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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue lin Gen Wei jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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On-line topical importance estimation:an effective focused crawling algorithm combining link and content analysis

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第8期10卷 1114-1124页

作者： Can WANG Zi-yu GUAN Chun CHEN Jia-jun BU jun-feng WANG huai-zhong lin School of Computer Science and Technology Zhejiang University Hangzhou 310027 China

Focused crawling is an important technique for topical resource discovery on the *** key issue in focused crawling is to prioritize uncrawled uniform resource locators(URLs) in the frontier to focus the crawling on relevant *** focused crawlers mainly rely on content ***-based techniques are not effectively exploited despite their *** this paper,we propose a new frontier prioritizing algorithm,namely the on-line topical importance estimation(OTIE) *** combines link-and content-based analysis to evaluate the priority of an uncrawled URL in the *** performed real crawling experiments over 30 topics selected from the Open Directory Project(ODP) and compared harvest rate and target recall of the four crawling algorithms:breadth-first,link-context-prediction,on-line page importance computation(OPIC) and our *** results showed that OTIE significantly outperforms the other three algorithms on the average target recall while maintaining an acceptable harvest ***,OTIE is much faster than the traditional focused crawling algorithm.

关键词： Focused crawlers Topical crawlers PageRank Classifiers On-line topical importance estimation (OTIE) algorithm

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Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Xue-Qian Wang Feng-Qi Zhang Xiao-Ya Cui Bing-Bing Fan Jia-Ming Guo Zhi-Min Guo Rui Huang Wen Huang Xu-Bo Li Meng-Ru Li Yan Ma Zhi-Hua Shen Yong-Gang Sun De-Zhuang Wang Fei-Yang Wang Li-Qiang Wang Nan Wang Tian-Li Wang Wei Wang Xiao-Yang Wang Yi-Han Wang Fu-Jie Yu Yu-Zhen Yin ling-Kun Zhang Yi Zhang Jian-Yang Zhang Qi Zhao Yu-Ping Zhao Xin-Dong Zhu Yasir Sohail Ya-Nan Chen Tao Feng Qi-Long Gao Hai-Yan He Yong-Jiang Huang Zeng-Bao Jiao Hua Ji Yao Jiang Qiang Li Xiao-Ming Li Wei-Bing Liao huai-jun lin Hui Liu Qi Liu Qing-Feng Liu Wei-Di Liu Xiong-jun Liu Yang Lu Yi-Ping Lu Wen Ma Xue-Fei Miao Jie Pan Qing Wang Hong-Hui Wu Yuan Wu Tao Yang Wei-Ming Yang Qian Yu Jin-Yu Zhang Zhi-Gang Chen Liang Mao Yang Ren Bao-Long Shen Xun-Li Wang Zhe Jia He Zhu Zhen-Duo Wu Si Lan School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Department of Physics City University of Hong KongHongKong 999077China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Department of Mechanical Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 100872China Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Institute of Advanced Wear&Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou 510632China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China School of Physical Sciences Great Bay UniversityDongguan 523000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon NeutralityUniversity of Science and Technology BeijingBeijing 100083China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China School of Computing Macquarie UniversitySydney 2113Australia Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China State Key Laborato

Owing to their exceptional properties,high-entropy alloys(HEAs)and high-entropy materials have emerged as promising research areas and shown diverse ***,the recent advances in the field are comprehensively reviewed,organized into five *** first section introduces the background of HEAs,covering their definition,significance,application prospects,basic properties,design principles,and *** subsequent section focuses on cutting-edge high-entropy structural materials,highlighting developments such as nanostructured alloys,grain boundary engineering,eutectic systems,cryogenic alloys,thin films,micro-nano-lattice structures,additive manufacturing,high entropy metallic glasses,nano-precipitate strengthened alloys,composition modulation,alloy fibers,and refractory *** the following section,the emphasis shifts to functional materials,exploring HEAs as catalysts,magneto-caloric materials,corrosion-resistant alloys,radiation-resistant alloys,hydrogen storage systems,and materials for ***,the review encompasses functional high-entropy materials outside the realm of alloys,including thermoelectric,quantum dots,nanooxide catalysts,energy storage materials,negative thermal expansion ceramics,and high-entropy wave absorption *** paper concludes with an outlook,discussing future directions and potential growth areas in the *** this comprehensive review,researchers,engineers,and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： High entropy alloys Cutting-edge structural materials Cutting-edgefunctional materials

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脊髓内脓肿的MRI诊断(1例报告并文献复习)

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实用放射学杂志 2008年第5期24卷 584-586页

作者：刘凤海刘怀军李林芳秦瑞平史朝霞河北医科大学第二医院医学影像科河北医科大学第二医院医学影像科河北石家庄050000

目的探讨脊髓脓肿的MRI表现,减少误诊率。方法分析现有病例影像学及临床资料并复习文献,总结脊髓脓肿的影像学特征。结果患者初诊MRI显示颈段脊髓及髓外异常信号,增强扫描脊髓内见明显多环状强化,环壁较光整,髓外肿物中等强化。1年后复... 详细信息

目的探讨脊髓脓肿的MRI表现,减少误诊率。方法分析现有病例影像学及临床资料并复习文献,总结脊髓脓肿的影像学特征。结果患者初诊MRI显示颈段脊髓及髓外异常信号,增强扫描脊髓内见明显多环状强化,环壁较光整,髓外肿物中等强化。1年后复查MRI显示原髓内病变基本消失,髓外残存小环状明显强化病变,CT示髓内小环状病变通过同水平棘突间隙与皮下相通。结论脊髓脓肿较少见,极易误诊,通过认真分析影像及临床资料有望提高正确诊断率,减少误诊的发生。

关键词：脊椎脊髓内脓肿磁共振成像

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Exergy analysis and performance enhancement of isopropanol-acetone-hydrogen chemical heat pump

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Frontiers in Energy 2017年第4期11卷 510-515页

作者： Min XU jun CAI Xiulan huai Institute of Engineering Thermophysics Chinese Academy of Sciences Beijing 100190 China

Exergy loss analysis was conducted to identify the irreversibility in each component of the isopropanol- acetone-hydrogen chemical heat pump （IAH-CHP）. The results indicate that the highest irreversibility on a system basis occurs in the distillation column. Moreover, the effect of operating parameters on thermodynamic performances of the IAH-CHP was studied and the optimal conditions were obtained. Finally, the potential methods to reduce the irreversibility of the IAH-CHP system were investigated. It is found that reactive distillation is apromising alternative. The enthalpy and exergy efficiency of the IAH-CHP with reactive distillation increases by 24.1% and 23.2%, respectively.

关键词： waste heat reuse chemical heat pump exergyanalysis isopropanol

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Green innovation for green light

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Science China(Life Sciences) 2023年第10期66卷 2443-2444页

作者： junling huai Rongcheng lin Key Laboratory of Photobiology Institute of BotanyChinese Academy of SciencesBeijing 100093China

In darkness,plants undergo skotomorphogenesis,which is characterized by long hypocotyls and closed *** contrast,light,such as far-red light,red light,and blue light,inhibits hypocotyl *** sense different wavelengths o... 详细信息

关键词： light closed

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Control of wall thickness and surface morphology of tungsten thin wall parts by adjusting selective laser melting parameters

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Journal of Iron and Steel Research International 2019年第2期26卷 182-190页

作者： Yan-jun Xie huai-chao Yang Xue-bing Wang lin Zhao Chun-jiang Kuang Wei Han Central Iron and Steel Research Institule Beijing 100081China Advanced Technology&Materials Co. Ltd.Beijing 100081China

The tungsten thin wall parts which were used as high-performance collimator devices were fabricated by optimizing selective laser melting laser *** effect of laser power and scan rate on wall thickness and surface morphology of tungsten山in wall parts was investigated,*** results indicated that the wall thickness increased with the enhancemem in laser power as a linear *** the contrary,the wall thickness decayed exponentially with the acceleration in laser sean ***,the wall thickness of the parts fabricated by laser double-pass melting was ihinner than that fabricated by laser single-pass *** addition,mathematic models for selecting suitable laser power and laser sean rate to fabricate specified tungsten thin wall parts were ***,the effects of laser parameters on the top surface roughness,adhesive parts and hot cracks were also discussed.

关键词： Selective laser melting Tungsten Laser power Scan rate Thin wall part Surface morphology

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Interaction Mechanism of Double Bubbles in Hydrodynamic Cavitation

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Journal of Thermal Science 2013年第3期22卷 242-249页

作者： Fengchao Li jun Cai Xiulan huai Bin Liu Institute of Engineering Thermophysics Chinese Academy of Sciences

Bubble-bubble interaction is an important factor in cavitation bubble dynamics. In this paper, the dynamic behaviors of double cavitation bubbles driven by varying pressure field downstream of an orifice plate in hydrodynamic cavitation reactor are examined. The bubble-bubble interaction between two bubbles with different radii is considered. We have shown the different dynamic behaviors between double cavitation bubbles and a single bubble by solving two coupling nonlinear equations using the Runge-Kutta fourth order method with adaptive step size control. The simulation results indicate that, when considering the role of the neighbor smaller bubble, the oscil-lation of the bigger bubble gradually exhibits a lag in comparison with the single-bubble case, and the extent of the lag becomes much more obvious as time goes by. This phenomenon is more easily observed with the increase of the initial radius of the smaller bubble. In comparison with the single-bubble case, the oscillation of the bigger bubble is enhanced by the neighbor smaller bubble. Especially, the pressure pulse of the bigger bubble rises intensely when the sizes of two bubbles approach, and a series of peak values for different initial radii are acquired when the initial radius ratio of two bubbles is in the range of 0.9～1.0. Although the increase of the center distance between two bubbles can weaken the mutual interaction, it has no significant influence on the enhancement trend. On the one hand, the interaction between two bubbles with different radii can suppress the growth of the smaller bubble; on the other hand, it also can enhance the growth of the bigger one at the same time. The significant en-hancement effect due to the interaction of multi-bubbles should be paid more attention because it can be used to reinforce the cavitation intensity for various potential applications in future.

关键词： Hydrodynamic cavitation, Double bubbles, Cavitation bubble dynamics

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Simulation of Heat Transfer with the Growth and Collapse of a Cavitation Bubble Near the Heated Wall

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Journal of Thermal Science 2013年第4期22卷 352-358页

作者： Bin Liu jun Cai Fengchao Li Xiulan huai Institute of Engineering Thermophysics Chinese Academy of Sciences University of Chinese Academy of Sciences

The growth and collapse behaviors of a single cavitation bubble near a heated wail and its effect on the heat transfer are numerically investigated. The present study is designed to reveal the mechanism of cavitation enhanced heat transfer from a microscopic perspective. In the simulation, the time-dependent Navier-Stokes equations are solved in an axisymmetric two-dimensional domain. The volume of fluid （VOF） method is employed to track the liquid-gas interface. It is assumed that the gas inside the bubble is compressible vapor, and the sur- rounding liquid is incompressible water. Mass transfer between two phases is ignored. The eaiculated bubble pro-files were compared to the available experimental data, and a good agreement was obtained. Then, the relationship among bubble motion, flow field and surface heat transfer coefficient was analyzed. On this basis, the effects of such factors as the initial distance between the bubble and the wall, the initial vapor pressure and the initial bubble nucleus size on the heat transfer enhancement are discussed. The present study is helpful to understand the heat transfer phenomenon in presence of cavitation bubble in liquid.

关键词： cavitation bubble bubble growth bubble collapse heat transfer enhancement

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噻吩酰亚胺衍生物二阶非线性光学性质的DFT研究

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原子与分子物理学报 2025年第1期42卷 20-28页

作者：蔺彬彬闫慧君哈尔滨学院食品工程学院化学系哈尔滨150086

采用密度泛函理论(DFT)CAM-B3LYP方法,计算研究了12个设计的噻吩酰亚胺衍生物的电子光谱和二阶非线性光学性质.结果表明,此类化合物有较大的第一超极化率β_(tot)值和β_(vec)值,且β_(tot)值和β_(vec)值随引入氰基数目的增加而显著增... 详细信息

采用密度泛函理论(DFT)CAM-B3LYP方法,计算研究了12个设计的噻吩酰亚胺衍生物的电子光谱和二阶非线性光学性质.结果表明,此类化合物有较大的第一超极化率β_(tot)值和β_(vec)值,且β_(tot)值和β_(vec)值随引入氰基数目的增加而显著增大.给/吸电子基团引起的电荷转移变化对体系β_(tot)值和β_(vec)值的影响大于分子六元杂环中N杂原子位置变化对其影响.

关键词：噻吩酰亚胺衍生物密度泛函理论二阶非线性光学性质电子光谱

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