Protective effects of Huanglian Wendan Decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus

作     者：LI Yue-Bi ZHANG Wei-Hua LIU Hua-Dong LIU Zhou MA Shi-Ping 

作者机构：Department of Pharmacology of Chinese Materia Medica China Pharmaceutical University Department of Basic Medical Sciences Nanjing University of Traditional Chinese Medicine 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2016年第14卷第11期

页      面：813-822页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 100706[医学-药理学] 1002[医学-临床医学] 0703[理学-化学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the Specialized Research Fund for the Doctoral Program of Higher Education(No.20113237120007) the Project supported by Jiangsu Province Traditional Chinese Medicine Administration of Science and Technology(No.LZ13001) the Project supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions(No.12KJD360002) 

主　　题：Diabetic encephalopathy Insulin signaling pathway Cognition Huanglian Wendan decoction 

摘      要：Huanglian Wendan decoction(HLWDD) has been used for the treatment of symptom of Re, one of major causes in diabetes and metabolic disorders, according to the theory of traditional Chinese medicine. The present study aimed at investigating the cerebral protective effects of HLWDD on diabetic encephalopathy(DE), one of the major diabetic complications. The effects of HLWDD and metformin were analyzed in the streptozocin(STZ) + high-glucose-fat(HGF) diet-induced DE rats by gastric intubation. In the present study, the effects of HLWDD on cognition deficits were investigated after 30-day intervention at two daily dose levels(3 and 6 g·kg^(-1)). To explore the potential mechanisms underlying the effects of HLWDD, we detected the alterations of neuronal damages, inflammatory cytokines, and impaired insulin signaling pathway in hippocampus of the DE rats. Based on our results from the present study, we concluded that the protective effects of HLWDD against the cognitive deficits and neuronal damages through inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus of the DE rats.