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Efficacy and safety of herbal medicines in treating gastric ulcer:A review

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World Journal of Gastroenterology 2014年第45期20卷 17020-17028页

作者： Wei-Ping bi Hui-bin Man Mao-qiang Man Department of Internal Medicine Wendeng Central Hospital Dermatology Service Veterans Affairs Medical Center Department of Dermatology University of California

Gastric ulcer is a common disorder of the digestive *** therapeutic regimens largely rely on Western ***,numerous studies have demonstrated that herbal medicines can effectively treat gastric ulcer in humans and various animal models via divergent *** review updates the efficacy and safety of herbal medicines in treating gastric ulcer,and the mechanisms of their action in humans and animal *** have demonstrated that the efficacy of herbal medicines is comparable or superior to that of drugs such as omeprazole or cimetidine in humans and animal models,and herbal medicines display fewer adverse *** mechanisms by which herbal medicines benefit gastric ulcer include stimulation of mucous cell proliferation,anti-oxidation,and inhibition of gastric acid secretion and H(+)/K(+)-ATPase *** herbal medicines also exhibit antimicrobial *** of herbal medicines could be a valuable alternative to treat gastric ulcer in humans effectively,with few adverse effects.

关键词： Herbal medicines Gastric ulcer Mechanism of action

Structure-Property Relationship Analysis of D-Penicillamine-Derivedβ-Polythioesters with Varied Alkyl Side Groups

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Chinese Journal of Polymer Science 2023年第10期41卷 1555-1562页

作者： Chun-Yan Lyu Wei Xiong Er-qiang Chen hua Lu Beijing National Laboratory for Molecular Sciences Center for Soft Matter Science and EngineeringKey Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

The ring-opening polymerization of heterocyclic monomers and the reversed ring-closing depolymerization of corresponding polymers with neutral thermodynamics are broadly explored to establish a circular economy of next-generation ***(PTEs),analogues of polyesters,are emerging materials for this purpose due to their high refractive index,high crystallinity,dynamic property and *** this work,we synthesize and polymerize a series of D-penicillamine-derivedβ-thiolactones(NRPenTL)with varied side chain alkyl groups,and study the structure-property relationship of the resulting *** obtained PTEs exhibit tunable glass transition temperature in a wide range of 130–50℃,and melting temperature of 90–105℃.In addition,copolymerizations of monomers with different side chains are effective in modulating material *** obtained homo and copolymers can be fully depolymerized to recycle *** work provides a robust molecular platform and detailed structure-property relationship of PTEs with potential of achieving sustainable plastics.

关键词： β-Polythioesters Geminal dimethyl Structure-property relationship Chemical recycling to monomers

Recent progress on multifunctional electromagnetic interference shielding polymer composites

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Journal of Materials Science & Technology 2023年第3期134卷 106-131页

作者： Ke Tian Danrong Hu Quan Wei qiang Fu hua Deng College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Rehabilitation Medicine Center and Institute of Rehabilitation Medicine Key Laboratory of Rehabilitation Medicine in Sichuan ProvinceWest China HospitalSichuan UniversityChengdu 610041China

The explosive development of electronic devices and wireless communication technology gives rise to the issue of electromagnetic pollution,known as electromagnetic interference(EMI).The accumulation of undesirable electromagnetic radiation in space disturbs the normal function of unshielded electronic appliances and poses seriously threat to human ***,the development of EMI shielding materials have emerged to solve the grim *** the complex application contexts,EMI shielding materials have evolved from traditional single-function to multi-functions to meet the ever-increasing application requirements in recent few *** paper provides detailed insight into the current re-search status and future challenges in the advancement of polymer-based EMI shielding materials with various ***,the basic theory of EMI shielding,factors influencing results and the dominating characterization technologies for EMI shielding properties are ***,the comprehensive descriptions of the seven types of multifunctional EMI shields are provided with respect to their structures,fabrication methods and specific ***,the corresponding critical scientific and technical issues are *** on our comprehensive analysis,the main challenges in the development of multifunctional EMI shielding materials are *** review aims to provide some guidance and inspire more efforts toward functional EMI shielding material research to satisfy the growing requirements for next-generation electronic systems.

关键词： Polymer-based composites Electromagnetic interference shielding Multiple losses Multifunctionality

A Pixel–Channel Hybrid Attention Model for Image Processing

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Tsinghua Science and Technology 2022年第5期27卷 804-816页

作者： qiang hua Liyou Chen Pan Li Shipeng Zhao Yan Li College of Mathematics and Information Science Hebei UniversityBaoding 071002China Research Center for Applied Mathematics and Interdisciplinary Sciences Beijing Normal UniversityZhuhai 519087China

In the field of image processing,better results can often be achieved through the deepening of neural network layers involving considerably more *** image classification,improving classification accuracy without introducing too many parameters remains a *** for image conversion,the use of the conversion model of the generative adversarial network often produces semantic artifacts,resulting in images with lower ***,to address the above problems,a new type of attention module is proposed in this paper for the first *** proposed approach uses the pixel-channel hybrid attention(PCHA) mechanism,which combines the attention information of the pixel and channel *** comparative results of using different attention modules on multiple-image data verify the superiority of the PCHA module in performing classification *** image conversion,we propose a skip structure(S-PCHA model) in the up-and down-sampling processes based on the PCHA *** proposed model can help the algorithm identify the most distinctive semantic object in a given image,as this structure effectively realizes the intercommunication of encoder and decoder ***,the results showed that the attention model could establish a more realistic mapping from the source domain to the target domain in the image conversion algorithm,thus improving the quality of the image generated by the conversion model.

关键词： deep learning attention mechanism image classification image processing convolutional neural networks

Protective effects of huanglian Wendan Decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus

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Chinese Journal of Natural Medicines 2016年第11期14卷 813-822页

作者： LI Yue-bi ZHANG Wei-hua LIU hua-Dong LIU Zhou MA Shi-Ping Department of Pharmacology of Chinese Materia Medica China Pharmaceutical University Department of Basic Medical Sciences Nanjing University of Traditional Chinese Medicine

huanglian Wendan decoction(HLWDD) has been used for the treatment of symptom of "Re", one of major causes in diabetes and metabolic disorders, according to the theory of traditional Chinese medicine. The present study aimed at investigating the cerebral protective effects of HLWDD on diabetic encephalopathy(DE), one of the major diabetic complications. The effects of HLWDD and metformin were analyzed in the streptozocin(STZ) + high-glucose-fat(HGF) diet-induced DE rats by gastric intubation. In the present study, the effects of HLWDD on cognition deficits were investigated after 30-day intervention at two daily dose levels(3 and 6 g·kg^(-1)). To explore the potential mechanisms underlying the effects of HLWDD, we detected the alterations of neuronal damages, inflammatory cytokines, and impaired insulin signaling pathway in hippocampus of the DE rats. Based on our results from the present study, we concluded that the protective effects of HLWDD against the cognitive deficits and neuronal damages through inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus of the DE rats.

关键词： Diabetic encephalopathy Insulin signaling pathway Cognition huanglian Wendan decoction

Removal of sulfamethoxazole by nanofiltration membrane

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第11期11卷 868-878页

作者： Su-hua WU hua-qiang CHU bing-zhi DONG Jun-ru ZHOU Yu huaNG School of Environmental Science and Engineering Tongji University Shanghai 200092 China Shanghai Purge Filtration Technology Co. Ltd Shanghai 200444 China

The retention of sulfamethoxazole (SMZ) by nanofiltration (NF) membranes is strongly influenced by the pH value of the solution. The retention of SMZ reaches its peak value when the solution pH rises above its pKa2 value as the compound transforms into a negatively charged species. Charge repulsion is the main mechanism involved in SMZ removal by NF membranes. In this study, the removal of SMZ by NF membranes, as a function of solution chemistry, was examined at pH 8.9 to investigate the effect of solution conditions on charge repulsion. The results show that the retention of negatively charged SMZ is relatively independent of SMZ concentration, and an increase in the ionic strength of the solution causes a relatively small reduction in retention. A small effect of humic acid (HA) on SMZ retention was noticed at pH 8.9, which can be explained by a small but insignificant improvement in the zeta potential of the membrane caused by HA at high pH values. However, it was found that SMZ concentration in the feed decreased significantly in solutions containing tannic acid (TA). The Adams-Bohart model was applied to our experimental data and was found to be suitable for describing the initial part of the breakthrough curves. The adsorptive parameters of the membrane were determined.

关键词： Pharmaceutically active compounds (PhACs) Nanofiltration (NF) membrane Electronic exclusion Adsorption Sulfamethoxazole (SMZ)

Unusual softening behavior of yield strength in niobium at high pressures

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Chinese Physics B 2018年第10期27卷 501-507页

作者： Qiu-Min Jing qiang He Yi Zhang Shou-Rui Li Lei Liu Qi-Yue Hou hua-Yun Geng Yan bi Yu-Ying Yu qiang Wu National Key Laboratory of Shock Wave and Detonation Physics Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China

In situ synchrotron angle-dispersive x-ray diffraction experiments on niobium powders have been conducted at pressures up to 61 GPa and room temperature using the diamond anvil cell technique. From the full width at half maximum of the measured diffraction lines, the yield strength was derived with the line-width analysis theory. The niobium powder sample was found to be compressed more packed firstly and then yielded at~14 GPa–18 GPa. Following an initial increase in the yield strength with pressure, an obvious decrease was observed occurring at ~42 GPa–47 GPa accompanying with a typical pressure dependence above 47 GPa. The experimentally observed anomalous softening of the yield strength in niobium surprisingly follows the trend of the predicted unusual softening in the shear modulus by the recent theoretical investigations. The possible mechanisms, applicable to interpret the yield strength softening of materials at high pressure,were also discussed in detail.

关键词： x-ray diffraction niobium diamond anvil cell yield strength anomalous softening

Trends and hotspots in gastrointestinal neoplasms risk assessment: A bibliometric analysis from 1984 to 2022

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2842-2861页

作者： qiang-qiang Fu Le Ma Xiao-Min Niu hua-Xin Zhao Xu-hua Ge hua Jin De-hua Yu Sen Yang Department of General Practice Yangpu HospitalSchool of MedicineTongji UniversityShanghai 200090China Shanghai General Practice and Community Health Development Research Center Shanghai 200090China Department of Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Oncology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200090China

BACKGROUND Gastrointestinal neoplasm(GN)significantly impact the global cancer burden and mortality,necessitating early detection and *** the evolution and current state of research in this field is *** To conducts a comprehensive bibliometric analysis of publications from 1984 to 2022 to elucidate the trends and hotspots in the GN risk assessment research,focusing on key contributors,institutions,and thematic *** This study conducted a bibliometric analysis of data from the Web of Science Core Collection database using the"bibliometrix"R package,VOSviewer,and *** analysis focused on the distribution of publications,contributions by institutions and countries,and trends in *** methods included data synthesis,network analysis,and visualization of international collaboration *** This analysis of 1371 articles on GN risk assessment revealed a notable evolution in terms of research focus and *** highlights the United States'critical role in advancing this field,with significant contributions from institutions such as Brigham and Women's Hospital and the National Cancer *** last five years,substantial advancements have been made,representing nearly 45%of the examined *** rates have dramatically increased,from 20 articles in 2002 to 112 in 2022,reflecting intensified research *** study underscores a growing trend toward interdisciplinary and international collaboration,with the Journal of Clinical Oncology standing out as a key publication *** shift toward more comprehensive and collaborative research methods marks a significant step in addressing GN *** This study underscores advancements in GN risk assessment through genetic analyses and machine learning and reveals significant geographical disparities in research *** calls for enhanced global collaboration and integration of artificial intelligence to improve cancer p

关键词： Gastrointestinal neoplasms bibliometric analysis Risk assessment Network analysis Research trends

Recent advances in asymmetric synthesis of 2-substituted indoline derivatives

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Chinese Chemical Letters 2020年第2期31卷 311-323页

作者： Ting-bi hua Cong Xiao Qing-Qing Yang Jia-Rong Chen College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China CCNU-uOttawa Joint Research Centre Key Laboratory of Pesticides&Chemical Biology Ministry of Education.College of ChemistryCentral China Normal UniversityWuhan 430079China

Enantiomerically pure 2-substituted indolines are an important class of nitrogen heterocycles that occur frequently in many alkaloid natural products and biologically active ***,the synthesis of such skeletons is of great *** past years have witnessed a number of remarkable advances in the development of efficient strategies to construct this class of chiral *** review summarizes the recent advances in asymmetric synthesis of 2-substituted indoline *** to the limitation of the length,this review only summarizes those works published from January of 2012 to January of ***,methods towards synthesis of fu sed and spirocyclic indolines will not be discussed in this review.

关键词： Indolines Asymmetric synthesis Enantioselectivity Nitrogen heterocycles Synthetic methods