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轮式动态模拟仪在高含水期原油不加热集输中的应用

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石油石化节能与计量 2024年第7期14卷 51-55页

作者：张晶姜怀洪小平刘杨张超黄凯大庆油田有限责任公司第四采油厂大庆油田有限责任公司设计院大庆油田有限责任公司钻探工程公司大庆油田有限责任公司第十采油厂

随着不断深入开发,油田集油管线内产液的流变性逐渐转变为高含水期“水包油”为主的流态,因而管道内的流动条件得以改善。通过前期开展的季节性停掺冷输试验证实,高含水期集输进站温度可以接近凝固点甚至低于凝固点。因此提出利用临界... 详细信息

随着不断深入开发,油田集油管线内产液的流变性逐渐转变为高含水期“水包油”为主的流态,因而管道内的流动条件得以改善。通过前期开展的季节性停掺冷输试验证实,高含水期集输进站温度可以接近凝固点甚至低于凝固点。因此提出利用临界粘壁温度作为采油井不加热集输边界条件,并利用轮式动态模拟分析仪测试单井临界粘壁温度,指导采油井平稳集输,应用后实现措施节气219.6×10^(4)m^(3),节电73.4×10^(4)kWh。

关键词：高含水期凝固点轮式动态模拟分析临界粘壁温度不加热集输

Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed glioblastoma: a multicenter, single-arm, phase Ⅱ trial

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Cancer Biology & Medicine 2024年第5期21卷 433-444页

作者： Shuzhen Lai Peijing Li Xiaohui Liu Guihong Liu Tieming Xie Xing Zhang Xiaoxuan Wang Jing Huang Yiqiang Tang Zhigang Liu Guoping Shen Chaoming Li Fangxiao Lu Lei Wang Fagui jiang Caixing Sun Yuanyuan Chen Ming Chen Department of Radiation Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Radiation Oncology Yuebei People’s Hospital Affiliated to the Medical College of Shantou UniversityShaoguan 512026China Chinese Academy of SciencesHangzhou 310022China Department of Radiation Oncology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 311403China Department of Radiation Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004China Chinese Academy of SciencesHangzhou 310022China State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.LtdNanjing 210000China Department of Radiation Oncology The Affiliated Huai’an First People’s Hospital of Nanjing Medical UniversityHuai’an 223399China Department of Radiation Oncology Jiangxi Cancer Hospital of Nanchang UniversityNanchang 330029China Department of Radiotherapy Dongguan Institute of Clinical Cancer ResearchDongguan Key Laboratory of Precision Diagnosis and Treatment for TumorsAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523059China The Cancer Center The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai 519000China Department of Radiation Oncology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Oncology Maoming People’s HospitalMaoming 525000China Department of Radiation Oncology Kecheng District People’s HospitalQuzhou 324003China Chinese Academy of SciencesHangzhou 310022China Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaSun Yat-sen University Cancer CenterGuangzhou 510060China United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University&Chinese Academy of Sciences Ion Medical Technology Co. LtdGuangzhou 510060China

Objective:Glioblastomas are highly vascularized malignant *** determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor,anlotinib,for a newly diagnosed ***:This multicenter,single-arm trial(NCT04119674)enrolled 33 treatment-naïve patients with histologically proven glioblastomas between March 2019 and November *** underwent treatment with the standard STUPP regimen[fractionated focal irradiation in daily fractions of 1.8-2 Gy given 5 d/w×6 w(total=54-60 Gy)]or radiotherapy plus continuous daily temozolomide(TMZ)(75 mg/m^(2)of body surface area/d,7 d/w from the first to the last day of radiotherapy),followed by 6 cycles of adjuvant TMZ(150-200 mg/m^(2)×5 d during each 28-d cycle)plus anlotinib(8 mg/d on d 1-14 of each 3-w cycle for 2 cycles during concomitant chemoradiotherapy,8 maximal cycles as adjuvant therapy,followed by maintenance at 8 mg/*** primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival(OS)and adverse events(AEs).Results:Thirty-three patients received the planned *** median PFS was 10.9 months(95%CI,9.9-18.7 months)and the 12-month PFS rate was 48.5%.The median OS was 17.4 months(95%CI,14.5-21.1 months)and the 12-month OS rate was 81.8%.The most common AEs included hypertriglyceridemia[58%(n=19)],hypoalbuminemia[46%(n=15)],and hypercholesterolemia[46%(n=15)]during concurrent chemoradiotherapy and leukopenia[73%(n=24)],hypertriglyceridemia[67%(n=22)],and neutropenia[52%(n=17)]during adjuvant *** patients discontinued treatment due to ***1(HR,5.6;95%CI,1.3-23.7;P=0.021)and RP1L1 alterations(HR,11.1;95%CI,2.2-57.2;P=0.004)were associated with a significantly shorter ***:Anlotinib plus the STUPP regimen has promising anti-tumor activity against glioblastoma and manageable ***1 and RP1L1 alterations might be novel predictive biomarkers of the response to anlotinib.

关键词： Glioblastoma anti-angiogenesis multi-kinase inhibitor anlotinib temozolomide progression-free survival

Molecular characterization of the ryanodine receptor from Adoxophyes orana and its response to lethal and sublethal doses of chlorantraniliprole

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Journal of Integrative Agriculture 2021年第6期20卷 1585-1595页

作者： SUN Li-na LIU Yan-di ZHANG huai-jiang YAN Wen-tao YUE Qiang QIU Gui-sheng Research Institute of Pomology Chinese Academy of Agricultural SciencesXingcheng 125100P.R.China

The insect ryanodine receptor(RyR)is a novel target of the anthranilic and phthalic insecticides,which have high activity against lepidopteran *** diamide insecticides have been used to control pests in orchards in *** enhance our understanding of the effects of diamides on RyRs,full-length cDNAs were isolated and characterized from the summer fruit tortrix moth,Adoxophyes orana,which is the most severe pest of stone and pome trees *** addition,the modulation of AoRyRmRNA expression by diamide insecticides was *** AoRyRmRNA obtained had an open reading frame(ORF)of 15402 bp nucleotides encoding 5113 amino acids,and shared high and low identity with its orthologs in other insects and mammals of 77–92 and 45–47%identity,*** alternative splice site with two exclusive exons was revealed in AoRyR(a/b).The usage of exon was more frequent in eggs and larvae than in pupae and *** real-time reverse transcription PCR(qRT-PCR)showed that AoRyRmRNA was expressed at all developmental stages,especially in eggs,male pupae and male *** expression levels of AoRyRmRNA in the whole body were up-regulated markedly after 3 rd instar larvae were treated with chlorantraniliprole at LC_(10),LC_(20)and LC_(50)*** results could provide the basis for further functional studies of Ao Ry R and for the development of new chemicals with selective activity against insects.

关键词： ryanodine receptor Adoxophyes orana chlorantraniliprole mRNA expression

Genome-wide identification and expression analysis of StPP2C gene family in response to multiple stresses in potato (Solanum tuberosum L.)

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Journal of Integrative Agriculture 2020年第6期19卷 1609-1624页

作者： WANG Yi-fan LIAO Yu-qiu WANG Ya-peng YANG jiang-wei ZHANG Ning SI huai-jun College of Life Science and Technology Gansu Agricultural UniversityLanzhou 730070P.R.China Gansu Provincial Key Laboratory of Aridland Crop Science Gansu Agricultural UniversityLanzhou 730070P.R.China College of Agronomy Gansu Agricultural UniversityLanzhou 730070P.R.China

The plant protein phosphatase 2Cs(PP2Cs)play an essential role in response to stress and abscisic acid(ABA)signaling ***,to date,no systemic characterization of the PP2Cs has yet bee n con ducted in potato(Solan um tuberosum L.).In the study,a comprehensive research was performed on genome-wide identification and expression analysis of StPP2C genes in potato.A total of 78 potato StPP2C genes were identified based on specific structure of PP2C domain,which were distributed across 11 out of 12 potato chromosomes and divided into 12(A-L)phylogenetic *** result from gene duplication an alysis showed that 14 StPP2Cs were in volved in gene tan dem duplication and 8 genes formed fragment duplicati on eve nts,which indicated that both tandem and fragment duplicati on contributed to the expa nsion of the gene family in ***-intron structural analysis showed that they had a wide range of exon *** of protei n con servative motif dem on strated that StPP2Cs contained more similar motif structures in the same phyloge netic *** c/s-elements in StPP2C gene promoter regions were mainly responded to light,phytohormone and abiotic *** of them exhibited tissue-specific expressi on patter ns,and some members could differe ntially express un der abiotic *** evidenee suggested that StPP2C genes may contribute to different functions in several physiological stress and environmental stress conditi *** study could provide new in sights to further in vestigate StPP2C functional characteristics responding to various stresses in potato.

关键词： protein phosphatase 2C expression pattern stress ABA potato

Effect of vibration frequency on primary phase and properties of grey cast iron fabricated by lost foam casting

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China Foundry 2020年第1期17卷 1-7页

作者： Bo-tao Xiao Zi-tian Fan Wen-ming jiang Jun-huai Xiang Xue-fang Yan jiangxi Key Laboratory of Surface Engineering Jiangxi Science and Technology Normal UniversityNanchang 330013China State Key Laboratory of Material Processing and Die&Mould Technology Huazhong University of Science&TechnologyWuhan 430074China

The properties of gray cast iron(GCI)are affected by density of matrix,size of flake graphite and primary *** this paper,the Y-type specimen of GCI was prepared by lost foam casting(LFC)with and without vibration,and the influence of vibration frequency on the density of matrix,size of primary phase,and properties of the GCI was *** results show that the length of the flake graphite and the size of the primary austenite in GCI firstly decrease and then increase with the increase of the vibration *** a vibration frequency of 35 Hz,the length of the flake graphite is the shortest,the primary austenite is the finest and the density of the matrix is the *** addition,the tensile strength,elongation and hardness of the GCI firstly increase and then decrease with the increase of the vibration frequency,due to the refinement of the primary phase and the increase of the matrix *** order to analyze the refinement mechanism of the primary phase of the GCI fabricated by the LFC with vibration,the solidification temperature fields of the GCI fabricated by the LFC with the vibration frequency of 0 and 35 Hz were *** results show that the vibration reduces the eutectic point of the GCI and increases the supercooling degree during the eutectic *** a result,the length of the flake graphite and the size of the primary austenite in GCI fabricated by LFC with the vibration frequency of 35 Hz decrease.

关键词： vibration frequency lost foam casting grey cast iron flake graphite properties

Lateral Ordered InGaAs Self-organized Quantum Dots Grown on (311) GaAs by Conventional Molecular Beam Epitaxy

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Chinese Physics Letters 1999年第1期16卷 68-70页

作者： XU huai-zhe jiang Wei-hong XU Bo ZHOU Wei WANG Zhan-guo Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing 100083

Self-assembled In_(x)Ga_(l-x)As quantum dots(QDs)on(311)and(100)GaAs surfaces have been grown by conventional solid source molecular beam *** ordering alignment of In_(x)Ga_(l-x)As QDs with lower In content around 0.3 has been observed on As-terminated(B type)*** direction of alignment orientation of the QDs formation differs from the direction of misorientation of the(311)B surface,and is strongly dependent upon the In content *** ordering alignment becomes significantly deteriorated as the In content is increased to above 0.5 or as the QDs are formed on(100)and(311)Ga-terminated(A type)substrates.

关键词： Epitaxy alignment

Quadrupolar matter-wave soliton in two-dimensional free space

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Frontiers of physics 2015年第4期10卷 119-125页

作者： Jia-Sheng Huang Xun-Da jiang huai-Yu Chen Zhi-Wei Fan Wei Pang Yong-Yao Li Department of Applied Physics College of Electronic Engineering South China Agricultural University Guangzhou 510642 China Department of Experiment Teaching Guangdong University of Technology Guangzhou 510006 China

We study two-dimensional （2D） matter-wave solitons in the mean-field models formed by electric quadrupole particles with long-range quadrupoleluadrupole interaction （QQI） in 2D free space. The existence of 2D matter-wave solitons in the free space was predicted using the 2D Gross Pitaevskii Equation （GPE）. We find that the QQI solitoms have a higher mass （smaller size and higher intensity） and stronger anisotropy than the dipol^dipole interaction （DDI） solitons under the same environmental parameters. Anisotropic solitomsoliton interaction between two identical QQI solitons in 2D free space is studied. Moreover, stable anisotropic dipole solitons are observed, to our knowledge, for the first time in 2D free space under anisotropic nonlocal cubic nonlinearity.

关键词： 2D matter-wave solitons quadrupole-quadrupole interaction anisotropy soliton-soliton interaction dipole solitons

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甲醇管道输送技术发展现状及挑战

油气储运 2024年第2期43卷 153-162页

作者：聂超飞姜子涛刘罗茜左丽丽苗青李博生苏怀黄梓耕国家管网集团科学技术研究总院分公司河北省廊坊市065000 中国石油大学(北京)·油气管道输送安全国家工程研究中心·城市油气输配技术北京市重点实验室

【目的】甲醇作为一种可再生、绿色的燃料,具有广阔的应用前景,但甲醇长距离管道输送技术在实际应用中还较为少见。【方法】对甲醇管道长距离输送技术的可行性及其面临的挑战开展了相关调研,收集了国内外甲醇输送管道的案例,梳理了甲醇... 详细信息

【目的】甲醇作为一种可再生、绿色的燃料,具有广阔的应用前景,但甲醇长距离管道输送技术在实际应用中还较为少见。【方法】对甲醇管道长距离输送技术的可行性及其面临的挑战开展了相关调研,收集了国内外甲醇输送管道的案例,梳理了甲醇长距离输送的工艺和设备要求,分析了甲醇输送过程中可能存在的安全风险,总结了工业甲醇管道规范标准建设的现状,厘清了甲醇长输管道目前存在的问题,并展望了其未来的发展方向。【结果】甲醇作为一种绿色燃料,在长距离管道输送方面展现出显著的应用前景。然而,实际技术实施过程中面临多项挑战,包括甲醇的物理化学特性对系统设计的特殊要求,如输送流速控制、设备选型等。同时,需要重点关注腐蚀、溶胀、泄漏及爆炸等安全风险。当前关于甲醇输送的实践案例有限,其整体技术的标准化和规范化水平有待提高。【结论】要实现甲醇管道输送技术的商业化和规模化应用,需系统性地解决技术和安全方面的各项挑战,包括提高甲醇纯度、优化输送工艺、选择适宜的耐腐蚀与抗溶胀材料,同时制定全面的安全标准和紧急响应策略。未来应加强基础科学研究和技术创新,建立完善的管理体制、政策支持框架,以确保甲醇管道输送的安全运行、经济效益及环境可持续性。

关键词：甲醇长输管道绿色阳光安全腐蚀溶胀

Discovery of novel dual inhibitors of VEGFR and PI3K kinases containing 2-ureidothiazole scaffold

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Chinese Chemical Letters 2016年第1期27卷 1-6页

作者： Lin Li Cun-Long Zhang Hong-Rui Song Chun-Yan Tan huai-Wei Ding Yu-Yang jiang Department of Chemistry Tsinghua University The Graduate School at Shenzhen Tsinghua University School of Pharmaceutical Engineering Shenyang Pharmaceutical University

A series of compounds possessing 2-（3-phenyl）ureidothiazol-4-formamide derivatives with a 2-ureidothiazole scaffold were designed and synthesized. Some compounds demonstrated inhibition of cell proliferation against both MDA-MB-231 and hep G2 cell lines using Sorafenib as the positive *** 6i showed a good to moderate inhibition on VEGFR-2 and PI3Ka which was proved by further molecular docking study. This study suggests that compound 6i is a potential dual inhibitor of VEGFR-2 and PI3Ka and is applicable for further investigation.

关键词： 2-Aminothiazole VEGFR PI3 KAnticancer