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Medicine in Novel Technology and Devices 2024年第1期21卷 39-44页

作者： huaiyu shi Andrew Kowalczewski Danny Vu Xiyuan Liu Asif Salekin Huaxiao Yang Zhen Ma Department of Biomedical&Chemical Engineering Syracuse UniversitySyracuseNYUSA BioInspired Institute for Material and Living Systems Syracuse UniversitySyracuseNYUSA Department of Mechanical&Aerospace Engineering Syracuse UniversitySyracuseNYUSA Department of Electrical Engineering&Computer Science Syracuse UniversitySyracuseNYUSA Department of Biomedical Engineering University of North TexasDentonTXUSA

Organoid Intelligence ushers in a new era by seamlessly integrating cutting-edge organoid technology with the power of artificial ***,three-dimensional miniature organ-like structures cultivated from stem cells,offer an unparalleled opportunity to simulate complex human organ systems in *** the convergence of organoid technology and AI,researchers gain the means to accelerate discoveries and insights across various *** intelligence algorithms enable the comprehensive analysis of intricate organoid behaviors,intricate cellular interactions,and dynamic responses to *** synergy empowers the development of predictive models,precise disease simulations,and personalized medicine approaches,revolutionizing our understanding of human development,disease mechanisms,and therapeutic *** Intelligence holds the promise of reshaping how we perceive in vitro modeling,propelling us toward a future where these advanced systems play a pivotal role in biomedical research and drug development.

关键词： Organoids Machinelearning Deep learning Artificial intelligence Stem cells

国家公园视角下城镇协同治理研究——以晋陕沿岸为例

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西安建筑科技大学学报（自然科学版） 2024年第3期56卷 409-417页

作者：张军飞赵文静史怀昱庞鹏飞西安建筑科技大学建筑学院陕西西安710055 陕西省城乡规划设计研究院陕西西安710016 西安建筑科技大学交叉创新研究院陕西西安710055

黄河流域是中华文明的重要发源地,近年来,黄河流域生态保护和高质量发展取得明显成效.然而,受自然地理条件和跨省协同治理难度影响,两岸治理仍存在不平衡不充分问题,特别是晋陕沿岸地区发展缓慢、特色不足.为更好地保护生态环境,促进经... 详细信息

黄河流域是中华文明的重要发源地,近年来,黄河流域生态保护和高质量发展取得明显成效.然而,受自然地理条件和跨省协同治理难度影响,两岸治理仍存在不平衡不充分问题,特别是晋陕沿岸地区发展缓慢、特色不足.为更好地保护生态环境,促进经济发展,研究以共建黄河国家文化公园为契机,提出联合周边省份,从实施生态系统保护修复、优化城镇空间结构、整合文化资源、搭建一体化设施网络、成立跨省协同治理机构、完善长效机制等方面推动区域高质量发展,以期实现生态共治、文化共荣、城镇共建、治理共赢,为新时期沿黄省际城镇协作共建与协同发展提供实践依据.

关键词：国家公园协同治理路径与实践黄河晋陕沿岸

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Micro-nanoarchitectonic of aluminum-hydrogel propellant with static stability and dynamic rheology

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 87-96页

作者： Huiyan Guo huaiyu Li Hongzhi Zhang Lun Pan Chengxiang shi Kang Xue Xiangwen Zhang Ji-Jun Zou Key Laboratory for Advanced Fuel and Propellant of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

The aluminum-water system is a promising propellant due to high energy and low signal characteristics,and the gel form is easier to store and *** this work,hydrogels of water and aluminum particles were prepared using the low-molecular-weight gellant *** various physical properties of gel systems,including the water loss rate,phase transition temperature,and centrifugal stability at different gellant and aluminum contents,were *** properties were assessed through shear thinning tests,thixotropy tests,strain sweep analysis,and frequency sweep *** microstructure of the gel was obtained through scanning electron microscopy *** results show that the aluminum-hydrogel network structure is composed of micron-scale aluminum and agarose nanosheets,and the unique micro-nanostructure endows the gel with excellent mechanical strength and thermal stability,which improve with increasing gellant and aluminum ***,the gel with 2% agarose and 20% aluminum had the best performance;the storage modulus reached 90647 Pa,which was within the linear viscoelastic region,and the maximum withstand pressure was 111.2 kPa,which was 118.8% greater than that of the pure ***,the gel demonstrates remarkable shear thinning behavior and can undergo gel-sol transformation upon shearing or heating to exceeding 114℃.

关键词： aluminum-water propellant gelled propellant rheological property mechanical strength

Profiling the responsiveness of focal adhesions of human cardiomyocytes to extracellular dynamic nano-topography

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Bioactive Materials 2022年第4期7卷 367-377页

作者： huaiyu shi Xiangjun Wu shiyang Sun Chenyan Wang Zacharias Vangelatos Ariel Ash-Shakoor Costas P.Grigoropoulos Patrick T.Mather James H.Henderson Zhen Ma Department of Biomedical&Chemical Engineering Syracuse UniversitySyracuseNY13244USA BioInspired Syracuse Institute for Materials and Living Systems Syracuse UniversitySyracuseNY13244USA Department of Mechanical Engineering University of CaliforniaBerkeleyPA94720USA Department of Chemical Engineering Bucknell UniversityLewisburgPA17837USA

Focal adhesion complexes function as the mediators of cell-extracellular matrix interactions to sense and transmit the extracellular *** studies have demonstrated that cardiomyocyte focal adhesions can be modulated by surface topographic ***,the response of focal adhesions to dynamic surface topographic changes remains *** study this dynamic responsiveness of focal adhesions,we utilized a shape memory polymer-based substrate that can produce a flat-to-wrinkle surface transition triggered by an increase of *** this dynamic culture system,we analyzed three proteins(paxillin,vinculin and zyxin)from different layers of the focal adhesion complex in response to dynamic extracellular topographic ***,we quantified the dynamic profile of cardiomyocyte focal adhesion in a time-dependent manner,which provides new understanding of dynamic cardiac mechanobiology.

关键词： Stimuli-responsive biomaterials Shape memory polymer Focal adhesion Costamere Dynamic mechanobiology Human induced pluripotent stem cells

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问题导向下的陕西规划智库建设探索

规划师 2018年第3期34卷 28-33页

作者：史怀昱陕西省城乡规划设计研究院

近年来,国家高度重视新型智库的建设,提出智库是现代化治理建设和国家软实力的重要组成部分,要高度重视、积极探索中国特色新型智库的组织形式和管理方式。在这一背景下,陕西省城乡规划设计研究院以问题为导向,提出"重点问题、重点研究... 详细信息

近年来,国家高度重视新型智库的建设,提出智库是现代化治理建设和国家软实力的重要组成部分,要高度重视、积极探索中国特色新型智库的组织形式和管理方式。在这一背景下,陕西省城乡规划设计研究院以问题为导向,提出"重点问题、重点研究;个性问题、针对研究;长期问题、跟踪研究;新型问题、展望研究"的原则,立足陕西自身特点,构建了专家型、参与型、服务型、公益型、平台型和智慧型规划智库,为政府决策提供了有力的支撑,为新型智库建设背景下城乡规划院的转型提供了参考。

关键词：新型智库政府职能规划院转型陕西

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陕西省分区城镇化路径研究

城市发展研究 2014年第12期21卷 88-96页

作者：文雯史怀昱石会娟陕西省城乡规划设计研究院

区域发展的不均衡现象是十分普遍的,各地区由于自然条件、历史基础、文化脉络、人口资源环境等原因均存在发展基础和发展模式的差异。进一步细化陕西省城镇化发展分区,从不同区域的现状特征、发展动力、面临挑战入手,探讨差异化城镇发... 详细信息

区域发展的不均衡现象是十分普遍的,各地区由于自然条件、历史基础、文化脉络、人口资源环境等原因均存在发展基础和发展模式的差异。进一步细化陕西省城镇化发展分区,从不同区域的现状特征、发展动力、面临挑战入手,探讨差异化城镇发展路径,提出分区城镇化发展的建议及措施。

关键词：分区城镇化陕西省

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新时期城市空间管控体系构建与榆林实践

规划师 2016年第3期32卷 120-124页

作者：史怀昱陈健陕西省城乡规划设计研究院

依据国家生态文明建设、新型城镇化等发展战略要求,结合城市规划思路的众多变化,文章以榆林中心城区为案例,围绕城市生态环境底线保护和历史文化传承两个主要方面,从时间、空间两个维度出发,根据既有的城市空间管制方法,将生态、文化要... 详细信息

依据国家生态文明建设、新型城镇化等发展战略要求,结合城市规划思路的众多变化,文章以榆林中心城区为案例,围绕城市生态环境底线保护和历史文化传承两个主要方面,从时间、空间两个维度出发,根据既有的城市空间管制方法,将生态、文化要素贯穿始终,构筑起以战略研究引导城市空间格局、以要素管控城市用地布局及以数字平台辅助实施管理的城市空间管制体系,以期有助于城市空间管制理论内涵和实践经验的进一步完善。

关键词：规划思路生态环境底线保护历史文化传承城市空间管控体系

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