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基于三维运动捕捉技术构建蒙医震脑术三维虚拟仿真平台的视觉呈现

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中国组织工程研究 2025年第18期29卷 3826-3832页

作者：白雪王星洪国萍贾茹铄韩琦郭怀钰牛泓凯张少杰朝鲁门内蒙古医科大学医学实验中心内蒙古自治区呼和浩特市010110 内蒙古医科大学基础医学院解剖学教研室内蒙古自治区呼和浩特市010110 内蒙古医科大学数字医学中心内蒙古自治区呼和浩特市010110 内蒙古自治区残疾人康复服务中心内蒙古自治区呼和浩特市010010 内蒙古大学计算机学院内蒙古自治区呼和浩特市010021 包头市蒙医中医医院内蒙古自治区包头市014040

背景:基于三维运动捕捉技术可以构建精准的、客观量化的医学虚拟仿真模型,有利于临床学习者精准、深入理解和掌握各种传统疗术。目前中医虚拟仿真模型已有报道,但蒙医传统疗术的虚拟仿真模型尚未见报道。目的:构建一种基于三维运动捕捉... 详细信息

背景:基于三维运动捕捉技术可以构建精准的、客观量化的医学虚拟仿真模型,有利于临床学习者精准、深入理解和掌握各种传统疗术。目前中医虚拟仿真模型已有报道,但蒙医传统疗术的虚拟仿真模型尚未见报道。目的:构建一种基于三维运动捕捉技术的交互式三维可视化的蒙医震脑术虚拟仿真模型。方法:使用Motion Analysis三维光学运动捕捉系统和足底测力台采集蒙医专家的运动捕捉数据,在Motion Builder软件中构建震脑术三维动作模型,使用Maya软件构建角色模型并与动作模型相匹配,运动Unity3D软件构建蒙医震脑术虚拟仿真系统,系统整合蒙医震脑术操作3D动画、运动学和动力学参数信息。结果与结论:通过三维运动捕捉技术和计算机仿真重现蒙医震脑术操作,能够显示施术者和受试者的运动姿态,记录关节运动的关键空间位置参数与变化情况,得出运动过程中的运动学、动力学参数。运用交互式三维虚拟仿真技术,实现蒙医震脑术的三维虚拟仿真的视觉呈现,为蒙医震脑术手法的标准化、数字化、可视化研究奠定基础。

关键词：蒙医震脑术三维运动捕捉技术足底测力台 Anybody 虚拟仿真三维可视化 Motion Builder Maya Unity3D 人工智能

Functional Janus Membranes:Promising Platform for Advanced Lithium Batteries and Beyond

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Energy & Environmental Materials 2023年第5期6卷 142-158页

作者： Dan Chan Yunfei Liu You Fan Huibo Wang Shi Chen Tianwei Hao Heng Li Zhengshuai bai huaiyu Shao Guichuan Xing Yanyan Zhang Yuxin Tang College of Chemical Engineering Fuzhou University Fuzhou 350116China Institute of Applied Physics and Materials Engineering University of MacaoMacao 999078China Department of Civil and Environmental Engineering Faculty of Science and Technology University of MacaoMacao 999078China State Key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

Separators or electrolyte membranes are recognized as the key components to guarantee ion transport in rechargeable ***,the ever-growing applications of the battery systems for diverse working environments bring new challenges,which require advanced battery membranes with high thermal stability,excellent mechanical strength,high voltage tolerance,***,it is highly desirable to design novel methods/concepts to solve the current challenges for battery membranes through understanding the mechanism of novel phenomena and electrochemical reactions in battery systems working under unconventional ***,the new emerging Janus separators or electrolyte membranes with two or more distinct chemical/physical properties arising from their asymmetric structure and composition,are promising to address the above challenges via rational design of their targeted *** this end,in this review,we first briefly cover the current challenges of the traditional battery membrane for battery devices working in unconventional ***,the state-of-art developments of the rational design of Janus membranes to overcome the above challenges for diverse battery applications are ***,we outline these latest developments,challenges,and future potential directions of the Janus *** review is aimed to provide basic guidance for developing functional separators or electrolyte membranes for advanced batteries.

关键词： batteries Janus membranes separators solid-state electrolytes

Osteoblastic microRNAs in skeletal diseases:Biological functions and therapeutic implications

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Engineered Regeneration 2022年第3期3卷 241-257页

作者： Lei Yu Wenming Li Peng Yang Wei Zhang Huaqiang Tao Gaoran Ge Huilin Yang Jiaxiang bai huaiyu Wang Dechun Geng Department of Orthopaedics The First Affiliated Hospital of Soochow University188 Shizi StreetSuzhouJiangsu 215006China Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Orthopaedic Institute Medical CollegeSoochow UniversitySuzhouJiangsu 215000China

Skeletal diseases normally represents a grievous imbalance between osteoblasts for bone formation and osteoclasts for bone resorption.A lack of osteogenic function can make it difficult to repair pathological bone ***,substantial efforts have been made to remedy these issues,with the aid of bioactive molecules,herbs and *** recent insights,the importance of epigenetic gene regulation is increasingly evident,especially *** can silence target genes by inhibiting mRNA translation or degrading mRNA molecules by binding to their 3′-untranslated *** is accumulating evidence indicating that the miRNAs significantly involved in osteogenic gene expression,signaling pathway intervention and programmed cell ***,numerous new target drugs(microRNA inhibitors or agonists)have been proposed to exploit its value in skeletal physiology and *** this review,we mainly discuss the role of microRNAs in the context of skeletal disease-associated osteoblast differentiation,the applications of microRNA polymorphisms as biomarkers for diagnostic and therapeutic targets,and the challenges to meet this *** summary provides novel horizon for improving the therapeutic effect of microRNAs,which may be beneficial to the further clinical translation of microRNAs in the treatments of skeletal diseases.

关键词： Skeletal diseases Osteogenesis Apoptosis MicroRNA Diagnosis Drug delivery

A programmed surface on polyetheretherketone for sequentially dictating osteoimmunomodulation and bone regeneration to achieve ameliorative osseointegration under osteoporotic conditions

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Bioactive Materials 2022年第8期7卷 364-376页

作者： Yanyan Zheng Ang Gao Jiaxiang bai Qing Liao Yuzheng Wu Wei Zhang Min Guan Liping Tong Dechun Geng Xin Zhao Paul K.Chu huaiyu Wang Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China School of Basic Medical Sciences and Forensic Medicine North Sichuan Medical CollegeNanchong637000China Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySuzhou215006China Department of Physics Department of Materials Science and EngineeringDepartment of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing100190China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong KongChina

Polyetheretherketone(PEEK)is a desirable alternative to conventional biomedical metals for orthopedic implants due to the excellent mechanical ***,the inherent bioinertness of PEEK contributes to inferior osseointegration of PEEK implants,especially under pathological conditions of ***,a programmed surface is designed and fabricated on PEEK to dictate osteoimmunomodulation and bone regeneration sequentially.A degradable hybrid coating consisting of poly(lactide-co-glycolide)and alendronate(ALN)loaded nano-hydroxyapatite is deposited on PEEK and then interleukin-4(IL-4)is grafted onto the outer surface of the hybrid coating with the aid of N_(2) plasma immersion ion implantation and subsequent immersion in IL-4 *** release of IL-4 together with ALN and Ca^(2+) during the first few days synergistically mitigates the early acute inflammatory reactions and creates an osteoimmunomodulatory microenvironment that facilitates bone ***,slow and sustained delivery of ALN and Ca^(2+) in the following weeks boosts osteogenesis and suppresses osteoclastogenesis simultaneously,consequently ameliorating bone-implant osseointegration even under osteoporotic *** taking into account the different phases in bone repair,this strategy of constructing advanced bone implants with sequential functions provides customizable and clinically viable therapy to osteoporotic patients.

关键词： Polyetheretherketone Surface modification Osteoimmunomodulation Sequential release Osteoporosis Osseointegration

Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine)Surface Engineering Strategy

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Research 2020年第1期2020卷 1768-1787页

作者： Ying Yang Peng Gao Juan Wang Qiufen Tu Long bai Kaiqin Xiong Hua Qiu Xin Zhao Manfred FMaitz huaiyu Wang Xiangyang Li Qiang Zhao Yin Xiao Nan Huang Zhilu Yang Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Institute of Health and Biomedical Innovation Queensland University of TechnologyBrisbane 4059Australia Australia-China Centre for Tissue Engineering and Regenerative Medicine Queensland University of TechnologyBrisbane 4059Australia Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Max Bergmann Center of Biomaterials Leibniz Institute of Polymer Research DresdenHohe Strasse 601069 DresdenGermany Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjinChina

Stenting is currently the major therapeutic treatment for cardiovascular ***,the nonbiogenic metal stents are inclined to trigger a cascade of cellular and molecular events including inflammatory response,thrombogenic reactions,smooth muscle cell hyperproliferation accompanied by the delayed arterial healing,and poor reendothelialization,thus leading to restenosis along with late stent *** address prevalence critical problems,we present an endothelium-mimicking coating capable of rapid regeneration of a competently functioning new endothelial layer on stents through a stepwise metal(copper)-catechol-(amine)(MCA)surface chemistry strategy,leading to combinatorial endothelium-like functions with glutathione peroxidase-like catalytic activity and surface *** from the stable nitric oxide(NO)generating rate at the physiological level(2:2×10^(-10) mol/cm^(2)/min lasting for 60 days),this proposed strategy could also generate abundant amine groups for allowing a high heparin conjugation efficacy up to∼1μg/cm^(2),which is considerably higher than most of the conventional heparinized *** resultant coating could create an ideal microenvironment for bringing in enhanced antithrombogenicity,anti-inflammation,anti-proliferation of smooth muscle cells,re-endothelialization by regulating relevant gene expressions,hence preventing restenosis in *** envision that the stepwise MCA coating strategy would facilitate the surface endothelium-mimicking engineering of vascular stents and be therefore helpful in the clinic to reduce complications associated with stenosis.

关键词： coating stepwise bringing

Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy

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Bioactive Materials 2022年第2期7卷 309-324页

作者： Meng Li Jiaxiang bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren Ang Gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang huaiyu Wang Guoqing Pan Dechun Geng Department of Orthopaedics The First Affiliated Hospital of Soochow University188 Shizi StreetSuzhou215006JiangsuChina Institute for Advanced Materials School of Materials Science and EngineeringJiangsu University301 Xuefu RoadZhenjiang212013JiangsuChina Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055GuangdongChina Department of Orthopaedics The First Affiliated Hospital of USTCUniversity of Science and Technology of China17 Lujiang RoadHefei230001AnhuiChina Department of Oncology The First Affiliated Hospital of USTCUniversity of Science and Technology of China17 Lujiang RoadHefei230001AnhuiChina

Polyetheretherketone(PEEK)has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical ***,its biological inertness,poor osteoinduction,and weak antibacterial activity make the clinical applications in a *** by the mussel adhesion mechanism,here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins(Mfps)-mimic peptide with clickable azido *** peptide enables mussel-like adhesion on PEEK biomaterial surfaces,leaving azido groups for the further steps of *** this study,antimicrobial peptide(AMP)and osteogenic growth peptide(OGP)were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue *** bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios,an optimal PEEK surface was finally obtained in this research,which could long-term inhibit bacterial growth,stabilize bone homeostasis and facilitate interfacial bone *** a word,this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants,in particular,achieving rational integration of multiple biofunctions to match clinical requirements.

关键词： Surface biomodification Polyetheretherketone Anti-infectivity and osteo-inductivity Mussel adhesion Bioorthogonal chemistry

Soft landing of runaway currents by ohmic field in J-TEXT tokamak

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Plasma Science and Technology 2020年第11期22卷 11-22页

作者： Jie HU Wei YAN Ruihai TONG Wei LI Zhongyong CHEN Anjue DAI Duwei HUANG Yunong WEI Tiankui MA Yuan HUANG Yang LI Wei ZHENG Zhifang LIN You LI huaiyu YANG Duoqin WANG Wei bai Yu ZHONG Jiangang FANG J-TEXT Team International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma Physics State Key Laboratory of Advanced Electromagnetic Engineering and TechnologySchool of Electrical and Electronic EngineeringHuazhong University of Science and Tech no logyWuhan 430074People's Republic of China Southwestern Institute of Physics Chengdu 610041.People's Republic of China Chengdu University Chengdu 610106People's Republic of China Beibu Gulf University Qinzhou 535000People's Republic of China

Recently,experimental studies on the soft landing of RE current by ohmic(OH)field have been performed in J-TEXT tokamak,as a possible auxiliary method to dissipate the RE *** optimized horizontal displacement control of the RE beam,the toroidal electric field has been scanned from 1.6 to—0.3 V m^-1 during the RE plateau *** growth rate of RE currents and the evolution of hard x-ray(HXR)emissions have been *** is found that when the toroidal electric field is less than 7-12 times the theoretical critical electric field,the decay of REs could be *** dissipation rate by the ohmic field can reach a maximum value of 3 MA s^-***,the results of HXR spectra analysis indicate the different behaviors of HXR emissions under the condition of different toroidal electric *** analysis of the ionized argon emissions and magnetic fluctuations shows that under the condition of different toroidal electric fields,the physical process of RE generation may be different.

关键词： tokamak disruption runaway electron hard x-ray

α-Fe单晶拉伸变形热-动力学的分子动力学模拟

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金属学报 2024年第6期60卷 848-856页

作者：柏智文丁志刚周爱龙侯怀宇刘伟刘峰南京理工大学材料科学与工程学院南京210094 西北工业大学凝固技术国家重点实验室西安710072 西北工业大学分析与测试中心西安710072

材料的微观结构和变形机制决定了其强度和塑性。特别是位错的成核和运动在晶体材料的塑性变形过程中起着至关重要的作用。本工作采用分子动力学模拟方法,研究了α-Fe沿着[010][111][110]及[112]晶向单向拉伸条件下的变形热-动力学行为,... 详细信息

材料的微观结构和变形机制决定了其强度和塑性。特别是位错的成核和运动在晶体材料的塑性变形过程中起着至关重要的作用。本工作采用分子动力学模拟方法,研究了α-Fe沿着[010][111][110]及[112]晶向单向拉伸条件下的变形热-动力学行为,分析了相应的位错产生和演变。结果表明,沿不同晶向拉伸时材料表现出不同的屈服强度,由高到低依次为[111][110][112][010]。沿不同的晶向拉伸时,位错密度变化趋势、位错类型及位错萌生时间均有不同,位错萌生时间越早,材料屈服强度越低。温度升高一般会使得单晶Fe在拉伸过程中位错萌生的时间提前,同时伴随弹性模量和强度的降低。对位错演化的热-动力学和广义稳定性分析表明,拉伸过程的热力学驱动力与动力学能垒的变化趋势相反,则广义稳定性数值与晶向及温度相关。

关键词： α-Fe 分子动力学位错热-动力学广义稳定性

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基于溶剂蒸发法的聚硫橡胶微胶囊的制备

高分子材料科学与工程 2024年第10期40卷 1-10页

作者：王璇杨杰白云龙苑旭雯杨怀玉中国科学院金属研究所辽宁沈阳110016 中国科学技术大学材料科学与工程学院安徽合肥230026 湖北汽车工业学院材料科学与工程学院湖北十堰442002

以液体聚硫橡胶(LPR)为芯材、聚苯乙烯(PS)为囊壁,采用溶剂蒸发法制备了LPR@PS微胶囊。通过对制约微球热力学稳态因素与动力学因素的调整制备了具有不同粒径大小、壳厚、表面形貌及结构的聚硫橡胶微胶囊,考察了乳化剂种类和用量、芯壁... 详细信息

以液体聚硫橡胶(LPR)为芯材、聚苯乙烯(PS)为囊壁,采用溶剂蒸发法制备了LPR@PS微胶囊。通过对制约微球热力学稳态因素与动力学因素的调整制备了具有不同粒径大小、壳厚、表面形貌及结构的聚硫橡胶微胶囊,考察了乳化剂种类和用量、芯壁质量比、搅拌速率、油水体积比以及温度与溶剂对液体聚硫橡胶包覆效果的影响。采用红外光谱、光学显微镜、扫描电镜等手段对微胶囊的结构和形貌进行了表征,通过硫醇基含量分析方法测定了微胶囊中液体聚硫橡胶的相对含量。实验结果表明,以1%的十二烷基硫酸钠(SDS)为乳化剂,芯壁质量比为4:10,在20℃条件下以500 r/min的速率搅拌18 h后可获得表面光滑、颗粒均匀、包覆膜完整的理想形貌的微胶囊,平均粒径为35.82μm。该条件制备的聚硫橡胶微胶囊中液体聚硫橡胶含量为28.44%,聚硫橡胶的包覆率为88.73%,聚硫橡胶密度下降19.86%。为新一代微胶囊基聚硫橡胶密封材料的研发与工业应用提供了新思路与技术支持。

关键词：聚硫橡胶聚苯乙烯微胶囊溶剂蒸发法表面形貌