页

作者： Xiaofei Tang Xiaokun Bu Naihong Zhang Xiaoxia Li huanjun huang Hong Bai Xi Yang Department of Immunology Tianjin Medical University Tianjin Key Laboratory of Cellular and Molecular Immunology Key Laboratory of Educational Ministry of China Tianjin China Laboratory fur Infection and Immunity Departments of Medical Microbiology and Immunology Faculty of Medicine University of Manitoba Winnipeg Manitoba Canada These authors contributed equally to this work Department of Immunology Tianjin Medical University 22 Qixiangtai Road Heping Distinct Tianjin 300070 China

We previously reported that massive infiltration of neutrophils in C3H/HeN （C3H） mice could not efficiently control Chlamydia muridarum （Cm） infection and might contribute to the high susceptibility of these mice to lung infection. To further define the nature of neutrophil responses in C3H mice during chlamydial infection, we examine the expression of adhesion molecules and CDllb related to neutrophils infiltration and activation, respectively, following intranasal Cm infection. The results showed that the expression of selectins （E-selectin, P-selectin and L-selectin）, and intercellular cell adhesion molecule-1 （ICAM-1） in the lung of C3H mice increased more significantly than in C57BL/6 （B6） mice, the more resistant strain. These results correlated well with the massive neutrophils infiltration in C3H mice. In contrast, CDllb expression on peripheral blood and lung neutrophils in C3H mice exhibited a significant reduction compared with B6 mice during the late phage of infection （day 14）. These findings suggest that the high-level expression of adhesion molecules in C3H mice may enhance neutrophils recruitment to the lung, but the decline of CDllb expression on neutrophils may attenuate neutrophil function. Therefore, CDllb down-regulation on neutrophils may contribute to the failure of C3H mice to control chlamydial lung infection.

关键词： Chlamydia trachomatis neutrophils selectins ICAM-1 CD11b

Type 1 T-cell responses in chlamydial lung infections are associated with local MIP-1a response

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2010年第5期7卷 355-360页

作者： Naihong Zhang Zhaoe Wang Xiaofei Tang Haiping Wang Hongzhao Li huanjun huang Hong Bai Xi Yang Department of Immunology Tianjin Medical UniversityTianjin Key Laboratory of Cellular and Molecular ImmunologyKey Laboratory of Educational Ministry of ChinaTianjinChina Laboratory for Infection and Immunity Departments of Medical Microbiology and ImmunologyFaculty of MedicineUniversity of ManitobaWinnipegManitobaCanada

Chemokines and their receptors are important mediators of leukocyte trafficking and recruitment and sometimes work as modulators of T-cell responses during infections and *** the biological activity of chemokines has been found to influence the course of ***,little is known about the role of chemokine responses during chlamydial lung *** therefore analyzed the dynamics of multiple chemokines,which are frequently associated with type 1(Th1)T cell immune responses,and their receptors for their expression in the lungs during Chlamydia muridarum(Cm)*** also examined the relationship between chemokine responses and the development of Th1 responses as well as the clearance of *** results showed that in parallel with the high levels of gamma interferon(IFN-c)and IL-12 production in the lungs and draining lymph nodes,and the expansion of IFN-c-producing CD4 and CD81 T cells,the production of the cell-related chemokines RANTES,IFN-c-inducible protein-10(IP-10)and macrophage inflammatory protein-1a(MIP-1a)and their receptor CCR1 was elevated in the lung tissues after ***,in a later phase of infection,the expression of RANTES and IP-10 remained elevated but the expression of MIP-1a and CCR1 decreased to a low level,which suggests a closer association with the pattern of Th1 cytokine responses in the process of *** results suggest a close association between the MIP-1a response and the Th1-type T-cell responses in chlamydial lung infections .

关键词： Chlamydial pneumonia MIP-1a RANTES Th1 response

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

关于青年运动的若干认识问题

中国青年研究 2006年第3期 84-87页

作者：黄华君广州中医药大学学生处

无产阶级政党历来重视青年的教育，重视青年组织和青年的训练，并把青年和青年运动视作革命事业必不可少的有生力量。列宁认为，革命力量的壮大，“必须更广泛和更大胆地、再更广泛和再更大胆地把青年组织起来，不要对青年存戒心”。指... 详细信息

无产阶级政党历来重视青年的教育，重视青年组织和青年的训练，并把青年和青年运动视作革命事业必不可少的有生力量。列宁认为，革命力量的壮大，“必须更广泛和更大胆地、再更广泛和再更大胆地把青年组织起来，不要对青年存戒心”。指出必须“用接收青年的办法”，把革命力量成倍地扩大，使无产阶级政党永远成为“先进阶级的青年的党”，并且明确提出“青年团和所有想走向共产主义的一般青年都应该学习共产主义”。

关键词：青年运动认识问题无产阶级政党革命力量青年组织共产主义革命事业先进阶级青年团

AEG1 induces COX-2 expression via activation of NF-κB and AP-1 in hepatoma HepG2 cells

在线全文

学校读者我要写书评

暂无评论

The Chinese-German Journal of Clinical Oncology 2013年第6期12卷 253-256页

作者： Huan Deng Zhenzhen Zhou Wei Tu Yujia Xia huanjun huang De'an Tian Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

Objective： The aim of this study was to investigate whether astrecyte elevated gene 1 （AEG1） regulates COX-2 expression in human hepatoma HepG2 cells and related pathways involved in this process. Methods： Human hepatoma HepG2 cells were transfected with pcDNA3.1（-）-AEG1 plasmid or psilencer2.0-AEGl-shRNA1 plasmid to up/down-regulate AEG1 expression, pcDNA3.1（-） and psilencer 2.0 empty vector plasmids were transfected respectively as control. Real-time RT-PCR was carried out to measure the expression levels of AEG1 and COX-2 mRNA. The expression levels of AEG1 and COX-2 protein were detected by Western blot. NF-KB signaling was blocked by PDTC, and AP-1 signaling was blocked by curcumin. Results： AEG1 mRNA and protein levels were increased after pcDNA3.1（-）-AEG1 transfection, and decreased after psilencer2.0-AEGl-shRNAs transfection. COX-2 mRNA and protein levels were increased in AEGl-overexpressing cells and decreased in AEGl-knockdown cells. Phosphorylations of p65 and c-jun were up-regulated in AEGl-overexpressing cells. Both PDTC and curoumin reduced COX-2 expression in HepG2 cells with AEG1 overexpression. Conclusion： AEG1- overexpressing and -knockdown HepG2 cells are established successfully. AEG1 could induce COX-2 expression though activating NF-KB and AP-1 in human hepatoma HepG2 cells.

关键词： hepatocellular carcinoma astrocyte elevated gene 1(AEG1) COX-2 NF-κB AP-1

Stretchable,Transparent,and Ultra-Broadband Terahertz Shielding Thin Films Based on Wrinkled MXene Architectures

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第9期16卷 110-122页

作者： Shaodian Yang Zhiqiang Lin Ximiao Wang Junhua huang Rongliang Yang Zibo Chen Yi Jia Zhiping Zeng Zhaolong Cao Hongjia Zhu Yougen Hu Enen Li huanjun Chen Tianwu Wang Shaozhi Deng Xuchun Gui State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China National Key Laboratory of Materials for Integrated Circuits Shenzhen Institute of Advanced Electronic MaterialsShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Guangdong Province Key Laboratory of Display Material and Technology Guangzhou 510275People’s Republic of China China Academy of Aerospace Science and Innovation Beijing 100176People’s Republic of China School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China GBA Branch of Aerospace Information Research Institute Chinese Academy of SciencesGuangzhou 510700People’s Republic of China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049People’s Republic of China Guangdong Provincial Key Laboratory of Terahertz Quantum Electromagnetics Guangzhou 510700People’s Republic of China

With the increasing demand for terahertz(THz)technology in security inspection,medical imaging,and flexible electronics,there is a significant need for stretchable and transparent THz electromagnetic interference(EMI)shielding *** EMI shielding materials,like opaque metals and carbon-based films,face challenges in achieving both high transparency and high shielding efficiency(SE).Here,a wrinkled structure strategy was proposed to construct ultra-thin,stretchable,and transparent terahertz shielding MXene films,which possesses both isotropous wrinkles(height about 50 nm)and periodic wrinkles(height about 500 nm).Compared to flat film,the wrinkled MXene film(8 nm)demonstrates a remarkable 36.5%increase in SE within the THz *** wrinkled MXene film exhibits an EMI SE of 21.1 dB at the thickness of 100 nm,and an average EMI SE/t of 700 dBμm^(−1)over the 0.1-10 *** calculations suggest that the wrinkled structure enhances the film’s conductivity and surface plasmon resonances,resulting in an improved THz wave ***,the wrinkled structure enhances the MXene films’stretchability and *** bending and stretching(at 30%strain)cycles,the average THz transmittance of the wrinkled film is only 0.5%and 2.4%,*** outstanding performances of the wrinkled MXene film make it a promising THz electromagnetic shielding materials for future smart windows and wearable electronics.

关键词： Terahertz Wrinkle structure Electromagnetic interference shielding MXene

在线全文

学校读者我要写书评

暂无评论

基于分数阶微积分的汽车空气悬架半主动控制

农业机械学报 2014年第7期45卷 19-25页

作者：吴光强黄焕军叶光湖同济大学汽车学院上海201804 东京大学生产技术研究所

为研究分数阶微积分在汽车空气悬架半主动控制中的应用效果,建立了4自由度半主动空气悬架非线性动力学模型。采用改进的Oustaloup滤波器算法来模拟分数阶微积分,进而建立分数阶天棚阻尼半主动悬架的仿真模型,将仿真结果与被动悬架和整... 详细信息

为研究分数阶微积分在汽车空气悬架半主动控制中的应用效果,建立了4自由度半主动空气悬架非线性动力学模型。采用改进的Oustaloup滤波器算法来模拟分数阶微积分,进而建立分数阶天棚阻尼半主动悬架的仿真模型,将仿真结果与被动悬架和整数阶天棚阻尼半主动悬架进行对比分析。分析结果表明:当汽车以20 m/s的速度行驶在B级路面时,与被动悬架相比,整数阶和分数阶天棚阻尼半主动悬架的车身垂向加权加速度均方根值分别减小了31.9%和43.9%,车身俯仰角加速度均方根值分别减小了23.1%和30.7%;基于分数阶微积分的天棚阻尼控制策略能更有效地抑制车身共振,改善乘坐舒适性。

关键词：车辆空气悬架分数阶微积分天棚阻尼控制平顺性

在线全文

学校读者我要写书评

暂无评论

基于组合代理模型的车身多学科设计优化

汽车工程 2016年第9期38卷 1107-1113页

作者：黄焕军张博文吴光强李凡同济大学汽车学院上海201804 东京大学生产技术研究所

本文对比分析了4种单一代理模型和两种组合代理模型的预测能力,并基于各代理模型进行正面碰撞安全性多目标优化,结果发现,组合代理模型不仅具有较好的预测精度和稳健性,还能促进最优解的搜索。基于上述分析,采用组合代理模型拟合正面碰... 详细信息

本文对比分析了4种单一代理模型和两种组合代理模型的预测能力,并基于各代理模型进行正面碰撞安全性多目标优化,结果发现,组合代理模型不仅具有较好的预测精度和稳健性,还能促进最优解的搜索。基于上述分析,采用组合代理模型拟合正面碰撞、侧面碰撞和白车身模态分析的各种响应,建立针对安全性的车身结构多学科优化模型,并用协同优化方法求解。结果表明:组合代理模型在多目标优化中有利于得到更满意的最优解;基于组合代理模型的车身结构多学科设计优化有效改善了汽车的碰撞安全性,并兼顾了轻量化和NVH性能。

关键词：车身组合代理模型碰撞安全性多学科优化协同优化

在线全文

学校读者我要写书评

暂无评论

深基坑支护与土方开挖现场管理研究

新技术新工艺 2017年第8期 44-47页

作者：黄欢君宁波建工工程集团有限公司浙江宁波315000

项目施工现场三合土厚土平均仅2.8m,其下有平均0.81m厚的粉质黏土,粉质黏土是该项目的含水层;而施工现场下部的淤泥质粉质黏土是粉质黏土长期沉积的结果,其黏性较大,流动性强于粉质黏土,也是施工中的重大安全隐患。施工过程中充分体现... 详细信息

项目施工现场三合土厚土平均仅2.8m,其下有平均0.81m厚的粉质黏土,粉质黏土是该项目的含水层;而施工现场下部的淤泥质粉质黏土是粉质黏土长期沉积的结果,其黏性较大,流动性强于粉质黏土,也是施工中的重大安全隐患。施工过程中充分体现了精益化管理带来的效益,工程质量全部达标,工期比预期缩短了12%,工程成本控制完全符合甲方的要求。

关键词：基地工程深基坑支护土方

15例腹腔炎性肌纤维母细胞瘤的临床病理分析

在线全文

学校读者我要写书评

暂无评论

华中科技大学学报（医学版） 2012年第2期41卷 221-225页

作者：喻研程斌黄焕军华中科技大学同济医学院附属同济医院消化内科武汉430030

目的报道和总结腹腔炎性肌纤维母细胞瘤的临床特点,以提高医生对该病的诊疗水平。方法收集15例患者的临床资料,分析和总结其主要的临床病理特点。结果本组病例包括男性8例,女性7例,发病年龄为4～63岁。发生部位包括肝脏(5例)、膀胱(3例... 详细信息

目的报道和总结腹腔炎性肌纤维母细胞瘤的临床特点,以提高医生对该病的诊疗水平。方法收集15例患者的临床资料,分析和总结其主要的临床病理特点。结果本组病例包括男性8例,女性7例,发病年龄为4～63岁。发生部位包括肝脏(5例)、膀胱(3例)、肠系膜(2例)、胃(1例)、脾(1例)、直肠(1例)、肾上腺(1例)、腹膜腔(1例)。多部位受累者2例。临床症状包括发热、乏力、纳差、肿块局部疼痛等。常伴有贫血,纤维蛋白原增高。病理学检查可见胶原性基质中呈束状排列的梭形细胞伴淋巴细胞、浆细胞等炎性细胞浸润。免疫组化显示梭形细胞表达波形蛋白Vim(15/15)、平滑肌肌动蛋白SMA(15/15)和肌特异性蛋白MSA(15/15),部分表达ALK(6/15)、Calponin(6/15)、Desmin(5/15)、CK(4/15)。13例行肿瘤完整切除,1例行肿瘤部分切除,1例仅行活检。随访11～65个月,13例术后无瘤生存。结论腹腔炎性肌纤维母细胞瘤是一种罕见的间叶源性肿瘤。累及部位不同导致临床表现多种多样。诊断主要依靠病理学检查和免疫组化检测。手术完整切除是大多数患者的有效治疗方法。

关键词：炎性肌纤维母细胞瘤临床病理