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Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1647-1659页

作者： Ju-hang Chu Lu-Yao huang Ya-Ru Wang Jun Li Shi-Long Han Hao Xi Wen-Xue Gao Ying-Yu Cui Ming-Ping Qian Department of General Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Interventional and Vascular Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Pathology Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Clinical Research Management Office Shanghai Tenth People’s HospitalShanghai 200072China Department of Cell Biology Institute of Medical GeneticsState Key Laboratory of CardiologyTongji University School of MedicineShanghai 200331China

BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of death due to its complexity,heterogeneity,rapid metastasis and easy recurrence after surgical *** demonstrated that combination therapy with transcatheter arterial chemoembolization(TACE),hepatic arterial infusion chemotherapy(HAIC),Epclusa,Lenvatinib and Sintilimab is useful for patients with advanced *** SUMMARY A 69-year-old man who was infected with hepatitis C virus(HCV)30 years previously was admitted to the hospital with abdominal *** computed tomography(CT)revealed a low-density mass in the right lobe of the liver,with a volume of 12.9 cm×9.4 cm×15 cm,and the mass exhibited a“fast-in/fast-out”pattern,with extensive filling defect areas in the right branch of the portal vein and an alpha-fetoprotein level as high as 657 ng/***,he was judged to have advanced *** treatment,the patient received three months of Epclusa,three TACE treatments,two HAIC treatments,three courses of sintilimab,and twenty-one months of *** the third month of treatment,the patient developed severe side effects and had to stop immunotherapy,and the Lenvatinib dose had to be *** pathological diagnosis indicated a complete *** patient recovered well after the operation,and no tumor recurrence was *** Multidisciplinary conversion therapy for advanced enormous HCC caused by HCV infection has a significant *** drug adjustments should be made during any treatment according to the patient's tolerance to treatment.

关键词： Hepatocellular therapy Conversion hepatectomy Interventional therapy Epclusa Lenvatinib Sintilimab Case report

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The UDP-glycosyltransferase OsUGT706D2 positively regulates cold and submergence stress tolerance in rice

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The Crop Journal 2024年第3期12卷 732-742页

作者： Qing Liu Lanlan Zhang Shuwei Lyu hang Yu Wenjie huang Liqun Jiang Jing Zhang Bingrui Sun Xingxue Mao Pingli Chen Junlian Xing Wenfeng Chen Zhilan Fan Shijuan Yan Chen Li Guangdong Key Laboratory of New Technology in Rice Breeding/Guangdong Rice Engineering Laboratory/Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China(Co-construction by Ministry and Province) Ministry of Agriculture and Rural AffairsRice Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640GuangdongChina Guangdong Key Laboratory for Crop Germplasm Resources Preservation and Utilization Agro-biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhou 510640GuangdongChina

In a genome-wide association study,we identified a rice UDP-glycosyltransferase gene,OsUGT706D2,whose transcription was activated in response to cold and submergence stress and to exogenous abscisic acid(ABA).OsUGT706D2 positively regulated the biosynthesis of tricin-4’-O-(syringyl alcohol)ether-7-O-glucoside at both the transcriptional and metabolic ***706D2 mediated cold and submergence tolerance by modulating the expression of stress-responsive genes as well as the abscisic acid(ABA)signaling *** of function of OsUGT706D2 increased cold and submergence tolerance and loss of function of OsUGT706D2 reduced cold *** positively regulated OsUGT706D2-mediated cold tolerance but reduced submergence *** findings suggest the potential use of OsUGT706D2 for improving abiotic stress tolerance in rice.

关键词： UDP-glycosyltransferase Rice Cold tolerance Submergence tolerance ABA

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Shouhui Tongbian Capsule in treatment of constipation: Treatment and mechanism development

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Chinese Herbal Medicines 2024年第2期16卷 239-247页

作者： Liping Gong hang Du Xin Guo Jianchao Li Xiaomin Zhu Xianhui Shen Zhiyan huang Kaiyi Wu Guimin Zhang Rong Sun The Second Hospital of Shandong University Jinan 250033China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Lunan Pharmaceutical Group Co.Ltd.Linyi 276006China Tianjin University of Traditional Chinese Medicine Tianjin 301617China Shandong University of Traditional Chinese Medicine Jinan 250355China Advanced Medical Research Institute Shandong UniversityJinan 250012China

Constipation is common in the diseases of the digestive system in *** the change in diet structure and the increase in life pressure,the prevalence rate increases year by *** traditional Chinese medicine(TCM),the location of the disease of constipation is in the large intestine,which is related to the dysfunction of lung,spleen,liver,kidney and other *** pathogenesis is conductive dysfunction of large *** on the theory,Shouhui Tongbian Capsule(SHTB)is composed of eight traditional Chinese medicines,including Polygoni multiflori Radix(Heshouwu in Chinese),Aloe(Luhui in Chinese),Cassiae Semen(Juemingzi in Chinese),Ginseng Radix et Rhizoma(Renshen in Chinese),Lycii Fructus(Gouqizi in Chinese),Asini Corii Colla(Ejiao in Chinese),Aurantii Fructus Immaturus(Zhishi in Chinese),and Atractylodis Macrocephalae Rhizoma(Baizhu in Chinese),which could help to release excessive turbid,and nourishing yin and supplementing qi in the *** study has been carried out to review the latest advances of SHTB in the treatment of *** results showed that significant effect of SHTB was found in the treatment of constipation,such as functional constipation,and constipation associated with tumor chemotherapy,colitis,type 2 diabetes and chronic cardiac ***,obvious adverse reactions were not *** could effectively treat five types of constipation,provide direction for the future exploration of SHTB in the treatment of other types of constipation。

关键词： constipation gastrointestinal hormones interstitial cells of cajal intestinal fluid secretion intestinal motility Shouhui Tongbian Capsule

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基于深度学习的通信辐射源指纹特征提取算法

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信号处理 2018年第1期34卷 31-38页

作者：黄健航雷迎科电子工程学院安徽合肥230037

针对在小样本条件下难以有效提取通信辐射源指纹特征的问题,设计了一种堆栈自编码网络的通信辐射源个体细微特征提取算法。首先通过预处理(高阶谱分析)将原始通信辐射源信号从时域转化到高维特征空间,然后利用大量无标签的通信辐射源高... 详细信息

针对在小样本条件下难以有效提取通信辐射源指纹特征的问题,设计了一种堆栈自编码网络的通信辐射源个体细微特征提取算法。首先通过预处理(高阶谱分析)将原始通信辐射源信号从时域转化到高维特征空间,然后利用大量无标签的通信辐射源高维样本训练堆栈自编码器网络,在此基础上,通过少量有标签的通信辐射源样本对softmax回归模型进行精校训练,从而获得面向通信辐射源指纹特征提取的深度学习网络。实际采集的通信电台数据集上的实验结果验证了该模型的可行性与有效性。

关键词：堆栈自编码器通信辐射源指纹特征提取

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足球运动专项无氧能力训练设计实证研究

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北京体育大学学报 2017年第6期40卷 105-113页

作者：水祎舟黄竹杭陕西师范大学体育学院体能训练与恢复研究中心陕西西安710119 北京体育大学北京100084

目的:旨在结合足球运动项目专项特征的基础上,探索不同形式与负荷控制要素的结合球训练方法与手段设计是否能够提升足球运动员专项无氧能力的训练效果。方法:以12名北京体育大学男子足球代表队队员为实验对象,利用Polar Team2团队心率... 详细信息

目的:旨在结合足球运动项目专项特征的基础上,探索不同形式与负荷控制要素的结合球训练方法与手段设计是否能够提升足球运动员专项无氧能力的训练效果。方法:以12名北京体育大学男子足球代表队队员为实验对象,利用Polar Team2团队心率监控系统与Lactate Pro便携式血乳酸测试仪,对所设计的结合球无氧训练方法与手段进行科学验证和监控分析;包括:1)2种不同持续时间的专项套路无氧最大速度练习;2)2种不同间歇比率的区域转换小场比赛无氧速度耐力练习;3)2种不同间歇比率四门小场比赛无氧速度耐力练习。结果:1)在专项套路练习中,2种练习形式的心率变化与运动强度之间呈现出非同步特征,而形式1的乳酸值接近于安静值,形式2则略有提升;2)在区域转换小场比赛中,2种练习形式在心率和乳酸值上没有明显的差异;3)四门小场比赛中,形式1练习的心率和血乳酸值均高于形式2。结论:不同负荷强度与训练控制要素下的结合球训练设计能够满足足球运动专项无氧能力训练的基本要求。

关键词：足球运动结合球专项无氧能力小场比赛训练设计

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精子DNA损伤在男性不育中的诊断价值

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中华医学遗传学杂志 2014年第1期31卷 60-64页

作者：费前进黄航金建远黄学锋浙江省温州医学院附属第一医院生殖中心 325000 浙江省温州医学院附属第一医院泌尿外科 325000

目的探讨精子DNA损伤（sperm DNA fragmentation, SDF）在男性不育症中的诊断价值。方法将本院生殖中心就诊的299例男性分为两组：原发性不育患者157例及正常生育对照组142人。根据世界卫生组织标准（1999年）对其进行常规精液参数（精... 详细信息

目的探讨精子DNA损伤（sperm DNA fragmentation, SDF）在男性不育症中的诊断价值。方法将本院生殖中心就诊的299例男性分为两组：原发性不育患者157例及正常生育对照组142人。根据世界卫生组织标准（1999年）对其进行常规精液参数（精子浓度、精子活动力和精子形态）测定，采用精子染色质扩散试验检测其SDF水平，即精子DNA碎片指数（DNA fragmentation index, DFI）。结果原发性不育组和正常生育对照组的精子DFI分别为（17．1±9．3）％和（14．2±9．0）％，两者相比差异有统计学意义（P〈0．01），两组男性的年龄、配偶年龄及精液常规参数比较差异均无统计学意义（P〉0．05）。精子DFI诊断男性不育的受试者工作特征曲线下面积为0．861，95％可信区间为0．814-0．907，诊断阈值为15．1％，敏感性为81．8％，特异性为88．2％。根据精子DFI对男性不育的诊断阈值，将299例男性分为DFI≥15．1％（A组）120例和DFI％15．1％（B组）179例，两组不育男性的百分率分别为79．2％和34．6％，两者比较差异有统计学意义（P〈O．01），两组男性发生不育的优势比为7．2（95％可信区间为4．2～12．3）。结论高水平SDF可降低男性的生育能力，精子DFI对男性不育有重要的诊断价值。

关键词：精子 DNA损伤男性不育

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Bone Research 2024年第1期12卷 122-136页

作者： Nan-Yu Zou Ran Liu Mei huang Yu-Rui Jiao Jie Wei Yangzi Jiang Wen-Zhen He Min huang Yi-Li Xu Ling Liu Yu-Chen Sun Mi Yang Qi Guo Yan huang Tian Su Ye Xiao Wei-Shan Wang Chao Zeng Guang-Hua Lei Xiang-hang Luo Chang-Jun Li Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Orthopaedics Xiangya Hospital of Central South UniversityChangshaHunan 410008China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangshaChina Hunan Key Laboratory of Joint Degeneration and Injury ChangshaHunan 410008China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina School of Biomedical Sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Orthopaedics The First Affiliated Hospital of Shihezi UniversityShiheziXinjiangChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain *** this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture *** injection of human rGCA in young mice induced SSPC senescence and delayed fracture *** deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC ***,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular *** of Plxnb2 in SSPCs impaired fracture *** of GCA-neutralizing antibody enhanced fracture healing in aged ***,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.

关键词： healing union senescence

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Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage

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Stroke & Vascular Neurology 2024年第4期9卷 429-438,I0131-I0146页

作者： Yujia Jin Yu-hui huang Yu-ping Chen Yao-dan Zhang Jiawen Li Kai-cheng Yang Xianghua Ye Lu-hang Jin Jian Wu Chang-zheng Yuan Feng Gao Lu-sha Tong Neurology Department The Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhouChina School of Public Health Zhejiang UniversityHangzhouChina Department of Neurology Tiantai People's Hospital of Zhejiang ProvinceTaizhouChina

Background and purpose Cortical superficial siderosis(cSS)and cerebral microbleed(CMB)have distinct effects on intracerebral haemorrhage(ICH).We aim to investigate the combined effect of cSS and CMB on outcomes after *** Based on a single-centre stroke registry database,patients with spontaneous ICH who had CT scan within 48 hours after ictus and MRI subsequently were *** patients were divided into four groups(cSS-CMB−,cSS-CMB+,cSS+CMB−,cSS+CMB+)according to cSS and CMB on susceptibility-weighted image of *** outcomes were haematoma volume on admission and unfavourable outcome defined as modified Rankin Scale scores≥3 at 3 *** outcomes were all-cause death,recurrence of stroke and ICH during follow-up(median follow-up 2.0 years,IQR 1.0-3.0 years).Results A total of 673 patients were identified from 1044 patients with spontaneous ICH.131(19.5%)had cSS and 468(69.5%)had *** with cSS+CMB+had the highest rate of poor outcome at 3 months,as well as all-cause death,recurrent stroke and ICH during *** cSS−patients,CMB was associated with smaller haematoma(β−0.13;95%CI−0.22 to−0.03;p=0.009),but it still increased risks of recurrent ICH(OR 4.6;95%CI 1.3 to 15.6;p=0.015)and stroke(OR 2.0;95%CI 1.0 to 4.0;p=0.049).These effects of CMB became unremarkable in the context of cSS+.Conclusions Patients with different combinations of cSS and CMB have distinct patterns of short-term and long-term *** CMB is related to restrained haematoma,it does not improve long-term outcomes.

关键词： superficial cerebral effect

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