Uncommon Bis-quinolizidine Alkaloids from the Hainan Sponge Neopetrosia chaliniformis

作     者：Bao Chen Xia-Juan Huan Ze-Hong Miao Nicole J.de Voogd Yu-Cheng Gu Chang-Yun Wang Yue-Wei Guo Xu-Wen Li Bao Chen;Xia-Juan Huan;Ze-Hong Miao;Nicole J.de Voogd;Yu-Cheng Gu;Chang-Yun Wang;Yue-Wei Guo;Xu-Wen Li

作者机构：Key Laboratory of Marine DrugsThe Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong266003 China State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences555 Zu Chong Zhi RoadZhangjiang Hi-Tech ParkShanghai201203 China Open Studio for Druggability Research of Marine Natural ProductsPilot National Laboratory for Marine Science and Technology(Qingdao)1 Wenhai RoadAoshanweiJimoQingdaoShandong266237 China SyngentaJealott's Hill International Research CentreBracknellBerkshireRG426EY United Kingdom Naturalis Biodiversity CenterP.O.Box 95172300 RALeidenthe Netherlands Leiden UniversityInstitute of Environmental SciencesP.O.Box 95182300 RALeidenthe Netherlands 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2021年第39卷第7期

页      面：1838-1842页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This research work was financially supported by the National Natural Science Foundation of China(Nos.81991521,82022069,42076099,41830535) the Shanghai Rising-Star Program(No.20QA1411100) the National Key Research and Development Program of China(No.2018YFC0310903) the Taishan Scholars Program,China.Bao Chen is thankful for the financial support of Syngenta-OUC-PhD Studentship Project 

主　　题：Sponge 1 Neopetrosia chaliniformis Alkaloids Configuration determination Cytotoxicity 

摘      要：Main observation and conclusion Two new bis-quinolizidine alkaloids,neopetrosiasins A(1)and B(2),possessing cis-and trans-quinolizidine nuclei,one known related analogue petrosin(3)and three known xestospongins(4-6),were isolated from the South China Sea sponge Neopetrosia chaliniformis.