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Prenatal prednisone exposure disturbs fetal kidney development and its characteristics

Journal of Environmental Sciences 2024年第11期145卷 75-87页

作者： Zhiping Xia Songdi Wang Wen Wang Yutang Liu Tianshu Yang Hui Wang Ying ao Department of Pharmacology Wuhan University School of Basic Medical SciencesWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan 430071China

Prednisone is a synthetic glucocorticoid that is commonly used in both human and veterinary ***,it is also recognized as an emerging environmental *** be exposed to prednisone actively or passively throughmultiple pathways and cause developmental toxicity to the ***,the impact of prenatal prednisone exposure(PPE)on fetal kidney development remains *** this study,pregnant mice were administered prednisone intragastrically during full-term pregnancy with different doses(0.25,0.5,or 1 mg/(kg·day)),or at the dose of 1 mg/(kg·day)in different gestational days(GD)(GD0-9,GD10-18,or GD0-18).The pregnant mice were euthanized on *** staining revealed fetal kidney dysplasia,with an enlarged glomerular Bowman’s capsule space and a reduced capillary network in the PPE *** expression of the podocyte and the mesangial cell marker genes was significantly reduced in the PPE ***,overall gene expression in renal tubules and collecting ducts were markedly *** of the above effects were more pronounced in high-dose,full-term pregnancy,and female *** on the mechanism of the female fetal kidney have revealed that PPE reduced the expression of Six2,increased the expression of Hnf1β,Hnf4α,and Wnt9b,and inhibited the expression of glial cell line-derived neurotrophic factor(GDNF)and Notch signaling *** conclusion,this study demonstrated that there is a sex difference in the developmental toxicity of PPE to the fetal kidney,and the time effect is manifested as full-term pregnancy>early pregnancy>mid-late pregnancy.

关键词： Prenatal prednisone exposure Kidney developmental toxicity Glomerulus Toxicity characteristics

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Evolution hydrothermal aging resistance mechanism study of zirconium and manganese doped CeO_(2)catalysts in soot catalytic combustion based on low Miller indices crystal surface effect

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Journal of Rare Earths 2024年第7期42卷 1272-1281,I0003页

作者： Zonglin Li Pan Wang Hong Ni Chengcheng ao Lidong Zhang Hefeng Zhang Kai Li School of Automotive and Traffic Engineering Jiangsu UniversityZhenjiang212013China State Environmental Protection Key Laboratory of Vehicle Emission Control and Simulation Chinese Research Academy of Environmental ScienceBeijing100012China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei230026China

The thermogravimetric analysis(TGA)experiments were carried out to reveal the mechanism of Zr and Mn doping on catalytic activity of CeO_(2)catalyst both fresh and after hydrothermal aging,and the lattice morphology and valence changes were characterized by means of Brunauer-Emmett-Teller(BET)method,X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and H_(2)-temperature programmed reduction(H_(2)-TPR).Density functional theory(DFT)and molecular thermodynamics calculations were applied to investigate the change in catalytic activity,crystal surface energy and crystal morphology caused by hydrothermal *** maximum reaction rate temperature of fresh Mn/CeO_(2)(389℃)is similar to that of CeO_(2)(371℃)and lower than that of Zr/CeO_(2)(447℃),but the catalytic performance of CeO_(2)decreases more severely after hydrothermal *** catalyst crystals show different degrees of crystal surface migration after hydrothermal aging,which leads to the reduction of Ce^(3+)/Ce^(4+) ratio and the active sites *** calculations indicate that the doping of Zr and Mn reduces the surface energy of the low Miller indices surface and increases the oxygen vacancy formation energy,leading to better thermal stability and lower catalytic *** Zr and Mn doping also changes the adsorption energy and Gibbs free energy of H_(2)O,which dominates the migration of(111)to(110)and(100)in the vapor *** crystal surface migration mechanism of CeO_(2)catalysts doped with Zr and Mn induced by H_(2)O molecules at high temperature obtained in this study can provide a valuable addition to the regeneration of CeO_(2)catalysts in the after-treatment systems of diesel engines.

关键词： Soot CeO_(2)-based catalyst CDPF Rare earth metal oxides DFT calculations

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Using Longitudinal Fins to Improve the Melting Performance of Stearic Acid in Thermal Energy Storage Devices

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Journal of Thermal Science 2024年第5期33卷 1672-1687页

作者： YAN Suying LIU Yiran ao Ci ZHao Xiaoyan ZHANG Na ZHANG Ruiying AHMADI Mohammad Hossein School of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot 010051China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China School of Materials Science and Engineering Inner Mongolia University of TechnologyHohhot 010051China Faculty of Mechanical Engineering Shahrood University of TechnologyShahroodIran

The heat transfer efficiency of a thermal energy storage unit(TESU)can be improved by the addition of novel longitudinal fins.A series of TESUs are analyzed using the finite volume method(FVM)to determine the effect of fin angle on the heat transfer *** the fin angle increases,the TES rate first increases,then decreases,reaching a maximum rate at 60°,where the melting time is less by 30.9%,28.58%,21.99%,9.02%,and 18.1%than at 0°,15°,30°,45°,and 80°,*** addition,it is found that the melting time of the phase change material is significantly greater at the bottom of the *** time percentage of this stage decreases as the fin angle increases through these percentages by 7%,14%,23%,33%,and 20%,***,the response surface methodology(RSM)is applied to optimize the longitudinal fin by minimizing the total melting *** analysis concludes that a fin angle of 58.68°reduces the complete melting time of the stearic acid by 44%below the time at 0°.These findings fill a gap in knowledge of the effect on melting performance of the design angle of longitudinal fins and provide a reference for the design of horizontally placed longitudinal finned thermal energy storage units.

关键词： thermal energy storage melting rate enhancement longitudinal fins fin angle phase change materials

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Effect of a cardiac telerehabilitation program during COVID-19 associated social isolation

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Sports Medicine and Health Science 2024年第3期6卷 273-278页

作者： Jo~ao Paulo Prado Giovane Galdino Institute of Motricity Sciences Federal University of AlfenasAlfenasMinas GeraisBrazil

This study aimed to compare the impact of a cardiac telerehabilitation(CTR)protocol aimed at patients with cardiovascular diseases(CVDs)during the period of coronavirus disease 2019(COVID-19)associated with social *** retrospective cohort study included 58 participants diagnosed with stable cardiovascular diseases(CVDs),which were divided into three groups:conventional cardiac rehabilitation(CCR)group(n?20),composed of patients undergoing conventional cardiac rehabilitation;cardiac telerehabilitation(CTR)group(n?18),composed of patients undergoing cardiac telerehabilitation and control group(n?20),composed of patients admitted for cardiac rehabilitation who had not started training *** results showed that body mass index was reduced(p?0.019)and quality of life was improved(e.g.,limitations due to physical aspects[p?0.021),vitality[p?0.045]and limitations due to emotional aspects[p?0.024])by CCR compared to *** outcomes were not improved by CTR(p>0.05).However,this strategy prevented clinical deterioration in the investigated *** CCR achieved a superior effect on clinical improvement and quality of life,CTR was relevant to stabilize the blood pressure and quality of life of patients with cardiovascular diseases during the period of COVID-19-associated social isolation.

关键词： COVID-19 Cardiac telerehabilitation Quality-of-life

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Perpendicular magnetization and exchange bias in epitaxial NiO/[Ni/Pt]_(2)multilayers

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Chinese Physics B 2022年第2期31卷 587-592页

作者： Lin-ao huang Mei-Yu Wang Peng Wang Yuan Yuan Ruo-Bai Liu Tian-Yu Liu Yu Lu Jia-Rui Chen Lu-Jun Wei Wei Zhang Biao You Qing-Yu Xu Jun Du National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093China College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093China School of Science Nanjing University of Posts and TelecommunicationsNanjing 210046China School of Physics Southeast UniversityNanjing 211189China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

The realization of perpendicular magnetization and perpendicular exchange bias(PEB)in magnetic multilayers is important for the spintronic ***(t)/[Ni(4 nm)/Pt(1 nm)]_(2)multilayers with varying the NiO layer thickness t have been epitaxially deposited on SrTiO;(001)*** magnetization can be achieved when t<25 *** magnetization originates from strong perpendicular magnetic anisotropy(PMA),mainly resulting from interfacial strain induced by the lattice mismatch between the Ni and Pt *** PMA energy constant decreases monotonically with increasing t,due to the weakening of Ni(001)orientation and a little degradation of the Ni–Pt ***,significant PEB can be observed though NiO layer has spin compensated(001)crystalline *** PEB field increases monotonically with increasing t,which is considered to result from the thickness dependent anisotropy of the NiO layer.

关键词： perpendicular magnetic anisotropy perpendicular exchange bias epitaxial growth random field model

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基于彩色和边缘信息融合的道路分割算法

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浙江大学学报（工学版） 2006年第1期40卷 29-32页

作者：刘加海白洪欢黄微凹浙江大学计算机科学与技术学院浙江杭州310028 浙江大学数学系浙江杭州310012

为了提高非结构化道路识别算法的有效性,提出了一种道路分割的新方法,建立了道路区域和非道路区域混合高斯彩色模型,根据像素隶属于彩色模型的概率进行基于彩色信息道路分割.利用彩色分割的结果对提取的图像边缘进行有效约束,抑止大量... 详细信息

为了提高非结构化道路识别算法的有效性,提出了一种道路分割的新方法,建立了道路区域和非道路区域混合高斯彩色模型,根据像素隶属于彩色模型的概率进行基于彩色信息道路分割.利用彩色分割的结果对提取的图像边缘进行有效约束,抑止大量非道路边沿所产生的图像边缘.并且将彩色分割结果和道路图像的边缘信息融合,利用道路图像边缘信息对真实道路边沿定位的精确性和彩色信息对道路区域分割的适应性,通过动态规划算法求解出真实的道路边沿.实验结果表明,提出的新方法可以有效地分割出道路区域,对各种路况具有良好的适应性.

关键词：视觉导航移动机器人道路分割

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Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3543-3560页

作者： Lixin Zhao Yuguang Zhu Hua Tao Xiying Chen Feng Yin Yingyi Zhang Jianfeng Qin Yongyin huang Bikun Cai Yonghao Lin Jiaxiang Wu Yu Zhang Lu Liang ao Shen Xi-Yong Yu The Fifth Affiliated Hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical PharmacologyNMPA&State Key LaboratorySchool of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China

Pulmonary fibrosis poses a significant health threat with very limited therapeutic options *** this study,we reported the enhanced expression of mesenchymal homobox 1(MEOX1)in pulmonary fibrosis patients,especially in their fibroblasts and endothelial cells,and confirmed MEOX1 as a central orchestrator in the activation of profibrotic *** high-throughput screening,we identified Ailanthone(AIL)from a natural compound library as the first small molecule capable of directly targeting and suppressing *** demonstrated the ability to inhibit both the activation of fibroblasts and endothelial-to-mesenchymal transition of endothelial cells when challenged by transforming growth factor-b1(TGF-b1).In an animal model of bleomycin-induced pulmonary fibrosis,AIL effectively mitigated the fibrotic process and restored respiratory ***,AIL acted as a suppressor of MEOX1 by disrupting the interaction between the transcription factor JUN and the promoter of MEOX1,thereby inhibiting MEOX1 expression and *** summary,our findings pinpointed MEOX1 as a cell-specific and clinically translatable target in ***,we demonstrated the potent anti-fibrotic effect of AIL in pulmonary fibrosis,specifically through the suppression of JUN-dependent MEOX1 activation.

关键词： Ailanthone MEOX1 Pulmonary fibrosis JUN TGF-b1 High-throughput screening Natural product

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Dynamic synthetic analysis of circulation field of tropical cyclones affecting Shanghai

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Frontiers of Earth Science 2024年第2期18卷 347-363页

作者： Wen GU Caijun YUE Zhihui HAN Yanqing Gao Yuqi TANG Xiangyu ao Yao Yao Shanghai Ecological Forecasting&Remote Sensing Center Shanghai 200030China Shanghai Marine Meteorological Centre Shanghai 200030China Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China Key Laboratory of Numerical Modeling for Tropical Cyclone(China Meteorological Administration) Shanghai 200030China

Eleven tropical cyclones(TCs)affected Shanghai and crossed the same latitude as Shanghai from 2007 to *** to similar tracks from best-track data,TCs that cause significant precipitation in Shanghai can be divided into three types:landfall TCs,nearshore northward TCs,and western *** on ERA5 reanalysis data,the dynamic synthesis method was used to synthesize TC circulation situations to compare thermal,dynamic,water vapor,and stability conditions within TC circulations during the period when they affected *** conclusions are as follows.1)When the three TC types are at the same latitude as Shanghai,they are all in the divergent field in the upper *** the landfall type,the subtropical high at 500 hPa is stronger and farther north than usual,and there is a high-pressure dam on the north side of the TCs.2)The warm advection of the three TC types at 925 hPa is located in the northern quadrant of the *** dynamic and water vapor conditions are good in the north-western quadrant of landfall and western TCs,and more favorable in the eastern quadrant of nearshore northward TCs.3)The favorable effects of all three types on precipitation in Shanghai come from the boundary *** vapor,upward motion,and instability conditions of landfall TCs are superior to the other two TC *** best water vapor,dynamic,and convective instability conditions are at the northern boundary in Shanghai during landfall TCs,and the main sources of water vapor in Shanghai come from the eastern and northern *** nearshore northward TCs,the main contribution to precipitation is from the eastern boundary,while better dynamic and water vapor conditions come from the western and northern boundaries during western *** above findings provide scientific and technical support for operational forecasting precipitation from TCs affecting mega-cities.

关键词： tropical cyclones dynamic synthetic analysis ERA5 reanalysis Shanghai similar track

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Effects of quantum noise on teleportation of arbitrary two-qubit state via five-particle Brown state

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Chinese Physics B 2024年第8期33卷 204-211页

作者：汪澳魏玉震姜敏李泳成陈虹黄旭 School of Electronics&Information Engineering Soochow UniversitySuzhou 215006China Key Laboratory of System Control and Information Processing Ministry of EducationShanghai 200240China School of Information Engineering Huzhou UniversityHuzhou 313000China

We propose a new protocol for quantum teleportation(QT)which adopts the Brown state as the quantum *** work focuses on the teleportation of a single unknown two-qubit state via a Brown state channel in an ideal *** validate the effectiveness of our proposed scheme,we conduct experiments by using the quantum circuit simulator ***,we investigate the effects of four noisy channels,namely,the phase damping noise,the bit-flip noise,the amplitude damping noise,and the phase-flip ***,we employ Monte Carlo simulation to elucidate the fidelity density under various noise *** analysis demonstrates that the fidelity of the protocol in a noisy environment is influenced significantly by the amplitude of the initial state and the noise factor.

关键词： quantum communication Brown state fidelity

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Optimal Virtual Battery Model for Aggregating Storage-Like Resources with Network Constraints

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1843-1847页

作者： Zhenfei Tan ao Yu Haiwang Zhong Xianfeng Zhang Qing Xia Chongqing Kang Department of Electrical Engineering and Sichuan Energy Internet Research Institute Tsinghua UniversityBeijing 100084China Science and Technology Institute of China Three Gorges Corporation Hubei 430010China

A virtual battery(VB)provides a succinct interface for aggregating distributed storage-like resources(SLR)to interact with a utility-level *** overcome the drawbacks of existing VB models,including conservatism and neglecting network constraints,this paper optimizes the power and energy parameters of VB to enlarge its flexibility *** optimal VB is identified by a robust optimization problem with decision-dependent *** algorithm based on the Benders decomposition is developed to solve this *** proposed method yields the largest VB satisfying constraints of both network and *** studies verify the superiority of the optimal VB in terms of security guarantee and less conservatism.

关键词： Aggregation decision-dependent uncertainty flexibility robust optimization virtual battery

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