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A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

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World Journal of Pediatrics 2024年第6期20卷 590-601页

作者： Meng-Jie Tang Xiao-Li Ma Xiang-Ling He Wei-Hua Pan Xiao-Hong Zhang Sha-Yi Jiang Ju Gao Fu Li Wei Yao Song Gu Wei-Ling Zhang Qiang Zhao Shi-Hao huang Yong-Jun Fang Wei Liu Hui-Zhong Niu Chun-Mei Wang Li-Rong Sun Hui Gao Yun-Peng Dai Shun-Gen huang Zhi-Yong Zhong Xi-Ge Wang Zhong-Rong Li Liang-Chun Yang Ye-ming Wu huan-Min Wang Xin Sun Xiao-Jun Yuan Department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China Medical Oncology Department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China Department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China Department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China Department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China Department of General Surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China Department of Pediatric General Surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's Hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Paediatric

Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2015 to June 2020 was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4-year 0S was 100%,97.3%,94.4%,and 86.8%,*** regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 299 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFP)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 ***≥8 years,R+,and E+were independent risk factors for *** with a declining AFP>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter Prospective study Survival

Morphology control of magnetic properties in cobalt nanowires

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Rare Metals 2023年第6期42卷 1994-1999页

作者： huan-huan Xu Qiong Wu ming Yue Cheng-Lin Li Hong-Jian Li College of Materials Science and Engineering Beijing University of TechnologyBeijing100124China

Cobalt nanowires with different shapes and sizes were synthesized by reduction of carboxylate salts of Co^(Ⅱ) in 1,2-butanediol using a solvothermal chemical *** well-crystallized Co nanowires with hexagonal closepacked(hep) phase are observed and the(002) crystalline direction is along the long axis of nano *** morphology control is strongly dependent on the reaction *** varying the amount of capping agent in proper ranges,the effect of reaction parameters on controlling the size and shape of Co nanowires is *** the amount of capping agent increasing,the aspect ratio of Co nanowires increases ***,the magnetic measurement of cobalt nanowires shows that the coercivity of the Co nanocrystals does not increase with the increase in aspect ratio monotonously,which suggests that the tip shape and micros tructure also play an important role in the magnetization reversal process of the Co nanocrystals,and the aspect ratio plays a much less role as the ratio value exceeds *** further understand the effect of size on the magnetic properties in the Co nanowires,micromagnetic simulations were performed,which confirms that the magnetic properties are barely affected by the aspect ratio larger than *** highest coercivity of624 kA·m^(-1) is obtained for ellipsoid nano wires with a mean length of 200 nm,which also displays a strong magnetic *** a result,the highest energy product of the wires reaches 248 kJ·m^(-3).

关键词： Co nanowires Morphology control Tip shape High energy product

结核分枝杆菌双组分系统PhoP蛋白的免疫学特性

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中国人兽共患病学报 2024年第4期40卷 352-358页

作者：李雪宁唤唤康健徐铭泽崔若囡代婷路延之薛飒柏银兰西北大学生命科学学院西安710069 空军军医大学基础医学院微生物与病原生物学教研室西安710032 空军军医大学军事医学创新中心西安710032

目的探究结核分枝杆菌双组分系统PhoP蛋白的免疫学特性。方法采用生物信息学方法预测PhoP蛋白的B细胞和T细胞表位。将Mtb H37Rv phoP基因克隆到pET-28a(+)原核表达载体上,并将重组质粒转化到*** BL21菌株中,经IPTG诱导表达及亲和层析法... 详细信息

目的探究结核分枝杆菌双组分系统PhoP蛋白的免疫学特性。方法采用生物信息学方法预测PhoP蛋白的B细胞和T细胞表位。将Mtb H37Rv phoP基因克隆到pET-28a(+)原核表达载体上,并将重组质粒转化到*** BL21菌株中,经IPTG诱导表达及亲和层析法纯化获得PhoP重组蛋白。用ELISA分析Mtb感染小鼠和TB患者血清中PhoP特异性抗体水平。PhoP重组蛋白经肌肉注射途径免疫小鼠,分离小鼠多抗血清,用ELISA和Western blot分别检测抗体效价和抗体特异性。分离小鼠脾细胞,用ELISpot和ELISA法分别检测分泌IFN-γ细胞频数及其分泌水平。结果经生物信息学预测发现PhoP含有24个B细胞抗原表位和11个优势T细胞表位。成功构建PhoP原核表达载体并获得纯化的PhoP蛋白。Mtb感染小鼠和TB患者血清中的PhoP特异性抗体显著升高,查准率分别为99.9%和82.5%,特异度均为100%。PhoP免疫小鼠诱导产生高水平特异性抗体,免疫小鼠脾细胞经抗原体外刺激后,IFN-γ的分泌水平和细胞频数均显著增加,IL-2和IL-10分泌水平上调。结论PhoP蛋白可诱导体液免疫应答和Th1型为主的细胞免疫。PhoP蛋白有良好的免疫原性,且具有一定的TB诊断效能。本研究为阐明PhoP在Mtb感染中的作用及其用于TB诊断奠定了一定的基础。

关键词：结核分枝杆菌双组分系统 PhoP 体液免疫应答细胞免疫应答

植物生长延缓剂对切花向日葵主要经济性状的影响

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山西农业科学 2024年第4期52卷 127-132页

作者：刘明梁均平何欢杨凌职业技术学院陕西咸阳712100 西安国际港务区住房和城乡建设局陕西西安710026

为了探究不同植物生长延缓剂对切花向日葵主要经济性状的影响,以文森特切花向日葵为试验材料,使用不同质量浓度的多效唑(40、80、160、240 mg/L)、矮壮素(100、200、400、800 mg/L)和缩节胺(50、100、150、200 mg/L)溶液对其进行叶面喷... 详细信息

为了探究不同植物生长延缓剂对切花向日葵主要经济性状的影响,以文森特切花向日葵为试验材料,使用不同质量浓度的多效唑(40、80、160、240 mg/L)、矮壮素(100、200、400、800 mg/L)和缩节胺(50、100、150、200 mg/L)溶液对其进行叶面喷施处理,以清水作为对照,在达到采收成熟度后,对不同处理条件下切花向日葵茎、叶、花性状进行测定。结果表明,与对照相比,12个处理下的切花向日葵均表现出株高降低、茎粗增加、节间缩短、茎干比增大、叶柄缩短、叶片增厚以及叶绿素含量增加、花盘直径增大等特点,表明文森特切花向日葵的经济性状得到明显改善,切花品质显著提升。其中,240 mg/L多效唑、800 mg/L矮壮素和150 mg/L缩节胺处理对切花向日葵经济性状的影响最为显著,240 mg/L多效唑处理下,切花向日葵株高降低24.1%,茎粗增加41.6%,叶片厚度增加52%,SPAD值增加47.5%,花盘直径增大26.3%;800 mg/L矮壮素处理下,其株高降低15.8%,茎粗增加35.7%,叶片厚度增加59.9%,SPAD值增加48%,花盘直径增大24.8%;150 mg/L缩节胺处理下,其株高降低22.2%,茎粗增加44.5%,叶片厚度增加74.8%,SPAD值增加39.3%,花盘直径增大22.7%。综合比较分析发现,240 mg/L多效唑处理下切花向日葵的经济性状最为突出,综合效果最好。

关键词：切花向日葵经济性状植物生长延缓剂多效唑矮壮素缩节胺

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一种平面静电离子阱非正弦镜像电荷/电流信号的定量转换新算法

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质谱学报 2024年第3期45卷 332-342,I0001页

作者：俞卓琦王伟民王华徐炳寅吴焕铭唐科奇丁力宁波大学浙江省先进质谱技术与分子检测重点实验室浙江宁波315211 宁波大学材料科学与化学工程学院浙江宁波315211 宁波大学材料科学与化学工程学院宁波大学质谱技术与应用研究院浙江宁波315211 盐城师范学院仪器分析中心江苏盐城224007

傅里叶变换质谱(FTMS)的质量分辨率取决于镜像电荷/电流的采集时间。为了在较短的时间内获得较高的分辨率,除增加分析器场强外,还可以利用镜像电荷信号中的高次谐波。平面静电离子阱获得的镜像电荷信号具有非正弦波形,其中包含许多高次... 详细信息

傅里叶变换质谱(FTMS)的质量分辨率取决于镜像电荷/电流的采集时间。为了在较短的时间内获得较高的分辨率,除增加分析器场强外,还可以利用镜像电荷信号中的高次谐波。平面静电离子阱获得的镜像电荷信号具有非正弦波形,其中包含许多高次谐波成分,增加了频谱分析的复杂程度,例如,难以辨认1个谱峰的谐波次数,以及当不同次的谐波发生重叠时出现定量困难。为了将多质荷比离子的镜像电荷信号转换成质谱,本文开发了一种新的定量算法,包含谱峰评分分类(SC)和最小二乘法拟合(LSF)。通过评分可以确定每个峰属于哪一次谐波,从而确定其对应的基频。打分算法列出所有候选离子的基频,并使用确定的基频构建所有基信号,然后用其对原频谱进行LSF,以确定每种质荷比离子的数量。使用48种不同质荷比离子的仿真镜像电荷信号对SCLSF算法进行测试。结果表明,该方法允许较宽的质量范围,即使在高噪声条件下,通过SC-LSF算法也能准确得到各种不同质荷比离子的数量。因为频谱中通常存在大量的空白频点,可以选择1个频点子集进行LSF,这相对于时域中的LSF,能够大大减少计算量,提高效率和准确度。此外,只有使用复数频谱数据进行LSF时才能获得良好的定量效果,而使用幅值数据则会对质荷比接近的离子定量造成较大的误差,这是因为质荷比接近的离子信号的低次谐波峰未能彻底分解,而复数的幅值不具有可加性,从而造成拟合的错误。

关键词：镜像电荷傅里叶变换质谱(FTMS) 定量算法谱峰评分分类(SC) 最小二乘法拟合(LSF)

社会支持视角下农村老年人互助养老行为及影响因素研究

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广西师范大学学报（哲学社会科学版） 2024年第2期60卷 59-74页

作者：王欢明钟峥云大连理工大学公共管理学院辽宁大连116023 中国人民大学公共管理学院北京100872

老龄化“城乡倒置”、养老资源“分布倒挂”现象加剧,互助养老成为解决我国农村养老问题的新途径。基于社会支持理论,运用CHARLS2018年数据,考察社会支持对农村老年人互助养老行为的影响,研究发现:正式社会支持中助推型公共政策能通过... 详细信息

老龄化“城乡倒置”、养老资源“分布倒挂”现象加剧,互助养老成为解决我国农村养老问题的新途径。基于社会支持理论,运用CHARLS2018年数据,考察社会支持对农村老年人互助养老行为的影响,研究发现:正式社会支持中助推型公共政策能通过“减少策略”和重构互助环境显著发挥促进作用;非正式社会支持中隔代照料正向作用显著;与农村老年人经济条件相关的变量均起到负向作用,互助养老行为的根本驱动与经济困境有关;非正式社会支持与正式社会支持存在交互效应,助推政策与照料孙子女具有互补性;低龄、无配偶且受教育水平较高的农村老年女性互助养老行为更强。研究结论有助于揭示互助养老行为影响因素以及柔性助推在其中的作用。

关键词：互助养老行为正式社会支持非正式社会支持助推

TPPU Protects Tau from H_2O_2-induced Hyperphosphorylation in HEK293/tau Cells by Regulating PI3K/AKT/GSK-3β Pathway

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第6期36卷 785-790页

作者： En-sheng YAO Yan TANG Xing-hua LIU ming-huan WANG Department of Neurology Tongji Hospital Tongji Medicine College Huazhong University of Science and Technology Wuhan 430030 China Department of Neurology Department of Geriatrics The First Affiliated Hospital School of Medicine Shihezi University Shihezi 832008 China

Neurofibrillary pathology of abnormally hyperphosphorylated tau is a hallmark of Alzheimer＇s disease（AD） and other *** 3-kinase（PI3K）/Akt/glycogen synthase kinase-3 beta（GSK-3β） signaling pathway is pivotal for tau *** of soluble epoxide hydrolase（s EH） metabolism has been shown to effectively increase the accumulation of epoxyeicosatrienoic acids（EETs）,which are cytochrome P450 metabolites of arachidonic acid and have been demonstrated to have neuroprotective ***,little is known about the role of s EH in tau *** present study investigated the role of a s EH inhibitor,1-（1-propanoylpiperidin-4-yl）-3-[4-（trifluoromethoxy）phenyl] urea（TPPU）,on H2O2-induced tau phosphorylation and the underlying signaling pathway in human embryonic kidney 293（HEK293）/Tau *** found that the cell viability was increased after TPPU treatment compared to control in oxidative *** blotting and immunofluorescence results showed that the levels of phosphorylated tau at Thr231 and Ser396 sites were increased in H2O2-treated cells but dropped to normal levels after TPPU administration.H2O2 induced an obvious decreased phosphorylation of GSK-3β at Ser9,an inactive form of GSK-3β,while there were no changes of phosphorylation of GSK-3β at *** pretreatment maintained GSK-3β Ser 9 ***,Western blotting results showed that TPPU upregulated the expression of *** protective effects of TPPU were found to be inhibited by wortmannin（WT,a specific PI3 K inhibitor）.In conclusion,these results suggested that the protective effect of TPPU on H2O2-induced oxidative stress is associated with PI3K/Akt/GSK-3β pathway.

关键词： TPPU tau GSK-3β Alzheimer's disease

宫颈癌同步放化疗预后及影响因素Cox回归预测模型构建

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医药论坛杂志 2024年第11期45卷 1147-1151页

作者：倪鸣杨弋弋周新欢叶永生李松南阳市中心医院妇科河南南阳473000

目的探讨宫颈癌同步放化疗预后及影响因素,并构建Cox回归预测模型。方法纳入2018年7月至2021年9月在南阳市中心医院收治106例Ⅱa~Ⅳ期宫颈癌患者为此次研究对象,均采用容积旋转调强放疗+铂类两药方案同步化疗,随访至2023年11月或死亡时... 详细信息

目的探讨宫颈癌同步放化疗预后及影响因素,并构建Cox回归预测模型。方法纳入2018年7月至2021年9月在南阳市中心医院收治106例Ⅱa~Ⅳ期宫颈癌患者为此次研究对象,均采用容积旋转调强放疗+铂类两药方案同步化疗,随访至2023年11月或死亡时截止。分析患者生存情况、影响预后的相关因素,并构建预后预测模型。结果对106例宫颈癌患者随访26~64个月,中位随访时间为45个月。死亡患者共40例,患者总生存率为62.26%。宫颈癌同步放化疗后总生存率与病理类型、分化程度、治疗前血红蛋白水平、完成放疗时间和临床分期有关(P9周(HR=2.052,P=0.029)和临床分期Ⅳa期(HR=2.026,P=0.041)均为影响宫颈癌同步放化疗预后死亡的独立风险因素(P<0.05)。根据多因素Cox比例风险回归模型分析结果,得到风险预测模型预后指数(PI)=2.373X1+2.259X2+2.143X3+2.052X4+2.026X5。X1、X2、X3、X4和X5分别为病理类型、分化程度、治疗前血红蛋白水平、完成放疗时间和临床分期。Hosmer-Lemeshowχ^(2)=6.235,P=0.621。ROC分析显示,Cox比例风险回归模型预测宫颈癌同步放化疗预后的AUC为0.859,95%CI为0.787~0.931。结论宫颈癌同步放化疗患者总生存率与病理类型、分化程度、治疗前血红蛋白水平、完成放疗时间和临床分期有关。

关键词：宫颈癌同步放化疗预后风险比例模型总生存率

Wavelet network based predistortion method for wideband RF power amplifiers exhibiting memory effects

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 625-630页

作者： JIN Zhe SONG Zhi-huan HE Jia-ming School of Information Science and Engineering Zhejiang University Hangzhou 310027 China Institute of Communication Technologies Ningbo University Ningbo 315211 China

RF power amplifiers (PAs) are usually considered as memoryless devices in most existing predistortion techniques. Nevertheless, in wideband communication systems, PA memory effects can no longer be ignored and memoryless predistortion cannot linearize PAs effectively. After analyzing PA memory effects, a novel predistortion method based on wavelet networks (WNs) is proposed to linearize wideband RF power amplifiers. A complex wavelet network with tapped delay lines is applied to construct the predistorter and then a complex backpropagation algorithm is developed to train the predistorter parameters. The simulation results show that compared with the previously published feed-forward neural network predistortion method, the proposed method provides faster convergence rate and better performance in reducing out-of-band spectral regrowth.

关键词： Power amplifiers. Predistortion. Memory effects. Wavelet networks