Latamoxef-induced severe thrombocytopenia during the treatment of pulmonary infection:A case report

作     者：Ruo-Ying Zhang Jun-Jie Zhang Jin-Meng Li Ying-Ying Xu Yue-Huan Xu Xin-Jun Cai 

作者机构：Department of PharmacyAffiliated Hangzhou Chest HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Out-patientZhejiang Medical and Health Group Hangzhou HospitalHangzhou 310000Zhejiang ProvinceChina Tuberculosis Treatment CentreAffiliated Hangzhou Chest HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第22期

页      面：7906-7912页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the Special Research Fund of Hospital Pharmacy of Zhejiang Pharmaceutical Society,No. 2019ZYY27 Zhejiang Medical and Health Science and Technology Plan,No. 2020KY741 and No. 2021KY910 

主　　题：Thrombocytopenia Latamoxef Adverse drug reactions Young onset Case report 

摘      要：BACKGROUND Latamoxef shows excellent antibacterial activity against anaerobic bacteria such as Bacteroides *** of thrombocytopenic toxicity of latamoxef are *** report presents a case of severe thrombocytopenia possibly induced by latamoxef,an infrequent adverse drug reaction in a young patient with tuberculosis and Crohn s disease in *** SUMMARY We reported a case of severe thrombocytopenia induced by latamoxef in a 28-year-old man with tuberculosis and Crohn s *** admission,the patient presented with a cough productive of bloody sputum,a chest computed tomogram suggested scattered mottled,high-density shadows in both *** tests indicated a platelet count of 140000/μ*** a pulmonary bacterial infection,the patient received anti-infection therapy with latamoxef(dose:2.0 g)intravenously *** the 9th day of treatment,the platelet count decreased to 44000/μ*** the 12th day,scattered purpura and ecchymosis appeared on the patient’s limbs and trunk,and the platelet count decreased to 9000/μL after latamoxef treatment for 15 *** days after discontinuation of latamoxef,the platelet count recovered to 157000/μL,and the area of scattered purpura and ecchymosis on the limbs and trunk *** platelet counts remained in the normal range,and no thrombocytopenia was found at follow-up 15 mo after *** For patients treated with latamoxef,platelet counts should be carefully followed,and caregivers should be vigilant for the appearance of scattered ecchymosis.