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Thin-walled and large-sized magnesium alloy die castings for passenger car cockpit:Application,materials,and manufacture

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China Foundry 2024年第5期21卷 525-545页

作者： Lei Zhan Yu-meng Sun Yang Song Chun-hua Kong Kai Ma Bai-xin Dong Hong-yu Yang Shi-li Shu feng qiu School of Automotive Engineering Jilin Communication PolytechnicChangchun 130012China Key Laboratory of Automobile Materials of Ministry of Education School of Materials Science and EngineeringNanling CampusJilin UniversityChangchun 130025China

In order to effectively reduce energy consumption and increase range mile,new energy vehicles represented by Tesla have greatly aroused the application of integrated magnesium(Mg)alloy die casting technology in ***,the application of Mg alloys in automobiles,especially in automotive cockpit components,is quite extensive,while it has almost disappeared for a period of time due to its relatively high cost,causing a certain degree of information loss in the application technology of Mg alloy parts in *** rapid development of automotive technology has led to a higher requirement for the automotive components compared with those traditional ***,whatever the components themselves,or the Mg alloy materials and die casting process have to face an increasing challenge,needing to be *** addition,owing to its high integration characteristics,the application of Mg alloy die casting technology in large-sized and thin-walled automotive parts has inherent advantages and needs to be expanded ***,it necessitates exploring advance Mg alloys and new product structures and optimizing die casting *** article summarizes and analyzes the development status of thin-walled and large-sized die casting Mg alloy parts in passenger car cockpit and corresponding material selection methods,die casting processes as well as mold design ***,this work will aid researchers in establishing a comprehensive understanding of the manufacture of thin-walled and large-sized die casting Mg alloy parts in automobile *** will also assist them in developing new Mg alloys with improved comprehensive performance and new processes to meet the high requirements for die casting automotive components.

关键词： Mg alloys thin wall large size automotive part die casting

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Hyphae-mediated bioassembly of carbon fibers derivatives for advanced battery energy storage

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Carbon Energy 2024年第6期6卷 140-150页

作者： Lei huang Zhong qiu Ping Liu Xinhui Xia feng Cao Xinping He Chen Wang Wangjun Wan Yongqi Zhang Yang Xia Wenkui Zhang Minghua Chen Jiancang Zhou Department of Critical Care Medicine Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouChina State Key Laboratory of Silicon Materials Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang ProvinceSchool of Materials Science&EngineeringZhejiang UniversityHangzhouChina College of Materials Science&Engineering Zhejiang University of TechnologyHangzhouChina State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhouChina Department of Engineering Technology Huzhou CollegeHuzhouChina Zhejiang Academy of Science and Technology for Inspection&Quarantine HangzhouZhejiangChina Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengduChina Key Laboratory of Engineering Dielectric and Applications(Ministry of Education) School of Electrical and Electronic EngineeringHarbin University of Science and TechnologyHarbinChina

Ingenious design and fabrication of advanced carbon-based sulfur cathodes are extremely important to the development of high-energy lithium-sulfur batteries,which hold promise as the next-generation power ***,for the first time,we report a novel versatile hyphae-mediated biological assembly technology to achieve scale production of hyphae carbon fibers(HCFs)derivatives,in which different components including carbon,metal compounds,and semiconductors can be homogeneously assembled with HCFs to form composite *** mechanism of biological adsorption assembly is also *** a representative,reduced graphene oxides(rGOs)decorated with hollow carbon spheres(HCSs)successfully co-assemble with HCFs to form HCSs@rGOs/HCFs hosts for sulfur *** this unique architecture,not only large accommodation space for sulfur but also restrained volume expansion and fast charge transport paths are ***,multiscale physical barriers plus chemisorption sites are simultaneously established to anchor soluble lithium ***,the designed HCSs@rGOs/HCFs-S cathodes deliver a high capacity(1189 mA h g^(-1)at 0.1 C)and good high-rate capability(686 mA h g^(-1)at 5 C).Our work provides a new approach for the preparation of high-performance carbon-based electrodes for energy storage devices.

关键词： bioassembly carbon fibers energy storage graphene lithium-sulfur batteries

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Electroacupuncture Promotes Functional Recovery after Facial Nerve Injury in Rats by Regulating Autophagy via GDNF and PI3K/m TOR Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第3期30卷 251-259页

作者： YAO Jun-peng feng Xiu-mei WANG Lu LI Yan-qiu ZHU Zi-yue YAN Xiang-yun YANG Yu-qing LI Ying ZHANG Wei Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu611137China Department of Rehabilitation Medicine Guanghan People’s HospitalGuanghanSichuan Province618399China Academic Affairs Office Chengdu University of Traditional Chinese MedicineChengdu611137China

Objective:To explore the mechanism of electroacupuncture(EA) in promoting recovery of the facial function with the involvement of autophagy,glial cell line-derived neurotrophic factor(GDNF),and phosphatidylinositol-3-kinase(PI3K)/mammalian target of rapamycin(mTOR) signaling ***:Seventy-two male Sprague-Dawley rats were randomly allocated into the control,sham-operated,facial nerve injury(FNI),EA,EA+3-methyladenine(3-MA),and EA+GDNF antagonist groups using a random number table,with 12 rats in each *** FNI rat model was established with facial nerve crushing *** intervention was conducted at Dicang(ST 4),Jiache(ST 6),Yifeng(SJ 17),and Hegu(LI 4) acupoints for 2 *** Simone’s 10-Point Scale was utilized to monitor the recovery of facial *** histopathological evaluation of facial nerves was performed using hematoxylin-eosin(HE) *** levels of Beclin-1,light chain 3(LC3),and P62 were detected by immunohistochemistry(IHC),immunofluorescence,and reverse transcriptionpolymerase chain reaction,***,IHC was also used to detect the levels of GDNF,Rai,PI3K,and ***:The facial functional scores were significantly increased in the EA group than the FNI group(P<0.05 or P<0.01).HE staining showed nerve axons and myelin sheaths,which were destroyed immediately after the injury,were recovered with EA *** expressions of Beclin-1 and LC3 were significantly elevated and the expression of P62 was markedly reduced in FNI rats(P<0.01);however,EA treatment reversed these abnormal changes(P<0.01).Meanwhile,EA stimulation significantly increased the levels of GDNF,Rai,PI3K,and mTOR(P<0.01).After exogenous administration with autophagy inhibitor 3-MA or GDNF antagonist,the repair effect of EA on facial function was attenuated(P<0.05 or P<0.01).Conclusions:EA could promote the recovery of facial function and repair the facial nerve damages in a rat model of *** may exert this neuroreparative effect through

关键词： electroacupuncture facial nerve injury autophagy glial cell line-derived neurotrophic factor phosphatidylinositol-3-kinase/mammalian target of rapamycin Chinese medicine

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Experiments and simulation on the overall DMG of long-haul cascade FM-EDFA systems

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Chinese Optics Letters 2024年第4期22卷 53-59页

作者：江歆睿武保剑严伟文峰邱昆 Key Laboratory of Optical Fiber Sensing and Communications Ministry of EducationUniversity of Electronic Science and Technology of ChinaChengdu 611731China

All-fiber few-mode erbium-doped fiber amplifiers(FM-EDFAs) with isolation and wavelength division multiplexers(IWDMs)have been developed to enable flexible pumping in different directions. The FM-EDFA can achieve >30 d B modal gain with<0.3 d B differential modal gain(DMG). We experimentally simulate the DMG performance of a cascade FM-EDFA system using the equivalent spectrum method. The overall DMG reaches 1.84 d B after 10-stage amplification. We also build a recirculating loop to simulate the system, and the developed FM-EDFA can support transmission up to 3270 km within a 2 d B overall DMG by optimizing the few-mode fiber length in the loop.

关键词： mode division multiplexing few-mode erbium-doped fiber amplifier gain equalization

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Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1283-1301页

作者： Qian Zhao Jiale Dong Han Liu Hui Chen huan Yu Shuyin Ye Shuangjin Yu Yu Li Longhui qiu Nazi Song Hongjiao Xu Qi Liu Zhiteng Luo Yuyi Li Rui Wang Guodong Chen Xianxing Jiang School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of Chiral Molecule and Drug DiscoverySun Yat-sen UniversityGuangzhou 510006China Organ Transplant Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510006China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510006China Shenzhen Turier Biotech.Co. Ltd.Shenzhen 518118China School of Life Sciences Key Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical SciencesLanzhou UniversityLanzhou 730000China

The role of co-agonists of glucagon-like peptide-1 receptor(GLP-1R)and glucagon receptor(GCGR)in chronic kidney disease(CKD)remains *** we found that GLP-1R and GCGR expression levels were lower in the kidneys of mice with CKD compared to healthy mice and were correlated with disease ***,GLP-1R or GCGR knockdown aggravated the progression of kidney injury in both diabetic db/db mice and non-diabetic mice undergoing unilateral ureteral obstruction(UUO).Based on the importance of GLP-1R and GCGR in CKD,we reported a novel monomeric peptide,1907-B,with dual-agonism on both GLP-1R and *** data confirmed that 1907-B had a longer half-life than long-acting semaglutide in rats or cynomolgus monkeys(~2-3 fold)and exhibited better therapeutic contribution to CKD than best-in-class monoagonists,semaglutide,or glucagon,in db/db mice and UUO *** lock-of-function models,including selective pharmacological activation and genetic knockdown,confirmed that 1907-B’s effects on ameliorating diabetic nephropathy in db/db mice,as well as inhibiting kidney fibrosis in UUO mice,were mediated through GLP-1 and glucagon *** findings highlight that 1907-B,a novel GLP-1R and GCGR co-agonist,exerts multifactorial improvement in kidney injuries and is an effective and promising therapeutic option for CKD treatment.

关键词： GLP-1 receptor Glucagon receptor Chronic kidney disease Diabetic nephropathy Kidney fibrosis Dual-agonism

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Seismic Response Analysis of Steel Structure Isolation System Under Long-Period Seismic Motion

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Journal of Architectural Research and Development 2024年第3期8卷 147-155页

作者： Long Yu Mei Sheng huan feng Jianan Hu Chuzhou Polytechnic Chuzhou 239000Anhui ProvinceChina Hefei Urban Construction Development Co. Ltd.Hefei 230031Anhui ProvinceChina

To analyze the seismic response of steel structure isolation systems under long-period seismic motion,a 9-story steel frame building was selected as the *** steel structure finite element models were established using *** spectrum analysis was conducted on the seismic motion to determine if it adhered to the characteristics of long-period seismic *** analysis of each structural model revealed that the isolation structure significantly prolonged the structural natural vibration period and enhanced seismic *** reactions and floor displacements of various structures notably increased under long-period seismic motion compared to regular seismic *** isolation bearings in the lower part of the structure proved more effective under long-period seismic *** seismic design engineering,it is essential to consider the impact of long-period seismic motion on structures and the potential failure of isolation bearings.

关键词： Long-period seismic motion Steel structure Mid-story isolation structure Isolation bearing Seismic performance

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Time-resolved ultra-small-angle X-ray scattering beamline(BL10U1)at SSRF

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Nuclear Science and Techniques 2024年第2期35卷 6-19页

作者： Wen-Qiang Hua Chun-Ming Yang Ping Zhou feng Tian Jin-You Lin Yu-Zhu Wang Xiao-Yun Li Xia-Ran Miao Chun-Xia Hong qiu-Shi huang Xin-Tong Zhao Yong-feng Men Jie Wang Xing-Yu Gao Xiu-Hong Li Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Key Laboratory of Advanced Micro Structural Materials MOEInstitute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji UniversityShanghai 200092China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

The construction of a new beamline,BL10U1,was completed at the Shanghai synchrotron radiation facility in *** multipurpose beamline was designed to provide X-ray scattering techniques such as ultra-small-angle X-ray scattering(USAXS),small-angle X-ray scattering(SAXS),wide-angle X-ray scattering,and microfocus SAXS(μSAXS)for a broad user *** realize fast time-resolved USAXS experiments,the beamline adopted an in-vacuum undulator with a total length of 1.6 m as the photon *** in-house cryogenic-cooled double multilayer monochromator was installed to deliver a photon flux of approximately 10^(13) photons/s at a photon energy of 10 *** three-year successful operation of this beamline demonstrated that the monochromator operated smoothly,as ***10U1 has three end stations in succession:USAXS end station,μSAXS end station,and end station for industrial *** minimum scattering vector q~0.0042 nm^(-1) at 10 keV can be achieved at the USAXS end station equipped with a 28 m-long and 1.8 m-diameter vacuum flight *** theμSAXS end station,a beam spot of less than 10×8μm was achieved for micro-SAXS *** contrast,in situ experimental instruments up to 5 m high and 8 m wide can be mounted at the industrial application end station,which offers industrial scientists the opportunity to use their large industrial ***10U1 opens up a new capability to investigate phenomena such as non-equilibrium and dynamic processes of materials with a wide length scale from angstroms to micrometers with millisecond time *** this paper,we also report beamline design considerations and commissioning results.

关键词： Synchrotron radiation Ultra-small-angle X-ray scattering Micro small-angle X-ray scattering USAXS Time resolved μSAXS

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Artesunate Induces Ferroptosis in Hepatic Stellate Cells and Alleviates Liver Fibrosis via the ROCK1/ATF3 Axis

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 36-51页

作者： Yingqian Wang Yujia Li Yangling qiu Min Shen Ling Wang Jiangjuan Shao feng Zhang Xuefen Xu Zili Zhang Mei Guo Shizhong Zheng Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing University of Chinese MedicineNanjingJiangsuChina Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhouJiangsuChina Jiangsu Key Laboratory of Therapeutic Material of Chinese Medicine Nanjing University of Chinese MedicineNanjingJiangsu China

Background and Aims:Development of fibrosis in chronic liver disease requires activation of hepatic stellate cells(HSCs)and leads to a poor ***(Art)is an ester derivative of artemisinin that can induce ferroptosis in HSCs,and activated transcriptional factor 3(ATF3)is an ATF/CREB transcription factor that is induced in response to *** this study,we examined the role of the Rho-associated protein kinase 1(ROCK1)/ATF3 axis in Art-induced ferroptosis in ***:HSC activation and ferroptosis were studied in vitro by western blotting,polymerase chain reaction,immunofluorescence,and other ***3 electrophoretic mobility and ROCK1 protein stability were assayed by western *** was used to detect the interaction of ROCK1 and ATF3,as well as ATF3 phosphorylation.A ubiquitination assay was used to verify ROCK1 ***3-interfering and Rock1-overexpressing mice were constructed to validate the anti-hepatic fibrosis activity of Art in ***:Art induced ferroptosis in HSCs following glutathione-dependent antioxidant system inactivation resulting from nuclear accumulation of unphosphorylated ATF3 mediated by ROCK1-ubiquitination in *** also decreased carbon tetrachloride-induced liver fibrosis in mice,which was reversed by interfering with Atf3 or overexpressing ***:The ROCK1/ATF3 axis was involved in liver fibrosis and regulation of ferroptosis,which provides an experimental basis for further study of Art for the treatment of liver fibrosis.

关键词： Ferroptosis Liver fibrosis Antioxidant system ATF3 ROCK1

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Interpenetrated Structures for Enhancing Ion Diffusion Kinetics in Electrochemical Energy Storage Devices

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Nano-Micro Letters 2024年第11期16卷 718-728页

作者： Xinzhe Xue Longsheng feng qiu Ren Cassidy Tran Samuel Eisenberg Anica Pinongcos Logan Valdovinos Cathleen Hsieh Tae Wook Heo Marcus A.Worsley Cheng Zhu Yat Li Department of Chemistry and Biochemistry University of California1156 High StreetSanta CruzCA 95064USA Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCA 94550USA

The architectural design of electrodes offers new opportunities for next-generation electrochemical energy storage devices(EESDs)by increasing surface area,thickness,and active materials mass loading while maintaining good ion diffusion through optimized electrode ***,conventional thick electrodes increase ion diffusion length and cause larger ion concentration gradients,limiting reaction *** demonstrate a strategy for building interpenetrated structures that shortens ion diffusion length and reduces ion concentration *** free-standing device structure also avoids short-circuiting without needing a *** feature size and number of interpenetrated units can be adjusted during printing to balance surface area and ion *** with a 3D-printed interpenetrated polymer substrate,we metallize it to make it *** substrate has two individually addressable electrodes,allowing selective electrodeposition of energy storage *** a Zn//MnO_(2) battery as a model system,the interpenetrated device outperforms conventional separate electrode configurations,improving volumetric energy density by 221%and exhibiting a higher capacity retention rate of 49%compared to 35%at temperatures from 20 to 0℃.Our study introduces a new EESD architecture applicable to Li-ion,Na-ion batteries,supercapacitors,etc.

关键词： Interpenetrated structure 3D printing Electrochemical energy storage Ion diffusion length Inter-electrode distance

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Structural and functional design of geopolymer adsorbents:a review

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Tungsten 2024年第1期6卷 48-76页

作者： Hai-Ze Jin Chen-Xi qiu Yan-Song Li Bao Liu Jun-Yi Liu Qiao Chen Xue-feng Lu Cui-Xia Li Qi-Kun Wang School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou 730050China State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou 730050China Shenyang Nonferrous Metals Research Institute Co. LTDShenyang 110000China Automotive Engineering Research Institute Jiangsu UniversityZhenjiang 212013China School of Materials Science and Engineering Jingdezhen Ceramic UniversityJingdezhen 333403China

The water pollution derived from the discharge of heavy metals,antibiotics,dyes and surfactants wastewater,*** seriously affected human survival and ecological *** an efficient and low-cost physical wastewater treatment process,the adsorption is a continuous hot spot in related scientific research and *** are non-crystal or semi-crystalline materials with high-efficiency adsorption performance due to the alkali metal ions that balance the electronegative aluminosilicate skeleton can be efficiently replaced by other cations in the aqueous *** related studies of different application conditions,service objects and morphological differences of geopolymer adsorbents based on structure-function design have been in-depth exploration and *** review aims to summarize the research progres s of the structure-function design based on the geopolymerization mechanism and kinetics and service *** overview of service characteristics and progress of geopolymers in the wastewater treatment field(e.g.,dyes,heavy metals,radionuclides,surfactants,antibiotics,ammonium,phosphorus,nitrogen and CO_(2),etc.)are systematically *** the evolution and development of morphological differences and the relationship of structure-function design of geopolymer adsorbents were compared and ***,the challenge worth overcoming,the trends worth considering and perspectives worth developing are highlighted.

关键词： Geopolymer Wastewater Adsorption Structure-function design Application

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