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Clinical Study of 224 Patients with Hypertriglyceridemia Pancreatitis

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Chinese Medical Journal 2015年第15期128卷 2045-2049页

作者： Xiao-li Zhang Fei li Ya-Min Zhen Ang li Yu fang Department of General Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China

Background：Hypertriglyceridenia （HTG） is the most common etiology of acute pancreatitis （AP） after alcohol and gallstone-induced *** of serum triglyceride （TG） levels to ≥ 1000 mg/dl in a patient with AP strongly indicates HTG as the *** absolute risk of pancreatitis based on serum TG ≤1000 mg/dl has not been clearly *** aims of this study were to address the role of elevated TG levels between 500 and 1000 mg/dl in the clinical course of HTG pancreatitis （HTGP）;and assess the relationship between the level of serum TG and disease ***：A total of 224 HTGP patients between 2007 and 2011 were divided into two ***,122 patients in Group A had serum TG 〉1000 mg/dl;102 patients in Group B had maximal TG levels between 500 and 1000 mg/dl accompanied by lactescent serum;100 patients with biliary AP and 99 patients with alcoholic AP hospitalized during the study period were enrolled as *** clinical and biochemical data were ***：The clinical presentation ofHTG-induced pancreatitis was similar to other *** form of AP in Group A was higher than Group B （Х^2 =4.002,P =0.045）.The severity with HTGP was significantly higher as compared to biliaryAP （Х^2 =33.533,P =0.000） and alcoholic AP （Х^2 =7.179,P =0.007）.Systemic complications with HTGP were significantly higher than biliary AP （Х^2 =58.763,P =0.000）.Conclusions：The study demonstrated that TG level ≥500 mg/dl should raise a high degree of suspicion,especially if no other etiology of AP is *** severity of HTGP seems to correlate directly with TG *** seems be more severe than other causes of AP.

关键词： Acute Pancreatitis Clinical Features Hypertriglyceridemia

Wind tunnel simulation experiment and investigation on the electrification of sandstorms

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Science China Earth Sciences 2004年第6期47卷 529-539页

作者： QU Jianjun YAN Muhong DONG Guangrong ZHANG Hongfa ZU Ruiping TUO Wanquan ZHAO Aiguo XIAO Zhenghua li fang YANG Bao Key Laboratory of Desert and Desertification Cold and Arid Regions Environmental and Engineering Research Institute and Shapotou Desert Research and Experiment Station Chinese Academy of Sciences Lanzhou 730000 China

Electric discharge phenomenon is often observed during the passage of sandstorms over desert regions and sometimes does great damage to human beings. Based on previous researches on the electrification of sandstorms by the scholars both at home and aboard,the authors conducted the simulation experiments on the electric fields of sandstorm-triggered creeping-saltating sand, suspending sand and watered suspending sand in the large-scale wind tunnel. According to the experimental results the electric field structure and its formation mechanism were analysed and discussed, the quantity of electric charges and electric field strengthwere measured and calculated, and finally several conclusions were drawn.

关键词： sand drift structure electrification mechanism wind tunnel simulation

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二维复式格子声子晶体带隙结构特性

物理学报 2005年第10期54卷 4511-4516页

作者：赵芳苑立波哈尔滨工程大学理学院物理系哈尔滨150001

借助于平面波展开法分析了二维复式格子声子晶体能带结构,计算了铝合金柱体按周期性结构排列在空气中形成的二维固/气复合体系的声子晶体,给出了复式蜂窝格子和复式Kagome格子的能带结构,进而对比分析了复式格子和简单格子的能带结构特... 详细信息

借助于平面波展开法分析了二维复式格子声子晶体能带结构,计算了铝合金柱体按周期性结构排列在空气中形成的二维固/气复合体系的声子晶体,给出了复式蜂窝格子和复式Kagome格子的能带结构,进而对比分析了复式格子和简单格子的能带结构特性.结果表明,与简单格子相比,复式格子的带隙出现在频率相对较低的位置;在f=0·091—0·6046范围内,将声子晶体排列为复式格子要优于简单格子,可以得到更宽带隙.此外,引入了带隙分布图,讨论了填充系数f对带隙数目、带隙宽度以及带隙上下边界频率的影响.

关键词：声子晶体复式格子带隙平面波算法结构特性宽带隙格子复式二维能带结构

A“T.E.S.T.”hydrogel bioadhesive assisted by corneal cross-linking for in situ sutureless corneal repair

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Bioactive Materials 2023年第7期25卷 333-346页

作者： Meiyan li Ruoyan Wei Chang liu Haowei fang Weiming Yang Yunzhe Wang Yiyong Xian Kunxi Zhang Yong He Xingtao Zhou Department of Ophthalmology EYE&ENT Hospital of Fudan University ShanghaiChina NHC Key Laboratory of Myopia(Fudan University) ShanghaiChina State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhouChina Shanghai Research Center of Ophthalmology and Optometry ShanghaiChina Department of Ophthalmology Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Polymer Materials School of Materials Science and EngineeringShanghai UniversityShanghaiChina

Corneal transplantation is an effective clinical treatment for corneal diseases,which,however,is limited by donor *** is of great clinical value to develop bioadhesive corneal patches with functions of“Transparency”and“Epithelium&Stroma generation”,as well as“Suturelessness”and“Toughness”.To simultaneously meet the“T.E.S.T.”requirements,a light-curable hydrogel is designed based on methacryloylated gelatin(GelMA),Pluronic F127 diacrylate(F127DA)&Aldehyded Pluronic F127(AF127)co-assembled bi-functional micelles and collagen type I(COL I),combined with clinically applied corneal cross-linking(CXL)technology for repairing damaged *** patch formed after 5 min of ultraviolet irradiation possesses transparent,highly tough,and strongly bio-adhesive *** cross-linking makes the patch withstand deformation near 600%and exhibit a burst pressure larger than 400 mmHg,significantly higher than normal intraocular pressure(10-21 mmHg).Besides,the slower degradation than GelMA-F127DA&AF127 hydrogel without COL I makes hydrogel patch stable on stromal beds in vivo,supporting the regrowth of corneal epithelium and *** hydrogel patch can replace deep corneal stromal defects and well bio-integrate into the corneal tissue in rabbit models within 4 weeks,showing great potential in surgeries for keratoconus and other corneal diseases by combining with CXL.

关键词： Tough hydrogel Bioadhesives Corneal patch CXL Sutureless repair

Non-proteolytic ubiquitination of OTUliN regulates NF-κB signaling pathway

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Journal of Molecular Cell Biology 2020年第3期12卷 163-175页

作者： Mengmeng Zhao Kun Song Wenzhuo Hao lingyan Wang Girish Patil Qingmei li lingling Xu fang Hua Bishi Fu Jens C.Schwamborn Martin E.Dorf Shitao li Department of Physiological Sciences Center for Veterinary Health SciencesOklahoma State UniversityStillwaterOK 74078USA Key Laboratory of Animal Immunology Henan Academy of Agricultural SciencesZhengzhouChina State Key Laboratory of Virology Medical Research InstituteWuhan UniversityWuhanChina Luxembourg Centre for Systems Biomedicine University of LuxembourgLuxembourg CityLuxembourg Department of Immunology Harvard Medical SchoolBostonMA 02115USA f These authors contributed equally to this work

NF-κB signaling regulates diverse processes such as cell death,inflammation,immunity,and *** activity of NF-κB is controlled by methionine 1-linked linear polyubiquitin,which is assembled by the linear ubiquitin chain assembly complex(LUBAC)and the ubiquitin-conjugating enzyme *** studies found that the deubiquitinase OTUliN breaks the linear ubiquitin chain,thus inhibiting NF-κB *** the essential role of OTUliN in NF-κB signaling has been established,the regulatory mechanism for OTUliN is not well *** discover the potential regulators of OTUliN,we analyzed the OTUliN protein complex by proteomics and revealed several OTUliN-binding proteins,including LUBAC and tripartite motif-containing protein 32(TRIM32).TRIM32 is known to activate NF-κB signaling,but the mechanism is not *** complement experiments found that TRIM32 is upstream of OTUliN and TRIM32-mediated NF-κB activation is dependent on *** of the E3 ligase domain showed that the E3 ligase activity is essential for TRIM32-mediated NF-κB *** experiments found that TRIM32 conjugates polyubiquitin onto OTUliN and the polyubiquitin blocks the interaction between HOIP and OTUliN,thereby activating NF-κB *** together,we report a novel regulatory mechanism by which TRIM32-mediated non-proteolytic ubiquitination of OTUliN impedes the access of OTUliN to the LUBAC and promotes NF-κB activation.

关键词： NF-κB LUBAC TNF linear ubiquitination TRIM proteomics

Endoscopic retrograde cholangiopancreatography in the treatment of pancreaticopleural fistula in children

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World Journal of Gastroenterology 2020年第37期26卷 5718-5730页

作者： Jing Zhang liu-Cun Gao Shu Guo Tian-Lu Mei Jin Zhou Guo-li Wang Fei-Hong Yu Yong-li fang Bao-Ping Xu Department of Gastroenterology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Clinical Research Center Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China China National Clinical Research Center of Respiratory Diseases Department of RespiratoryBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

BACKGROUND Pancreaticopleural fistula(PPF)is a rare disease,especially in *** treatment and surgery are traditional therapies,but surgery is *** emergence of endoscopic retrograde cholangiopancreatography(ERCP)has provided a new noninvasive treatment for PPF and may become the first choice for children with *** To explore the treatment response to ERCP for PPF in *** Seven children with PPF were hospitalized in the Gastroenterology Department of Beijing Children’s Hospital from December 2007 to May *** on these seven patients’clinical characteristics,diagnosis,treatments,and outcomes were analyzed,and their treatment responses following surgery and ERCP were *** correlation between the length of hospital stay and conservative treatment was ***-reviewed articles written in English and Chinese published from January 2009 to December 2019 were obtained from various open data sources and *** The seven patients comprised three boys and four girls with a mean age of 6.57±3.26 *** main symptoms were chest tightness and pain(n=4),intermittent fever(n=3),dyspnea(n=3),and abdominal pain(n=1),and all patients had bloody pleural *** seven patients were diagnosed with PPF by magnetic resonance cholangiopancreatography,and all were initially treated conservatively for a mean of 34.67±22.03 d with a poor *** five patients who underwent ERCP,one required surgery because of intubation failure;thus,the success rate of ERCP was 80%.Two patients were successfully treated with surgery(100%).The postoperative hospital stay of the two patients treated by surgery was 20 and 30 d,respectively(mean of 25 d),and that of the four patients treated by ERCP ranged from 12 to 30 d(mean of 19.25±8.85 d).The recovery time after ERCP was short[time to oral feeding,4-6 d(mean,5.33±1.15 d);duration of closed thoracic drainage,2-22 d(mean,13.3 d)].Analysis of previous cases of PPF published worldw

关键词： Pancreaticopleural fistula Childhood Endoscopic retrograde cholangiopancreatography Magnetic resonance cholangiopancreatography Diagnostic Treatment

金属丝棉结构在电焊烟尘处理中的过滤性能研究

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中国安全科学学报 2011年第3期21卷 110-113页

作者：杨利芳范怀良哈尔滨工业大学工业设计系

电焊烟尘对人危害极大,必须加以净化才能排放到空气中。然而电焊作业烟尘量极大,由于过滤效率低,导致小型移动式电焊除尘器应用受到限制。为了更好地利用移动式除尘器净化电焊烟尘,研究高效过滤材料变得非常重要。通过数值模拟金属丝绵... 详细信息

电焊烟尘对人危害极大,必须加以净化才能排放到空气中。然而电焊作业烟尘量极大,由于过滤效率低,导致小型移动式电焊除尘器应用受到限制。为了更好地利用移动式除尘器净化电焊烟尘,研究高效过滤材料变得非常重要。通过数值模拟金属丝绵的除尘效率、过滤压力损失及残余压降等影响过滤性能的因素,将金属丝绵应用于移动式除尘器。为了更好地发挥金属丝绵的过滤性能,设计特殊的过滤结构,并在电焊烟尘除尘器中应用以提高除尘器的过滤效率。结果表明,金属丝绵应用于电焊除尘器可以获得理想的除尘效果,并且可以克服很多现有电焊除尘器的缺点。

关键词：电焊烟尘金属丝棉过滤性能过滤结构电焊清灰

Tongxinluo promotes endothelium-dependent arteriogenesis to attenuate diabetic peripheral arterial disease

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World Journal of Diabetes 2023年第3期14卷 234-254页

作者： Jiao-Jiao Gu Yun-Long Hou Yi-Hui Yan Jie li Ya-Ru Wei Kun Ma Xiao-Qi Wang Jie-Han Zhang Dan-Dong Wang Cui-Ru li Dong-Qi li ling-ling Sun huai-lin Gao Graduate School Hebei University of Chinese MedicineShijiazhuang 050090Hebei ProvinceChina Graduate School Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Graduate school Hebei Yiling Pharmaceutical Research InstituteShijiazhuang 050035Hebei ProvinceChina Graduate school Henan University of Traditional Chinese MedicineShijiazhuang 450000Hebei ProvinceChina

BACKGROUND Peripheral arterial disease(PAD)has become one of the leading causes of disability and death in diabetic *** blood supply to the hindlimbs,especially by promoting arteriogenesis,is currently the most effective strategy,in which endothelial cells play an important ***(TXL)has been widely used for the treatment of cardio-cerebrovascular diseases and extended for diabetes-related vascular *** To investigate the effect of TXL on diabetic PAD and its underlying *** An animal model of diabetic PAD was established by ligating the femoral artery of db/db *** Doppler imaging and micro-computed tomography(micro-CT)were performed to assess the recovery of blood flow and *** cell function related to arteriogenesis and cellular pyroptosis was assessed using histopathology,Western blot analysis,enzyme-linked immunosorbent assay and real-time polymerase chain reaction *** vitro,human vascular endothelial cells(HUVECs)and human vascular smooth muscle cells(VSMCs)were pretreated with TXL for 4 h,followed by incubation in high glucose and hypoxia conditions to induce cell ***,indicators of HUVEC pyroptosis and function,HUVECVSMC interactions and the migration of VSMCs were *** Laser Doppler imaging and micro-CT showed that TXL restored blood flow to the hindlimbs and enhanced *** also inhibited endothelial cell pyroptosis via the reactive oxygen species/nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3/Caspase-1/GSDMD signaling *** addition,TXL restored endothelial cell functions,including maintaining the balance of vasodilation,acting as a barrier to reduce inflammation,and enhancing endothelial-smooth muscle cell interactions through the Jagged-1/Notch-1/ephrin-B2 signaling *** results were observed in *** TXL has a pro-arteriogenic effect in the treatment of diabetic PAD,and the m

关键词： Diabetic peripheral arterial disease Arteriogenesis Endothelial cell Inflammation Pyroptosis

Surface modification of small intestine submucosa in tissue engineering

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Regenerative Biomaterials 2020年第4期7卷 339-348页

作者： Pan Zhao Xiang li Qin fang fanglin Wang Qiang Ao Xiaohong Wang Xiaohong Tian Hao Tong Shuling Bai Jun Fan Department of Tissue Engineering School of Fundamental SciencesChina Medical University77 Puhe AvenueShenbei New DistrictShenyang 110122China Department of Cell Biology School of Life SciencesChina Medical University77 Puhe AvenueShenbei New DistrictShenyang 110122China and 3Cardiac Surgery Liaoning First Hospital of China Medical UniversityNo.155 Nanjing StreetHeping DistrictShenyangLiaoning 110122China

With the development of tissue engineering,the required biomaterials need to have the ability to promote cell adhesion and proliferation in vitro and in ***,surface modification of the scaffold material has a great influence on biocompatibility and functionality of *** small intestine submucosa(SIS)is an extracellular matrix isolated from the submucosal layer of porcine jejunum,which has good tissue mechanical properties and regenerative activity,and is suitable for cell adhesion,proliferation and *** recent years,SIS is widely used in different areas of tissue reconstruction,such as blood vessels,bone,cartilage,bladder and ureter,*** paper discusses the main methods for surface modification of SIS to improve and optimize the performance of SIS bioscaffolds,including functional group bonding,protein adsorption,mineral coating,topography and formatting modification and drug *** addition,the reasonable combination of these methods also offers great improvement on SIS surface *** article makes a shallow review of the surface modification of SIS and its application in tissue engineering.

关键词： small intestinal submucosa surface modification in vitro scaffold tissue engineering