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精密薄壁轴套柔性检验方法及工序能力评价

现代制造工程 2025年第1期 94-102页

作者：李厚佳许耀东张梦梦朱欢欢上海工程技术大学制造工程系上海200437 上海市高级技工学校制造工程系上海200437

航空航天零件要求精度高,合格率要达到100%,常采用三坐标测量来提高测量精度,减少人员测量带来的误差。精密薄壁轴套零件作为连接元件在工作中起到轴向定位和径向紧固的作用,对机械传动起着重要的作用。为保证零件的测量精度和合格率,... 详细信息

航空航天零件要求精度高,合格率要达到100%,常采用三坐标测量来提高测量精度,减少人员测量带来的误差。精密薄壁轴套零件作为连接元件在工作中起到轴向定位和径向紧固的作用,对机械传动起着重要的作用。为保证零件的测量精度和合格率,需要将测量产生的工艺误差控制在零件公差的1/3以内,工艺误差包含定位误差、夹紧变形误差等。试验利用光固化柔性夹具对轴套进行夹紧,减少金属夹具对轴套产生的变形和损伤,消除夹紧变形误差。利用对同一个轴套零件进行重复测量,获得定位误差引起的标准不确定度,并结合工序能力计算,来判定测量方法的可行性。

关键词：柔性夹具三坐标测量垂直度不确定度概率工序能力

Transcriptome-wide association studies: a view from Mendelian randomization

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Quantitative Biology 2021年第2期9卷 107-121页

作者： huanhuan zhu Xiang Zhou Department of Biostatistics University of MichiganAnn ArborMl 48109USA Center for Statistical Genetics University of MichiganAnn ArborMl 48109USA

Background:Genome-wide association studies(GWASs)have identified thousands of genetic variants that are associated with many complex ***,their biological mechanisms remain largely ***-wide association studies(TWAS)have been recently proposed as an invaluable tool for investigating the potential gene regulatory mechanisms underlying variant-trait ***,TWAS integrate GWAS with expression mapping studies based on a common set of variants and aim to identify genes whose GReX is associated with the *** methods have been developed for performing TWAS and/or similar integrative *** such method has a different modeling assumption and many were initially developed to answer different biological ***,it is not straightforward to understand their modeling property from a theoretical ***:We present a technical review on thirteen TWAS ***,we show that these methods can all be viewed as two-sample Mendelian randomization(MR)analysis,which has been widely applied in GWASs for examining the causal effects of exposure on *** different TWAS methods from an MR perspective provides us a unique angle for understanding their benefits and *** systematically introduce the MR analysis framework,explain how features of the GWAS and expression data influence the adaptation of MR for TWAS,and re-interpret the modeling assumptions made in different TWAS methods from an MR *** finally describe future directions for TWAS methodology ***:We hope that this review would serve as a useful reference for both methodologists who develop TWAS methods and practitioners who perform TWAS analysis.

关键词： transcriptome-wide association studies genome-wide association studies expression mapping studies

消肿止痛方坐浴后外用痔科生肌散在混合痔术后患者中的临床效果

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广西医学 2025年第1期47卷 66-71页

作者：朱欢欢颜蕾冯泽宇无锡市中医医院肛肠科江苏省无锡市214000

目的探讨消肿止痛方坐浴后外用痔科生肌散在混合痔术后患者中的临床效果。方法选取82例混合痔术后患者作为研究对象,按照随机数字表法将其分为对照组和研究组,各41例。对照组采用消肿止痛方坐浴治疗,研究组采用消肿止痛方坐浴后外用痔... 详细信息

目的探讨消肿止痛方坐浴后外用痔科生肌散在混合痔术后患者中的临床效果。方法选取82例混合痔术后患者作为研究对象,按照随机数字表法将其分为对照组和研究组,各41例。对照组采用消肿止痛方坐浴治疗,研究组采用消肿止痛方坐浴后外用痔科生肌散治疗。比较两组患者的临床疗效,术后恢复情况(肛周疼痛缓解时间、肛缘水肿缓解时间、创面愈合时间),治疗前、治疗2周后的中医证候积分、肛周疼痛视觉模拟量表(VAS)评分及肛缘水肿评分,治疗前、治疗1个月后的肛门功能(肛门感觉、控大便、肛门闭合、肛管最大收缩压、肛管静息压及肛管高压带长度),以及并发症发生情况。结果研究组的总有效率高于对照组,肛周疼痛缓解时间、肛缘水肿缓解时间及创面愈合时间短于对照组(P<0.05)。治疗2周后,两组患者的中医证候积分、肛周疼痛VAS评分及肛缘水肿评分低于治疗前,且研究组的上述指标低于对照组(P<0.05)。治疗1个月后,两组患者的肛门感觉评分、控大便评分、肛门闭合评分、肛管高压带长度低于或短于治疗前,肛管最大收缩压、肛管静息压高于治疗前,且研究组的上述指标改善程度优于对照组(P<0.05)。研究组的并发症总发生率低于对照组(P<0.05)。结论消肿止痛方坐浴后外用痔科生肌散可减轻混合痔术后患者肛周疼痛及肛缘水肿症状,减少并发症的发生,提高治疗效果,促进肛门功能的恢复。

关键词：混合痔痔科生肌散外用消肿止痛方坐浴术后效果

Circulating tumor cells: Biological features and survival mechanisms

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BIOCELL 2023年第8期47卷 1771-1781页

作者： XIAOFENG LI JINYANG ZHENG JINFENG zhu XIN HUANG huanhuan zhu BINGDI CHEN Department of Oncology Affiliated Quanzhou First Hospital of Fujian Medical UniversityQuanzhouChina Department of Pathology Affiliated Quanzhou First Hospital of Fujian Medical UniversityQuanzhouChina Department of Medical Oncology Affiliated Quanzhou First Hospital of Fujian Medical UniversityQuanzhouChina Department of Dermatology School of MedicineTongji HospitalTongji UniversityShanghaiChina Department of Central Laboratory Shanghai Tenth People’s HospitalShanghaiChina Shanghai East Hospital The Institute for Biomedical Engineering&Nano ScienceTongji University School of MedicineShanghaiChina

Circulating tumor cells(CTCs)are neoplastic cells that are detached from primary tumors and enter *** and characterization of CTCs are of significance in cancer diagnosis,prognosis,and treatment *** survival in the bloodstream is a limiting step for the development of metastases in distant *** technological advances,especially in single-cell molecular analyses have uncovered heterogeneous CTC survival *** epithelial-to-mesenchymal transition(EMT),increasing stem cell-like properties,and forming cell clusters enable CTCs to adapt to the harsh microenvironment of the *** and releasing several immunosuppressive molecules help CTCs escape from anti-cancer immune *** review article summarizes the biological characteristics of CTCs and focuses on the recent understanding of the mechanisms by which CTCs survive in ***,the clinical and therapeutic implications of CTCs are discussed.

关键词： Anoikis Circulating tumor cells Heterogeneity Immune evasion Plasticity

Does CMIP6 Inspire More Confidence in Simulating Climate Extremes over China?

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Advances in Atmospheric Sciences 2020年第10期37卷 1119-1132页

作者： huanhuan zhu Zhihong JIANG Juan LI Wei LI Cenxiao SUN and Laurent LI Joint International Research Laboratory of Climate and Environment Change Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisasterNanjing University of Information Science and TechnologyNanjing 210044China Key Laboratory of Meteorological Disaster of Ministry of Education Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisasterNanjing University of Information Science and TechnologyNanjing 210044China Laboratoire de Météorologie Dynamique CNRSSorbonne UniversitéEcole Normale SupérieureEcole PolytechniqueParis 75005France

Based on climate extreme indices calculated from a high-resolution daily observational dataset in China during 1961–2005,the performance of 12 climate models from phase 6 of the Coupled Model Intercomparison Project(CMIP6),and 30 models from phase 5 of CMIP(CMIP5),are assessed in terms of spatial distribution and interannual *** CMIP6 multi-model ensemble mean(CMIP6-MME)can simulate well the spatial pattern of annual mean temperature,maximum daily maximum temperature,and minimum daily minimum ***,CMIP6-MME has difficulties in reproducing cold nights and warm days,and has large cold biases over the Tibetan *** performance in simulating extreme precipitation indices is generally lower than in simulating temperature *** to CMIP5,CMIP6 models show improvements in the simulation of climate indices over *** is particularly true for precipitation indices for both the climatological pattern and the interannual variation,except for the consecutive dry *** arealmean bias for total precipitation has been reduced from 127%(CMIP5-MME)to 79%(CMIP6-MME).The most striking feature is that the dry biases in southern China,very persistent and general in CMIP5-MME,are largely reduced in *** ascent together with more abundant moisture can explain this reduction in dry *** biases for total precipitation,heavy precipitation,and precipitation intensity in the eastern Tibetan Plateau are still present in CMIP6-MME,but smaller,compared to CMIP5-MME.

关键词： CMIP6 CMIP5 intercomparison climate extremes

Experimental models for preclinical research in kidney disease

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Zoological Research 2024年第5期45卷 1161-1174页

作者： Jin Miao huanhuan zhu Junni Wang Jianghua Chen Fei Han Weiqiang Lin Kidney Disease Center First Affiliated HospitalZhejiang University School of MedicineInstitute of NephrologyZhejiang UniversityKey Laboratory of Kidney Disease Prevention and Control TechnologyZhejiang ProvinceZhejiang Clinical Research Center of Kidney and Urinary System DiseaseHangzhouZhejiang 310003China Department of Nephrology Center for Regeneration and Aging MedicineFourth Affiliated Hospital of School of Medicineand International School of MedicineInternational Institutes of MedicineZhejiang UniversityYiwuZhejiang 322000China

Acute kidney injury(AKI)and chronic kidney disease(CKD)are significant public health issues associated with a long-term increase in mortality risk,resulting from various etiologies including renal ischemia,sepsis,drug toxicity,and diabetes *** preclinical models have been developed to deepen our understanding of the pathophysiological mechanisms and therapeutic approaches for kidney *** these,rodent models have proven to be powerful tools in the discovery of novel therapeutics,while the development of kidney organoids has emerged as a promising advancement in the *** review provides a comprehensive analysis of the construction methodologies,underlying biological mechanisms,and recent therapeutic developments across different AKI and CKD ***,this review summarizes the advantages,limitations,and challenges inherent in these preclinical models,thereby contributing robust evidence to support the development of effective therapeutic strategies.

关键词： Acute kidney injury Chronic kidney disease Mouse models

Intercomparison of multi-model ensemble-processing strategies within a consistent framework for climate projection in China

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Science China Earth Sciences 2023年第9期66卷 2125-2141页

作者： huanhuan zhu Zhihong JIANG Laurent LI Wei LI Sheng JIANG Panyu ZHOU Weihao ZHAO Tong LI Key Laboratory of Meteorological Disaster of Ministry of Education Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisasterNanjing University of Information Science and TechnologyNanjing 210044China Laboratoire de Météorologie Dynamique CNRSSorbonne UniversitéEcole Normale SupérieureEcole PolytechniqueParis 75005France School of Mathematics and Statistics Nanjing University of Information Science and TechnologyNanjing 210044China

Climate change adaptation and relevant policy-making need reliable projections of future *** based on multi-model ensemble are generally considered as the most efficient way to achieve the ***,their efficiency varies and inter-comparison is a challenging task,as they use a variety of target variables,geographic regions,time periods,or model ***,we construct and use a consistent framework to evaluate the performance of five ensemble-processing methods,i.e.,multimodel ensemble mean(MME),rank-based weighting(RANK),reliability ensemble averaging(REA),climate model weighting by independence and performance(ClimWIP),and Bayesian model averaging(BMA).We investigate the annual mean temperature(Tav)and total precipitation(Prcptot)changes(relative to 1995–2014)over China and its seven subregions at 1.5 and 2℃warming levels(relative to pre-industrial).All ensemble-processing methods perform better than MME,and achieve generally consistent results in terms of median *** they show different results in terms of inter-model spread,served as a measure of uncertainty,and signal-to-noise ratio(SNR).ClimWIP is the most optimal method with its good performance in simulating current climate and in providing credible future *** uncertainty,measured by the range of 10th–90th percentiles,is reduced by about 30%for Tav,and 15%for Prcptot in China,with a certain variation among *** on ClimWIP,and averaged over whole China under 1.5/2℃global warming levels,Tav increases by about 1.1/1.8℃(relative to 1995–2014),while Prcptot increases by about 5.4%/11.2%,*** of projections is found dependent on investigated regions and *** projection for Tav is credible across all regions,as its SNR is generally larger than 2,while the SNR is lower than 1 for Prcptot over most regions under 1.5℃*** largest warming is found in northeastern China,with increase of 1.3(0.6–1.7)/2.0(1.4–2.6)℃(ensemble’s median and range

关键词： Multi-model ensemble simulation Ensemble-processing strategy Global warming targets Climate projection uncertainty assessment Regional climate change in China

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Development of the National Air Quality Health Index-China,2013−2018

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China CDC weekly 2021年第4期3卷 61-64,I0002,I0003,I0004,I0005页

作者： Qinghua Sun huanhuan zhu Wanying Shi Yu Zhong Yingjian Zhang Tiantian Li China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijingChina Hebei University of Science and Technology ShijiazhuangHebeiChina Jinan Municipal Center for Disease Control and Prevention JinanShandongChina

What is already known about this topic?While the establishment of an air quality health index(AQHI)in some countries yielded positive outcomes in communicating health risks of air pollution,China lagged behind in developing its own *** research studies of AQHI were conducted in China,but this scientific research has not yet been applied to *** is added by this report?This report introduced the method of calculation of Chinese AQHI to be launched in pilot *** index in this report was established on the basis of fully drawing on international experience and considering Chinese *** are the implications for public health practice?The purpose of this report is to guide unified application of the AQHI throughout China and translate scientific evidence into public services to promote public *** on the AQHI construction method in this report,an AQHI real-time computing platform and data transfer interface will be *** release of AQHI aims to communicate health risk of air pollution and provide scientific health protective guidance to the general public,accordingly to protect people’s health.

关键词： pollution Quality communicating

In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy

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Nano Research 2017年第1期10卷 37-48页

作者： Bingmei Sun Jinrui Wu Shaobin Cui huanhuan zhu Wei An Qingge Fu Chengwei Shao Aihua Yao Bingdi Chen Donglu Shi School of Materials Science and Engineering Tongji University Caoan Road4800 Shanghai201804 China The Institute for Translational Nanomedicine Shanghai East Hospital The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 China School of Mechanical Engineering Tongji University Shanghai 200092 China Department of Emergency Changhai Hospital Second Mifitary Medical University Shanghai 200433 China Radiology Department of Changhai Hosptial Second Military Medical University Shanghai 200433 China Materials Science and Engineering Program Department of Mechanical and Materials Engineering College of Engineering and Appfied Science University of Cincinnati Cincinnati Ohio 45221-0012 USA

Graphene oxide/gold nanorod （GO/GNR） nanohybrids were synthesized with a GO- and gold-seed-mediated in situ growth method at room temperature by mixing polystyrene sulfonate （PSS） functionalized GO, secondary growth solution, and gold seeds. Compared with ex situ preparation methods of GO/GNRs or graphene （G）/GNRs, the in situ synthesis of GO/GNRs addressed the issue of the aggregation of the GNRs before their attachment onto the GO. The method is straightforward and environment-friendly; The GO/GNRs showed a remarkable photothermal effect in vitro. The temperature of the GO/GNR nanohybrids increased from 25 to 49.9 ℃ at a concentration of 50 μg/mL after irradiation with an 808-nm laser （0.4 W/cm2） for 6 min. Additionally; the GO/GNRs exhibited good optical and morphological stability and photothermal properties after six cycles of laser irradiation. Upon injection of the GO/GNRs into xenograft tumors, excellent computed tomography （CT） imaging properties and photothermal effect were obtained. The preclinical CT agent iohexol was combined with the GO/GNRs and further enhanced CT imaging. Therefore, the GO/GNR nanohybrids have great potential for predse CT-image-guided tumor photothermal treatment.

关键词： graphene oxide/goldnanorods in situ growth computed tomographyimaging photothermal therapy