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Inhibition of Tumor Growth in Mice by Endostatin Derived from Abdominal Transplanted Encapsulated cells

Acta Biochimica et Biophysica Sinica 2007年第4期39卷 278-284页

作者： huaining teng~(1.3) ying zhang~2 wei wang~2 xiaojun ma~2* jian fei~1* 1 laboratory of molecular cell biology,institute of biochemistry and cell biology,model organism research center,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china 2 laboratory of Biomedical material Engineering,Dalian institute of Chemical Physics,chinese academy of sciences,Dolian 116023,china 3 Department of Urology,Changzheng Hospital,Second Military Medical University,shanghai 200003,china laboratory of molecular cell biology Institute of Biochemistry and Cell Biology Model Organism Research Center Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031 China Department of Urology Changzheng Hospital Second Military Medical UniversityShanghai 200003 China laboratory of Biomedical material Engineering Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023 China

Endostatin,a C-terminal fragment of collagen 18a,inhibits the growth of established tumorsand metastases in vivo by inhibiting ***,the purification procedures required for large-scale production and the attendant cost of these processes,together with the low effectiveness in clinicaltests,suggest that alternative delivery methods might be required for efficient therapeutic use of *** the present study,we transfected chinese hamster ovary(CHO)cells with a human endostatin geneexpression vector and encapsulated the CHO cells in alginate-poly-L-lysine *** release ofbiologically active endostatin was confirmed using the chicken chorioallantoic membrane *** encap-sulated endostatin-expressing CHO cells can inhibit the growth of primary tumors in a subcutaneous B 16tumor model when injected into the abdominal cavity of *** results widen the clinical applicationof the microencapsulated cell endostatin delivery system in cancer treatment.

关键词： microencapsulation endostatin CHO tumor gene therapy

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Enhancement of germ cell apoptosis induced by ethanol in transgenic mice overexpressing Fas Ligand

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cell research 2003年第5期13卷 361-367页

作者： JIA HUA HU, JIE jianG, ying HUA ma, NA YANG, maO HU zhang, MIN WU, jian fei, LI HE GUO 1 laboratory of molecular cell biology, institute of biochemistry and cell biology, shanghai institutes for biological sciences, chinese academy of sciences, shanghai 200031, china 2 College of life science, Zhejiang University, Hangzhou 310027, china 3 shanghai research center for Biomodel organism, shanghai 201203, china laboratory of molecular cell biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China College of life science Zhejiang University Hangzhou China Department of Neurology Beth Israel Deaconess Medical Center and Harvard Medical School Boston USA Department of Chemistry Auburn University Auburn USA shanghai research center for Biomodel organism Shanghai China

It was suggested that chronic ethanol exposure could result in testicular germ cell apoptosis, but the mechanism is still unclear. In the present study, we use a model of transgenic mice ubiquitously overexpressing human FasL to investigate whether Fas ligand plays a role in ethanol-induced testicular germ cell apoptosis. Both wild-type (WT) mice and transgenic (TG) mice were treated with acute ethanol (20％ v/v) by introperitoneal injection for five times. After ethanol injection, WT mice displayed up-regulation of Fas ligand in the testes, which was shown by FITC-conjugated flow cytometry and western blotting. Moreover, TG mice exhibited significantly more apoptotic germ cells than WT mice did after ethanol injection, which was demonstrated by DNA fragmentation, PI staining flow cytometry and TUNEL staining. In addition, histopathological examination revealed that degenerative changes of epithelial component of the tubules occurred in FasL overexpressing transgenic mice while testicular morphology was

关键词： Fas ligand ethanol apoptosis testes transgenic mouse.

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Plant regeneration in the new era:from molecular mechanisms to biotechnology applications

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Science china(Life sciences) 2024年第7期67卷 1338-1367页

作者： Chunli Chen Yuxin Hu Momoko Ikeuchi Yuling Jiao Kalika Prasad ying Hua Su Jun Xiao Lin Xu weibing Yang Zhong Zhao Wenkun Zhou Yun Zhou jian Gao Jia-wei wang National Key laboratory for Germplasm Innovation&Utilization of Horticultural Crops Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China College of Life Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key laboratory of Plant molecular Physiology Institute of BotanyChinese Academy of Sciences(CAS)China National Botanical GardenBeijing 100093China Division of biological sciences Graduate School of Science and TechnologyNara Institute of Science and TechnologyNara 630-0192Japan State Key laboratory of Protein and Plant Gene research School of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua center for Life sciences Center for Quantitative BiologyAcademy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Indian institute of Science Education and research Pune 411008IndiaThiruvananthapuram 695551India State Key laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai’an 271018China Sino-German Joint research center on Agricultural biology Shandong Agricultural UniversityTai’an 271018China Key laboratory of Plant cell and Chromosome Engineering Institute of Genetics and Developmental Biology(IGDB)CASBeijing 100101China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) IGDBCASBeijing 100101China National Key laboratory of Plant molecular Genetics CEMPSInstitute of Plant Physiology and Ecology(SIPPE)CASShanghai 200032China CEPAMS SIPPECASShanghai 200032China Hefei National laboratory for Physical sciences at the Microscale CEMPSSchool of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China State Key laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China Department of Botany and Plant Pathology and center for Plant biology Purdue UniversityWest Lafayette 47907USA School of Life Science and Technology Shang

Plants or tissues can be regenerated through various *** animal regeneration,cell totipotency and pluripotency are the molecular basis of plant *** systematic studies on Arabidopsis thaliana gradually unravel the fundamental mechanisms and principles underlying plant ***,plant hormones,cell division,epigenetic remodeling,and transcription factors play crucial roles in reprogramming somatic cells and reestablishing meristematic *** research on basal non-vascular plants and monocot crops has revealed that plant regeneration differs among species,with various plant species using distinct mechanisms and displaying significant differences in regenerative *** multi-omics studies at the single-cell level,tracking plant regeneration processes in real-time,and deciphering the natural variation in regenerative capacity will ultimately help understand the essence of plant regeneration,improve crop regeneration efficiency,and contribute to future crop design.

关键词： apical meristem model species regeneration phytohormone plant cell reprogramming somatic embryogenesis

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Reduced clinical severity during 2022 shanghai Spring epidemic of SARS-CoV-2 omicron BA.2 variant infection——an integrated account of virus pathogenicity and vaccination effectiveness

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National Science Review 2024年第4期11卷 24-27页

作者： Xingyue Wu Yao Chen Kangli Cao Yao Shen Xueling Wu Yilin Yang Zhongshu Kuang Qingrun Li Zhenzhen Lu Yichen Jia Mian Shao Guorong Gu Xiangwei wang Ye Yao ying wang Shaodie Chen Zhigao Yu wei wei Longfei Ding Lulu Lan Tianwen Gu Xiangyu Long jian Sun Lingyu Xing Jiayuan Shen Yi Han Yue Luo Sucheng Mu Mengna Lin Xiaoyan zhang Rong Zeng jianqing Xu Guoping Zhao Lihong Huang Zhenju Song Department of Emergency Medicine Clinical Center for Bio-Therapy Department of Biostatistics and Department of UrologyShanghai Key Laboratory of Lung Inflammation and Injury Zhongshan Hospital Fudan University Department of Respiratory and Critical Care Medicine Shanghai Pudong Hospital Fudan University Department of Pulmonology Renji Hospital Shanghai Jiao Tong University School of Medicine Key laboratory of Systems biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences shanghai Public Health Clinical center Fudan University Department of Biostatistics School of Public Health Key Laboratory of Public Health Safety of Ministry of Education and Shanghai Institute of Infectious Disease and Biosecurity School of Public Health Fudan University shanghai institute of Immunology Department of Immunology and Microbiology Shanghai Institute of Virology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationSchool of Medicine Shanghai Jiao Tong University State Key laboratory of Genetic Engineering Fudan Microbiome CenterSchool of Life Sciences Fudan University Bio-Med Big Data center Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

The emergence of SARS-Co V-2 variant of concern omicron BA.2 led to high infection incidence rates as well as reduced severity of COVID-19 during the shanghai Spring epidemic of 2022 [1]. We assessed the role of viral pathogenicity and the effectiveness of inactivated vaccines in a retrospective observational study including 10 258 confirmed COVID-19cases identified between April and June of 2022, from four COVID-19 designated hospitals located in two areas of shanghai, namely the West Bund and the East Bund, where the populations’ demographic characteristics varied significantly (Table S1, Fig. S1).

关键词： REPLICATION

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Protective Effect of Salidroside on Mitochondrial Disturbances via Reducing Mitophagy and Preserving Mitochondrial Morphology in OGD-induced Neuronal Injury

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Current Medical Science 2021年第5期41卷 936-943页

作者： Cai-ying HU Qian-ying zhang Jie-hui CHEN Bin WEN wei-jian HANG Kai XU Juan CHEN Ben-hong HE Department of Cardiology Wuhan Red Cross HospitalWuhan 430015China Department of biochemistry and molecular biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Clinical laboratory Affiliated Wuhan Mental Health CenterTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Division of Cardiology Department of Internal Medicineand Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological DisordersTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Cardiovascular Medicine Lichucm People's Hospital Lichuan 445400China

Salidroside is the active ingredient extracted from Rhodiola rosea,and has been reported to show protective effects in cerebral ischemia,but the exact mechanisms of neuronal protective effects are still *** this study,the protective effects of salidroside(1 jimol/L)in ameliorating neuronal injuries induced by oxygen-glucose deprivation(OGD),which is a classical model of cerebral ischemia,were *** results showed that after 8 h of OGD,the mouse hippocampal neuronal cell line HT22 cells showed increased cell death,accompanied with mitochondrial fragmentation and augmented ***,the cell viability of HT22 cells showed significant restoration after salidroside *** morphology and mitochondrial function were effectively preserved by salidroside *** protective effects of salidroside were further related to the prevention of mitochondrial *** results showed that mTOR could be recruited to the mitochondria after salidroside treatment,which might be responsible for inhibiting excessive mitophagy caused by ***,salidroside was shown to play a protective role in reducing neuronal death under OGD by safeguarding mitochondrial function,which may provide evidence for further translational studies of salidroside in ischemic diseases.

关键词： salidroside mitochondria quality control oxygen-glucose deprivation mTOR

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Producing Designer Oils in Industrial Microalgae by Rational Modulation of Co-evolving Type-2 Diacylglycerol Acyltransferases

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molecular Plant 2017年第12期10卷 1523-1539页

作者： Yi Xin Yandu Lu Yi-ying Lee Li wei Jing Jia Qintao wang Dongmei wang Fali Bai Hanhua Hu Qiang Hu Jin Liu Yantao Li jian Xu Single-cell center CAS Key Laboratory of Biofuels and Shandong Laboratory of Energy Genetics Qingdao Institute of BioEnergy and Bioprocess TechnologyChinese Academy of Sciences Qingdao Shandong 266101 China institute of marine and Environmental Technology University of Maryland Center for Environmental Science and University of Maryland Baltimore CountyBaltimore MD 21202 USA institute for Food and Bioresource Engineering and Department of Energy and Resource Engineering College of Engineering Peking University Beijing 100871China center for Microalgal Biotechnology and Biofuels Institute of Hydrobiology Chinese Academy of Sciences Wuhan Hubei 430072 China Diatom biology Group Institute of Hydrobiology Chinese Academy of Sciences Wuhan Hubei 430072 China Core laboratory Qingdao Institute of BioEnergy and Bioprocess Technology Chinese Academy of Sciences Qingdao Shandong 266101 China University of chinese academy of sciences Beijing 100049 China These authors contributed equally to this article.

Microalgal oils, depending on their degree of unsaturation, can be utilized as either nutritional supplements or fuels; thus, a feedstock with genetically designed and tunable degree of unsaturation is desirable to maximize process efficiency and product versatility. Systematic profiling of ex vivo （in yeast）, in vitro, and in vivo activities of type-2 diacylglycerol acyltransferases in Nannochloropsis oceanica （NoDGAT2s or NoDGTTs）, via reverse genetics, revealed that NoDGAT2A prefers saturated fatty acids （SFAs）, NoDGAT2D prefers monounsaturated fatty acids （MUFAs）, and NoDGAT2C exhibits the strongest activity toward polyunsaturated fatty acids （PUFAs）. As NoDGAT2A, 2C, and 2D originated from the green alga, red alga, and eukaryotic host ancestral participants of secondary endosymbiosis, respectively, a mecha- nistic model of oleaginousness was unveiled, in which the indigenous and adopted NoDGAT2s formulated functional complementarity and specific transcript abundance ratio that underlie a rigid SFA：MUFA：PUFA hierarchy in triacylglycerol （TAG）. By rationally modulating the ratio of NoDGAT2A＇：2C^D transcripts, a bank of N. oceanica strains optimized for nutritional supplement or fuel production with a wide range of degree of unsaturation were created, in which proportion of SFAs, MUFAs, and PUFAs in TAG varied by 1.3-, 3.7-, and 11.2-fold, respectively. This established a novel strategy to simultaneously improve productivity and quality of oils from industrial microalgae.

关键词： biofuels degree of unsaturation genetic engineering diacylglycerol acyltransferase Nannochloropsis

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Precision Medicine:What Challenges Are We Facing?

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Genomics, Proteomics & Bioinformatics 2016年第5期14卷 253-261页

作者： Yu Xue Eric-Wubbo Lameijer Kai Ye Kunlin zhang Suhua Chang Xiaoyue wang jianmin Wu Ge Gao Fangqing Zhao jian Li Chunsheng Han Shuhua Xu Jingfa Xiao Xuerui Yang Xiaomin ying Xuegong zhang wei-Hua Chen Yun Liu zhang zhang Kun Huang Jun Yu MOE Key Lahoratory of molecular Biophysics College of Life Science and Technology and the Collaborative Innovation Center for Brain ScienceHuazhong University of Science and TechnologyWuhan 430074China School of Electronic and Information Engineering.Xi'an Jiaotong University.Xi'an 710049 China CAS Key laboratory of Mental Health Institute of PsychologyChinese Academy of SciencesBeijing 100101China State Key laboratory of'Medical molecular biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100005China MOE Beijing Key Laboratory of Carcinogenesis and Translatiooal ResearchCenter for Cancer BioinformaticsPeking University Cancer Hospital&InstituteBeijing 100142China center for Bioinformatics State Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking UniversityBeijing 100871China Beijing institutes of Life Science.chinese academy of sciences Beijing 100101China MOE Key Lahoratory of Developnlental Genes and Human Disease Institute of Life SciencesSoutheast UniversityNanjing 210096China State Key laboratory of Stem cell and Reproductive biology Institute of Zoology Chinese Academy of SciencesBeijing 100101China max Planck Independent research Group on Population Genomics CAS-MPG Partner Institute for Computational Biology(PICB)Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China CAS Ker laboratory of Genome sciences and Information Chinese Academy of Sciences.Beijing 100101China MOE Key laboratory of Bioinformatics School of Life sciences Center for Synthetic and Systems BiologyTsinghua UniversityBeijing 100084China Computational Omics Lahoratory Center of Computational BiologyBeijing Institute of Basic Medical SciencesBeijing 100850China Bioinformatics Division TNLIST and MOE Key Laboratory for Bioinformatics Department of AutomationTsinghua UniversityBeijing 100084China Department of Bioinformatics and Systems biology College of LifeScience and Technol

Following the publication of the US National research Council （N RC） report ＂ Toward PrecMon Medicine.＂ Building a Knowledge Network for Biomedical research and a New Taxonomy of Diseases＂ in 2011 [1], several n... 详细信息

关键词： PMI Precision Medicine data We

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DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines

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Protein & cell 2023年第7期14卷 534-539页

作者： Ya-Hui Zhao wei jiang Hai Gao Guo-Zheng Pang Yu-Shuang Wui Yuan-Xian wang Meng-Yao Sheng Jia-ying Xie Wan-Ling Wu Zhi-jian Ji Ya-Rui Du Lei zhang Xiao-Qin wang Colum P.Walsh Hai jiang Guo-Liang Xu Dan Zhou shanghai Key laboratory of Medical Epigenetics Laboratory of Cancer EpigeneticsInstitutes of Biomedical SciencesMedical College of Fudan UniversityChinese Academy of Medical Sciences(RU069)Shanghai 200032China State Key laboratory of molecular biology Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai200031China center for Medical research and Innovation Shanghai Pudong HospitalFudan UniversityShanghai 201399China Department of Hematology Huashan Hospital of Fudan UniversityShanghai 200040China Department of Chemistry and institutes of Biomedical Science Shanghai Medical CollegeFudan UniversityShanghai 200032China Genomic Medicine research Group Biomedical SciencesUlster UniversityColeraine BT521SAUnited Kingdom Centre for research and Development Region Gavleborg/Uppsala UniversityGavle SE-80187Sweden

Dear Editor,Cytidine analogs,such as decitabine(DAC)and cytarabine(ara-C),have been widely used in the clinical treatment for several cancer types,including myelodysplastic syndrome and acute myeloid leukemia(AML;Appelbaum et al.1999;Saba 2007).However,drug resistance causing treatment failure and disease relapse is an unresolved problem to *** cancer cells rely on the salvage enzymes cytidine deaminase(CDA)and dCMP deaminase(DCTD)to inactivate these cytidine derivative drugs by deamination(Jamieson et al.1987;Ebrahem et al.2012).It is imperative to develop new categories of chemotherapeutic nucleosides to overcome the drug resistance caused by such increased cellular deamination activity.

关键词： cancer drugs

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Antagonism of estrogen-mediated cell proliferation by raloxifene in prevention of ageing-related prostatic hyperplasia

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Asian Journal of Andrology 2010年第5期12卷 735-743页

作者： Rui Yang Yu-Xia ma Lin-Feng Chen ying Zhou Zhan-Po Yang Yan Zhu Xiao-Ling Du jian-Dang Shi Hong-Shun ma Ju zhang Bioactive materials Key Lab of Ministry of Education Department of Biochemistry and Molecular Biology College of Life Sciences Nankai University Tianjin 300071 China Dana Farber Cancer institute Harvard Medical School Boston MA 02445 USA Department of Urology Tianjin First Central Hospital Tianjin 300192 China molecular Cardiology research institute Tufts Medical Center Tufts University School of Medicine Boston MA 02111 USA

Estrogen has important roles in the initiation and development of benign prostatic hyperplasia （BPH）. Regulators of the estrogen receptor （ER） are tissue- and cell-specific. We evaluated the effect of estrogen antagonist, raloxifene （Ral）, on the prevention and treatment of BPH by investigating its effect on the proliferation of two different prostate cell lines： a stromal cell line, WPMY-1, and a benign prostatic hyperplasia epithelial cell line, BPH-1. We additionally evaluated its effect on prostatic hyperplasia induced by estrogen and androgen in a rat model. The effect of Ral on the prevention of prostatic hyperplasia was analyzed by haematoxylin and eosin staining and quantitative immunohistochemistry （IHC） for proliferating cell nuclear antigen and α-smooth muscle actin. In vitro and in vivo, tamoxifen （Tam）, another anti-estrogen drug, and finasteride （Fin）, a drug for the clinical treatment of BPH, served as efficacy controls. The in vitro data showed that neither Ral nor Tam alone affected the proliferation of WPMY-1 and BPH-1, but both antagonized the effect of oestradiol in promoting the proliferation of the two cells. Results from the IHC staining of the rat prostates indicated that, similar to Tam and Fin, Ral inhibited the proliferation of stromal cells in vivo. Interestingly, in contrast to Tam, both Ral and Fin inhibited the proliferation of epithelial cells. Furthemore, Ral treatment much strongly decreased the number of prostatic acini and the surrounding layers of smooth muscle cells than Fin （P 〈 0.05）. Our data showed for the first time that Ral may have a role in the response of the rat prostate to selective ER modulators.

关键词： estrogen prostatic hyperplasia raloxifene rats

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Induction of a 55 kDa acetylcholinesterase protein during apoptosis and its negative regulation by the Akt pathway

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分子细胞生物学报:英文版 2011年第4期3卷 250-259页

作者： Jing Xie Hua jiang Yi-Han Wan Ai-ying Du Kai-Jie Guo Te Liu wei-Yuan Ye Xin Niu Jun Wu Xiao-Qin Dong Xue-Jun zhang laboratory of molecular cell biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of Sciences320 YueYang RoadShanghai 200031China International Peace maternity and Child Care center Medical School of Jiao-Tong UniversityShanghai 200030China

Acetylcholinesterase(AChE)is emerging as an important contributor to apoptosis in various cell ***,overexpression of AChE does not initiate apoptosis,and cells which express AChE at basal levels grow normally,suggesting that AChE may function differently between normal and apoptotic *** this study,we determined that an AChE-derived protein(∼55 kDa)positively correlated with cellular apoptotic *** 55 kDa AChE protein was not a result of a novel splice variant of the AChE primary ***,it was determined to be a cleaved fragment of the full-length 68 kDa AChE protein that could not be inhibited by cycloheximide(CHX)but could be suppressed by caspase inhibitors in apoptotic PC-12 ***,activation of the Akt cascade abolished the 55 kDa protein,and both AChE protein forms(68 and 55 kDa)accumulated in the nucleus during *** a mouse model for ischemia/reperfusion(I/R)-induced acute renal failure,the 55 kDa AChE protein was detected in the impaired organs but not in the normal ones,and its levels correlated with the genotype of the *** summary,a 55 kDa AChE protein resulting from the cleavage of 68 kDa AChE is induced during apoptosis,and it is negatively regulated by the Akt *** study suggests that an alternative form of AChE may play a role in apoptosis.

关键词： acetylcholinesterase apoptosis 55 kDa AChE caspase PI3K/Akt pathway

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