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Hypoxia-inducible factor 1-alpha and lactate dehydrogenase-A axis in metabolic changes and aggression in esophageal squamous-cell carcinoma

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 322-333页

作者： Xia Chen Hai-Yan liu Wu-Bi Zhou li-li Zhang Jian huang Da-Wei Bao Department of Pathology The Affiliated Huaian No.1 People's Hospital of Nanjing Medical UniversityHuai’an 223300Jiangsu ProvinceChina

BACKGROUND Esophageal squamous-cell carcinoma(ESCC)is a highly aggressive cancer,predominantly affecting populations in Eastern Asia and parts of *** pathogenesis is influenced by both genetic and environmental *** recent therapeutic advances,survival rates remain dismal,underscoring an urgent need for novel therapeutic *** To investigate the role of hypoxia-inducible factor 1-alpha(HIF1A)in the progression of ESCC and its impact on the metabolic enzyme lactate dehydrogenase A(LDHA),which is crucial for the glycolytic pathway in hypoxic tumor *** Utilizing transcriptomic data from multiple public databases,we analyzed differential gene expression and conducted gene ontology and transcription factor network *** regulatory impact of HIF1A on LDHA was specifically examined through integrative analysis with HIF1A ChIP-seq data and confirmed via siRNA-mediated knockdown experiments in ESCC cell *** Our findings reveal a significant upregulation of HIF1A in ESCC tissues,associated with poor ***1A directly regulates LDHA,enhancing glycolysis under hypoxic conditions and contributing to tumor *** of HIF1A in cell lines not only reduced LDHA expression but also altered key pathways related to cell cycle and *** The critical role of the HIF1A-LDHA axis in ESCC highlights its potential as a therapeutic target,underscoring the need for future clinical trials to validate the efficacy of HIF1A inhibitors in enhancing treatment outcomes.

关键词： Esophageal squamous-cell carcinoma Hypoxia-inducible factor 1-alpha Lactate dehydrogenase A Metabolic reprogramming Therapeutic target

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Alternative splicing drives the functional diversification of a b HLH transcription factor in the control of growth and drought tolerance in rice

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Science Bulletin 2025年第2期70卷 153-156页

作者： Min Ning Qinyan li Ya Wang Qingmao li Yonghong Tao Fan Zhang Fengyi Hu liyu huang Key Laboratory of Biology and Germplasm Innovation of Perennial Rice from Ministry of Agriculture and Rural Affairs School of AgricultureYunnan UniversityKunming 650091China Cereal Crops Research Institute Henan Academy of Agricultural SciencesZhengzhou 450002China Wenshan Academy of Agricultural Sciences Wenshan 663000China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China

Given the increase in global climate change,reconciling the increasing demand for food production with dwindling water resources poses a formidable *** ensure sustainable rice production and global food security,a thorough exploration of the genetic mechanism that underlies the delicate balance between growth and drought tolerance in rice is *** sessile nature of plants has driven their adaptive evolution,enabling them to regulate gene expression and exhibit physiological and developmental plasticity in response to environmental changes[1].Alternative splicing(AS),a prevalent phenomenon in plants,plays a crucial role in the regulation of posttranscriptional gene expression[2].AS serves as an essential mechanism involved in both developmental processes and stress responses[3–5].

关键词： drought mechanism tolerance

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi li Yang Wei Kang Zhou Xin huang Xing Zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New EnergyCollaborative Innovation Center of Chemistry for Energy Materials(iChEM)Fudan UniversityShanghai 200433China Department of Chemistry Boston CollegeChestnut HillMA 02467USA School of Materials Science and Engineering Anhui University of TechnologyMa’anshan 243002AnhuiChina

Sodium-ion batteries (SIBs) with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials(>1 V).Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material (tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na_(4)TDC) has been developed with low redox potential (lic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na_(4)TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg cm^(-2).By pairing with a thick Na_(3)V_(2)(PO_(4))_(3)cathode (20.6 mg cm^(-2)),the as-fabricated full cell exhibited high operating voltage (2.8 V),excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na_(4)TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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Tunable siloxane-induced amphiphilic interphase for high-performance gel polymer-based sodium metal batteries

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Science Bulletin 2025年第3期70卷 317-322页

作者： Jialin lin Weiping li Pei huang Suting Weng Tuoya Naren Chengzuo Gong Chaoping liang Weijie li Yuejiao Chen libao Chen Chunxiao Zhang Xuefeng Wang Weifeng Wei State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Laboratory for Advanced Materials and Electron Microscopy Institute of PhysicsChinese Academy of SciencesBeijing 100190China

The ever-growing pursuit for high-energy and low-cost rechargeable batteries has driven the ceaseless research on sodium metal batteries(SMBs)with metallic Na anode,a low redox potential of-2.71 V(*** hydrogen electrode),and a high specific capacity of 1166 mAh ***,its hyperreactivity with liquid electrolytes can cause uncontrollable parasitic reactions and raise safety ***,gel polymer electrolytes(GPEs)in SMBs have attracted immense interest owing to their high energy densities and high safety standards[1],[2].

关键词： polymer pursuit performance

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The comprehensive assessment of epigenetics changes during skin development

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Fundamental Research 2025年第1期5卷 228-240页

作者： Lei, li Jiang, ling Hu, Yibo Chen, Menglu huang, Jinhua Chen, Jing Zeng, Qinghai Department of Dermatology Third Xiangya Hospital Central South University Changsha 410013 China

Epigenetic regulation is critical to multiple physiological and pathological processes. However, little is known regarding the epigenetic changes during neonatal skin development and skin aging, and in response to ultraviolet (UV) exposure. The transcriptomes of human skin samples from different ages or irradiated with different types and doses of UV light were analyzed using R (version 4.0.3) software. The epigenetic landscape of the skin, including histone modifications, genetic imprinting and m6A modification, which are mainly involved in collagen formation, extracellular matrix organization, immune function and keratinization, underwent significant changes during neonatal to adult development. Epigenetic effectors such as IGF2BP2, GATA2, GATA3, CPA4 and CDK1 were significantly correlated with extracellular matrix organization, and VEGFA, CDK1 and PRKCB with skin immune function. The m6A readers such as IGF2BP2, IGF2BP3, HNRNPA2B1 and EIF3G showed significant correlation with extracellular matrix organization, metabolism, or antigen processing and presentation. Small doses of UV exposure only induced changes in the expression levels of some epigenetic effectors, without any significant effect on the overall epigenetic landscape. However, the minimal erythema dose of UV exposure altered multiple epigenetic effectors regulating extracellular matrix organization, cell-matrix adhesion, innate immune response, mitochondrial function and mRNA processing. In addition, epigenetic changes following UV exposure were more pronounced in the elderly skin compared to the younger skin. In conclusion, histone modifications, genetic imprinting and m6A modification play critical roles during skin development, and a large dose of UV exposure can significantly change the expression of multiple epigenetic effectors. © 2022

关键词： Aging Epigenetics m6A Skin development Ultraviolet

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High-throughput screening and evaluation of double-linker metal–organic frameworks for CO_(2)/H_(2)adsorption and separation

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Chinese Physics B 2025年第2期34卷 408-417页

作者： Ji-Long huang Xiu-Ying liu Hao Chen Xiao-Dong li Jing-Xin Yu School of Physics Henan University of TechnologyZhengzhou 450001China R&D Center for Advanced Energy Materials Henan University of TechnologyZhengzhou 450001China

The capture of CO_(2)from CO_(2)/H_(2)gas mixtures in syngas is a crucial issue for hydrogen production from steam methane reforming in industry,as the presence of CO_(2)directly affects the purity of H_(2).A combination of a high-throughput screening method and grand canonical Monte Carlo simulation was utilized to evaluate and screen 1725 metal–organic frameworks(MOFs)in detail as a means of determining their adsorption performance for CO_(2)/H_(2)gas *** adsorption and separation performance of double-linker MOFs was comprehensively evaluated using eight evaluation indicators,namely,the largest cavity diameter,accessible surface area,pore occupied accessible volume,porosity,adsorption selectivity,working capacity,adsorbent performance score and percent *** optimal performance frameworks were screened to further study their single-component adsorption and binary competitive adsorption of CO_(2)/H_(2)*** CO_(2)adsorption selectivity at different CO_(2)/H_(2)feed ratios was also evaluated,which indicated their excellent adsorption and separation *** microscopic adsorption mechanisms for CO_(2)and H_(2)at the molecular level were investigated by analyzing the radial distribution function and density *** study may provide directional guidance and reference for subsequent experiments on the adsorption and separation of CO_(2)/H_(2).

关键词： metal–organic framework adsorption separation high-throughput screening grand canonical Monte Carlo simulation

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An application of a seismic nodal system with seismic ambient noise near Kunlun Station, Antarctica: estimating ice thickness and firn structure

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Earth and Planetary Physics 2025年第02期 323-336页

作者： YuQiao Chen Peng Yan YuanDe Yang XueKe huang Fei li Chinese Antarctic Center of Surveying and Mapping Wuhan University Key Laboratory of Polar Environment Monitoring and Public Governance (Wuhan University) Ministry of Education Courant Institute of Mathematical Sciences New York University Department of Earth and Space Sciences Southern University of Science and Technology

The thickness and upper densification structure of an ice sheet are important parameters for dynamic ice sheet modeling and glacier mass balance studies. Seismic ambient noise methods, such as the horizontal-to-vertical spectral ratio(H/V) method and ambient noise cross-correlation method, are becoming increasingly popular in glacier structure investigations. During China's 39th expedition to Antarctica, seismic ambient noise experiments were conducted to investigate the structure of the ice sheet at Kunlun Station, Dome A,using a seismic nodal system. We obtained a broad band(0.1–10 Hz) H/V curve with a 1-hour noise record from a seismic node. In addition, we extracted the Rayleigh wave dispersion curve with 5-day noise cross-correlation functions from a linear dense seismic *** clear peaks were observed in the H/V curve — a lower peak at ～0.17 Hz and two higher frequency peaks at ～3 Hz and ～6 Hz. We inverted the ice sheet thickness using the lower frequency portion of the H/V curve and inverted the upper structure of the ice sheet using the higher frequency portion of the H/V curve jointly with the dispersion curve. Our estimations from ambient noise observations were consistent with those derived from the BedMachine ice sheet thickness dataset and the density profile determined by ground-penetrating radar investigations at the same site.

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Assessment of ecological geological vulnerability in Mu Us Sandy Land based on GIS and suggestions of ecological protection and restoration

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China Geology 2025年第1期8卷 117-140页

作者： Jian-yu liu Hong-feng Nie liang Xu Chun-lei Xiao Wei li Guo-li Yuan Yan-peng huang Xin-yang Ji Tian-qi li China Aero Geophysical Survey&Remote Sensing Center for Natural Resources China Geological SurveyMinistry of Natural ResourcesBeijing 100083China China University of Geosciences(Beijing) Beijing 100083China

Eco-geological vulnerability assessment is a significant research topic within the field of eco-geology,but it remains poorly *** Mu Us Sandy Land,located in the central part of the farming-pastoral ecotone in northern China,plays a critical role in maintaining the ecological security pattern in this ***,this sandy land also faces severe sandy desertification and ecological *** study conducted a regional eco-geological vulnerability assessment of the Mu Us Sandy Land using a comprehensive index evaluation method based on eco-geological theories and survey *** construct an appropriate index system for the eco-geological vulnerability assessment of the Mu Us Sandy Land,the study considered the sandy land’s unique characteristics and identified 15 factors of five categories,namely geology,meteorology,soil,topography,and *** paper calculated the comprehensive weights of all the indices using the analytic hierarchy process(AHP)and the entropy weight method(EWM).Furthermore,it established the eco-geological vulnerability index(EGVI)and obtained the assessment *** results showed that the eco-geological vulnerability of the Mu Us Sandy Land gradually intensifies from east to west,manifested as vulnerable eco-geological conditions ***,extremely vulnerable zones are found in the northwestern and southeastern parts of the study area,highly vulnerable zones in the western and southern parts,moderately vulnerable zones in the central part,and slightly and potentially vulnerable zones in the eastern and southern *** with high spatial autocorrelations include the northern Uxin Banner-Otog Banner-Angsu Town area,the surrounding areas of Hongdunjie Town in the southeastern part of the study area,the Hongshiqiao Township-Xiaohaotu Township area,Otog Front Banner,and Bainijing Town,which should be prioritized in the ecological conservation and ***,the paper proposed suggestions for

关键词： Eco-geological vulnerability Analytic hierarchy process Entropy weight method Evaluation and zonation Mu Us Sandy Land Geology-meteorology-soil-topography-vegetation Precipitation and groundwater Environmental protection and restoration Environmental restoration engineering Inner Mongolia Plateau

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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo li Xingwei Lei liuyang Tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong he Jie Peng Qingyun lin Meng li Weibin Chen Pei liu Tao huang Zhencheng huang Yuying liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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