Design of high stability thin-film transistor biosensor for the diagnosis of bladder cancer

作     者：Yingxue Li Bo Zeng Yujie Yang Huageng Liang Yanbing Yang Quan Yuan Yingxue Li;Bo Zeng;Yujie Yang;Huageng Liang;Yanbing Yang;Quan Yuan

作者机构：Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education)College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China Institute of Chemical Biology and NanomedicineState Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Department of UrologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Key Laboratory for Micro-/Nano-Optoelectronic Devices of Ministry of EducationSchool of Physics and ElectronicsHunan UniversityChangsha 410082China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2020年第31卷第6期

页      面：1387-1391,F0003页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(No.2017YFA0208000) the National Natural Science Foundation of China(Nos.21925401,21904033,21675120) Changsha Municipal Science and Technology Projects,China(No.kq1901030) 

主　　题：IGZO Field-effect transistors NMP22 Bladder cancer Urine detection 

摘      要：Bladder cancer is the most common malignant tumor in the urinary system,with high morbidity,mortality and recurrence after ***,current bladder cancer urine diagnosis methods are limited by the low accuracy and specificity due to the low abundance of bladder cancer biomarkers in the urine with complex biological ***,we present a high stability indium gallium zinc oxide field effect transistor(IGZO-FET)biosensor for efficient identification of bladder cancer biomarkers from human urine *** recognition molecular functionalized IGZO-FET biosensor exhibits stable electronic and sensing performance due to the large-area fabrication of IGZO thin-film *** to the excellent electrical performance of IGZO-FET,the IGZO-FET biosensor exhibits high sensitivity and extremely low detection limit(2.7 amol/L)towards bladder cancer *** IGZO-FET biosensor is also able to directly detect bladder tumor biomarker in human urine with high sensitivity and specificity,and could differentiate bladder cancer patients’urine samples from healthy donors *** results indicate that our designed high-performance biosensor shows great potential in the application of portable digital bladder cancer diagnosis devices.