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FSTL1在急性冠脉综合征患者血清中的表达水平及临床意义

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国际检验医学杂志 2018年第8期39卷 942-946页

作者：陈特毕小云徐华建侯玉磊谌海兰李德涛张莉萍吴燕重庆医科大学附属第一医院医学检验科重庆400016 重庆医科大学附属第一医院输血科重庆400016

目的观察卵泡抑素样蛋白-1(FSTL1)在不同类型的急性冠状动脉综合征(ACS)患者血清中的水平变化及其临床诊断价值。方法收集临床确诊的ACS患者(ACS组)98例,分为ST段抬高型心肌梗死组(STEMI组)34例、非ST段抬高型心肌梗死组(NSTEMI组)28例... 详细信息

目的观察卵泡抑素样蛋白-1(FSTL1)在不同类型的急性冠状动脉综合征(ACS)患者血清中的水平变化及其临床诊断价值。方法收集临床确诊的ACS患者(ACS组)98例,分为ST段抬高型心肌梗死组(STEMI组)34例、非ST段抬高型心肌梗死组(NSTEMI组)28例、不稳定心绞痛组(UA组)36例,同时选取冠状动脉造影结果阴性的患者20例作为对照组。用酶联免疫吸附试验(ELISA)方法测定4组血清中FSTL1的水平,分析FSTL1与其他指标的相关性及诊断价值。结果 ACS各组血清FSTL1水平明显高于对照组,差异有统计学意义(P<0.05)。ACS组血清FSTL1水平与心肌肌钙蛋白(cTNT)、Gensini评分和超敏C反应蛋白(hs-CRP)水平成正相关,相关系数(r)分别为0.210、0.236、0.219。FSTL1诊断ACS的ROC曲线下面积(AUC)可达0.910(95%CI:0.832~0.988),但次于cTNT。FSTL1最佳界值为5.65μg/L,特异度84.2%,灵敏度77.5%。FSTL1联合cTNT和HDL对诊断ACS的效能最高,AUC=0.945(95%CI:0.909~0.981)。结论 ACS患者血清的FSTL1水平与炎性反应及冠状动脉狭窄程度存在一定的相关性,对于判断患者冠状动脉狭窄的严重程度及预后具有一定的临床价值。

关键词：卵泡抑素样蛋白-1 急性冠脉综合征冠脉狭窄体外诊断

Bioprinted mesenchymal stem cell microfiber-derived extracellular vesicles alleviate unilateral renal ischemia-reperfusion injury and fibrosis by inhibiting tubular epithelial cells ferroptosis

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Bioactive Materials 2024年第10期40卷 649-664页

作者： Qiang Guo Jianwei Chen Jianjian Wu Zijun Mo Lei Ye Wenwen Zhong Yi Zhang huajian Lai Yifei Zhang Jianguang Qiu Tao xu Dejuan Wang Department of Urology The Sixth Affiliated HospitalSun Yat-sen UniversityNo 26 Yuancun Erheng RoadGuangzhou510655China Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou510655China Bio-intelligent Manufacturing and Living Matter Bioprinting Center Research Institute of Tsinghua University in ShenzhenTsinghua UniversityShenzhen518057China Department of Research and Development Huaqing Zhimei(Shenzhen)Biotechnology Co.Ltd.ShenzhenGuangdong Province518107China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China

Renal unilateral ischemia-reperfusion injury(UIRI)constitutes a significant global health challenge,with poor recovery leading to chronic kidney disease and subsequent renal *** vesicles(EVs)present substantial potential benefits for renal ***,the limited yield and efficacy of EVs produced through traditional methodologies(2D-EVs)severely restrict their widespread ***,the efficient and effective strategies for using EVs in UIRI treatment and their mechanisms remain largely *** this study,we propose an innovative approach by integrating bioprinted mesenchymal stem cell microfiber extracellular vesicles production technology(3D-EVs)with a tail vein injection method,introducing a novel treatment strategy for *** comparison of the biological functions of 2D-EVs and 3D-EVs,both in vitro and in vivo,reveals that 3D-EVs significantly outperform ***,in vitro,3D-EVs demonstrate a superior capacity to enhance the proliferation and migration of NRK-52E cells and mitigate hypoxia/reoxygenation(H/R)-induced injuries by reducing epithelial-mesenchymal transformation,extracellular matrix deposition,and *** vivo,3D-EVs exhibit enhanced therapeutic effects,as evidenced by improved renal function and decreased collagen deposition in UIRI mouse *** further elucidate the mechanism by which 3D-EVs derived from KLF15 ameliorate UIRI-induced tubular epithelial cells(TECs)ferroptosis through the modulation of SLC7A11 and GPX4 *** findings suggest that bioprinted mesenchymal stem cells microfiberderived EVs significantly ameliorate renal UIRI,opening new avenues for effective and efficient EV-based therapies in UIRI treatment.

关键词： Bioprinted 3D-EVs Unilateral renal ischemia-reperfusion injury KLF15 Ferroptosis

Experiments on Exploration of Shallow Fine Structures and the Construction of the 1-D Velocity Model in the Pingtan Island,Fujian

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Earthquake Research in China 2019年第2期33卷 265-275页

作者： GUO Yang xu Jiajun LIN Chen JIN Xing YAO huajian YANG Hongfeng CAI Huiteng Fujian Earthquake Agency Fuzhou 350003China School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China School of Earth Sciences and Engineering Nanjing UniversityNanjing 210046China Earth System Science Programme Faculty of ScienceThe Chinese University of Hong KongHong Kong 999077China

112 short-period seismographs were set up in the 400 km^2 area of Pingtan Island and its surrounding areas in *** combined observations of the airgun source and ambient noise source were carried out using a dense array to receive the 387 airgun signals excited around the island and one month of continuous ambient noise *** 1-D P-wave and S-wave shallow velocity model of Pingtan Island is obtained by the inversion of the airgun body wave’s first arrival time data,and the reliability of the velocity model is verified by using the surface wave phase velocity dispersion curve,which can provide initial model for subsequent 3-D *** experimental results show that this experiment is a successful demonstration of local scale green non-destructive detection,which can provide basic data for shallow surface structure research and strong vibration simulation of the Pingtan Island.

关键词： Pingtan Island Fujian Dense array Airgun Ambient noise 1-D velocity model

Corrigendum to“Synergistically targeting synovium STING pathway for rheumatoid arthritis treatment”[Bioact Mater 24(2022)37–53]

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Bioactive Materials 2024年第10期40卷 665-666页

The authors regret that two images in Fig.3A were originally misplaced by a careless *** corrected versions of these images are provided *** corrections do not alter any findings and conclusions reported in this *** a... 详细信息

关键词： correction finding mistake

Highly efficient twin-field quantum key distribution with neural networks

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Science China(Information Sciences) 2023年第8期66卷 281-282页

作者： Jingyang LIU Qingqing JIANG huajian DING Xiao MA Mingshuo SUN Jiaxin xu Chun-Hui ZHANG Shipeng XIE Jian LI Guigen ZENG Xingyu ZHOU Qin WANG Institute of Quantum Information and Technology Nanjing University of Posts and Telecommunications Key Lab of Broadband Wireless Communication and Sensor Network Technology Ministry of Education Telecommunication and Networks National Engineering Research Center Nanjing University of Posts and Telecommunications

Quantum key distribution(QKD) allows two legitimate parties, Alice and Bob, to share a series of random bits that are secured by the laws of quantum mechanics. As a remarkable theoretical progress towards longer distances, the proposal of twin-field QKD(TF-QKD) [1] shows the capability to break a repeaterless bound and provides a key rate in the square-root scale of channel transmittance(i.e.,

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Chimera states of phase oscillator populations with nonlocal higher-order couplings

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Chinese Physics B 2024年第4期33卷 402-407页

作者：伍勇刚余华健郑志刚徐灿 School of Mathematical Sciences Huaqiao UniversityQuanzhou 362021China Institute of Systems Science and College of Information Science and Engineering Huaqiao UniversityXiamen 361021China

The chimera states underlying many realistic dynamical processes have attracted ample attention in the area of dynamical ***, we generalize the Kuramoto model with nonlocal coupling incorporating higher-order interactions encoded with simplicial *** works have shown that higher-order interactions promote coherent ***, we uncover the fact that the introduced higher-order couplings can significantly enhance the emergence of the incoherent ***, we identify that the chimera states arise as a result of multi-attractors in dynamic ***, we review that the increasing higher-order interactions can significantly shape the emergent probability of chimera *** the observed results can be well described in terms of the dimension reduction *** study is a step forward in highlighting the importance of nonlocal higher-order couplings, which might provide control strategies for the occurrence of spatial-temporal patterns in networked systems.

关键词： synchronization complex system coupled oscillators phase transition

A Review on 3D Hand Pose and Shape Reconstruction from Color Images

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A Review on 3D Hand Pose and Shape Reconstruction from Color...

10-甲基吖啶盐与活泼金属在固相研磨条件下的新颖反应研究

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作者： huajian Leng Yuting Ge Chi xu Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education

The task of hand reconstruction aims to estimate the shape and pose of hands from the input images. Deep learning algorithms have shown remarkable performance in the field of computer vision in recent years, promoting the development of related algorithms. This article reviews the 3D hand reconstruction technologies, introducing the research background, value,and directions, summarizing the characteristics of datasets and evaluation metrics, and discussing the types of parametric, non-parametric, and joint mesh representation methods;it then outlines research directions in single-hand, hand-object interaction,and two-hand reconstruction, and analyzes their progress. Finally, it summarizes both the hand datasets and the algorithms, and provides a perspective on the future development of hand reconstruction.

关键词： Hand Reconstruction Computer Vision Deep Learning Hand Datasets

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有机化学 2009年第2期29卷 289-291页

作者：许华建徐小岚冯乙巳合肥工业大学化学工程学院合肥230009 安徽医科大学化学教研室合肥230032

在固相研磨条件下,10-甲基吖啶碘盐与碱金属Li,Na和K反应生成9,10-二氢-10-甲基吖啶(AcrH2)和10-甲基-9-吖啶酮(Acr=O),产率比较高.这些反应是通过金属将电子转移给10-甲基吖啶碘盐而得以发生的.

关键词：辅酶NADH模型物固相研磨电子转移

Spatial distribution and network morphology of epicardial,endocardial,interstitial,and Purkinje cell-associated elastin fibers in porcine left ventricle

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Bioactive Materials 2023年第1期19卷 348-359页

作者： Xiaodan Shi Song Zhang Yue Liu Bryn Brazile Jim Cooley J.Ryan Butler Sara R.McMahan Karla L.Perez Jiazhu xu Timothy Eastep Kytai T.Nguyen Pietro Bajona Matthias Peltz huajian Gao Yi Hong Jun Liao Department of Bioengineering University of Texas at ArlingtonArlingtonTX76010USA College of Engineering and College of Veterinary Medicine Mississippi State UniversityMississippi StateMS39762USA School of Engineering Brown UniversityProvidenceRI02912USA College of Engineering Nanyang Technical University308232Singapore Department of Cardiovascular and Thoracic Surgery University of Texas Southwestern Medical CenterDallasTX75390USA Allegheny Health Network-Drexel University College of Medicine PittsburghPA15212USA

Cardiac extracellular matrices(ECM)play crucial functional roles in cardiac *** studies have mainly focused on collagen,the major structural ECM in heart *** role of elastin in cardiac mechanics,however,is poorly *** this study,we investigated the spatial distribution and microstructural morphologies of cardiac elastin in porcine left *** demonstrated that the epicardial elastin network had location-and depth-dependency,and the overall epicardial elastin fiber mapping showed certain correlation with the helical heart muscle fiber *** compared to the epicardial layer,the endocardial layer was thicker and has a higher elastin-collagen ratio and a denser elastin fiber network;moreover,the endocardial elastin fibers were finer and more wavy than the epicardial elastin fibers,all suggesting various interface *** myocardial interstitial elastin fibers co-exist with the perimysial collagen to bind the cardiomyocyte bundles;some of the interstitial elastin fibers showed a locally aligned,hinge-like structure to connect the adjacent cardiomyocyte *** collagen-elastin combination reflects an optimal design in which the collagen provides mechanical strength and elastin fibers facilitate recoiling during ***,cardiac elastin fibers,along with collagen network,closely associated with the Purkinje cells,indicating that this ECM association could be essential in organizing cardiac Purkinje cells into“fibrous”and“branching”morphologies and serving as a protective feature when Purkinje fibers experience large deformations in *** short,our observations provide a structural basis for future in-depth biomechanical investigations and biomimicking of this long-overlooked cardiac ECM component.

关键词： Heart ECM Epicardial elastin Endocardial elastin Interstitial elastin Purkinje-cell associated elastin