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Duodenal-jejunal bypass improves hypothalamic oxidative stress and inflammation in diabetic rats via glucagon-like peptide 1-mediated Nrf2/HO-1 signaling

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World Journal of Diabetes 2024年第2期15卷 287-304页

作者： huai-jie wang Li-Bin Zhang Si-Peng Sun Qing-Tao Yan Zhi-Qin Gao Fang-Ming Fu Mei-Hua Qu Translational Medical Center Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Endocrinology Weifang Second People's HospitalWeifang 261041Shandong ProvinceChina Department of Pediatric Surgery Weifang People’s HospitalWeifang 261041Shandong ProvinceChina School of Bioscience and Technology Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Endocrinology Jinan Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)is often accompanied by impaired glucose utilization in the brain,leading to oxidative stress,neuronal cell injury and *** studies have shown that duodenal jejunal bypass(DJB)surgery significantly improves brain glucose metabolism in T2DM rats,the role and the metabolism of DJB in improving brain oxidative stress and inflammation condition in T2DM rats remain *** To investigate the role and metabolism of DJB in improving hypothalamic oxidative stress and inflammation condition in T2DM *** A T2DM rat model was induced via a high-glucose and high-fat diet,combined with a low-dose streptozotocin injection.T2DM rats were divided into DJB operation and Sham operation *** surgical intervention was carried out on T2DM *** differential expression of hypothalamic proteins was analyzed using quantitative proteomics *** related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of T2DM rats were analyzed by flow cytometry,quantitative real-time PCR,Western blotting,and *** Quantitative proteomics analysis showed significant differences in proteins related to oxidative stress,inflammation,and neuronal injury in the hypothalamus of rats with T2DM-DJB after DJB surgery,compared to the T2DM-Sham groups of *** stress-related proteins(glucagon-like peptide 1 receptor,Nrf2,and HO-1)were significantly increased(P<0.05)in the hypothalamus of rats with T2DM after DJB *** surgery significantly reduced(P<0.05)hypothalamic inflammation in T2DM rats by inhibiting the activation of NF-κB and decreasing the expression of interleukin(IL)-1βand *** surgery significantly reduced(P<0.05)the expression of factors related to neuronal injury(glial fibrillary acidic protein and Caspase-3)in the hypothalamus of T2DM rats and upregulated(P<0.05)the expression of neuroprotective factors(C-fos,Ki67,Bcl-2,and BDNF),thereby reducing hypot

关键词： Duodenal jejunal bypass surgery Type 2 diabetes mellitus Neuron apoptosis Inflammatory Oxidative stress Hypothalamic injury

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METTL3 regulates glucose transporter expression in placenta exposed to hyperglycemia through the mTOR signaling pathway

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Chinese Medical Journal 2024年第13期137卷 1563-1575页

作者： jie Ning Jing huai Shuxian wang jie Yan Rina Su Muqiu Zhang Mengtong Liu Huixia Yang Department of Obstetrics and Gynaecology Peking University First HospitalBeijing 100034China Beijing Key Laboratory of Maternal Foetal Medicine of Gestational Diabetes Mellitus Beijing 100034China Peking University Beijing 100034China

Background:Alterations in the placental expression of glucose transporters(GLUTs),the crucial maternal-fetal nutrient transporters,have been found in women with hyperglycemia in pregnancy(HIP).However,there is still uncertainty about the underlying effect of the high-glucose environment on placental GLUTs expression in ***:We quantitatively evaluated the activity of mammalian target of rapamycin(mTOR)and expression of GLUTs(GLUT1,GLUT3,and GLUT4)in the placenta of women with normal pregnancies(CTRL,n=12)and pregnant women complicated with poorly controlled type 2 diabetes mellitus(T2DM,n=12)by *** addition,BeWo cells were treated with different glucose concentrations to verify the regulation of ***,changes in the expression of GLUTs following the activation or suppression of the mTOR pathway were also assessed using MHY1485/rapamycin(RAPA)treatment or small interfering RNA(siRNA)-mediated silencing ***,we further explored the alteration and potential upstream regulatory role of methyltransferase-like 3(METTL3)when exposed to ***:mTOR,phosphorylated mTOR(p-mTOR),and GLUT1 protein levels were upregulated in the placenta of women with T2DM compared with those *** BeWo cells,mTOR activity increased with increasing glucose concentration,and the expression of GLUT1,GLUT3,and GLUT4 as well as GLUT1 cell membrane translocation were upregulated by hyperglycemia to varying *** the drug-mediated and genetic depletion of mTOR signaling in BeWo cells suppressed GLUTs expression,whereas MHY1485-induced mTOR activation upregulated GLUTs ***,high glucose levels upregulated METTL3 expression and nuclear translocation,and decreasing METTL3 levels suppressed GLUTs expression and mTOR activity and vice ***,in METTL3 knockdown BeWo cells,the inhibitory effect on GLUTs expression was eliminated by activating the mTOR signaling pathway using ***:High-g

关键词： Glucose transporters Hyperglycemia Type 2 diabetes mellitus Pregnancy Mammalian target of rapamycin Methyltransferase-like 3

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Seismicity changes and numerical simulation of coseismic deformation following the 2022 M_(s)6.8 Luding earthquake in Sichuan,China

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Science China Earth Sciences 2024年第8期67卷 2507-2521页

作者： Qiu MENG Zitao wang huai ZHANG Key Laboratory of Computational Geodynamics of Chinese Academy of Sciences College of Earth and Planetary SciencesUniversity of Chinese Academy of SciencesBeijing 100049China Institute of Earthquake Forecasting China Earthquake AdministrationBeijing 100036China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China Beijing Yanshan Earth Critical Zone National Research Station Beijing 101408China

The Xianshuihe fault is a major tectonic boundary between the Sichuan-Yunnan rhombic and Bayanhar blocks in Southwest *** an average left-lateral strike-slip movement of 10–15 mm/yr,it is a fast-moving strike-slip continental *** September 5,2022,the Ms6.8 Luding earthquake occurred along the Moxi segment of the Xianshuihe fault,reaching a maximum intensity of IX and resulting in a significant number of casualties and severe property *** earthquake broke the long-standing seismic quiescence of the Xianshuihe fault,which lasted for more than 40 years,and was followed by a significant number of *** outstanding question is how the behavior of the Xianshuihe fault and major earthquakes changed following this *** this study,we examined the changes in regional seismicity following the Luding earthquake and identified the potential for future strong earthquakes along the Xianshuihe *** used a finite element numerical method to simulate the environment of the seismogenic fault and its adjacent *** addition,we used the coseismic slip model of the Luding earthquake with the split-node method to calculate how the stress and strain fields in the surrounding area were affected by the2022 *** stress changes were resolved in the main faults,and the seismicity of adjacent faults was analyzed in conjunction with the observed seismic *** results indicate that regional tectonic movement primarily occurred to the southeast along the Moxi *** stress field is approximately north-south in tension and east-west in *** in the stress field in the epicentral region of the Luding earthquake exceeded 1 *** maximum displacement of the coseismic deformation field was concentrated between Moxi town and Tuanjie village,and the Coulomb stress of the fault zone in this region experienced the largest ***,the b-value of the Gutenberg-Richter magnitude-frequency relationship at the epicenter a

关键词： Luding earthquake Seismicity Coulomb failure stress change Finite element numerical simulation

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A three-dimensional co-continuous network structure polymer electrolyte with efficient ion transport channels enabling ultralong-life all solid-state lithium metal batteries

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Journal of Energy Chemistry 2024年第7期94卷 635-645页

作者： Meng wang Hu Zhang Yewen Li Ruiping Liu huai Yang School of Chemical&Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China Beijing Advanced Innovation Center for Materials Genome Engineering&School of Materials Science and Engineering Peking UniversityBeijing 100871China

Solid polymer electrolytes(SPEs)have emerged as one of the most promising candidates for the construction of solid-state lithium batteries due to their excellent flexibility,scalability,and interface compatibility with ***,a novel all-solid polymer electrolyte(PPLCE)was fabricated by the copolymer network of liquid crystalline monomers and poly(ethylene glycol)dimethacrylate(PEGDMA)acts as a structural frame,combined with poly(ethylene glycol)diglycidyl ether short chain interspersed serving as mobile ion transport *** preparaed PPLCEs exhibit excellent mechanical property and out-standing electrochemical performances,which is attributed to their unique three-dimensional cocontinuous structure,characterized by a cross-linked semi-interpenetrating network and an ionic liquid phase,resulting in a distinctive nanostructure with short-range order and long-range ***,the addition of PEGDMA is proved to be critical to the comprehensive performance of the PPLCEs,which effectively modulates the microscopic morphology of polymer networks and improves the mechanical properties as well as cycling stability of the solid *** used in a lithiumion symmetrical battery configuration,the 6 wt%-PPLCE exhibites super stability,sustaining operation for over 2000 h at 30 C,with minimal and consistent overpotential of 50 *** resulting Li|PPLCE|LFP solid-state battery demonstrates high discharge specific capacities of 160.9 and 120.1 mA h g^(-1)at current densities of 0.2 and 1 C,*** after more than 300 cycles at a current density of 0.2 C,it retaines an impressive 73.5%***,it displayes stable cycling for over 180 cycles at a high current density of *** super cycle stability may promote the application for ultralong-life all solid-state lithium metal batteries.

关键词： Solid-state electrolyte Lithium-metal batteries Liquid crystalline polymer Copolymer 3D co-continuous structure Long cycle stability

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Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping

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Journal of Pharmaceutical Analysis 2024年第3期14卷 335-347页

作者： Ding-Jun Hao Yue Qin Shi-jie Zhou Bu-huai Dong Jun-Song Yang Peng Zou Li-Ping wang Yuan-Ting Zhao Department of Spine Surgery Honghui HospitalXi'an Jiaotong UniversityXi'an710054China Department of Anesthesiology Honghui HospitalXi'an Jiaotong UniversityXi'an710054China Department of Cardiovascular Medicine Honghui HospitalXi'an Jiaotong UniversityXi'an710054China State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China HospitalSichuan UniversityChengdu610041China

Hyaluronan and proteoglycan link protein 1(Hapln1)supports active cardiomyogenesis in zebrafish hearts,but its regulation in mammal cardiomyocytes is *** study aimed to explore the potential regulation of Hapln1 in the dedifferentiation and proliferation of cardiomyocytes and its therapeutic value in myocardial infarction with human induced pluripotent stem cell(hiPSC)-derived cardiomyocytes(CMs)and an adult mouse model of myocardial ***-CMs and adult mice with myocardial infarction were used as in vitro and in vivo models,*** single-cell RNA sequencing data were retrieved for bioinformatic *** results showed that recombinant human Hapln1(rhHapln1)promotes the proliferation of hiPSC-CMs in a dose-dependent *** a physical binding protein of Hapln1,versican interacted with Nodal growth differentiation factor(NODAL)and growth differentiation factor 11(GDF11).GDF11,but not NODAL,was expressed by ***11 expression was unaffected by rhHapln1 ***,this molecule was required for rhHapln1-mediated activation of the transforming growth factor(TGF)-β/Drosophila mothers against decapentaplegic protein(SMAD)2/3 signaling in hiPSC-CMs,which stimulates cell dedifferentiation and *** mouse Hapln1(rmHapln1)could induce cardiac regeneration in the adult mouse model of myocardial *** addition,rmHapln1 induced hiPSC-CM *** conclusion,Hapln1 can stimulate the dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping and subsequent activation of the TGF-β/SMAD2/3 signaling ***1 might be an effective hiPSC-CM dedifferentiation and proliferation agent and a potential reagent for repairing damaged hearts.

关键词： Hapln1 Versican GDF11 iPSC-CMs Cardiomyocyte proliferation

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Mechanical properties and thermal deformation behavior of low-cost titanium matrix composites prepared by a structure-optimized Y_(2)O_(3) crucible

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Journal of Iron and Steel Research International 2024年第3期31卷 738-751页

作者： Qian Dang Gang Huang Ye wang Chi Zhang Guo-huai Liu Zhao-dong wang The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150004HeilongjiangChina School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870LiaoningChina

A porous yttrium oxide crucible with both thermal shock resistance and erosion resistance was developed by structural *** structure-optimized yttrium oxide crucible was proved to be suitable for melting highly reactive titanium ***-cost(TiB+Y2O_(3))-reinforced titanium matrix composites were prepared by vacuum induction melting using the prepared *** thermal deformation behavior and microstructure evolution of(TiB+Y2O_(3))-reinforced tita-nium matrix composites were investigated at deformation temperatures of 900-1100℃with strain rates of 0.001-1 *** results showed that the prepared yttrium oxide crucible had both thermal shock and erosion resistance,the low-cost titanium matrix composites could be prepared by the developed yttrium oxide crucibles which were homogeneous in composition and highly sensitive to strain rate and deformation temperature,and the peak and theological stresses decreased with increasing deformation temperature or decreasing strain *** addition,the average thermal deformation activation energy of the composites was calculated to be 574.6 kJ/mol by establishing the Arrhenius constitutive equation in consideration of the strain variables,and the fitting goodness between the predicted stress value and the measured value was 97.624%.The calculated analysis of the hot processing map showed that the best stable thermal deformation zone was located in the deformation temperature range of 1000-1100℃and strain rate range of 0.001-0.01 s^(-1),where the peak dissipation coefficient wasη=71%.In this zone,the deformation of the reinforcement and matrix was harmonious,the reinforcement was less likely to fracture,dynamic recrystallization occurred more fully and the alloy exhibited near steady rheological characteristics.

关键词： Yttrium oxide crucible Titanium matrix composite Thermal deformation behavior Constitutive equation Hot processing map Microstructure evolution

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Extending the detection limit:innovations in infrared quantum dot photodetectors reaching up to 18μm

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Light(Science & Applications) 2024年第8期13卷 1445-1447页

作者： Chong Wu wang Qi jie wang Centre for OptoElectronics and Biophotonics School of Electrical and Electronic EngineeringNanyang Technological UniversitySingapore 639798Singapore Centre for Disruptive Photonic Technologies School of Physical and Mathematical SciencesNanyang Technological UniversitySingaporeSingapore

A regrowth method was used to synthesize large-sized colloidal quantum dots(CQDs).With the assistance of doping engineering,the synthesized CQD detectors demonstrate exceptional long-wavelength infrared detection performance,reaching up to 18μm,significantly extending the spectral response limit for CQD-based infrared *** detectors also achieve a reasonably high detectivity of 6.6×10^(8)Jones.

关键词： limit quantum sized

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Electrolytes additives for Zn metal anodes: regulation mechanism and current perspectives

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Rare Metals 2024年第9期43卷 4162-4197页

作者： Yu-Zhe Zhang huai-Sheng Ao Qi Dong Shao-jie Zhang Zhi-Guo Hou Na-Na wang Xue-Song Xie Jian Rong Zhong-Yu Li School of Environmental Science and Engineering Changzhou University School of Petrochemical Engineering Changzhou University Hefei National Laboratory for Physical Science at Microscale School of Chemistry and Materials Science University of Science and Technology of China Institute for Superconducting and Electronic Materials Australian Institute for Innovative Materials Innovation Campus University of Wollongong Department of Chemical and Materials Engineering University of Alberta

With distinct advantages such as high gravimetric and volumetric capacity(5855 mAh·cm-3and 820mAh·g-1), low redox potential(-0.762 V vs. standard hydrogen electrode（SHE）), high abundance, low toxicity and intrinsic safety of Zn metal anode, Zn-ion batteries have become a potential alternative to Li-ion ***, several challenges still need to be addressed prior to the practical applications of Zn-ion batteries, such as dendrite growth during Zn plating/stripping and interfacial side reactions on the Zn surface. Such issues can be addressed by introducing additives to regulate the components and structures of the electrolyte. In this review, we systematically discussed the core issues of metallic Zn anodes and comprehensively summarized a novel perspective of the regulation mechanism of inhibiting dendrite growth or interfacial side reactions in Zn anodes by introducing additives into aqueous ***, some discussions and prospects for aqueous Zn ion batteries（AZIBs） are presented for future research.

关键词： AZIBs Current perspectives Electrolyte additives Regulation mechanism Zn metal anode

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Cavitation research with computational fluid dynamics:From Euler-Euler to Euler-Lagrange approach

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Journal of Hydrodynamics 2024年第1期36卷 1-23页

作者： Bin Ji Zi-yang wang huai-yu Cheng Rickard E.Bensow State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan430072China Department of Mechanics and Maritime Sciences Chalmers University of TechnologyGothenburgSweden

Unsteady cavitating flow often contains vapor structures with a wide range of different length scales,from micro-bubbles to large cavities,which issues a big challenge to precisely investigate its evolution mechanism by computational fluid dynamics(CFD)*** present work reviews the development of simulation methods for cavitation,especially the emerging Euler-Lagrange ***,the progress of the numerical investigation of hot and vital issues is discussed,including cavitation inception,cloud cavitation inner structure and its formation mechanism,cavitation erosion,and cavitation *** is indicated that the Euler-Lagrange method can determine cavitation inception point *** cloud cavitation,the Euler-Lagrange method can reveal the source of microbubbles and their distribution law inside the shedding *** method also has advantages and great potential in assessing cloud cavitation-induced erosion and *** the ever-growing demands of cavitation simulation accuracy in basic research and engineering applications,how to improve the Euler-Lagrange method’s stability and applicability is still an open *** further promote the application of this advanced CFD simulation technology in cavitation research,some key issues are to be solved and feasible suggestions are put forward for further work.

关键词： numerical simulation Euler-Euler method Euler-Lagrange method bubble dynamicsgy,Gothenburg,Sweden

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Quaternion-Based Adaptive Trajectory Tracking Control of a Rotor-Missile with Unknown Parameters Identification

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Defence Technology（防务技术） 2024年第1期31卷 375-386页

作者： jie Zhao Zhongjiao Shi Yuchen wang Wei wang Beijing Institute of Technology Beijing 100081China

This paper investigates the adaptive trajectory tracking control problem and the unknown parameter identification problem of a class of rotor-missiles with parametric system ***,considering the uncertainty of structural and aerodynamic parameters,the six-degree-of-freedom(6Do F) nonlinear equations describing the position and attitude dynamics of the rotor-missile are established,respectively,in the inertial and body-fixed reference ***,a hierarchical adaptive trajectory tracking controller that can guarantee closed-loop stability is proposed according to the cascade characteristics of the 6Do F ***,a memory-augmented update rule of unknown parameters is proposed by integrating all historical data of the regression *** long as the finitely excited condition is satisfied,the precise identification of unknown parameters can be ***,the validity of the proposed trajectory tracking controller and the parameter identification method is proved through Lyapunov stability theory and numerical simulations.

关键词： Rotor-missile Adaptive control Parameter identification Quaternion control

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