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On a Discrete Version of Alexandrov's Projection Theorem

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Acta Mathematica Sinica,English Series 2013年第8期29卷 1597-1606页

作者： huan XIONG School of Mathematical Sciences Peking University

In this paper, we consider a discrete version of Aleksandrov＇s projection theorem. We prove that an origin-symmetric convex lattice set, whose lattice＇s y-coordinates＇ absolute values are not bigger than 2, can be uniquely determined by its lattice projection counts if its cardinality is not 11. This partly answers a question on the discrete version of Aleksandrov＇s projection theorem which was proposed by Gardner, Gronchi and Zong in 2005.

关键词： Aleksandrov's projection theorem convex lattice set discrete geometry

Efficient nano-enabled therapy for gastrointestinal cancer using silicasome delivery technology

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Science China Chemistry 2021年第11期64卷 1946-1957页

作者： Zhenhan Feng huan Meng CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing100190China University of Chinese Academy of Sciences Beijing100049China

The gastrointestinal tract is an eight-meter-long pathway that includes various organs,which runs from the mouth to the *** certain pathological circumstances,tumors can develop in one of these *** these tumors could be surgically removed at an early stage of their development,the disease could be incurable and fatal if they *** this article,we review our recent progress in the development of a series of rationally designed mesoporous silica nanoparticles(MSNP),which includes the use of a supported lipid bilayer(***),to provide more efficacious and well-tolerated chemotherapy and/or chemo-immunotherapy for the different types of gastrointestinal(GIT)cancer,such as pancreatic ductal adenocarcinoma(PDAC)and colorectal cancer(CRC).Through the use of our silicasome platform,we were able to deliver single-drug or synergistic drug combinations to orthotopic PDAC tumors in murine Kras and human-derived PDAC *** also developed a scalable silicasome formulation for the weak-base anticancer drug,irinotecan,leading to a highly potent treatment option for mice with reduced *** address the complex and heterogeneous tumor microenvironment(TME),we have discussed the impact of stroma nanoengineering by transcytosis activation or vascular access improvement,which could enhance the effectiveness of nanocarriers in ***,we have upgraded our drug-delivering silicasome as a chemoimmunotherapy platform that implements immunogenic cell death(ICD)as an endogenous vaccination *** cointerference occurs in regionally overexpressed immune checkpoint pathways,it was possible to generate a"hot"tumor microenvironment and propagate anticancer immunity,leading to long-lasting anticancer *** advanced preclinical results are promising and expected to generate a positive impact by providing efficacious and safe nanocarriers that can be placed into the pipeline of novel nanomedicine for the management of GIT cancer.

关键词： silicasome gastrointestinal cancer drug delivery chemotherapy immunotherapy

Engineering Multifunctional Thylakoid as an Oxygen Self-Supplying Photosensitizer for Esophageal Squamous Cell Carcinoma-Targeted Photodynamic Therapy

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CCS Chemistry 2023年第11期5卷 2519-2533页

作者： yingqiu Qi Hui Wang Anni Du Chen Liu Xiaofan Sun Xiaocao Meng Jinxiu Shen Sai-Yang Zhang Li-Rong Zhang Bing Jiang Guangjun Nie huan Min Department of Pharmacology School of Basic Medical SciencesState Key Laboratory of Esophageal Cancer Prevention and TreatmentNanozyme Medical CenterZhengzhou UniversityZhengzhou 450001 Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450001 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaZhongguancunBeijing 100190

Photodynamic therapy(PDT)has emerged as an alternative treatment strategy for esophageal squamous cell carcinoma(ESCC).However,the clinical therapeutic efficiency of PDT is severely limited by poorly targeted photosensitizer delivery,insufficient oxygen supply,and neutralization by excessive glutathione(GSH)in tumor ***,an engineered multifunctional thylakoid nanostructure,TMEM@PLGA@GA(abbreviated as TEPG),composed of a thylakoid membrane(TM)and ESCC cell membrane(EM)-fused biomembrane(TM-EM)shell and gambogic acid(GA)-loaded poly(lactic-co-glycolic acid)nanocore,was designed for enhanced PDT for *** fused with EM,TM-EM exhibits a tumor targeting advantage due to the homologous affinity of tumor membrane *** catalase present on TM-EM catalytically decomposes endogenous hydrogen peroxide into oxygen to alleviate hypoxia in the tumor ***,when TEPG was selectively internalized by ESCC cells,GA was released to consume the excessive intracellular *** infrared irradiation,the PDT effects were enhanced by the self-oxygen supply and GSH scavenging ability provided by *** in vivo study showed that TEPG effectively induced ESCC tumor cell apoptosis and greatly inhibited the growth of ESCC tumors under infrared *** study constructed an engineered multifunctional thylakoid-based nanomedicine as an integrated solution to enhance PDT for ESCC.

关键词： esophageal squamous cell carcinoma thylakoid tumor targeting photodynamic therapy

Finite Groups Whose Character Graphs Associated with Codegrees Have No Triangles

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Algebra Colloquium 2016年第1期23卷 15-22页

作者： huan Xiong Institut fur Mathematik Universitat Zurich Winterthurerstrasse 190 CH-8057 Zurich Switzerland

Motivated by Problem 164 proposed by Y. Berkovich and E. Zhmud＇ in their book ＂Characters of Finite Groups＂, we give a characterization of finite groups whose irreducible character codegrees are prime powers. This is based on a new kind of character graphs of finite groups associated with codegrees. Such graphs have close and obvious connections with character codegree graphs. For example, they have the same number of connected components. By analogy with the work of finite groups whose character graphs （associated with degrees） have no triangles, we conduct a result of classifying finite groups whose character graphs associated with codegrees have no triangles in the latter part of this paper.

关键词： finite group character graph codegree

Sums of Fourier coefficients of cusp forms of level D twisted by exponential functions

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Frontiers of Mathematics in China 2017年第3期12卷 655-673页

作者： huan LIU School of Mathematics Shandong University Jinan 250100 China

Let g be a holomorphic or Maass Hecke newform of level D and nebentypus XD, and let ag（n） be its n-th Fourier coefficient. We consider the sum S1=∑ X〈n≤2x ag（n）e（an β） and prove that S1 has an asymptotic formula when β = 1/2 and α is close to ±2 √q/D for positive integer q ≤ X/4and X sufficiently large. And when 0 〈β 〈 1 and α, β fail to meet the above condition, we obtain upper bounds of S1. We also consider the sum S2 = ∑n〉0 ag（n）e（an β） Ф（n/X） with Ф（x） ∈ C c ∞（0,＋∞） and prove that S2 has better upper bounds than S1 at some special α and β.

关键词： exponential sums cusp form Fourier coefficients

Synthesis and luminescence properties of Ca_2SiO_4-based red phosphors with Sm^(3+) doping for white LEDs

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International Journal of Minerals,Metallurgy and Materials 2012年第7期19卷 663-667页

作者： Jin-jun Cai huan-huan Pan Yi Wang School of Applied Physics and Materials Wuyi University Jiangmen 529020 China

Sm3＋-activated Ca2SiO4 red phosphors were prepared by the conventional high-temperature solid-state reaction method, and the effects of sodium （Na＋） and samarium （Sm3＋） ions doping concentrations on their crystal structure and luminescent properties were investigated by X-ray diffraction （XRD） and fluorescent spectrofluorometer. XRD patterns demonstrate that a well-crystalline structure forms in the phosphors when they are treated by calcination at 1200~C for 4 h, and the excitation spectra exhibit good absorption in the range between 350 and 420 nm. Under the irradiation of 405 nm near-ultraviolet （NUV） light, the spectra of the phosphors show a main emission peak at 601 nm attributed to the 4G5/2→6H7/2 transition of Sm3＋ ions, and its intensity is greatly influenced by the concentrations of Sm3＋ and Na2CO3. When the concentrations of Sm3＋ ions and Na2CO3 are 2mol% and 6mol%, respectively, the optimal emission intensity can be obtained. From strong absorption in the near ultraviolet zone, the Na0.06Sm0.02Ca1.92SiO4 phosphor is a promising red-emitting phosphor for white light emitting diodes （W-LEDs）.

关键词： light emitting diodes phosphors photoluminescence doping samarium calcium silicate

A review and perspective on molybdenum-based electrocatalysts for hydrogen evolution reaction

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Rare Metals 2020年第4期39卷 335-351页

作者： Wei Hua huan-huan Sun Fei Xu Jian-Gan Wang Nano Energy Materials School of Materials Science and EngineeringNorthwestern Poly technical UniversityXi'an 710072China Shaanxi Joint Laboratory of Graphene(NPU) Xi'an 710072China

Water electrolysis has been considered as a sustainable way for producing renewable energy of ***,this process requires a low-cost and high-efficient hydrogen evolution reaction(HER)catalyst to improve the overall reaction ***(Mo)-based electrocatalysts are regarded as the promising candidates to replace the benchmark but expensive Ptbased HER catalysts,due to their high activity and stability in a wide pH *** this review,we present a comprehensive and critical summary on the recent progress in the Mo-based electrodes for HER,including molybdenum alloys,molybdenum sulfides,molybdenum selenides,molybdenum carbides,molybdenum phosphides,molybdenum borides,molybdenum nitrides,and molybdenum *** attention is mainly focused on the synthetic methods of Mo-based materials,the strategies for increasing the catalytic activity,and the relationship between structure/composition and electrocatalytic ***,the future development and perspectives of Mo-based electrocatalysts toward high HER performance are proposed.

关键词： Mo-based materials Electrocatalysts Hydrogen evolution reaction Water splitting

A PAIR OF COUPLING METRICS FOR SOFTWARE NETWORKS

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Journal of Systems Science & Complexity 2011年第1期24卷 51-60页

作者： huan LI Bing LI Center of Modern Educational Technology Shanghai University of Political Science and Law Shanghai 201701 China State Key Laboratory of Software Engineering Wuhan University Wuhan 430072 China

Complex networks are everywhere. A typical example is software network. How to measure and control coupling interactions of software components is a largely explored research problem in software network. In terms of graph theory and linear algebra, this paper investigates a pair of coupling metrics to evaluate coupling interactions between the classes of object-oriented systems. These metrics differ from the majority of existing metrics in three aspects： Taking into account the strength that one class depends on other ones, reflecting indirect coupling, and distinguishing various coupling interaction. An empirical comparison of the novel measures with one of the most widely used coupling metrics is described. Specifically, an experiment about the relationships of this pair metrics is conducted. The result shows that software complexity derived from coupling interaction could not be accurately reflected by one dimension of coupling metric for negative correlation.

关键词： Complex network coupling metric software network software system

Ionic liquids for electrochemical energy storage devices applications

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Journal of Materials Science & Technology 2019年第4期35卷 674-686页

作者： huan Liu Haijun Yu College of Materials Science & Engineering Key Laboratory of Advanced Functional MaterialsMinistry of EducationBeijing University of Technology

Ionic liquids, defined here as room-temperature molten salts, composed mainly of organic cations and(in)organic anions ions that may undergo almost unlimited structural variations with melting points below 100?C. They offer a unique series of physical and chemical properties that make them extreme important candidates for several energy applications, especially for clean and sustainable energy storage and conversion materials and devices. Ionic liquids exhibit high thermal and electrochemical stability coupled with low volatility, create the possibility of designing appropriate electrolytes for different type batteries and supercapacitors. Herein, varieties of ionic liquids applications are reviewed on their utilization as electrolytes for Li-ion batteries, Na-ion batteries, Li-O_2(air) batteries, Li-Sulfur(Li-S) batteries, supercapacitors and as precursors to prepare and modify the electrode materials, meanwhile,some important research results in recent years are specially introduced, and the perspective on novel application of ionic liquids is also discussed.

关键词： Ionic liquids Batteries Supercapacito Electrolyte Electrode