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头孢克肟颗粒有关物质测定方法的改进

药物分析杂志 2024年第2期44卷 351-358页

作者：黄冰娥蔡国伟高琳苏燕琼王健松广州白云山医药集团股份有限公司、白云山制药总厂、广东省化学药原料与制剂关键技术研究重点实验室广州510515

目的:改进头孢克肟颗粒有关物质的液相色谱测定方法。方法:使用高效液相色谱仪,选择YmC-Triart C_(18)色谱柱(250 mm×4.6 mm,5μm),以0.05 mol·L^(-1)甲酸铵溶液(ph 4.7)-甲醇为流动相,流速1 mL·min^(-1),进行梯度洗脱,进样量为10μL... 详细信息

目的:改进头孢克肟颗粒有关物质的液相色谱测定方法。方法:使用高效液相色谱仪,选择YmC-Triart C_(18)色谱柱(250 mm×4.6 mm,5μm),以0.05 mol·L^(-1)甲酸铵溶液(ph 4.7)-甲醇为流动相,流速1 mL·min^(-1),进行梯度洗脱,进样量为10μL,检测波长为254 nm。结果:将该色谱条件应用于头孢克肟颗粒有关物质的检测,对比了本文方法与药典方法(含USP PF 2018版)中有关物质测定方法之间的差异,并完成了专属性、线性、准确度、精密度和耐用性等系统的方法学验证。药典方法均无法同时使主要降解杂质A1~A4或杂质B1~B4基线分离,且无法用于测定聚合物杂质B及聚合物杂质d。本文方法头孢克肟、各特定杂质之间的分离度均符合要求(R≥1.5),可同时检测并定量聚合物B及聚合物d,分离度优于药典方法。结论:本方法改进了头孢克肟、各杂质间的分离度,杂质检出个数更多,能准确定量各特定杂质,灵敏度较高,重复性较好,适用于头孢克肟的质量控制。

关键词：头孢克肟有关物质特定杂质降解杂质聚合物高效液相色谱法分离度基线分离

Efficacy of the herbal pair, Radix Achyranthis Bidentatae and Eucommiae Cortex, in preventing glucocorticoid-induced osteoporosis in the zebrafish m.d.l

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Journal of Integrative m.d.cine 2022年第1期20卷 83-90页

作者： Joon-ho Lee Yuan-ji wei Zhong-yan Zhou Yu-ming Hou Cheng-long Wang Li-bo Wang Hong-jin Wu Yu Zhang wei-wei dai Central Laboratory of Science and Technology department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cardiovascular department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Objective: In traditional Chinese m.d.cine, the herbal pair, Radix Achyranthis Bidentatae(RAB) and Eucommiae Cortex(EC), is widely used to treat osteoporosis. Herein, we determined whether this herbal pair can be used to ameliorate glucocorticoid(GC)-induced osteoporosis(GIOP) and find its optimal dosage in ***: The characteristics of the aqueous extract of RAB and EC were separately characterized using high-performance liquid chromatography. Osteoporosis was induced in 5-day post-fertilization zebrafish larvae by exposing them to 10 lmol/L dexamethasone(dex) for 96 h. Seven combinations of different ratios of RAB and EC were co-administered. Treatment efficacy was determined by calculating zebrafish vertebral area and sum brightness, via alizarin red staining, and by detecting alkaline phosphatase(ALP)activity. multiple regression analysis was conducted to test the optimal dosage ***: According to the Chinese pharmacopoeia(2015), b-ecdysone(b-Ecd) is a major bioactive marker in RAB extract, while pinoresinol diglucoside(PdG) is the major marker in EC extract. Both of b-Ecd and PdG content values aligned with the Chinese pharmacopoeia standards. Treatment with 10 lmol/L dex reduced zebrafish vertebral area, sum brightness, and ALP activity, but RAB and EC attenuated these effects. Combining 50 mg/m L RAB and 50 mg/m L EC was optimal for preventing GIOP in *** transcription-quantitative polymerase chain reaction was used to evaluate the m RNA expression of osteogenesis-related genes. A treatment of 10 lmol/L dex decreased runt-related transcription factor 2(Runx2), osteogenic protein-1(OP-1), bone c-carboxyglutamic acid-containing protein(BGLAP), and bcatenin levels. This effect was counteracted by RAB and EC co-treatment(P dditionally, the effect of using the two herbal extracts together was better than single-herb treatments separately. These results demonstrated that RAB and EC preserve osteoblast function in the pre

关键词： Glucocorticoid Osteoporosis Radix Achyranthis Bidentatae Eucommiae Cortex Zebrafish

Liquefaction of Banana Pseudo-stem and Preparation of Polyurethane Adhesive from Liquefied Products

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Journal of Wuhan University of Technology(materials Science) 2018年第6期33卷 1437-1443页

作者： ZHOU wei ZHANG Yueang College of materials and Chemical Engineering Hainan University

Banana pseudo-stem was liquefied in the mixture of polyhydric alcohols of polyethylene glycol(PEG400) and glycerol. Hydroxyl value of liquefied products ranged from 294.8 to 370.2 mg KOH/g and m_n was about 430. Liquefied products(LBPP) could be used as raw materials for polyurethane by reacting with 4, 4'-diphenylmethane diisocyanate(4, 4'-mdI) and PEG400 to synthesize liquefied product-based polyurethane(LBPP-PU) adhesive. To analyze in depth the creation of urethane linkage among LBPP, PEG400 and 4, 4'-mdI, factors which had effects on the residue content were all investigated. They were characterized by FT-IR and TG. The shear strength of LBPP-PU adhesive was improved when decreasing the percentage of the substitution of PEG400 by LBPP. The adhesive strength was obtained from T-peel of aspen/polyurethane adhesive joints, and the maximum lap shear strength(4.40 mPa) was obtained when 16.70% of LBPP was added to the LBPP & PEG400 system.

关键词： liquefaction banana pseudo-stem polyhydric alcohols polyurethane adhesive

Qualitative and Quantitative Analysis for the Quality Control of Rhizoma Coptidis by HPLC-dAd and HPLC-ESI-mS

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Chemical Research in Chinese Universities 2010年第5期26卷 735-741页

作者： dOU Sheng-shan ZHU Shuang-lai dAI wei-xing ZHANG wei-dong ZHANG Yi LIU Run-hui School of pharmacy Second Military Medical University Shanghai 200433 P. R. China School of pharmacy Shanghai Jiaotong University Shanghai 200240 P. R. China School of pharmacy Jiangxi University of Traditional Chinese Medicine Nanchang 330004 P. R. China School of pharmacy Chengdu University of Traditional Chinese Medicine Chengdu 610075 P. R. China

For quality control purpose, an approach of fingerprinting and simultaneous quantification of five major bioactive constituents of Rhizoma Coptidis was established via a high-performance liquid chromatograph coupled with a photodiode array UV detector（HPLC-dAd） and an electrospray ionization mass spectrometer（HPLC-ESI/mS） The compounds were identified on the basis of the comparison of their mass spectra with literature data and those of standard samples and quantified by the HPLC-dAd method. Baseline separation was achieved on an XTerra C18 column（5 μm, 250 mm×4.6 mm i. d.） with linear gradient elution of formate buffer（consisting of 0.5% formic acid, adjusted to ph=4.5 with ammonia） and acetonitrile（consisting of 0.2% formic acid and 0.2% triethylamine）. The me- thod was validated for linearity（r^2〉0.9995）, repeatability（RSd〈3.1%）, intra- and inter-day precision（RSd〈1.8%） with recovery（99.9%-105.1%）, limits of detection（0.15-0.35 μg/mL）, and limits of quantification（0.53-0.82 μg/mL）. The similarities of 32 batches of Rhizoma Coptidis and their classification according to their manufacturers were based on the retention time and peak areas of the characteristic compounds. The five compounds were selected for quality assessment ofRhizoma coptidis via partial least squares analysis（PLS）.

关键词： Rhizoma Coptidis HPLC-dAd HPLC-mS Partial least squares analysis Quality control

High drug loading and ph-responsive nanom.d.cines driven by dynamic boronate covalent chemistry for potent cancer immunotherapy

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Nano Research 2021年第11期14卷 3913-3920页

作者： wei Jiang Han Zhou Qin Wang Ziqi Chen Wang dong Zixuan Guo Yong Li wei Zhao meixiao Zhan Yucai Wang Ligong Lu Zhuhai Interventional m.d.cal Center Zhuhai Precision Medical CenterZhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai519000China division of molecular m.d.cine Hefei National Laboratory for Physical Sciences at Microscalethe CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Life SciencesUniversity of Science and Technology of ChinaHefei230026China

Tumor cells undergoing immunogenic cell death (ICd) have emerged as an in situ therapeutic vaccine helping to activate a persistent anti-tumor response. Several chemotherapeutic agents have been demonstrated to induce ICd, however accompanied with severe adverse effects in the clinic, weakening its immune responses. Herein, to elicit an intensive ICd while minimizing the systemic toxicity, we introduce a tumor targeting peptide m.d.fied bortezomib (BTZ) loading nanom.d.cine (i-NPBTZ) for the efficient delivery and controlled release of BTZ in tumors. This system is constructed by conjugating BTZ to PEGylated polyphenols via a ph-sensitive covalent boronate-phenol bond that allows them to self-assemble into nanovesicles in neutral condition with high drug loading efficiency. Once accumulated in acidic environment, BTZ-phenolic network is disassembled and thereby accelerates the release of BTZ from nanocarriers. The released BTZ selectively kill tumor cells with a concomitant evocation of tumor-specific cytotoxic T cells by triggering ICd in vivo. This can finally lead to an extended tumor ablation and prevention of distant metastasis in a syngeneic tumor mouse m.d.l, while reducing the systemic toxicity of BTZ. In general, our system offers a novel concept with clinical potential to exploit ICd for potentiating tumor immunotherapy and also provides an excellent example of the application of polymer-drug interaction for efficient drug delivery and controllable release.

关键词： bortezomib boronate-phenolic network ph-responsiveness immunogenic cell death cancer immunotherapy

高压氧治疗对神经病理性疼痛大鼠疼痛行为及脊髓胶质细胞活化的影响

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中华航海医学与高气压医学杂志 2024年第2期31卷 229-232页

作者：王万胜奚海艳李伟冯真真滨州医学院附属医院康复医学科滨州256603 滨州医学院附属医院妇科滨州256603

目的探究高压氧(HBO)治疗对坐骨神经慢性压迫性损伤(CCI)所致神经病理性疼痛大鼠疼痛行为及脊髓胶质细胞活化的影响。方法选取36只成年雄性Sd大鼠,按照随机数字表法分为假手术组(S组)、CCI组和CCI+HBO组,每组12只。CCI+HBO组大鼠于造模... 详细信息

目的探究高压氧(HBO)治疗对坐骨神经慢性压迫性损伤(CCI)所致神经病理性疼痛大鼠疼痛行为及脊髓胶质细胞活化的影响。方法选取36只成年雄性Sd大鼠,按照随机数字表法分为假手术组(S组)、CCI组和CCI+HBO组,每组12只。CCI+HBO组大鼠于造模后第1天开始给予HBO治疗,1 h/d,连续10 d。所有大鼠在造模前1 d及造模后第1、3、7、10天检测机械反射阈值(WmT)和热反射潜伏期(TWL)。第10天HBO治疗结束后,运用免疫荧光技术和RT-qPCR技术检测各组大鼠L4~L5节段脊髓组织胶质纤维酸性蛋白(GFAP)和离子钙结合衔接分子1(Iba-1)的表达水平。结果造模后第10天,与S组比较,CCI组大鼠的mWT明显降低、TWL明显缩短,脊髓GFAP和Iba-1表达水平明显增加(PmWT明显增高、TWL值明显延长,脊髓GFAP和Iba1表达水平明显下降(P<0.05或P<0.01)。结论HBO治疗可减轻CCI大鼠的神经病理性疼痛,可能是通过抑制大鼠脊髓胶质细胞的活化来实现的。

关键词：高压氧神经病理性疼痛小胶质细胞星形胶质细胞

Bi-large Neutrino mixing See-Saw mass matrix with Texture Zeros and Leptogenesis

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Communications in Theoretical physics 2006年第6期45卷 1073-1084页

作者： CHAO wei HE Xiao-Gang LI Xue-Qian department of physics Nankai University Tianjin 300071 China NCTS/TPE Department of Physics National Taiwan University Taipei China

We study constraints on neutrino properties for a class of bi-large mixing See-Saw mass matrices with texture zeros and with the related dirac neutrino mass matrix to be proportional to a diagonal matrix of the form.d.ag （e, 1, 1）. Texture zeros may occur in the light （class a）） or in the heavy （class b）） neutrino mass matrices. Each of these two classes has 5 different forms which can produce non-trivial three generation mixing with at least one texture zero. We tind that two types of texture zero mass matrices in both class a and class b can be consistent with present data on neutrino masses and mixing. None of the neutrinos can have zero masses and the lightest of the light neutrinos has a mass larger than about 0.046 eV for class a and 0.0027 eV for class b. In these m.d.ls although the CK.m CP violating phase vanishes, the non-zero majorana phases can exist and can play an important role in producing the observed baryon asymmetry in our universe through leptogenesis mechanism. The requirement of producing the observed baryon asymmetry can further distinguish different m.d.ls and also restrict the See-Saw scale to be in the range of 10^12- 10^15 GeV. We also discuss RG effects on V^13.

关键词： neutrino neutrino mass matrix neutrino masses and mixing bi-large mixing matrix

Quantum secret sharing between multiparty and multiparty with Bell states and Bell measurements

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Science China(physics,mechanics & Astronomy) 2010年第12期53卷 2238-2244页

作者： SHI RunHua HUANG LiuSheng YANG wei ZHONG Hong National High Performance Computing Center at Hefei Department of Computer Science and TechnologyUniversity of Science and Technology of ChinaHefei230027China School of Computer Science and Technology Anhui UniversityHefei 230039China Suzhou Institute for Advanced Study USTCSuzhou 215123China

We present a quantum secret sharing scheme between multiparty (m members in Group 1) and multiparty (n members in Group 2), and analyze its security. This scheme takes EPR pairs in Bell states as quantum resources. In order to obtain the shared key, all members only need to perform Bell measurements, rather than perform any local unitary operation. The total efficiency in this scheme approaches 100% as the classical information exchanged is not necessary except for the eavesdropping checks.

关键词： quantum information quantum cryptography quantum secret sharing

A water-stable metal-organic framework as a luminescent Fe^(3+) sensor under weak acidic and weak basic conditions

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Science China Chemistry 2017年第12期60卷 1581-1587页

作者： Yali Zhu Xinhui Zhou Liang Li Yujian You wei Huang Key Laboratory for Organic Electronics and Information displays & Institute of Advanced materials Nanjing University of Posts &Telecommunications Key Laboratory of Flexible Electronics & Institute of Advanced materials Jiangsu National Synergetic Innovation Center for Advanced Materials Nanjing Tech University

A three-dimensional （3d） metal-organic framework （mOF） ZnL＇O.5H20＂O.75dmF （H2L=9-（pyridin-4-yl）-9H-carbazole- 3,6-dicarboxylic acid, dmF=N,N-dimethylformam.d.） has been synthesized under solvotherrnal condition. Crystal structure analysis shows that, in ZnL, each dinuclear Zn2（COO）2 unit is doubly-bridged to the other two by the carbazole moieties to form the 1d chains, which are further connected together by pyridine moieties to lead to the 3d framework. ZnL exhibits both high structural stability and good luminescent stability in water with the ph range of 4-10. ZnL displays the luminescent quenching response for Fe3＋ in water with good linear correlation between the quenching efficiency and the concentration with Ksv of 10800 m 1 in the low concentration range of 0-0.1 mm. Interestingly, it is observed that the sensing performance for Fe3＋ is stable in the ph range of 4-9, enabling ZnL to detect Fe3＋ ions in weak acidic and weak basic solutions.

关键词： 9-(pyridin-4-yl)-9H-earbazole-3,6-dicarboxylie acid mOFs water stability Fe3+ sensor ph