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Ultrasensitive detection of IgE levels based on magnetic nanocapturer linked immunosensor assay for early diagnosis of cancer

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Chinese Chemical Letters 2022年第4期33卷 1855-1860页

作者： Yongxin Liu Mengda Cao Zhongxi huang Changmin Yu Naidi Yang qiong wu Liang Shi Wenjie Duan Yi Zhu Jifu Wei Lin Li Wei huang Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211816China Research Division of Clinical Pharmacology&Clinical Allergy Center the First Affiliated Hospital of Nanjing Medical UniversityDepartment of PharmacyJiangsu Institute of Cancer Research&the Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Pharmacy Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210044China State Key Laboratory of Coordination Chemistry Nanjing UniversityNanjing 210023China Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)Xi’an 710072China The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China

Rapid and accurate detection of immunoglobulin E(Ig E) in serum and reduction of serum dosage are of great significance for clinical detection. Herein, we described a rapid magnetic separation of Ig E from patient serum based on Fe3 O4@Si O2-NTA@026 sdab as the capture probe and multiple horseradish peroxidase(HRP)-labeled antibodies linked gold nanoparticles(Au NPs) as chemiluminescence(CL) signal amplifier for ultrasensitive detection of total Ig E. Results showed that the limit of detection of our immunosensor system in serum samples was 0.03 k U/L, which is lowest in comparison with current methods, and far lower than that of Immuno CAP for Ig E detection(0.1 k U/L). Furthermore, our immunosensor possessed satisfied repeatability and accuracy, as well as good stability. In comparison with the Immuno CAP for the quantitative detection of Ig E, highly consistent results were achieved in 20 serum samples. Specially, this method was also successfully utilized for assessing the Ig E traces in breast cancer patients,which provides a new idea for the diagnosis of early cancer. Therefore, we believe that such versatile immunosensor will offer an alternative method for the on-site monitoring and determination of various Ig E-related diseases.

关键词： Gold nanoparticles Magnetic nanocapturer IgE detection Ultrasensitive immunosensor Cancer

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Liver Transplantation Outcomes of HBV-,HCV-,and Alcohol-induced Hepatocellular Carcinoma in the United States:Analysis of National Inpatient Samples

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Current Medical Science 2023年第3期43卷 520-525页

作者： Si-si ZHANG Jin-feng ZHANG Jing-qiong WANG Jing TANG Zi-long wu Jing huang Jun XUE Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective Liver transplantation is a current treatment option for hepatocellular carcinoma(HCC).The United States National Inpatient Sample database was utilized to identify risk factors that influence the outcome of liver transplantation,including locoregional recurrence,distant metastasis,and in-hospital mortality,in HCC patients with concurrent hepatitis B infection,hepatitis C infection,or alcoholic *** This retrospective cohort study included HCC patients(n=2391)from the National Inpatient Sample database who underwent liver transplantation and were diagnosed with hepatitis B or C virus infection,co-infection with hepatitis B and C,or alcoholic cirrhosis of the liver between 2005 and *** between HCC etiology and post-transplant outcomes were examined with multivariate analysis *** Liver cirrhosis was due to alcohol in 10.5%of patients,hepatitis B in 6.6%,hepatitis C in 10.8%,and combined hepatitis B and C infection in 24.3%.Distant metastasis was found in 16.7%of patients infected with hepatitis B and 9%of hepatitis C *** recurrence of HCC was significantly more likely to occur in patients with hepatitis B than in those with alcohol-induced *** After liver transplantation,patients with hepatitis B infection have a higher risk of local recurrence and distant *** care and patient tracking are essential for liver transplant patients with hepatitis B infection.

关键词： alcoholic hepatitis hepatocellular carcinoma liver cirrhosis National Inpatient Sample(NIS)transplantation viral hepatitis

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Raman spectra evidence for the covalent-like quasi-bonding between exfoliated MoS2 and Au films

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Science China(Information Sciences) 2021年第4期64卷 157-165页

作者： Xinyu huang Lei ZHANG Liwei LIU Yang QIN Qiang FU qiong wu Rong YANG Jun-Peng LV Zhenhua NI Lei LIU Wei JI Yeliang WANG Xingjiang ZHOU Yuan huang Institute of Physics Chinese Academy of Sciences Department of Materials Science and Engineering College of Engineering Peking University College of Materials Science and Engineering Key Laboratory of Advanced Functional MaterialsMinistry of Education of China Beijing University of Technology School of Information and Electronics MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesBeijing Institute of Technology Songshan Lake Materials Laboratory School of Science Beijing University of Posts and Telecommunications School of Physics Southeast University Department of Physics and Beijing Key Laboratory of Optoelectronic Functional Materials & Micro-Nano Devices Renmin University of China

Gold-enhanced mechanical exfoliation method attracts broad interests in recent years, which has been widely used for preparing large-area and high-quality 2D single crystals. Even many calculations predict that there is strong interaction between Au film and the exfoliated 2D crystals, direct experimental evidence is still lacking. Here, we perform Raman spectroscopy measurements for few layer MoSwith and without Au film underneath. The main peaks of MoSon Au film show no obvious change at higher frequency,however, the breathing and shear modes at low-frequency are suppressed, especially for breathing *** contrast, both breathing modes and shear modes can be detected on suspended MoSand the samples are transferred from Au film to SiO/Si. These comparison results provide direct evidence for the existence of covalent-like quasi-bonding at the interface of Au film and the exfoliated MoScrystal. This MoS/Au interface interaction presents a special pinning-effect for low-frequency rigid vibration. Similar pinning-effect is also discovered in WS/Au system. Our work reports the suppression of low-frequency Raman modes of MoS, WSon Au film, which will deliver new inspiration for studying other interactions between layered materials and solid surfaces.

关键词： MoS2 Raman spectroscopy gold-enhanced mechanical exfoliation low-frequency raman modes covalent-like quasi-bonding

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Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer's disease

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Neural Regeneration Research 2023年第9期18卷 2019-2028页

作者： Li-Fen Liu Yu-Tong Liu Dan-Dan wu Jie Cheng Na-Na Li Ya-Ni Zheng Liang huang qiong-Lan Yuan Department of Neurology Shanghai Tongji HospitalTongji University School of MedicineShanghaiChina Department of Radiology University of Nebraska Medical CenterOmahaNEUSA Department of Human Anatomy Histology&EmbryologyTongji University School of MedicineShanghaiChina

Extracellular amyloid beta(Aβ) plaques are main pathological feature of Alzheimer’s ***,the specific type of neuro ns that produce Aβ peptides in the initial stage of Alzheimer’s disease are *** this study,we found that 5-hydroxytryptamin receptor 3A subunit(HTR3A) was highly expressed in the brain tissue of transgenic amyloid precursor protein and presenilin-1 mice(an Alzheimer’s disease model) and patients with Alzheimer’s *** investigate whether HTR3A-positive interneurons are associated with the production of Aβ plaques,we performed double immunostaining and found that HTR3A-positive interneurons were clustered around Aβ plaques in the mouse *** amyloid precursor protein-positive or β-site amyloid precursor protein cleaving enzyme-1-positive neurites near Aβ plaques were co-localized with HTR3A *** results suggest that HTR3A-positive interneurons may partially contribute to the generation of Aβ *** treated 5.0-5.5-month-old model mice with tro pisetron,a HTR3 antagonist,for 8 consecutive *** found that the cognitive deficit of mice was partially reversed,Aβ plaques and neuroinflammation we re remarkably reduced,the expression of HTR3 was remarkably decreased and the calcineurin/nuclear factor of activated T-cell 4 signaling pathway was inhibited in treated model *** findings suggest that HTR3A interneurons partly contribute to generation of Aβ peptide at the initial stage of Alzheimer’s disease and inhibiting HTR3 partly reve rses the pathological changes of Alzheimer’s disease.

关键词： 5-hydroxytryptamin receptor 3 Alzheimer’s disease amyloid beta plaques calcineurin cognitive deficits HTR3 interneurons iCa2+ nuclear factor of activated T-cells transgenic amyloid precursor protein and presenilin-1 mice tropisetron

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Characteristics of inorganic phosphorus fractions and their correlations with soil properties in three non-acidic soils

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Journal of Integrative Agriculture 2022年第12期21卷 3626-3636页

作者： ZHANG Nai-yu WANG qiong ZHAN Xiao-ying wu Qi-hua huang Shao-min ZHU Ping YANG Xue-yun ZHANG Shu-xiang Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences/National Engineering Laboratory for Improving Quality of Arable LandBeijing 100081P.R.China TERRA Gembloux Agro-Bio TechUniversity of LiegeGembloux 5030Belgium Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Institute of Bioengineering Guangdong Academy of Sciences/Guangdong Modern Agricultural Technology Research and Development CenterGuangzhou 510316P.R.China Institute of Plant Nutrient Agricultural Resources and Environmental SciencesHenan Academy of Agricultural SciencesZhengzhou 450002P.R.China Institute of Agricultural Resources and Environment Jilin Academy of Agricultural SciencesChangchun 130033P.R.China College of Natural Resources and Environment Northwest A&F UniversityYangling 712100P.R.China

Understanding the characteristics and influences of various factors on phosphorus(P)fractions is of significance for promoting the efficiency of soil *** on long-term experiments on black soil,fluvo-aquic soil,and loess soil,which belong to Phaeozems,Cambisols,and Anthrosols in the World Reference Base for Soil Resources(WRB),respectively,five fertilization practices were selected and divided into three groups:no P fertilizer(CK/NK),balanced fertilizer(NPK/NPKS),and manure plus mineral fertilizer(NPKM).Soil inorganic P(Pi)fractions and soil properties were analyzed to investigate the characteristics of the Pi fractions and the relationships between Pi fractions and various soil *** results showed that the proportion of Ca_(10)-P in the sum of total Pi fractions was the highest in the three soils,accounting for 33.5%in black soil,48.8%in fluvo-aquic soil,and 44.8%in loess ***-term fertilization practices resulted in periodic changes in soil Pi accumulation or *** black soil and fluvo-aquic soil,the Pi accumulation was higher in the late period(10–20 years)of fertilization than in the early period(0–10 years)under NPK/NPKS and NPKM,whereas the opposite result was found in loess *** Pi accumulation occurred in all Pi fractions in black soil;mainly in Ca_(8)-P,Fe-P,and Ca_(10)-P in fluvo-aquic soil;and in Ca_(2)-P,Ca_(8)-P,and O-P in loess *** CK/NK,the soil Pi was depleted mainly in the early period in each of the three *** addition to the labile Pi(Ca_(2)-P)and moderately labile Pi(Ca_(8)-P,Fe-P,Al-P),the Ca_(10)-P in black soil and fluvo-aquic soil and O-P in loess soil could also be used by *** analysis showed that soil properties explained more than 90%of the variation in the Pi fractions in each soil,and the explanatory percentages of soil organic matter(SOM)were 43.6%in black soil,74.6%in fluvo-aquic,and 38.2%in loess ***,decisions regarding the application of P fertilizer should consider

关键词： non-acidic soils long-term fertilization phosphorus fractions soil properties organic matter

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Three-in-one incidence of hepatocellular carcinoma,cholangiocellular carcinoma,and neuroendocrine carcinoma:A case report

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World Journal of Clinical Cases 2022年第29期10卷 10575-10582页

作者： Yang wu Chao-Bang Xie Yi-Huai He Di Ke qiong huang Kai-Fei Zhao Rong-Shu Shi Department of Intervention The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Infection The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Pathology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Primary hepatic neuroendocrine carcinoma(NEC)is rare,and a combination with hepatocellular carcinoma(HCC)and cholangiocarcinoma(CCA)is extremely *** date,only four combination cases have been *** present paper describes the fifth *** SUMMARY A 32-year-old Chinese man with chronic hepatitis B was hospitalized for persistent upper abdominal *** computed tomography(CT)examination revealed a liver *** tumor was located in the 7th and 8th segments of the liver,and CT and magnetic resonance imaging findings were consistent with the diagnosis of *** examinations revealed the following:Alanine aminotransferase,243 U/L;aspartate aminotransferase,167 U/L;alpha-fetoprotein,4519μg/*** right lobe hepatectomy was performed on the liver *** pathology showed low differentiation HCC plus medium and low differentiation CCA combined with *** month after the surgery,the patient suffered from epigastric pain *** metastasis was detected by CT,and tumor transcatheter arterial chemoembolization was ***,the liver tumor was progressively increased and enlarged,and after 1 mo,the patient died of liver *** This is a rare case,wherein the tumor is highly aggressive,grows rapidly,and metastasizes in a short *** and laboratory tests can easily misdiagnose or miss such cases;thus,the final diagnosis relies on pathology.

关键词： Neuroendocrine carcinoma Hepatocellular carcinoma Mixed neuroendocrine neoplasm Combined hepatocellular-cholangiocarcinoma Cholangiocarcinoma Cholangiocellular carcinoma Case report

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Osteoprotegerin,interleukin and hepatocyte growth factor for prediction of diabetes and hypertension in the third trimester of pregnancy

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World Journal of Clinical Cases 2020年第22期8卷 5529-5534页

作者： Su-Jing huang Hong-Wei Wang Hai-Fang wu Qiu-Yuan Wei Shu Luo Lin Xu Hong-qiong Guan Department of Obstetrics The Second Affiliated Hospital of Hainan Medical CollegeHaikou 570311Hainan ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)raises the risk of high blood pressure and may cause a series of life-threatening complications in pregnant *** and management of GDM and gestational hypertension(GH)in pregnancy helps to control and reduce these risks and prevent adverse effects on mothers and their ***,the majority criteria used for screening of diabetes mellitus is oral glucose tolerance tests,and blood pressure test is usually used for the screening and diagnosis of ***,these criteria might not anticipate or detect all GDM or GH ***,new specific predictive and diagnostic tools should be evaluated for this *** study selected three biomarkers of osteoprotegerin(OPG),interleukin(IL)and hepatocyte growth factor(HGF)for GDM and GH predication and *** To explore the feasibility of changes in placental and serum OPG,IL and HGF as tools for prediction and diagnosis of diabetes and hypertension in pregnant *** From January 2018 to January 2019,44 pregnant women with GDM and GH were selected as an observation group,and 44 healthy pregnant women were selected as a control group in the same *** OPG,IL and HGF were compared between the two *** The levels of OPG and HGF in the observation group were lower than in the control group,and the level of IL-1βwas higher in the observation group than in the control group(all P<0.05).Furthermore,OPG and HGF were negatively associated with gestational diabetes and gestational hypertension,while IL-1βwas positively associated with GDM complicated with GH(all P<0.05).CONCLUSION The evaluation of serum OPG,HGF and IL-1βlevels in patients with coexistent gestational diabetes complicated with hypertension can predict the degree of disease and play an important role in the follow-up treatment and prognosis prediction.

关键词： Third trimester of pregnancy Osteoprotegerin Interleukin Hepatocyte growth factor Gestational diabetes mellitus Gestational hypertension

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Primary signet-ring cell carcinoma of the extrahepatic bile duct:A case report

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1356-1362页

作者： Chao-Bang Xie Yang wu Feng Li Kai-Fei Zhao Rong-Shu Shi qiong huang Jin Ao Di Ke Department of Radiology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Pathology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Signet ring cell carcinoma(SRCC)is a specific type of mucinous secretory adenocarcinoma,which contains abundant mucus in the cytoplasm and pushes the nucleus to one side of the cell membrane,forming a round or oval,and the nuclear deviations give the cells a signet ring-like *** often originates in the gastrointestinal tract,especially in the ***,primary SRCC of the extrahepatic bile duct is extremely ***,little is known about its epidemiology,treatment,and *** SUMMARY An 82-year-old female was admitted with abdominal pain,jaundice,and skin pruritus for 2 *** had no specific family *** examination presented normal vital signs,icteric sclera,visible jaundice,and mild tenderness in the right upper abdominal ***-related cell markers were within normal ***-enhanced computed tomography revealed a thickened wall of the common bile duct,strengthened with intrahepatic bile duct dilation and multiple round-like lesions in the *** addition,the lymph nodes in the hepatic hilum area,the pancreatic head area,and around the abdominal aorta were ***,a preoperative diagnosis of cholangiocarcinoma was *** alleviate jaundice and prolong the overall survival,percutaneous transhepatic cholangiopancreatic drainage(PTCD)was *** the operation,segmental stenosis of the extrahepatic bile duct and a vine-like expansion of the intrahepatic bile duct was ***,a biliary biopsy was performed under fluoroscopy to determine the nature and origin of the *** pathological diagnosis of the biopsy was ***,a diagnosis of primary SRCC of extrahepatic bile duct with distant lymph node metastasis and multiple liver metastases was made based on the radiographic,PTCD,and pathological *** tumor was diagnosed as T3N1M1 stage *** our aggressive approach,the patient died of liver failure after 1 *** This is the only

关键词： Cholangiocarcinoma Adenocarcinoma Signet ring cell carcinoma Extrahepatic bile duct Case report

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基于多步高阶差分格式求解时域Maxwell方程(英文)

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计算物理 2008年第3期25卷 263-268页

作者：黄志祥沙威吴先良陈明生安徽大学计算智能与信号处理教育部重点实验室安徽合肥230039

提出基于无穷维哈密尔顿系统及分裂算子理论的多步高阶差分格式,求解时域Maxwell方程.在时间方向上,针对Maxwell方程采用不同阶数的辛算法进行差分离散;在空间方向上,采用四阶差分格式进行差分离散.探讨多步高阶差分格式的稳定性及数值... 详细信息

提出基于无穷维哈密尔顿系统及分裂算子理论的多步高阶差分格式,求解时域Maxwell方程.在时间方向上,针对Maxwell方程采用不同阶数的辛算法进行差分离散;在空间方向上,采用四阶差分格式进行差分离散.探讨多步高阶差分格式的稳定性及数值色散性,最后给出数值计算结果.结果表明,五级四阶格式为最有效的多步高阶差分格式,具有高精度、占用较少的计算机资源等优点,适用于长时间的数值模拟.

关键词：多步高阶差分格式无穷维哈密尔顿系统分裂算子 Maxwell方程

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具有可重构特征的轨道角动量天线技术研究进展

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电子与信息学报 2024年第4期46卷 1173-1185页

作者：吴杰胡俊张忠祥沙威黄志祥吴先良合肥师范学院电子信息系统仿真设计安徽省重点实验室合肥230601 东南大学毫米波全国重点实验室南京210096 合肥工业大学微电子学院合肥230601 浙江大学信息与电子工程学院杭州310027 安徽大学信息材料与智能感知安徽省实验室合肥230039

轨道角动量(OAM)因其模式具有理论上无穷且正交互不干扰的特点,在扩展信道容量方面展现出良好的优势,为解决日趋紧张的频谱资源提供了一种新型设计自由度。面对复杂多样的无线通信场景,设计具有可重构特征的OAM天线,是实现多模态复用、... 详细信息

轨道角动量(OAM)因其模式具有理论上无穷且正交互不干扰的特点,在扩展信道容量方面展现出良好的优势,为解决日趋紧张的频谱资源提供了一种新型设计自由度。面对复杂多样的无线通信场景,设计具有可重构特征的OAM天线,是实现多模态复用、智能信息感知和人工智能天线的物理层基础。该文首先结合可重构天线实现机理,给出了OAM可重构天线设计的方法及具备的特点;然后,系统性综述了具有可重构特征的OAM天线的研究进展;最后,对未来设计具有可重构特征的OAM天线研究进行了展望。

关键词：涡旋电磁波轨道角动量天线可重构复用

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