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Application of inverse method to estimation of boundary conditions during investment casting simulation

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Acta Metallurgica Sinica(English Letters) 2009年第6期22卷 429-434页

作者： Haipeng JIN Jiarong LI dong pan National Key Laboratory of Advanced High Temperature Structural Materials Institute of AeronauticalMaterials Beijing 100095 China Key Lab for Advanced Materials Processing Technology MOE Department of Mechanical EngineeringTsinghua University Beijing 100084 China

Inverse method was used in single crystal superalloy DD6 processing simulation during solidification. Numerical modeling coupled with experiments has been used to estimate the interface heat transfer coefficient （IHTC） between the surface of slab casting and inner mold. Calculated temperature dependent values of IHTC were obtained from a numerical solution. The calculated temperatures agreed well with the measurement of cooling profile.

关键词： Numerical simulation Single crystal Inverse method Boundary conditions

Screening for metabolic dysfunction-associated fatty liver disease:Time to discard the emperor’s clothes of normal liver enzymes?

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World Journal of Gastroenterology 2024年第22期30卷 2839-2842页

作者： Chen-Xiao huang Xiao-dong Zhou Calvin Q pan Ming-hua Zheng Metabolic Dysfunction-Associated Fatty Liver Disease Research Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Cardiovascular Medicine The Key Laboratory of Cardiovascular Diseases of WenzhouThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Division of Gastroenterology and Hepatology Department of MedicineNew York University Langone HealthNew York University Grossman School of MedicineNew YorkNY 11355United States Institute of Hepatology Wenzhou Medical UniversityKey Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang ProvinceWenzhou 325000Zhejiang ProvinceChina

Metabolic dysfunction-associated fatty liver disease(MAFLD)is the most prevalent chronic liver condition *** liver enzyme-based screening methods have limitations that may missed diagnoses and treatment *** Chen et al,the risk of developing MAFLD remains elevated even when alanine aminotransferase levels fall within the normal ***,there is an urgent need for advanced diagnostic techniques and updated algorithms to enhance the accuracy of MAFLD diagnosis and enable early *** paper proposes two potential screening methods for identifying individuals who may be at risk of developing MAFLD:Lowering these thresholds and promoting the use of noninvasive liver fibrosis scores.

关键词： Metabolic dysfunction-associated fatty liver disease Non-alcoholic fatty liver disease Alanine aminotransferase Liver enzymes Screening Noninvasive liver fibrosis scores

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao pan Chenzhe Ma Bin Qi Qingqiang Min Ming Li huabing Chen Hengte Ke Xingyue Ji Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： Zhen-Nan pan Hao-Lin Zhang Kun-huan Zhang Jia-Qian Ju Jing-Cai Liu Shao-Chen Sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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Design high-performance narrowband emitters for blue light-emitting diodes through manipulating resonance structure of aromatic heterocycles

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Science China Chemistry 2025年

作者： Yue Yu Lei Xu Wenle Tan Yuyu pan Jiyin Xiao Bohan Wang Guangjun Tian Yuguang Ma Lei Ying Institute of Polymer Optoelectronic Materials and Devices Guangdong Basic Research Center of Excellence for Energy and Information Polymer Materials State Key Laboratory of Luminescent Materials and Devices South China University of Technology School of Petrochemical Engineering Shenyang University of Technology Key Laboratory for Microstructural Material Physics of Hebei Province School of Science Yanshan University

Narrowband light-emitting materials play critical roles in improving the color gamut and energy consumption of electroluminescence. Herein we demonstrated that by regulating the ground state resonance structure form of emitters with polycyclic aromatic heterocycles, the high-energy vibration of the C–C bond can be effectively suppressed, resulting in narrow emission like classical cyanine dyes. The designed compounds consist of twist and planar conformation, while having differences in the orientation of the positioning electron-donating(nitrogen) and electron-accepting(carbonyl) groups in the polycyclic aromatic hydrocarbon skeleton. The resulting compound Ac-Ph-Ac with a dominated zwitterionic resonance structure exhibits a relatively wide electroluminescent profile with the full width at half maximum(FWHM) of 42 nm and moderate device performance. In contrast, the “soliton transition” of 2AcPh based on the cyanine limit character effectively suppresses C–C stretching vibration in the polycyclic aromatic heterocycle skeleton, leading to a narrow electroluminescent profile with FWHM of 30 nm(0.16 eV)associated with an impressively high external quantum efficiency of 28.52%, which is among the highest efficiencies of so far reported non-sensitized organic light-emitting diodes.

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A Comparative Study of CNN-and Transformer-Based Visual Style Transfer

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Journal of Computer Science & Technology 2022年第3期37卷 601-614页

作者： hua-Peng Wei Ying-Ying Deng Fan Tang Xing-Jia pan Wei-Ming dong School of Artificial Intelligence Jilin UniversityChangchun 130012China National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China Youtu Laboratory Tencent IncorporatedShanghai 200233China

Vision Transformer has shown impressive performance on the image classification *** that most existing visual style transfer(VST)algorithms are based on the texture-biased convolution neural network(CNN),here raises the question of whether the shape-biased Vision Transformer can perform style transfer as *** this work,we focus on comparing and analyzing the shape bias between CNN-and transformer-based models from the view of VST *** comprehensive comparisons,we propose three kinds of transformer-based visual style transfer(Tr-VST)methods(Tr-NST for optimization-based VST,Tr-WCT for reconstruction-based VST and Tr-AdaIN for perceptual-based VST).By engaging three mainstream VST methods in the transformer pipeline,we show that transformer-based models pre-trained on ImageNet are not proper for style transfer *** to the strong shape bias of the transformer-based models,these Tr-VST methods cannot render style *** further analyze the shape bias by considering the influence of the learned parameters and the structure *** prove that with proper style supervision,the transformer can learn similar texture-biased features as CNN *** the reduced shape bias in the transformer encoder,Tr-VST methods can generate higher-quality results compared with state-of-the-art VST methods.

关键词： transformer convolution neural network visual style transfer comparative study

Taxonomy notes on Vandeae(Orchidaceae)from China:Five new species and two new records

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Plant Diversity 2021年第5期43卷 379-389页

作者： Jian-Wu Li Ji-dong Ya De-Ping Ye Cheng Liu Qiang Liu Rui pan Zai-Xing He Bo pan Jie Cai dong-Liang Lin Xiao-hua Jin Herbarium(HITBC) Center for Integrative ConservationXishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMengla YunnanCN-666303PR China Core Batanical Gardens Chinese Academy of SciencesMenglunMengla YunnanCN-666303PR China Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesLanhei Road 132HeilongtanKunmingYunnanCN-650201PR China Pu'er Forestry and Grassland Bureau Pu'erYunnanCN-665000PR China Yunnan Forestry Technological College Jindian RoadPanlong DistrictKunmingYunnan CN-650000PR China Ning'er Forestry and Grassland Bureau Ning'erYunnanCN-665100PR China Xishuangbanna State Nature Reserve YiwuMenglaYunnanCN-666306PR China National Herbarium(PE)and State Key Lab of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesNanxincun 20XiangshanBeijing CN-100093PR China

Five new species(Gastrochilus yei,Gastrochilus minimus,Luisia simaoensis,Taeniophyllum xizangense,Tuberolabium subulatum)and two newly recorded species(Cleisostoma tricornutum,Luisia inconspicua)of Vandeae(Orchidaceae)from China are described and *** yei is similar to *** and ***,but differs from them by having an epichile not lobed,the apex of the hypochile not bilobed,and a tine on the apex of the *** minimus is similar to ***,but can be distinguished from the latter by having a flabellate epichile that is densely hirsute on the adaxial surface and an inconspicuous central cushion;in addition,the hypochile of *** has a keel that extends to the apex of the *** xizangense is similar to *** and ***,but it is distinguished from them by having much bigger flowers,inflorescences densely covered with short-bristly hairs,papillae on the external surface of sepals,and bigger triangular-ovate *** simaoensis is similar to L magniflora and L ramosii,but can be easily distinguished from them by having lateral sepals longer than dorsal sepals and petals,lip with irregular and waved margins,and lip with bilobed *** inconspicua is moved from Gastrochilus to Luisia based on phylogenetic analyses of plastid matK sequence *** subulatum is similar to ***,but it can be easily distinguished from the latter by having an inflorescence much shorter than the leaves,yellow sepals and petals,and many small papillae outside the lip lobes.

关键词： New species New records Orchidaceae Vandeae China

Behavior of large post-liquefaction deformation in saturated Nanjing fine sand

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Earthquake Engineering and Engineering Vibration 2011年第2期10卷 187-193页

作者： pan hua Chen Guoxing Liu Hanlong Wang Binghui Institute of Geotechnical Engineering Nanjing University of Technology Nanjing 210009 China Geotechnical Research Institute Hohai University Nanjing 210098 China

Laboratory tests on the large post-liquefaction deformation of saturated Nanjing fine sand were performed by using a hollow cylinder apparatus. The stress-strain responses and the characteristics of excess pore water pressure after liquefaction were studied. It was found that the relationship between deviatoric stress and axial strain presented a sigmoid curve, and there was a good linearity relationship between normalized pore water pressure and deviatoric stress. On this basis, a constitutive model of stress-strain responses and a dissipation model of excess pore water pressure were established. It was found that the results predicted by the two models were in good agreement with the experimental data. The influence of relative densities and confining pressure on the characteristics of liquefied soil were studied, The results showed the relative densities and initial effective confining pressure all had an important influence on the stress-strain responses of liquefied saturated Nanjing fine sand. However, the dissipation model of excess pore water pressure after liquefaction was only affected by the confining pressure.

关键词： saturated Nanjing fine sand large post-liquefaction deformation constitutive model dissipation model of excess pore water pressure