Circulating tumor cells: Biological features and survival mechanisms

作     者：XIAOFENG LI JINYANG ZHENG JINFENG ZHU XIN HUANG HUANHUAN ZHU BINGDI CHEN 

作者机构：Department of OncologyAffiliated Quanzhou First Hospital of Fujian Medical UniversityQuanzhouChina Department of PathologyAffiliated Quanzhou First Hospital of Fujian Medical UniversityQuanzhouChina Department of Medical OncologyAffiliated Quanzhou First Hospital of Fujian Medical UniversityQuanzhouChina Department of DermatologySchool of MedicineTongji HospitalTongji UniversityShanghaiChina Department of Central LaboratoryShanghai Tenth People’s HospitalShanghaiChina Shanghai East HospitalThe Institute for Biomedical Engineering&Nano ScienceTongji University School of MedicineShanghaiChina 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2023年第47卷第8期

页      面：1771-1781页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Science Foundation of Fujian Province of China(2019J01596) 

主　　题：Anoikis Circulating tumor cells Heterogeneity Immune evasion Plasticity 

摘      要：Circulating tumor cells(CTCs)are neoplastic cells that are detached from primary tumors and enter *** and characterization of CTCs are of significance in cancer diagnosis,prognosis,and treatment *** survival in the bloodstream is a limiting step for the development of metastases in distant *** technological advances,especially in single-cell molecular analyses have uncovered heterogeneous CTC survival *** epithelial-to-mesenchymal transition(EMT),increasing stem cell-like properties,and forming cell clusters enable CTCs to adapt to the harsh microenvironment of the *** and releasing several immunosuppressive molecules help CTCs escape from anti-cancer immune *** review article summarizes the biological characteristics of CTCs and focuses on the recent understanding of the mechanisms by which CTCs survive in ***,the clinical and therapeutic implications of CTCs are discussed.