检索结果-南通市图书馆

Early kidney injury during long-term adefovir dipivoxil therapy for chronic hepatitis B

World Journal of Gastroenterology 2015年第12期21卷 3657-3662页

作者： Hong-Yu Jia Feng Ding Jian-yang Chen Jiang-Shan Lian Yi-Min Zhang Lin-Yan Zeng Dai-Rong Xiang Liang Yu Jian-Hua Hu Guo-Dong Yu huan Cai Ying-Feng Lu Lin Zheng Lan-juan Li Yi-Da yang Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases State Key Laboratory for Diagnosis and Treatment of Infectious Disease First Affiliated Hospital of Zhejiang University School of Medicine

AIM: To evaluate urine β2-microglobulin(β2-M), retinol-binding protein(RBP) excretion, and renal impairment with adefovir dipivoxil(ADV) for chronic hepatitis B. METHODS: We enrolled 165 patients with chronic hepatitis B infection who were treated with ADV monotherapy(n = 90) or ADV plus lamivudine combination therapy(n = 75). An additional 165 chronic hepatitis B patients treated with entecavir were recruited as controls. We detected serum creatinine, urine β2-M, and RBP levels, and estimated the glomerular filtration rate(e GFR) at the initiation of antiviral therapy and every 6 mo for a period of five years. RESULTS: Urine β2-M abnormalities were observed in patients during the first(n = 3), second(n = 7), third(n = 11), fourth(n = 16), and fifth(n = 21) year of ADV treatment. Urinary RBP abnormalities were observed in patients during the first(n = 2), second(n = 8), third(n = 12), fourth(n = 15), and fifth(n = 22) year of ADV treatment. e GFR decreased 20%-30% from baseline in 20 patients, 30%-50% in 12 patients, and > 50% in 3 patients during the five years of treatment. Further analysis indicated that decreases in e GFR of ≥ 30% relative to the baseline level correlated significantly with urine RBP and β2-M abnormalities. In contrast, both serum creatinine and e GFR remained stable in patients treated with entecavir, and only one of these patients developed a urine β2-M abnormality, and two developed urine RBP abnormalities during the five years of treatment. CONCLUSION: Urine RBP and β2-M are biomarkers of renal injury during long-term ADV treatment for chronic hepatitis B, and indicate when treatment should be switched to entecavir.

关键词： Adefovir dipivoxil Entecavir Retinol binding prote

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Isolated anti-Ro/La antibody-negative fetal complete atrioventricular block:a case report

引用

Chinese Medical Journal 2020年第1期133卷 97-98页

作者： huan-huan Huo Ya-juan Wei Yan-Hua Qi Bao-Min Liu Department of Ultrasound the Second Affiliated HospitalXi'an Jiaotong UniversityXi'anShaanxi 710004China

To the Editor:A 28-year-old woman(P1G0 at 30 weeks of gestation)was referred to our diagnostic center for an irregular fetal cardiac *** risk factors were noted and the tests for detecting maternal auto-antibodies(anti-Ro/La,anti-dsDNA,and anti-nuclear antibodies)were *** fetal systematic ultrasonic examination was *** fetal echocardiogram revealed that the fetal cardiac structure and function were normal;neither hydrops nor any other malformations were detected.

关键词： fetal cardiac neither

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis of Mesoporous Molecular Sieve MCM-41 in Extremely Dense System

引用

Chinese Chemical Letters 1997年第7期8卷 649-652页

作者： Guang huan LIU Rui juan GAO Hong XU Jin Xiang DONG(Research Institute of special Chemicals. Taiyuan University of Technology, Taiyuan, Shanxi 030024) TAIYUAN UNIV TECHNOL RES INST SPECIAL CHEMTAIYUAN 020024SHANXIPEOPLES R CHINA

Mesoporous molecular sieve MCM-41 has been synthesized in the extremely dense system (with H2O/Si<10) and characterized by XRD, N-2 adsorption isotherm as well as probe reactions of cracking of cumene and isomerizatio... 详细信息

关键词： MCM Synthesis of Mesoporous Molecular Sieve MCM-41 in Extremely Dense System SiO

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Short-term Preoperative Octreotide for Thyrotropin-secreting Pituitary Adenoma

引用

Chinese Medical Journal 2017年第8期130卷 936-942页

作者： Hong-juan Fang Yu Fu huan-Wen Wu Yi-Lin Sun yang-Fang Li Ya-Zhuo Zhang Li-Yong Zhong Department of Endocrinology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Pathology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China Department of Ultropathology Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China Beijing Neurosurgical Institute Beijing Institute for Brain Disorders Brain Tumor Center Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background： Thyrotropin-secreting pituitary adenomas （TSHomas） are a rare cause of hyperthyroidism. Somatostatin （SST） analogs work by interacting with somatostatin receptors （SSTRs）. This study aimed to evaluate short-term preoperative octreotide （OCT） use in TSHoma patients and to investigate SSTR2 and SSTR5 expression and observe structural changes in tumor tissue. Methods： We reviewed records and samples from eight TSHoma patients treated between July 2012 and July 2015. We tested immunohistochemically for SSTR2/5 expression and examined TSHoma cells for morphological changes. Signed rank sum test was used to compare the efficacy of short-term preoperative OCT treatment. Results： OCT treatment （median time： 7.9 days, range： 3-16 days; median total dose： 1.8 mg, range： 0.94.2 mg） led to significant decrease in all patients＇ thyroid hormone levels （FT3 [nmol/L]： 8.33 [7.02, 12.29] to 4.67 [3.52, 5.37] [P = 0.008]; FT4 [pmol/L]： 25.36 [21.34, 28.99] to 16.66 [14.88, 21.49] [P = 0.016]; and TSH [gU/ml]： 5.80 [4.37, 6.78] to 0.57 [0.19, 1.24] [P = 0.008]）. All the eight tumor specimens expressed high SSTR2 protein levels; 5/8 expressed high SSTRS, but 3/8 that expressed low SSTR5 presented a significantly higher TS H suppression rate （P = 0.036）. Electron microscopy showed subcellular level impairments, including clumped nuclear chromatin and reduced cytoplasmic volume. Golgi complexes were observed in the OCT-treated TSHoma specimens. Conclusions： OCT can control hormone levels and damage the ultrastructure of tumor cells and organelles. Short-term response to OCT may be related to SSTR5 expression. Preoperative SST analog treatment for TSHoma could be considered as a combination therapy.

关键词： Electron Microscopy Somatostatin Analogs Somatostatin Receptor Therapy Thyrotropin-secreting Pituitary Adenoma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes

引用

Natural Products and Bioprospecting 2015年第3期5卷 159-166页

作者： Ji-huan Qin Jun-Zeng Ma Xing-Wei yang Ying-Jie Hu juan Zhou Lin-Chun Fu Ru-Hua Tian Shan Liu Gang Xu Xiao-Ling Shen Laboratory of Chinese Herbal Drug Discovery Tropical Medicine InstituteGuangzhou University of Chinese MedicineGuangzhou 510405People’s Republic of China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China

6a-Hydroxylup-20(29)-en-3-on-28-oic acid(1),a natural triterpenoid,was found to possess the ability in a dose-dependent manner inhibiting hormone-induced adipocyte differentiation in 3T3-L1 preadipocytes,and restoring glucose consuming ability in dexamethasone(DXM)-induced insulin resistant 3T3-L1 *** 1 was also found to ameliorate DXM-induced adipocyte dysfunction in lipolysis and adipokine *** studies revealed that 1 inhibited adipocyte differentiation in 3T3-L1 preadipocytes via down-regulating hormone-stimulated gene transcription of peroxisome proliferator-activated receptor c and CCAAT-enhancer-binding protein alpha which are key factors in lipogenesis,and restored DXM-impaired glucose consuming ability in differentiated 3T3-L1 adipocytes via repairing insulin signaling pathway and activating down-stream signaling transduction by phosphorylation of signaling molecules PI3K/p85,Akt2 and AS160,thus leading to increased translocation of glucose transporter type 4 and transportation of glucose.

关键词： 6a-Hydroxylup-20(29)-en-3-on-28-oic acid 3T3-L1 Adipocyte differentiation Dexamethasone induced insulin resistance Adipocyte dysfunction PI3K/Akt2 signaling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel pyrazole fused heterocyclic ligands:Synthesis,characterization,DNA binding/cleavage activity and anti-BVDV activity

引用

Chinese Chemical Letters 2015年第5期26卷 534-538页

作者： Chao Han Yan-Chun Guo Dan-Dan Wang Xing-Jie Dai Feng-juan Wu huan-Fei Liu Gui-Fu Dai Jing-Chao Tao College of Chemistry and Molecular Engineering Zhengzhou University School of Life Sciences Zhengzhou University

A series of novel pyrazole fused heterocyclic derivatives were synthesized via a two-step procedure or a one-pot two step method, and their catalytic DNA cleavage abilities and anti-BVDV activities were also evaluated. The results obtained indicated that compounds 3b-3c could catalyze the cleavage of supercoiled DNA （pUC 19 plasmid DNA） to nicked DNA under physiological conditions with high yields via a hydrolytic mechanism. The studies on anti-viral activities against bovine viral diarrhea virus （BVDV） demonstrated that some of the pyrazole derivatives showed pronounced anti-BVDV activity with interesting ECso values and no significant cytotoxicity. Among them, compound 31 showed the highest antiviral activity （ECso = 0.12 μmol/L） and was 10 fold more than that of the positive control ribavirin （ECso = 1.3 μmol/L）, which provided a potential candidate for the development of anti-BVDV agents.

关键词： Synthesis Tetramic acids DNA binding/cleavage Pyrazole derivatives Anti-BVDV

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antifeedant and Antiviral Diterpenoids from the Fresh Roots of Euphorbia jolkinii

引用

Natural Products and Bioprospecting 2014年第2期4卷 91-100页

作者： Chun-Shuai huang Shi-Hong Luo Yao-Lan Li Chun-huan Li juan Hua Yan Liu Shu-Xi Jing Ying Wang Min-Jie yang Sheng-Hong Li State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Graduate University of Chinese Academy of Sciences Beijing 100049China Institute of Traditional Chinese Medicine and Natural Products Jinan UniversityGuangzhou 510632China

The perennial herbaceous plant Euphorbia jolkinii(Euphorbiaceae)is a noxious weed widely distributed in the grasslands of northwestern Yunnan and has greatly threatened the local *** investigation on the fresh roots of *** afforded six new diterpenoids 1,2,4–6,and 8,together with fifteen known *** structures were elucidated on the basis of 1D and 2D NMR and other spectroscopic ***,lathyrane,abietane,and ent-kaurane diterpenoids were reported from this plant for the first *** compounds were evaluated for their antifeedant and anti-RSV(respiratory syncytial virus)*** 2 and ingenol(3)exhibited moderate antifeedant activity against a generalist insect herbivore,Spodoptera exigua,with EC50 values of 17.88 and 17.71 lg/cm2 *** 19 showed significant anti-RSV activity,with 50%inhibition(IC50)value of 10.0 lM and selective index of *** 1 and 2 were less active against RSV virus,both with IC50 value of 25 lM,and with selective indices of 1.0 and 3.2 *** findings provided new evidence for the biological functions and utilization of the diversified diterpenoid metabolites in the roots of this rich but harmful plant.

关键词： Euphorbia jolkinii Diterpenoids Antifeedant activity Antiviral activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

混杂Petri网系统中同步距离的确定及同步控制器的设计

引用

控制理论与应用 2012年第7期29卷 884-892页

作者：方欢陆阳黄镇谨杨娟合肥工业大学计算机与信息学院安徽合肥230009 安徽理工大学理学院安徽淮南232001

目前,对于广义混杂Petri网的变迁公平关系和同步距离都只有极少结论,本文对广义混杂Petri网,给出了两个变迁(组)之间公平关系和同步距离的形式定义,并通过修剪的不变行为状态(invariant behavior,IB)演化图给出确定变迁同步距离的方法,... 详细信息

目前,对于广义混杂Petri网的变迁公平关系和同步距离都只有极少结论,本文对广义混杂Petri网,给出了两个变迁(组)之间公平关系和同步距离的形式定义,并通过修剪的不变行为状态(invariant behavior,IB)演化图给出确定变迁同步距离的方法,得出了判定变迁公平关系的充要条件,还证明了变迁公平关系、同步距离和修剪的IB演化图之间的联系.本文的方法对简单离散Petri网不仅能得到已有的相关结论,而且推广了同步距离概念适用的范围.最后,以混杂运输控制系统为例,以同步距离为基础设计同步控制器,说明同步距离在实现同步控制结构设计上的有效性.

关键词：广义混杂Petri网变迁公平关系同步距离同步控制器性质判定

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structurally Divergent Synthesis of Azetidines,5,6-Dihydro-1,3-oxazines and 2,3-Dihydro-1,4-oxazines through Palladium-Catalyzed Tandem Allylic Substitution Reaction

引用

Chinese Journal of Chemistry 2024年第22期42卷 2773-2778页

作者： Ru-Fang Meng Yu-juan Kong Xiao-Yan Wu huan Zhang Wei Wang Wen-Jie Liang Lan Zheng Chenxiang Lin Wei Su Jun-An Xiao Guangxi Key Laboratory of Natural Polymer Chemistryand Physics Nanning Normal UniversityNanningGuangxi 530001China

Comprehensive Summary A regiodivergent synthesis of azetidines,5,6-dihydro-1,3-oxazines and 2,3-dihydro-1,4-oxazines has been achieved through palladium-catalyzed tandem allylic substitution *** protocol provides a variety of heterocycles in satisfactory yields with good to excellent regioselectivities under mild reaction conditions.

关键词： Palladium catalysis Annulation Azetidine Domino reactions Regioselectivity Allylic dicarbonate Allylic substitution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Uncommon Bis-quinolizidine Alkaloids from the Hainan Sponge Neopetrosia chaliniformis

引用

Chinese Journal of Chemistry 2021年第7期39卷 1838-1842页

作者： Bao Chen Xia-juan huan Ze-Hong Miao Nicole J.de Voogd Yu-Cheng Gu Chang-Yun Wang Yue-Wei Guo Xu-Wen Li Key Laboratory of Marine Drugs The Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong266003 China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences555 Zu Chong Zhi RoadZhangjiang Hi-Tech ParkShanghai201203 China Open Studio for Druggability Research of Marine Natural Products Pilot National Laboratory for Marine Science and Technology(Qingdao)1 Wenhai RoadAoshanweiJimoQingdaoShandong266237 China Syngenta Jealott's Hill International Research CentreBracknellBerkshireRG426EY United Kingdom Naturalis Biodiversity Center P.O.Box 95172300 RALeidenthe Netherlands Leiden University Institute of Environmental SciencesP.O.Box 95182300 RALeidenthe Netherlands

Main observation and conclusion Two new bis-quinolizidine alkaloids,neopetrosiasins A(1)and B(2),possessing cis-and trans-quinolizidine nuclei,one known related analogue petrosin(3)and three known xestospongins(4-6),w... 详细信息

关键词： Sponge 1 Neopetrosia chaliniformis Alkaloids Configuration determination Cytotoxicity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：