Liver Transplantation Outcomes of HBV-,HCV-,and Alcohol-induced Hepatocellular Carcinoma in the United States:Analysis of National Inpatient Samples
作者机构：Cancer CenterUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China
出 版 物：《当代医学科学(英文)》 (Current Medical Science)
年 卷 期：2023年第43卷第3期
页 面：520-525页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
主 题：alcoholic hepatitis hepatocellular carcinoma liver cirrhosis National Inpatient Sample(NIS)transplantation viral hepatitis
摘 要：Objective Liver transplantation is a current treatment option for hepatocellular carcinoma(HCC).The United States National Inpatient Sample database was utilized to identify risk factors that influence the outcome of liver transplantation,including locoregional recurrence,distant metastasis,and in-hospital mortality,in HCC patients with concurrent hepatitis B infection,hepatitis C infection,or alcoholic *** This retrospective cohort study included HCC patients(n=2391)from the National Inpatient Sample database who underwent liver transplantation and were diagnosed with hepatitis B or C virus infection,co-infection with hepatitis B and C,or alcoholic cirrhosis of the liver between 2005 and *** between HCC etiology and post-transplant outcomes were examined with multivariate analysis *** Liver cirrhosis was due to alcohol in 10.5%of patients,hepatitis B in 6.6%,hepatitis C in 10.8%,and combined hepatitis B and C infection in 24.3%.Distant metastasis was found in 16.7%of patients infected with hepatitis B and 9%of hepatitis C *** recurrence of HCC was significantly more likely to occur in patients with hepatitis B than in those with alcohol-induced *** After liver transplantation,patients with hepatitis B infection have a higher risk of local recurrence and distant *** care and patient tracking are essential for liver transplant patients with hepatitis B infection.
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