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A comprehensive review of research progress in Chinese medicines for primary liver cancer treatment

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Traditional Medicine Research 2022年第2期7卷 1-10页

作者： Kui Liao Le-Yi Gong Yi Yang Yi-Mei He Fang-Liang Wang Yuan-qiong huang Zhi-Gui wu Department of Pharmacy Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China School of Pharmacy Southwest Medical UniversityLuzhou 646000China Department of Nephropathy Luzhou Traditional Chinese Medicine HospitalLuzhou 646000China.

Primary liver cancer seriously threatens human health,affects the quality of life,and has a high mortality *** Chinese medicine(TCM)has long been used in the prevention,treatment,and adjuvant treatment of primary liver *** trials were conducted in recent years to evaluate the efficacy and safety of *** mechanism of action of TCM in primary liver cancer treatment also received extensive *** study summarizes the common monomial Chinese herbal medicines and their components,formulae,and the proprietary Chinese medicines used to treat primary liver *** medicines include Chansu(Bufonis venenum),Kushen(Sophorae flavescentis radix),Renshen(Ginseng radix et rhizoma),and Jianghuang(Curcumae longae rhizoma).This study also reviewed the literature on liver cancer treatment using *** results confirmed the safety and efficacy of TCM in liver cancer *** possible mechanisms involved are also listed,including influencing the cell cycle,inducing cancer cell apoptosis and autophagy,inhibiting cancer cell angiogenesis and metastasis,regenerating the microenvironment and DNA methylation,and regulating the innate immune *** primary liver cancer patients who often have a long disease course,Chinese herbal medicine often plays a role in protecting and conditioning the *** aimed at finding more traditional Chinese herbal medicines and their mechanisms of action should be *** study aimed to provide a scientific reference for further research and the rational clinical application of TCM for primary liver cancer treatment.

关键词： primary liver cancer traditional Chinese medicine clinical evaluation pharmacological mechanism

Exhaled breath diagnostics of lung and gastric cancers in China using nanosensors

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Cancer Communications 2020年第6期40卷 273-278页

作者： Alaa Gharra Yoav Y.Broza Guiping Yu Weidong Mao Dong Shen Lichun Deng Chun wu qiong Wang Xia Sun Jianming huang Zhuoqi Xuan Bing huang Song wu Yana Milyutin Viki Kloper-Weidenfeld Hossam Haick Department of Chemical Engineering and Russell Berrie Nanotechnology Institute Technion-Israel Institute of TechnologyHaifaIsrael Department of Oncology Jiangyin Hospital Affiliated to Southeast University Medical CollegeJiangyinJiangsu214400P.R.China Department of Gastrointestinal Surgery Jiangyin Hospital Affiliated to Southeast University Medical CollegeJiangyinJiangsu214400P.R.China Department of Chest Surgery Jiangyin Hospital Affiliated to Southeast University Medical CollegeJiangyinJiangsu214400P.R.China

Dear Editor,Breath analysis is a promising diagnostic approach for various conditions[1,2].It is based on the identification of volatile organic compounds(VOCs)emitted in the breath,which creates a unique volatolomic signature[3].Owing to their characteristics,VOCs can be measured non-intrusively from the breath or other body sources[3,4].Several studies have shown the diagnostic potential for a variety of conditions based on VOC analysis[5-9].Malignant diseases,where early detection is crucial,are the main focus of VOC analysis,with lung cancer(LC)and gastric cancer(GC)being the most *** and GC together were responsible for approximately 2.5 million deaths globally in 2018[10].The aim of VOC analysis of the breath using sensors is to identify a“VOC-print”comprising the total abundances and ratios of the compounds in the breath,giving an overall unique chemical pattern[11].

关键词： lung gastric breath

β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

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Bone Research 2024年第2期12卷 302-313页

作者： Jie huang Tong wu Yi-Rong Jiang Xuan-Qi Zheng Huan Wang Hao Liu Hong Wang Hui-Jie Leng Dong-Wei Fan Wan-qiong Yuan Chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal Disease 100191 BeijingChina Engineering Research Center of Bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

Awareness is essential for differential delay eyeblink conditioning with soft-tone but not loud-tone conditioned stimuli

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Neuroscience Bulletin 2014年第3期30卷 433-440页

作者： He huang Bing wu qiong Li Juan Yao Xuan Li Yi Yang Guang-Yan wu Jian-Feng Sui Department of Physiology College of Basic Medical Sciences Third Military Medical University Experimental Center of Basic Medicine College of Basic Medical Sciences Third Military Medical University

The role of awareness in differential delay eyeblink conditioning （DEC） remains controversial. Here, we investigated the involvement of awareness in differential DEC with a soft or a loud tone as the conditioned stimulus （CS）. In the experiment, 36 participants were trained in differential DEC with a soft tone （60 dB） or a loud tone （85 dB） as the CS, paired with a corneal air-puff as the unconditioned stimulus （US）. After conditioning, awareness of the relationship between assessed with a 17-item the CS and the US was true/false questionnaire. Interestingly, during differential DEC with a soft-tone CS, a higher proportion of differential conditioned responses （CRs） was evident in participants who were aware than those who were unaware. In contrast, when a loud tone was used as the CS, the proportion of differential CRs of the aware participants did not differ significantly from those who were unaware over any of the blocks of 20 trials. In unaware participants, the percentage of differential CRs with a loud-tone CS was significantly higher than that with a soft-tone CS; however in participants classified as aware, the percentage of differential CRs with a loud-tone CS did not differ significantly from that with a soft-tone CS. The present findings suggest that awareness is critical for differential DEC when the delay task is rendered more difficult.

关键词： awareness differential delay eyeblinkconditioning soft-tone conditioned stimulus loudtone conditioned stimulus

Rapid gene expression change in a novel synthesized allopolyploid population of cultivated peanut×Arachis doigoi cross by cDNA-SCoT and HFO-TAG technique

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Journal of Integrative Agriculture 2017年第5期16卷 1093-1102页

作者： HE Liang-qiong TANG Rong-hua JIANG Jing XIONG Fa-qian huang Zhi-peng wu Hai-ning GAO Zhong-kui ZHONG Rui-chun HE Xin-hua HAN Zhu-qiang Cash Crops Research Institute/Guangxi Crop Genetic Improvement and Biotechnology Laboratory Guangxi Academy of Agricultural SciencesNanning 530007P.R.China Guangxi University Nanning 530004P.R.China

AIIopolyploidy has played an important role in plant evolution and heterosis. Recent studies indicate that the process of wide hybridization and （or） polyploidization may induce rapid and extensive genetic and epigenetic changes in some plant species. To better understand the allopolyploidy evolutionism and the genetic mechanism of Arachis interspecific hybridization, this study was conducted to monitor the gene expression variation by cDNA start codon targeted polymorphism （cDNA-SCoT） and cDNA high-frequency oligonucleotide-targeting active gene （cDNA-HFO-TAG） techniques, from the hybrids （F1） and newly synthesized allopolyploid generations （S0-$3） between tetraploid cultivated peanut Zhongkaihua 4 with diploid wild one Arachis doigoi. Rapid and considerable gene expression variations began as early as in the FI hybrid or immediately after chromosome doubling. Three types of gene expression changes were observed, including complete silence （gene from progenitors was not expressed in all progenies）, incomplete silence （gene expressed only in some progenies） and new genes activation. Those silent genes mainly involved in RNA transcription, metabolism, disease resistance, signal transduction and unknown functions. The activated genes with known function were almost retroelements by cDNA-SCoT technique and all metabolisms by cDNA-HFO-TAG. These findings indicated that interspecific hybridization and ploidy change affected gene expression via genetic and epigenetic alterations immediately upon allopolyploid formation, and some obtained transcripts derived fragments （TDFs） probably could be used in the research of molecular mechanism of Arachis allopolyploidization which contribute to thwe genetic diploidization of newly formed allopolyploids. Our research is valuable for understanding of peanut evolution and improving the utilization of putative and beneficial genes from the wild peanut.

关键词： peanut allopolyploidy gene expression start codon-targeted polymorphism high-frequency oligonucleotide-targeting active gene

Ribonucleotide reductase small subunit M2 promotes the proliferation of esophageal squamous cell carcinoma cells via HuR-mediated mRNA stabilization

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Acta Pharmaceutica Sinica B 2024年第10期14卷 4329-4344页

作者： Jing Zhang qiong wu Yifei Xie Feng Li Huifang Wei Yanan Jiang Yan Qiao Yinhua Li Yanan Sun Han huang Mengmeng Ge Dengyun Zhao Zigang Dong Kangdong Liu Pathophysiology Department School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450000China China-US(Henan)Hormel Cancer Institute Zhengzhou 450000China Tianjian Laboratory for Advanced Biomedical Sciences Zhengzhou 450052China State Key Laboratory of Esophageal Cancer Prevention and Treatment Zhengzhou 450000China Cancer Chemoprevention International Collaboration Laboratory Zhengzhou 450000China The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000China

Esophageal squamous cell carcinoma(ESCC),a malignancy of the digestive system,is highly prevalent and the primary cause of cancer-related deaths worldwide due to the lack of early diagnostic biomarkers and effective therapeutic *** ribonucleotide reductase(RNR)expression has been confirmed to be causally linked to *** study demonstrated that ribonucleotide reductase small subunit M2(RRM2)is significantly upregulated in ESCC tissue and that its expression is negatively correlated with clinical ***,HuR promotes RRM2 mRNA stabilization by binding to the adenine/uridine(AU)-rich elements(AREs)within the 3′UTR,resulting in persistent overexpression of ***,bifonazole is identified as an inhibitor of HuR via computational screening and molecular docking *** disrupts HuR-ARE interactions by competitively binding to HuR at F65,R97,I103,and R153 residues,resulting in reduced RRM2 ***,bifonazole exhibited antitumor effects on ESCC patient-derived xenograft(PDX)models by decreasing RRM2 expression and the dNTP *** summary,this study reveals the interaction network among HuR,RRM2,and bifonazole and demonstrated that bifonazole is a potential therapeutic compound for ESCC through inhibition of the HuR/RRM2 axis.

关键词： Esophageal squamous cell carcinoma(ESCC) Bifonazole Ribonucleotide reductase small subunit M2(RRM2) AU-rich elements(AREs) Hu antigen R(HuR) mRNA stability dNTP Cell proliferation

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基于逻辑运算的折半划分测试数据压缩方法

系统仿真学报 2015年第6期27卷 1324-1328页

作者：吴琼黄丽安庆师范学院科技处安徽安庆246011 安庆师范学院安徽安庆246011

提出一种新的,基于逻辑运算的折半划分压缩方法。将测试集按单位长度M进行划分,分成若干块,再对块内数据块内数据为全"0"、"1"序列和"10"、"01"交替序列等四种序列进行逻辑运算,将它们全部变换成全"0"序列,对于不能转化的序列,需对它们... 详细信息

提出一种新的,基于逻辑运算的折半划分压缩方法。将测试集按单位长度M进行划分,分成若干块,再对块内数据块内数据为全"0"、"1"序列和"10"、"01"交替序列等四种序列进行逻辑运算,将它们全部变换成全"0"序列,对于不能转化的序列,需对它们不断进行折半划分,当达到预先规定的最小长度时停止划分,直接用代码字编码。代码字的长度可以通过折半的次数来换算,而且通过逻辑运算化为全0序列,更加易于编码,与传统的编码方法比,解压结构简单,降低了解压和压缩成本。

关键词：数据压缩逻辑运算折半划分交替序列

Evolutionary timescale of chalcidoid wasps inferred from over one hundred mitochondrial genomes

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Zoological Research 2023年第3期44卷 467-482页

作者： Jia-Chen Zhu Hui Xiao Pu Tang Xiao-Fei Li Xuan-Kun Li Chao-Dong Zhu qiong wu Jin-Hua Xiao Cornelis van Achterberg Da-Wei huang Xue-Xin Chen State Key Laboratory of Rice Biology Ministry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insect PestsProvincial Key Lab of Biology of Crop Pathogens and Insect Pests of ZhejiangInstitute of Insect SciencesZhejiang UniversityHangzhouZhejiang 310058China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Florida Museum of Natural History University of FloridaGainesvilleFL 32611 USA College of Life Sciences Nankai UniversityTianjin 300071China

Chalcidoidea is one of the most biologically diverse groups among *** are characterized by extraordinary parasitic lifestyles and extensive host ranges,among which several species attack plants or serve as ***,higher-level chalcidoid relationships remain ***,we performed mitochondrial phylogenomic analyses for major clades(18out of 25 families)of Chalcidoidea based on 139 mitochondrial *** compositional heterogeneity and conflicting backbone relationships in Chalcidoidea were assessed using various datasets and tree *** phylogenetic results supported the monophyly of 16families and polyphyly of Aphelinidae and *** preferred topology recovered the relationship(Mymaridae+(Signiphoridae+Leucospidae)+(Chalcididae+((Perilampidae+Eucharitidae)+remaining Chalcidoidea))).The monophyly of Agaonidae and Sycophaginae was rejected,while the gall-associated((Megastigmidae+Ormyridae)+(Ormocerinae+Eurytomidae))relationship was supported in most results.A six-gene inversion may be a synapomorphy for most families,whereas other derived gene orders may introduce confusion in phylogenetic signals at deeper *** estimates suggested that Chalcidoidea arose near the Jurassic/Cretaceous boundary and that two dynamic shifts in diversification occurred during the evolution of *** hypothesized that the potential codiversification between chalcidoids and their hosts may be crucial for accelerating the diversification of *** state reconstruction analyses supported the hypothesis that gallinducers were mainly derived from parasitoids of gallinducers,while other gall-inducers were derived from phytophagous *** together,these findings advance our understanding of mitochondrial genome evolution in the major interfamilial phylogeny of Chalcidoidea.

关键词： Mitochondrial genome Chalcidoidea Compositional heterogeneity Divergence time Evolution of host and gall associations

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基于高阶辛算法求解Maxwell方程

系统工程与电子技术 2006年第3期28卷 342-344页

作者：吴琼黄志祥吴先良安徽大学计算智能与信号处理教育部重点实验室安徽合肥230039

为克服标准时域有限差分(FDTD)方法的缺陷,引入一种新的数值计算方法———高阶辛算法求解Maxwell方程,即在时间上用高阶辛差分格式离散,空间分别采用二阶及四阶精度的差分格式离散。系统地分析了高阶辛算法的稳定性及数值色散性,通过... 详细信息

为克服标准时域有限差分(FDTD)方法的缺陷,引入一种新的数值计算方法———高阶辛算法求解Maxwell方程,即在时间上用高阶辛差分格式离散,空间分别采用二阶及四阶精度的差分格式离散。系统地分析了高阶辛算法的稳定性及数值色散性,通过理论上的分析及数值计算表明,在空间采用相同的二阶精度的差分离散格式时,高阶辛算法的稳定性与FDTD法相当;四阶辛算法结合四阶精度的空间差分格式较FDTD法具有更为优越的数值色散性———各向同性。结合二维TMz波的数值计算结果表明,高阶辛算法较FDTD法有着更强的计算优势。

关键词：时域有限差分高阶辛算法稳定性