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Inhibition of KL-6/MUC1 glycosylation limits aggressive progression of pancreatic cancer

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World Journal of Gastroenterology 2014年第34期20卷 12171-12181页

作者： huan-Li xu Xin Zhao Ke-Ming Zhang Wei Tang Norihiro Kokudo Department of Pharmacology School of Basic Medical SciencesCapital Medical University Department of Hepatobiliary Surgery 302 Hospital of Chinese People’s Liberation Army Hepato-Biliary-Pancreatic Surgery Division Department of SurgeryGraduate School of MedicineUniversity of TokyoTokyo 113-8654Japan

AIM: To evaluate the significance of KL-6/MUC1 (a type of MUC1) glycosylation in pancreatic cancer progression.

关键词： Benzyl-N-acetyl-alpha-galactosaminide Glycosylation KL-6/MUC1 Pancreatic carcinoma Tunicamycin

MAGI-2 downregulation:a potential predictor of tumor progression and early recurrenee in Han Chinese patients with prostate cancer

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Asian Journal of Andrology 2020年第6期22卷 616-622页

作者： Zhi Cao Jin Ji Fu-Bo Wang Chen Kong huan xu Ya-Long xu Xi Chen Yong-Wei Yu Ying-Hao Sun Department of Urology Changhai HospitalNavy Medical UniversityShanghai 200433China Department of Traditional Chinese Medicine NewJiangwan City Community Health Service CentreShanghai 200433China Department of Pathology Changhai HospitalNavy Medical UniversityShanghai 200433China

Membrane-associated guanylate kinase(MAGUK)family protein MAGUK invert 2(MAGI-2)has been demonstrated to be involved in the tumorigenic mechanism of prostate *** objective of this study was to investigate the expression of MAGI・2 at mRNA and protein *** prog no stic value of MAGI-2 in Han Chin ese patie nts with prostate cancer was also *** expression data of MAGI・2 were assessed through database retrieval,analysis of sequencing data from our group,and tissue immunohistochemistry using digital scoring system(H・score).The clinical,pathological,and follow-up data were *** expression of MAGI-2 in prostate tumor tissues and prostate normal tissues was evaluated and ***-2 expression was associated with clinical parameters including tumor stage,lymph node status,Gleason score,PSA level,and biochemical recurrenee of prostate *** relative expression of MAGI-2 mRNA was lower in the tumor tissue in The Cancer Genome Atlas(TCGA)database and sequencing data(P<0.001).There was no difference in MAGI-2 protein expression between tumor and normal tissues in tissue microarray(TMA)***-2 expression was associated with pathological tumor stage(P=0.02),Gleason score(P=0.05),and preoperation prostate-specific antigen(PSA;P=0.04).A positive correlation was identified between MAGI-2 and phosphatase and tensin homolog deleted on chromosome 10(PTEN)expressions through the analysis of TCGA and TMA data(P<0.0001).Patients with higher MAGI-2 expression had longer biochemical recurrence-free survival in the univariate analysis(P=0.005),which in dicates an optimal prog no stic value of MAGI-2 in Han Chin ese patie nts with prostate can cer.I n con elusion,MAGI-2 expressi on gradually decreases with tumor progression,and can be used as a predictor of tumor recurrence in Chinese patients.

关键词： biochemical recurrenee Chinese patients MAGI-2 prostate cancer tissue microarray

Development and Validation of a Deep Learning Predictive Model Combining Clinical and Radiomic Features for Short-Term Postoperative Facial Nerve Function in Acoustic Neuroma Patients

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Current Medical Science 2023年第2期43卷 336-343页

作者： Meng-yang WANG Chen-guang JIA huan-qing xu Cheng-shi xu Xiang LI Wei WEI Jin-cao CHEN Department of Neurosurgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China School of Medical Information Engineering Anhui University of Chinese MedicineHefei 230012China

Objective This study aims to construct and validate a predictable deep learning model associated with clinical data and multi-sequence magnetic resonance imaging(MRI)for short-term postoperative facial nerve function in patients with acoustic *** A total of 110 patients with acoustic neuroma who underwent surgery through the retrosigmoid sinus approach were *** data and raw features from four MRI sequences(T1-weighted,T2-weighted,T1-weighted contrast enhancement,and T2-weighted-Flair images)were *** correlation analysis along with least absolute shrinkage and selection operator regression were used to screen combined clinical and radiomic ***,machine learning,and convolutional neural network(CNN)models were constructed to predict the prognosis of facial nerve function on the seventh day after *** operating characteristic(ROC)curve and decision curve analysis(DCA)were used to evaluate model performance.A total of 1050 radiomic parameters were extracted,from which 13 radiomic and 3 clinical features were *** The CNN model performed best among all prediction models in the test set with an area under the curve(AUC)of 0.89(95%CI,0.84–0.91).Conclusion CNN modeling that combines clinical and multi-sequence MRI radiomic features provides excellent performance for predicting short-term facial nerve function after surgery in patients with acoustic *** such,CNN modeling may serve as a potential decision-making tool for neurosurgery.

关键词： acoustic neuroma convolutional neural network facial nerve function machine learning multi-sequence magnetic resonance imaging

Latamoxef-induced severe thrombocytopenia during the treatment of pulmonary infection:A case report

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World Journal of Clinical Cases 2022年第22期10卷 7906-7912页

作者： Ruo-Ying Zhang Jun-Jie Zhang Jin-Meng Li Ying-Ying xu Yue-huan xu Xin-Jun Cai Department of Pharmacy Affiliated Hangzhou Chest HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Out-patient Zhejiang Medical and Health Group Hangzhou HospitalHangzhou 310000Zhejiang ProvinceChina Tuberculosis Treatment Centre Affiliated Hangzhou Chest HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Latamoxef shows excellent antibacterial activity against anaerobic bacteria such as Bacteroides *** of thrombocytopenic toxicity of latamoxef are *** report presents a case of severe thrombocytopenia possibly induced by latamoxef,an infrequent adverse drug reaction in a young patient with tuberculosis and Crohn's disease in *** SUMMARY We reported a case of severe thrombocytopenia induced by latamoxef in a 28-year-old man with tuberculosis and Crohn's *** admission,the patient presented with a cough productive of bloody sputum,a chest computed tomogram suggested scattered mottled,high-density shadows in both *** tests indicated a platelet count of 140000/μ*** a pulmonary bacterial infection,the patient received anti-infection therapy with latamoxef(dose:2.0 g)intravenously *** the 9th day of treatment,the platelet count decreased to 44000/μ*** the 12th day,scattered purpura and ecchymosis appeared on the patient’s limbs and trunk,and the platelet count decreased to 9000/μL after latamoxef treatment for 15 *** days after discontinuation of latamoxef,the platelet count recovered to 157000/μL,and the area of scattered purpura and ecchymosis on the limbs and trunk *** platelet counts remained in the normal range,and no thrombocytopenia was found at follow-up 15 mo after *** For patients treated with latamoxef,platelet counts should be carefully followed,and caregivers should be vigilant for the appearance of scattered ecchymosis.

关键词： Thrombocytopenia Latamoxef Adverse drug reactions Young onset Case report

复杂基质对固体废物二噁英类检测提取内标回收率的影响研究

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山西化工 2025年第1期45卷 89-90,122页

作者：江小艳贺毅张晶徐欢胡军红广州环投设计研究院有限公司广东广州510000

为探究固体废物二噁英类检测过程中复杂基质对提取内标回收率产生的影响,本研究选取一批典型环境复杂基质固体废物样品和高性价比的添加物铜片和双氧水开展试验。结果表明,双氧水对固体废物样品具有一定的净化作用,但无法降低干扰物质... 详细信息

为探究固体废物二噁英类检测过程中复杂基质对提取内标回收率产生的影响,本研究选取一批典型环境复杂基质固体废物样品和高性价比的添加物铜片和双氧水开展试验。结果表明,双氧水对固体废物样品具有一定的净化作用,但无法降低干扰物质对提取内标回收率的影响;铜片能有效去除固体废物样品中二噁英类检测的干扰物质,从而提高提取内标回收率,回收率随着铜片加入量的增加而逐步升高,达到一定量后,上升趋势趋于平缓。研究结果对固体废物中二噁英类测定提取内标回收率的影响提供了数据支持,且为深入研究复杂基质样品中二噁英类检测工作提供了技术支撑。

关键词：二噁英类检测内标回收率固体废物铜片双氧水

Hydrothermal Self-assembly Synthesis of Mn3O4Reduced Graphene Oxide Hydrogel and Its High Electrochemical Performance for Supercapacitors

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Chinese Journal of Chemistry 2013年第10期31卷 1290-1298页

作者： Li Li Zhongai Hu Yuying Yang Pengju Liang Ailian Lu huan xu Yingying Hu Hongying Wu Key Laboratory of Eco-Environment-Related Polymer Materials' of Ministry of Education Key Laboratory of Polymer Materials' of Gansu Province College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou Gansu 730070 China Department of Chemistry and Chemical Engineering College of Life Science Tarim University Alar Xinjiang 843300 China

In the present work Mn3O4/reduced graphene oxide hydrogel （Mn3O4-rGOH） with three dimensional （3D） networks was fabricated by a hydrothermal self-assembly route. The morphology, composition, and microstructure of the as-obtained samples were characterized using powder X-ray diffraction （XRD）, X-ray photoelectron spectroscopy （XPS）, thermogravimetry analysis （TG）, atomic absorption spectrometry （AAS）, field emission scanning electron microscopy （FESEM） and transmission electron microscope （TEM）. Moreover, the electrochemical behaviors were evaluated by cyclic voltammogram （CV）, galvanostatic charge-discharge and electrochemical impedance spectroscopy （EIS）. The test results indicated that the hydrogel with 6.9% Mn3O4 achieved specific capacitance of 148 F.g^-1 at a specific current of 1 A.g^-1, and showed excellent cycling stabilily with no decay after 1200 cycles. In addition, its specific capacitance could retain 70% even at 20 A.g^- 1 in comparison with that at 1 A.g ^-1 and the operating window was up to 1.8 V in a neutral electrolyte.

关键词： reduced graphene oxide Mn3O4 self-assembly hydrogel supercapacitor

Astrometric Observations of NEA 1998 HH49 Using the Daocheng 50 cm Telescope

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Research in Astronomy and Astrophysics 2024年第7期24卷 71-78页

作者： huan xu Xiang-Ming Cheng Yi-Gong Zhang Teng-Fei Song Zhen-Jun Zhang Qing-Yu Peng Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Engineering Laboratory on Applied Astronomical Technology of Yunnan Kunming 650216China School of Information Engineering Kunming UniversityKunming 650214China School of Computer Science and Information Engineering Anyang Institute of TechnologyAnyang 455000China Department of Computer Science Jinan UniversityGuangzhou 510632China Sino-French Joint Laboratory for Astrometry Dynamics and Space ScienceJinan UniversityGuangzhou 510632China

This study details an astrometric observation campaign of the Near-Earth Asteroid 1998 HH49,conducted with the aim of refining our understanding of its physical *** the 50 cm telescope located at the Wumingshan Mountain in Daocheng,Sichuan,images were obtained over four nights,from 2023 October 19 to October *** observations were processed using Astrometrica software,facilitating the precise determination of the asteroid's *** observational results were compared with the ephemerides from three distinct sources to verify accuracy:the Jet Propulsion Laboratory(JPL)Horizons System,the Institut de Mécanique Céleste et de Calcul deséphémérides(IMCCE)Miriade,and the Near-Earth Objects Dynamic Site(NEODyS-2).When compared with the JPL ephemeris,a mean observed-minus-calculated(O-C)result of 0.″07 in the *** and-0.″35 in the *** was ***,the comparison with the IMCCE ephemeris yielded mean O-C results of 0.″08 in the *** and-0.″06 in the *** comparison with the NEODyS-2 ephemeris yielded the mean O-C results of 0.″06 in ***-0.″49 in *** study's findings demonstrate a general consistency between the observed data and the ephemeris predictions,with minor discrepancies observed across the data ***,both the JPL and NEODyS-2 ephemerides show that the residuals in the *** exceed those in the *** disparities may result from atmospheric differential color refraction,ephemeris discrepancies,observational errors,and other ***,it is worth noting that further investigation is required due to the potential influence of additional ***,the Daocheng 50 cm Telescope exhibits the ability to conduct high-precision positional measurements.

关键词： astrometry ephemerides time

Mesozoic basins and associated palaeogeographic evolution in North China

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Journal of Palaeogeography 2015年第2期4卷 189-202页

作者： Yong-Qing Liu Hong-Wei Kuang Nan Peng huan xu Peng Zhang Neng-Sheng Wang Wei An Institute of Geology Chinese Academy of Geological Sciences

In North China, the Mesozoic terrestrial basins, sedimentary palaeogeography and tectonic settings involved five evolutionary stages：（1） the Early-Middle Triassic, （2） the Late Triassic to Early-Middle Jurassic, （3） the Late Jurassic to early Early Cretaceous, （4） the middle-late Early Cretaceous and （5） the Late Cretaceous. The regional punctuated tectonic events occurred during these evolutionary stages. During the Early-Middle Triassic （stage 1）, the Xingmeng Orogenic Belt （XMOB, i.e., east- ern part of Central Asia Orogenic Belt, CAOB） of the northern North China was settled in the transition of tectonic environment from syn-orogenic compression to post-orogenic extension with intensive uplifting. It is a main provenance in the unified Ordos-North China *** united continental plate of China and the Qinling-Dabie-Sulu Orogenic Belt formed due to convergence and collision between the North China Plate and the Yangtze Plate along two suture zones of the Mianlue and the Shangdan in the terminal Middle Triassic. During the Late Triassic to the Early-Middle Jurassic （stage 2）, the Late Triassic mafic or alkaline rocks and intrusions occurred on the northern and southern margins of North China Craton （NCC） and XMOB, implying that intensified extension happened all over the North China （early phase of stage 2）. Additionally, in the late phase of stage 2, the basic volcanic- filing faulted basins were widely distributed in the northeastern North China during the Early- Middle Jurassic, including a series of smalt- to medium-sized basins with coal-bearing strata and some volcanic rocks in other areas of North China, which was the result of subduction of the Palaeo-Pacific Plate during the Early-Middle Jurassic. An active continental margin with accretionary complex developed in the eastern Heilongjiang of China, Japan and the Far East of Russia at that time. However, in the end of the Early-Middle Jurassic, because of the Yan- shanian orogeny characterized by com

关键词： Mesozoic basin orogenic belt tectonic zone palaeogeography North China

Prioritizing landscapes for mitigating the impacts of onshore wind farms on multidimensional waterbird diversity in the Yellow Sea

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Current Zoology 2024年第6期70卷 752-764页

作者： Shanshan Zhao huan xu Tianhou Wang Hepeng Li Xiuzhen Li Ningning Liu Xiao Song Feng Guan xuechu Chen Aichun xu Ben Li College of Life Sciences Yangtze River Delta Institute of Biodiversity Conservation and UtilationChina Jiliang UniversityHangzhou 310018China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200062China Shanghai Wildlife and Protected Natural Areas Research Center Shanghai 200336China School of Life Science East China Normal UniversityShanghai 200062China Zhejiang Academy of Forestry Hangzhou 310023China School of Life Sciences Fudan UniversityShanghai 200433China Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration School of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China

Ongoing wind energy developments play a key role in mitigating the global effects of climate change and the energy crisis;however,they have complex ecological consequences for many flying *** Yellow Sea coast is considered as an ecological bottleneck for migratory waterbirds along the East Asian–Australasian flyway(EAAF),and is also an important wind farm base in ***,the effects of large-scale onshore wind farms along the EAAF on multidimensional waterbird diversity,and how to mitigate these effects,remain *** we examined how wind farms and their surrounding landscapes affected multidimensional waterbird diversity along the Yellow Sea ***,functional,and phylogenetic diversity of the waterbird assemblages,and mean pairwise distances and nearest taxon distances with null models were quantified in relation to 4 different wind turbine *** also measured 6 landscape ***-dimensional waterbird diversity(taxonomic,functional,and phylogenetic diversity)significantly decreased with increasing wind turbine *** and phylogenetic structures tended to be clustered in waterbird communities,and environmental filtering drove waterbird community ***,waterbird diversity was regulated by a combination of wind turbine density and landscape variables,with edge density of aquaculture ponds,in addition to wind turbine density,having the greatest independent contribution to waterbird *** results suggest that attempts to mitigate the impact of wind farms on waterbird diversity could involve the landscape transformation of wind farm regions,for example,by including high-edge-density aquaculture ponds(i.e.,industrial ponds)around wind farms,instead of traditional low-edge-density aquaculture ponds.

关键词： East China coast environmental filtering mitigation measure renewable energy sustainable development waterbird conservation