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Design of high stability thin-film transistor biosensor for the diagnosis of bladder cancer

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Chinese Chemical Letters 2020年第6期31卷 1387-1391,F0003页

作者： Yingxue Li Bo Zeng Yujie Yang huageng liang Yanbing Yang Quan Yuan Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education) College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China Institute of Chemical Biology and Nanomedicine State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Key Laboratory for Micro-/Nano-Optoelectronic Devices of Ministry of Education School of Physics and ElectronicsHunan UniversityChangsha 410082China

Bladder cancer is the most common malignant tumor in the urinary system,with high morbidity,mortality and recurrence after ***,current bladder cancer urine diagnosis methods are limited by the low accuracy and specificity due to the low abundance of bladder cancer biomarkers in the urine with complex biological ***,we present a high stability indium gallium zinc oxide field effect transistor(IGZO-FET)biosensor for efficient identification of bladder cancer biomarkers from human urine *** recognition molecular functionalized IGZO-FET biosensor exhibits stable electronic and sensing performance due to the large-area fabrication of IGZO thin-film *** to the excellent electrical performance of IGZO-FET,the IGZO-FET biosensor exhibits high sensitivity and extremely low detection limit(2.7 amol/L)towards bladder cancer *** IGZO-FET biosensor is also able to directly detect bladder tumor biomarker in human urine with high sensitivity and specificity,and could differentiate bladder cancer patients’urine samples from healthy donors *** results indicate that our designed high-performance biosensor shows great potential in the application of portable digital bladder cancer diagnosis devices.

关键词： IGZO Field-effect transistors NMP22 Bladder cancer Urine detection

Construction of high stability indium gallium zinc oxide transistor biosensors for reliable detection of bladder cancer-associated microRNA

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Chinese Chemical Letters 2022年第2期33卷 979-982页

作者： Jing Guo Ruichen Shen Xuejie Shen Bo Zeng Nianjun Yang huageng liang Yanbing Yang Quan Yuan Key Laboratory of Biomedical Polymers of Ministry of Education College of Chemistry and Molecular SciencesSchool of MicroelectronicsWuhan UniversityWuhan 430072China Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Institute of Chemical Biology and Nanomedicine State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Institute of Materials Engineering University of SiegenSiegen 57076Germany

Bladder cancer is the most common malignant tumours with high morbidity, mortality and ***, currently developed detection methods for bladder cancer-associated urine biomarkers are hindered by their extremely low abundance. Hence, the exploration of a highly sensitive and selective approach for the detection of trace bladder cancer-associated biomarkers in human urine is of vital importance for the diagnosis of bladder cancer. Herein, we developed a highly reliable indium gallium zinc oxide field effect transistor(IGZO FET) biosensor for the detection of bladder cancer-related biomarker micro RNA. The single-stranded DNA-functionalized IGZO FET biosensors exhibit high sensing reproducibility and stability with an ultralow detection limit of 19.8 amol/L. The device could also be used for quantitative detection of trace micro RNA in human urine samples and can effectively distinguish bladder cancer patients from healthy donors. The development of high performance IGZO FET biosensors presents new opportunities for the achievement of early-stage diagnosis of bladder cancer.

关键词： Bladder cancer Field-effect transistors IGZO miRNA Urine

Folic acid-modified Exosome-PH20 enhances the efficiency of therapy via modulation of the tumor microenvironment and directly inhibits tumor cell metastasis

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Bioactive Materials 2021年第4期6卷 963-974页

作者： Chunxiang Feng Zhiyong Xiong Cheng Wang Wen Xiao Haibing Xiao Kairu Xie Ke Chen huageng liang Xiaoping Zhang Hongmei Yang Department of Pathogenic Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

High accumulation of hyaluronan(HA)in the tumor microenvironment leads to an increase in the interstitial pressure and reduction perfusion of ***,high molecular-weight(HMW)-HA suppresses M1 macrophage polarization,enhances M2 polarization,and induces *** treatment have attempted to decrease the quantity of HA in ***,hyaluronidase-driven HA degradation driven accelerates tumor cell metastasis,which is a major cause of mortality in cancer ***,we designed a novel exosome-based drug delivery system(DDS),named Exos-PH20-FA,using genetic engineering to express human hyaluronidase(PH20)and self-assembly techniques to modify the exosomes with folic acid(FA).Our results show that Exos-PH20-FA degraded HMW-HA to low-molecular-weight(LMW)-***,LMW-HA polarized macrophages to the M1 phenotype and reduced the number of relevant immunosuppressive immunocytes which changed the immune microenvironment from an immunosuppressive to immunosupportive ***,we demonstrated Exos-PH20-FA directly reduced hyaluronidase-induced metastasis of tumor *** tumor treatment also allowed an enhanced delivery of chemotherapy by tumor-targeting effect with FA *** findings indicate that Exos-PH20-FA improves tumor treatment efficiency and reduces the side effects of hyaluronidase treatment,namely tumor cell *** all-in-one exosome-based HA targeting DDS maybe a promising treatment that yields more efficient and safer results.

关键词： Hyaluronidase Exosomes Tumor microenvironment Metastasis Tumor immunotherapy

Circularly polarized light emission and detection by chiral inorganic semiconductors

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Frontiers of Optoelectronics 2024年第2期17卷 43-49页

作者： Zha Li Wancai Li Dehui Li Wei Tang huageng liang Huaibing Song Chao Chen liang Gao Jiang Tang Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China International Health Care Center National Center for Global Health and MedicineTokyo 162‑8655Japan Hepato‑Biliary‑Pancreatic Surgery Division Department of SurgeryThe University of Tokyo HospitalTokyo 113‑8655Japan Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Faculty of Materials Science and Chemistry China University of GeosciencesWuhan 430074China

Chiral inorganic semiconductors with high dissymmetric factor are highly desirable,but it is generally difficult to induce chiral structure in inorganic semiconductors because of their structure rigidity and *** this study,we introduced chiral ZnO film as hard template to transfer chirality to CsPbBr_(3) film and PbS quantum dots(QDs)for circularly polarized light(CPL)emission and detection,*** prepared CsPbBr_(3)/ZnO thin film exhibited CPL emission at 520 nm and the PbS QDs/ZnO film realized CPL detection at 780 nm,featuring high dissymmetric factor up to around *** electron transition based mechanism is responsible for chirality transfer.

关键词： High dissymmetric factor Circularly polarized light emission Semiconductor Hard template,Chirality

人工反射弧治疗脊柱裂并发先天性尿失禁后的脑干功能重塑

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临床泌尿外科杂志 2009年第7期24卷 508-509页

作者：梁华庚肖传国华中科技大学同济医学院附属协和医院泌尿外科武汉430022

目的:探讨人工反射弧治疗脊柱裂并发先天性尿失禁后的脑干功能重塑机制。方法:应用功能磁共振(functional magnetic rcsonance imaging,fMRI)建立人工反射弧手术前后患者脑干功能图谱。结果:术前患者脑干无激活,术后患者脑干出现激活。... 详细信息

目的:探讨人工反射弧治疗脊柱裂并发先天性尿失禁后的脑干功能重塑机制。方法:应用功能磁共振(functional magnetic rcsonance imaging,fMRI)建立人工反射弧手术前后患者脑干功能图谱。结果:术前患者脑干无激活,术后患者脑干出现激活。结论:建立人工反射弧后,脊柱裂并发先天性尿失禁患者脑干形成了新的控尿中枢。

关键词：脊柱裂尿失禁人工反射弧功能磁共振

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前列腺针穿刺过程中软组织的损伤研究

浙江工业大学学报 2022年第3期50卷 261-269页

作者：张丹方胜梁华庚浙江工业大学信息工程学院浙江杭州310023 华中科技大学同济医学院附属协和医院湖北武汉430022

探究在前列腺癌的穿刺诊断过程中,柔性针在进针时对人体前列腺所造成的损伤。首先,建立柔性针的悬臂梁模型,利用有限元方法对柔性针和前列腺所构成的耦合模型进行求解;然后,在Abaqus有限元软件中对前列腺穿刺过程进行数值模拟与分析,探... 详细信息

探究在前列腺癌的穿刺诊断过程中,柔性针在进针时对人体前列腺所造成的损伤。首先,建立柔性针的悬臂梁模型,利用有限元方法对柔性针和前列腺所构成的耦合模型进行求解;然后,在Abaqus有限元软件中对前列腺穿刺过程进行数值模拟与分析,探究穿刺活检针的倾角、直径和速度在穿刺时对前列腺的影响;最后,通过引入损伤指数对患者穿刺部位进行评估。实验结果表明:通过有限元软件能够模拟前列腺穿刺手术的整体过程及状态;柔性针直径越大,前列腺软组织的损伤越严重;柔性针的针尖尖端越锋利,前列腺软组织穿刺时组织损伤越小;在穿刺时穿刺速度对组织损伤也存在一定的影响。研究可为医生的术前规划提供一定的理论支持。

关键词：前列腺针穿刺有限元分析组织损伤

肾脏肿瘤组织的高分辨魔角旋转核磁共振~1H谱研究

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江苏医药 2010年第4期36卷 446-448页

作者：杨永霞梁华庚李承龙广东药学院基础学院物理与电子学教研室 510006 华中科技大学同济医学院附属协和医院泌尿外科无锡市第二人民医院普通外科

目的应用高分辨魔角旋转核磁共振1H谱研究肾脏肿瘤组织的代谢变化。方法选取肾癌肿瘤组织和癌旁对比组织标本,分别作病理分析和高分辨魔角旋转核磁共振1H谱检测。结果通过对比发现乳酸、胆碱类物质(胆碱、磷酸胆碱和甘油磷酸胆碱)及肌... 详细信息

目的应用高分辨魔角旋转核磁共振1H谱研究肾脏肿瘤组织的代谢变化。方法选取肾癌肿瘤组织和癌旁对比组织标本,分别作病理分析和高分辨魔角旋转核磁共振1H谱检测。结果通过对比发现乳酸、胆碱类物质(胆碱、磷酸胆碱和甘油磷酸胆碱)及肌醇在肾癌组织中明显升高。结论肾癌组织的代谢特征明显不同于癌旁对比组织,这可以为肾癌的诊断提供分子水平上的代谢依据。

关键词：磁共振1H谱肾肿瘤代谢

脊柱裂并发脑积水的发病率及相关问题初探(附46例报告)

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临床泌尿外科杂志 2009年第9期24卷 683-684页

作者：梁华庚贾斌杨栋何朝宏杜茂信肖传国华中科技大学同济医学院附属协和医院泌尿外科武汉430022 郑州大学第二附属医院泌尿外科上海同济大学医学院

目的:初步探讨成年人脊柱裂并发脑积水的发病率及相关问题。方法:使用磁共振(MRI)成像技术采集46例成年人脊柱裂患者的颅部解剖像,扫描参数为TR/TE 3 900 ms/15 ms,层数42层,层厚3 mm,视窗20 cm×20 cm,矩阵512×512。结果:46例患者中,2... 详细信息

目的:初步探讨成年人脊柱裂并发脑积水的发病率及相关问题。方法:使用磁共振(MRI)成像技术采集46例成年人脊柱裂患者的颅部解剖像,扫描参数为TR/TE 3 900 ms/15 ms,层数42层,层厚3 mm,视窗20 cm×20 cm,矩阵512×512。结果:46例患者中,20例发现不同程度的脑积水,占本组脊柱裂患者的43.5%;MRI成像可见侧脑室明显扩大,基底节、下丘脑严重萎缩。结论:国内脊柱裂患者并发脑积水的发生率远低于西方文献报道(约为85%);其并发脑积水的机制尚不明确,所引起的一系列综合征需引起临床重视。更精确的结果尚需更大样本的深入研究。

关键词：脊柱裂脑积水磁共振

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肾透明细胞癌合并单一肩胛骨转移1例

临床泌尿外科杂志 2022年第8期37卷 646-648页

作者：王军侯亚信梁华庚章小平华中科技大学同济医学院附属协和医院泌尿外科武汉430022

肾透明细胞癌合并单一的肩胛骨转移在转移性肾癌中十分少见,通常患者的初发表现为肩胛骨的肿物与疼痛,易被误诊,常常需要全面的检查来给患者制定个体化的治疗方案,目前手术治疗联合免疫治疗为转移性肾癌的有效方式。现报道1例肾透明细... 详细信息

肾透明细胞癌合并单一的肩胛骨转移在转移性肾癌中十分少见,通常患者的初发表现为肩胛骨的肿物与疼痛,易被误诊,常常需要全面的检查来给患者制定个体化的治疗方案,目前手术治疗联合免疫治疗为转移性肾癌的有效方式。现报道1例肾透明细胞癌合并单一的肩胛骨转移及病例回顾。

关键词：肾细胞癌肩胛骨转移