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An unprotected vulnerable relict subtropical coniferdKeteleeria evelyniana:Its forests,populations,growth and endangerment by invasive alien plant species in China

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Plant Diversity 2024年第5期46卷 648-660页

作者： Cindy Q.Tang Min-Rui Du huan-chong wang You-Cai Shi Jia-Le Zeng Shu-Li Xiao Peng-Bin Han Jian-Ran Wen Shi-Qian Yao Ming-Chun Peng chong-Yun wang Yong-Ping Li Jordi López-Pujol Institute of Ecology and Geobotany College of Ecology and Environmental ScienceYunnan UniversityBuilding#3Guozhong DalouDongwaihuan South RoadUniversity TownChenggong New DistrictKunming 650504YunnanChina College of Life Sciences Yunnan UniversityShengming Kexueyuan Building#2Chenggong CampusDongwaihuan South RoadUniversity TownChenggong New DistrictKunming 650504YunnanChina College of Natural Resources Yunnan UniversityChenggong CampusDongwaihuan South RoadUniversity TownChenggong New DistrictKunming 650504YunnanChina Botanic Institute of Barcelona(IBB CSIC-CMCNC)Passeig del Migdia s/nBarcelona 08038CataloniaSpain Escuela de Ciencias Ambientales Universidad Espíritu Santo(UEES)Samborondon 091650Ecuador

Relict subtropical coniferous forests in China face severe fragmentation,resulting in declining populations,and some are under significant threat from invasive alien *** the crucial importance of understanding forest dynamics,knowledge gaps persist,particularly regarding the impact of invasive plants on vulnerable natives like Keteleeria *** this study,we investigated the impact of invasive plants on the regeneration of forests dominated by ***,a subtropical relict species in southwestern *** this purpose,we characterized forest dynamics of 160 forest plots featuring *** as the primary dominant species and determined whether the presence of invasive plants was correlated with regeneration of *** identified four distinct forest types in which *** was *** found that radial growth of *** trees is faster in younger ageclasses today than it was for older trees at the same *** population structure of *** in each forest type exhibited a multimodal age-class ***,three forest types lacked established saplings younger than 10 years old,a situation attributed to the dense coverage of the invasive alien Ageratina *** invasive species resulted in a reduction of understory species ***,our analysis uncovered a significant negative correlation in phylogenetic relatedness(net relatedness index)between native and invasive alien plant species in eastern *** suggests closely related invasive species face heightened competition,hindering successful *** together,our findings indicate that successful establishment and habitat restoration of *** seedling/saplings require effective measures to control invasive plants.

关键词： Keteleeria evelyniana Age structure Regeneration Species diversity Invasive alien species Phylogenetic relatedness

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Immunological disturbance effect of exogenous histamine towards key immune cells

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Food Science and Human Wellness 2024年第4期13卷 1856-1863页

作者： Yanan Liu huan Li chong wang Shanjun Chen Renjie Lian Weiqiang wang Linglin Fu Yanbo wang Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Jinghai Group Co. Ltd.Rongcheng 264307China Jinhua Jinnian Ham Co. Ltd.Jinhua 321041China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China

Histamine in food has attracted widespread attention due to the potential toxicity and associated health ***,its influences on immunological components,especially the function of key immune cells,are still poorly *** this work,we explored the effects of exogenous histamine on the function of key immune cells such as intestinal epithelial cells,dendritic cells,and T *** results showed that histamine could affect the expression of allergy-related genes in CMT93 cells at a high dose of ***,it’s found that histamine could cause an imbalance in the levels of relevant immune factors secreted by dendritic cells and T cells,especially those related to *** the same time,the proportion of MHC class IIpositive dendritic cells and the proportion of T helper 2(Th2)cells in CD4^(+)T cells increased after histamine *** concluded that the presence of a certain level of histamine in food may affect the expression of allergy-related cytokines,disrupt the balance of the immune homeostasis,and potentially lead to adverse immune *** work demonstrated the importance of including the estimation of histamine’s immune safety in aquatic products rather than merely considering the potential risk of food poisoning.

关键词： Histamine Immunological disturbance Food allergy Immune factor Edible safety

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Metal-organic framework and its composites modulate macrophage polarization in the treatment of inflammatory diseases

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Chinese Chemical Letters 2024年第5期35卷 45-56页

作者： Feifei wang Hang Yao Xinyue Wu Yijian Tang Yang Bai Hui chong huan Pang School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China School of Pharmacy Changzhou UniversityChangzhou 213164China State Key Laboratory of Coordination Chemistry Nanjing UniversityNanjing 210023China

Metal-organic framework(MOF)is a periodic sexual network structure with large surface area and high porosity,which is assembled by inorganic nodes and organic ligands through coordinate covalent *** have the advantages of controllable pore size and shape,large specific surface area,easy modification and more active *** addition,MOF based nanoenzymes display excellent enzyme catalytic activity due to their special structure and multiple exposed metal active sites,controlling the production of reactive oxygen species(ROS)in cells or the body,and thus regulating the polarization of *** article reviews the mechanism of MOF material regulating macrophage polarization and the function of macrophages with different *** utilizing the excellent properties of MOFs and the advantages of combining them with bioactive materials,we have discovered their excellent applications in the treatment of inflammatory ***,we discussed the current challenges and prospects faced by MOF based composite *** expect that the research in this developing field will play a more important role in combating inflammatory diseases in the field of nanomedicine.

关键词： Metal-organic framework Inflammation Macrophage polarization Reactive oxygen species Nanozyme activity

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Pairs of thiol-substituted 1,2,4-triazole-based isomeric covalent inhibitors with tunable reactivity and selectivity

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Chinese Chemical Letters 2024年第7期35卷 329-335页

作者： Shiqi Xu Zi Ye Shuang Shang Fengge wang huan Zhang Lianguo Chen Hao Lin Chen Chen Fang Hua chong-Jing Zhang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing Key Laboratory of Active Substance Discovery and Druggability EvaluationInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study(BZ0150)Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000China

Covalent bioactive compounds are successfully used in clinic and attracted intense research efforts in the fundamental study as well as drug *** advantageous effects of covalent compounds compared with non-covalent ones are highly dependent on electrophilic ***,electrophilic warheads with tunable reactivity and selectivity are highly demanded in fields of medicinal chemistry and chemical ***,we report a novel electrophilic warhead,chloromethyl group activated by thiol-substituted 1,2,***,a pair of regioisomers could be simultaneously occurred in the step of alkylation during the synthesis of this unique *** is a rare example that the alkylation could simultaneously generate these two separable regioisomers of 1,2,4-triazole at the nitrogen or sulfur *** covalent-working mechanism of this new warhead is confirmed by various chemoproteomics experiments including target identification and binding site ***,the reactivity and selectivity of this new electrophilic warhead could be efficiently tuned by virtue of stereo ***,one pair of regioisomers(19S and 19X)induced distinct modes of cell *** 19S could induce apoptosis of colon cancer cells while 19X could induce both apoptosis and ***,this study provides pairs of novel electrophilic warheads that could be useful not only in supporting the design of covalent compounds for drug discovery but also in providing chemical probes for the fundamental biological study.

关键词： Electrophilic warhead Covalent inhibitor 1,2,4-Triazole Chemical proteomics GSTO1

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One stone two birds:electrochemical and colorimetric dual-mode biosensor based on copper peroxide/covalent organic framework nanocomposite for ultrasensentive norovirus detection

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Food Science and Human Wellness 2024年第2期13卷 920-931页

作者： Guobao Ning Quanmei Duan huan Liang Huifang Liu Min Zhou Chunlan Chen chong Zhang Hui Zhao Canpeng Li School of Chemical Science and Technology Yunnan UniversityKunming 650091China Laboratory for Conservation and Utilization of Bio-resource Yunnan UniversityKunming 650091China Kunming Customs Technology Center Kunming 650228China

Norovirus(NoV)is regarded as one of the most common causes of foodborne diarrhea in the *** is urgent to identify the pathogenic microorganism of the diarrhea in short *** this work,we developed an electrochemical and colorimetric dual-mode detection for NoV based on the excellent dual catalytic properties of copper peroxide/COF-NH_(2)nanocomposite(CuO_(2)@COF-NH_(2)).For the colorimetric detection,NoV can be directly detected by the naked eye based on CuO_(2)@COF-NH_(2)as a laccase-like nonazyme using“peptide-NoV-antibody”recognition *** colorimetric assay displayed a wide and quality linear detection range from 1 copy/mL to 5000 copies/mL of NoV with a low limit of detection(LOD)of 0.125 copy/*** the electrochemical detection of NoV,CuO_(2)@COF-NH_(2)showed an oxidation peak of copper ion from Cu^(+)to Cu^(2+)using“peptide-NoV-antibody”recognition *** electrochemical assay showed a linear detection range was 1-5000 copies/mL with a LOD of 0.152 copy/***'s worthy to note that this assay does not need other electrical signal molecule,which provide the stable and sensitive electrochemial detection for *** electrochemical and colorimetric dual-mode detection was used to detect NoV in foods and faceal samples,which has the potential for improving food safety and diagnosing of NoV-infected diarrhea.

关键词： Norovirus Specific peptides Electrochemical and colorimetric assay Dual-mode Copper peroxide/covalent organic framework

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Navigating the labyrinth of long non-coding RNAs in colorectal cancer:From chemoresistance to autophagy

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3376-3381页

作者： Jia-Mei Yu chong-Qi Sun huan-huan Xu Ya-Li Jiang Xing-Yu Jiang Si-Qi Ni Ting-Yu Zhao Ling-Xiang Liu Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Hematology and Oncology Department of Geriatric Lung Cancer Research LaboratoryJiangsu Province Geriatric HospitalNanjing 210009Jiangsu ProvinceChina Central Laboratory The Friendship Hospital of Ili Kazakh Autonomous PrefectureIli&Jiangsu Joint Institute of HealthYining 835000Xinjiang Uyghur Autonomous RegionChina

Long non-coding RNAs(lncRNAs),with transcript lengths exceeding 200 nucleotides and little or no protein-coding capacity,have been found to impact colorectal cancer(CRC)through various biological *** expression can regulate autophagy,which plays dual roles in the initiation and progression of cancers,including *** expression of lncRNAs is associated with the emergence of ***,it has been confirmed that targeting autophagy through lncRNA regulation could be a viable approach for combating *** recent studies titled“Human β-defensin-1 affects the mammalian target of rapamycin pathway and autophagy in colon cancer cells through long non-coding RNA TCONS_00014506”and“Upregulated lncRNA PRNT promotes progression and oxaliplatin resistance of colorectal cancer cells by regulating HIPK2 transcription”revealed novel insights into lncRNAs associated with autophagy and oxaliplatin resistance in CRC,*** this editorial,we particularly focus on the regulatory role of lncRNAs in CRC-related autophagy and chemoresistance since the regulation of chemotherapeutic sensitivity by intervening with the lncRNAs involved in the autophagy process has become a promising new approach for cancer treatment.

关键词： Long non-coding RNA Autophagy Chemoresistance Oxaliplatin Colorectal cancer

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Forest characteristics and population structure of Glyptostrobus pensilis, a globally endangered relict species of southeastern China

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Plant Diversity 2019年第4期41卷 237-249页

作者： Cindy Q. Tang Yongchuan Yang Arata Momohara huan-chong wang Hong Truong Luu Shuaifeng Li Kun Song Shenhua Qian Ben LePage Yi-Fei Dong Peng-Bin Han Masahiko Ohsawa Buu Thach Le Huu Dang Tran Minh Tri Dang Ming-Chun Peng chong-Yun wang Institute of Ecology and Geobotany School of Ecology and Environmental ScienceYunnan UniversityDongwaihuan South RoadUniversity TownChenggong New DistrictKunmingYunnan 650504China The Nature Conservancy Society of Japan Mitoyo Bldg.2F1-16-10 ShinkawaChuo-kuTokyo 104-0033Japan Key Laboratory of Three Gorges Reservoir Region's Eco-Environment Ministry of EducationChongqing UniversityChongqing 400045China Graduate School of Horticulture Chiba University648 MatsudoChiba 271-8510Japan Institute of Botany Yunnan UniversityKunmingYunnan 650091China Southern Institute of Ecology Vietnam Academy o f Science and TechnologyHo Chi Minh CityViet Nam Research Institute of Resource Insects Chinese Academy of ForestryKunmingYunnan 650224China School o f Ecological and Environmental Sciences East China Normal UniversityShanghai 200241China Pacific Gas and Electric Company 3401 Crow Canyon RoadSan RamonCA 94583USA The Academy of Natural Science 1900 Benjamin Franklin ParkwayPhiladelphiaPA 19W3USA

The Chinese water pine Glyptostrobus pensilis is the sole surviving species of the genus Glyptostrobus. It is endemic to southern China, central Vietnam, and eastern Laos, and today it is nearly extinct in the wild. Forest community characteristics and population structure of G. pensilis in China have remained un-known up to now. We investigated six swamp forest stands and analyzed their forest community characteristics (i.e. vertical stratification, species composition, and diversity) and population structure, including the frequency distribution of DBH (diameter at breast height) and age-classes as found in Fujian Province, southeastern China. The vertical stratifications of all the forest stands were rather simple. The remaining wild specimens ranged from roughly 15 to some 357 years for an average of ca. 85 years, with only a few individuals less than 20 years old. Compared with the stands and populations of G. pensilis in Vietnam, the taxonomic compositions of the stands in the two regions were different, except for the dominant species-G. pensilis. The Shannon-Wiener index showed the overstory of each stand had much lower diversity (0.26 on average) in Fujian Province than that (1.97 on average) in Vietnam, whereas the diversity indices were about the same (around 2.41) for the understories in the two regions. Furthermore, we discovered 18 G. pensilis seedlings at the study sites in Fujian Province. This discovery demonstrates that G. pensilis regeneration is extremely poor and its populations are declining, although these populations are rela-tively healthier than those in Vietnam.

关键词： Age-class Fujian Province Glyptostrobus Regeneration Relict plant Vietnam

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Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

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Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： ZHANG Ya Li SU Wen Zhe wang Rui Chen LI Yan ZHANG Jun Feng LIU Sheng Hui HU Dan He XU chong Xiao YIN Jia Yu YIN Qi Kai HE Ying LI Fan FU Shi Hong NIE Kai LIANG Guo Dong TAO Yong XU Song Tao MA Chao Feng wang huan Yu Shaanxi University of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510000GuangdongChina Shandong Center for Disease Control and Prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National Center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

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我国社区教育教师专业化研究的审思与展望——基于Nvivo的内容分析

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成人教育 2024年第1期44卷 32-40页

作者：秦琼江欢张冲江苏开放大学教务处南京210036 江苏开放大学人事处南京210036

社区教育教师专业化是社区教育发展的重要议题。采用内容分析法,利用Nvivo11软件,从理论基础、现实境遇和实践理路三个维度审视我国社区教育教师专业化研究,不难发现:在理论基础方面,社区教育教师专业化的概念内涵不断丰富、价值意义逐... 详细信息

社区教育教师专业化是社区教育发展的重要议题。采用内容分析法,利用Nvivo11软件,从理论基础、现实境遇和实践理路三个维度审视我国社区教育教师专业化研究,不难发现:在理论基础方面,社区教育教师专业化的概念内涵不断丰富、价值意义逐渐彰显;在现实境遇方面,受基础薄弱、保障滞后、培养缺失等多重因素制约,社区教育教师专业化水平不高;在实践理路方面,社区教育教师专业化发展应沿着“建立多主体的参与体系,构建全周期的发展体系,形成全方位的保障体系”三条路径前行。未来,我们需要紧扣内涵、适应需求、抓住重点、聚焦实际、遵循理路,分门别类、立足时代、围绕标准、紧扣能力、多种方法开展社区教育教师专业化研究。

关键词：社区教育教师专业化研究现状未来展望内容分析

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基于水下安装工况的液缸举升系统仿真分析

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船舶 2024年第2期35卷 114-123页

作者：雷静希李欢王充成都工业学院智能制造学院成都611730 宝鸡石油机械有限责任公司宝鸡721002

该文依托新型液缸举升系统,研究隔水管柱下放水下防喷器和钻柱下放水下采油树的数学模型,以探究钻柱补偿功能辅助水下设备精准操作的可行性和性能。在AMESim软件平台上搭建液缸举升系统水下安装工况仿真模型,进行4级海况下开启和关闭主... 详细信息

该文依托新型液缸举升系统,研究隔水管柱下放水下防喷器和钻柱下放水下采油树的数学模型,以探究钻柱补偿功能辅助水下设备精准操作的可行性和性能。在AMESim软件平台上搭建液缸举升系统水下安装工况仿真模型,进行4级海况下开启和关闭主动钻柱补偿时水下安装工况的仿真研究,分析单次提升下放操作的最大安全操作高度,探讨不同海况对于水下安装作业的影响。研究表明:液缸举升系统因其自身具备的主动补偿功能,大幅提高了水下安装作业的安全性,作业海况对水下安装的作业窗口和极限操作高度均有较大影响。该研究结果可为液缸举升系统的国产工程化落地及现场应用提供一定的理论指导。

关键词：液缸举升系统水下安装钻柱补偿水下防喷器水下采油树

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