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PROTECTION OF CARBON MONOXIDE INHALATION ON LIPOPOLY-SACCHARIDE-INDUCED MULTIPLE ORGAN INJURY IN RATS

Chinese Medical Sciences Journal 2007年第3期22卷 169-176页

作者： Shao-hua Liu Xin-rong xu Ke Ma Bing xu Intensive Care Unit the First Affiliated Hospital of Nanjing Medicial University Nanjing 210029

Objective To observe the protection of carbon monoxide （CO） inhalation on lipopolysaccharide （LPS）-induced rat multiple organ injury. Methods Sprague-Dawley rats with multiple organ injury induced by 5 mg/kg LPS intravenous injection were exposed to room air or 2.5 × 10 ^-4 （V/V） CO for 3 hours. The lung and intestine tissues of rats were harvested to measure the expression of heme oxygenase-1 （ HO-1 ） with reverse transcription-polymerase chain reaction, the levels of pulmonary tumor necrosis factor-or （ TNF-α）, interleukin-6 （ IL-6）, and intestinal platelet activator factor （ PAF）, intercellular adhesion molecule-1 （ICAM-1） with enzyme-linked immunosorbent assay, the content of maleic dialdehyde （MDA） and the activity of myeloperoxidase （MPO） with chemical method, the cell apoptosis rate with flow cytometry, and the pathological changes with light microscope. Results CO inhalation obviously up-regulated the expression of HO-1 in lung （5.43 ± 0. 92） and intestine （6. 29 ± 1.56） in LPS ＋ CO group compared with （ 3.08 ± 0. 82） and （ 3.97 ± 1.16 ） in LPS group （ both P 〈 0. 05 ）. The levels of TNF-ot, IL-6 in lung and PAF, ICAM-1 in intestine ofLPS ＋ CO group were 0. 91 ±0. 25,0. 64 ±0.05, 1. 19 ± 0. 52, and 1.83 ±0. 35 pg/mg, respectively, significantly lower than the corresponding values in LPS group （ 1.48 ± 0. 23, 1.16 ± 0. 26, 1.84 ± 0. 73, and 3.48 ± 0. 36 pg/mg, all P 〈 0. 05 ）. The levels of MDA, MPO, and cell apoptosis rate in lung and intestine of LPS ＋ CO group were 1.02 ± 0. 23 nmol/mg, 1.74 ± 0. 17 nmol/mg, 7.18 ± 1.62 U/mg, 6. 30 ±0. 97 U/mg, 1.60% ±0. 34%, and 30. 56% ±6. 33%, respectively, significantly lower than the corresponding values in LPS group （ 1.27 ± 0. 33 nmol/mg, 2. 75 ± 0. 39 nmol/mg, 8. 16 ± 1.49 U/mg, 7. 72 ± 1.07 U/mg, 3.18% ±0. 51%, and 41.52% -＋3.36%, all P 〈0.05）. In addition, injury of lung and intestine induced by LPS was attenuated at presence of CO inhalation. Conclusion CO inhalation protects rat lung and intestine from LP

关键词： carbon monoxide lung intestine multiple organ injury

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Physiognomy： Personality Traits Prediction by Learning

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International Journal of Automation and computing 2017年第4期14卷 386-395页

作者： Ting Zhang Ri-Zhen Qin Qiu-Lei Dong Wei Gao hua-rong xu Zhan-Yi Hu National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing 100190 China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Beijing 100190 Chins University of Chinese Academy of Sciences Beijing 100049 China Department of Computer Science &: Technology Xiamen Institute of Technology Xiamen 361024 China

Evaluating individuals＇ personality traits and intelligence from their faces plays a crucial role in interpersonal relationship and important social events such as elections and court sentences. To assess the possible correlations between personality traits （also measured intelligence） and face images, we first construct a dataset consisting of face photographs, personality measurements, and intelligence measurements. Then, we build an end-to-end convolutional neural network for prediction of personality traits and intelligence to investigate whether self-reported personality traits and intelligence can be predicted reliably from a face image. To our knowledge, it is the first work where deep learning is applied to this problem. Experimental results show the following three points： 1）＂Rule-consciousness＂ and ＂Tension＂ can be reliably predicted from face images. 2） It is difficult, if not impossible, to predict intelligence from face images, a finding in accord with previous studies. 3） Convolutional neural network （CNN） features outperform traditional handcrafted features in predicting traits.

关键词： Personality traits physiognomy face image deep learning convolutional neural network (CNN).

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Leaf Turgor Potential, Plant Growth and Photosynthesis in Organically Fertilized Sweet Corn

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Pedosphere 2004年第2期14卷 165-170页

作者： xuHui-Liant WANGXiao-Ju WANGJi-hua xurong-Ya ZHAOAi-hua InternationalNatureFarmingResearchCenter HataNagano390-1401（Japan）.E-mail：huilian@janis.or.jp SaitamaCenterofEnvironmentalSciences Saitama347-0115（Japan） BeijingAcademyofAgricultureandForestrySciences Beijing100081（China）

A greenhouse pot experiment was conducted using a complete random design with six replications. A pressure-volume curve analysis was employed to study the effects of organic fertilizers on plant water relations in sweet corn (Zea mays L. cv. Honey-bantam) in terms of leaf osmotic concentration (Cs), osmotic potentials at full turgid status (πFT) and at incipient plasmolysis (πIP), and of symplastic (ζsym) and apoplastic (ζapo) fractions in the tissue water compartment in relation to photosynthetic capacity (Pc) and dry mass accumulation. At the seedling stage (day 15), plants with chemical fertilizer treatments showed lower πFT, πIP and ζapo and higher Cs, ζsym and PC than those with organic fertilizer treatments. Compared to PC and relative growth, where values from day 15 to day 75 were first lower for organic treatments and then higher, ζsym and Cs values were similar, while πFT and πIP were opposite being higher then lower. Dry mass production with organic fertilizer was higher than or close to the chemical fertilizer treatments in the later growth stage (day 75), though dry mass production with chemical fertilizers was much higher in the early and middle growing stages (days 15 and 45). Increased photosynthesis and dry mass production in later growth stages due to organic fertilizers were associated with increased osmotic concentration in the tissue and the symplastic fraction of the tissue water compartment. These might favor stomatal opening and biochemical activities.

关键词： leaf photosynthesis osmotic potential sweet corn (Zea mays L.) turgor potential water potential

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Melanoma differentiation-associated gene-7, MDA-7/IL-24, selectively induces growth suppression, apoptosis in human hepatocellular carcinoma cell line HepG2 by replication-incompetent adenovirus vector

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World Journal of Gastroenterology 2006年第11期12卷 1774-1779页

作者： Cong-Jun Wang Xin-Bo xue Ji-Lin Yi Kun Chen Jian-WeiZheng Jian Wang Jian-Ping Zeng rong-hua xu Department of Biliary and Pancreatic Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM： To investigate the effect of replication-incompetent adenovirus vector expressing MDA-7/IL-24 on tumor growth and apoptosis in human hepatocellular carcinoma （HCC） cell line HepG2 and normal liver cell line L02. METHODS： We constructed the recombinant replication-incornpetent ***-7 virus vector and infected it into the human HCC cell line HepG2 and normal liver cell line L02. RT-PCR was performed to detect the rnRNA expressing in cells, by ELISA was used to detect MDA-7/IL-24 protein expression in the culture supernatant. The effect of apoptosis induced by ***-7 was confirmed by Hoechst staining and flow cytometry assay with Annexin-V and PI staining. MTT assay was used to determine growth inhibition of HepG2 cells, and cell-cycle and hypodiploidy analyses were performed by flow cytometry. RESULTS： Recombinant replication-defective virus expressing MDA-7/IL-24 was constructed successfully. RTPCR showed that the ***-7 could mediate the expression of the exogenous gene MDA-7/IL-24 into HepG2 and L02. The concentration of MDA-7/IL-24 protein in supernatant was 130 pg/mL and 110 pg/mL in ***-7-infected L02 and HepG2 ceils, respectively. ***-7 infection obviously induced apoptosis （from 2.604±0.72% to 33.64±13.2%, P=0.00012） and growth suppression in HepG2 （inhibition ratio IR=68%） and an increase in the percentage of specific cancer cell types at the G2/M phase of the cell cycle （from 6.44% to 32.29%, P〈 0.01）, but not in L02 ***： These results confirm selectively induction of apoptosis and growth suppression by the mda-7/ IL-24 gene with replication-incompetent adenovirus vector in human hepatocellular carcinoma cell line HepG2.

关键词： Cancer gene therapy Hepatocellular carcinoma (HCC) Apoptosis Growth suppression MDA-7/IL-24

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Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges

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Nano-Micro Letters 2025年第3期17卷 168-216页

作者： Shuai Zhong Lirou Su Mingkun xu Desmond Loke Bin Yu Yishu Zhang rong Zhao Guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China College of Integrated Circuits Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Precision Instruments Tsinghua UniversityBeijing 100084People’s Republic of China Center for Brain‑Inspired Computing Research Tsinghua UniversityBeijing 100084People’s Republic of China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power *** fully leverage its advantages,convertingthe external analog signals to spikes is an essential *** including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area *** efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory *** can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory *** review summarizesand benchmarks the recent progress of artificial sensory *** starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial ***,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also ***,we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

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董事会特征与内部控制目标的实现——来自中国上市公司的经验证据

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财经理论与实践 2012年第5期33卷 64-68,119页

作者：宋文阁荣华旭南京财经大学会计学院江苏南京210046

以2009～2011年中国A股上市公司为研究样本,实证研究了董事会特征与内部控制各目标之间的关系。研究发现,董事会特征与财务报告可靠性、经营效率效果以及法律遵循性之间的相关关系与假设并不完全契合。独立董事比例和审计委员会的设置... 详细信息

以2009～2011年中国A股上市公司为研究样本,实证研究了董事会特征与内部控制各目标之间的关系。研究发现,董事会特征与财务报告可靠性、经营效率效果以及法律遵循性之间的相关关系与假设并不完全契合。独立董事比例和审计委员会的设置与内部控制目标的实现显著正相关,在各指标间无差异。董事会会议频率对内部控制目标的实现作用不显著。董事长与CEO两职合一一定程度上能够提高企业的经营效益,但与财务报告可靠性、法律法规遵循性却呈负相关关系。

关键词：董事会特征内部控制独立董事

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Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai xu Zhen Gu hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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股权激励、制度环境与盈余管理——基于上市公司数据的实证分析

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经济经纬 2012年第3期29卷 90-94页

作者：宋文阁荣华旭南京财经大学会计学院江苏南京210046 享通集团江苏苏州215234

笔者以沪深交易所2006年～2008年所有实施股权激励的A股上市公司数据为样本,实证研究了股权激励与盈余管理之间的关系,研究发现股权激励数量与盈余管理程度显著正相关,行权限制期与盈余管理程度显著负相关。国有上市公司股权激励的盈余... 详细信息

笔者以沪深交易所2006年～2008年所有实施股权激励的A股上市公司数据为样本,实证研究了股权激励与盈余管理之间的关系,研究发现股权激励数量与盈余管理程度显著正相关,行权限制期与盈余管理程度显著负相关。国有上市公司股权激励的盈余管理效应比非国有上市公司明显,市场化程度高的地区上市公司股权激励的盈余管理效应较之于市场化程度低的地区要弱一些。此外,高质量的外部审计可以有效地抑制企业的盈余管理程度。

关键词：股权激励制度环境盈余管理

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Effect of fragile histidine triad gene transduction on proliferation and apoptosis of human hepatocellular carcinoma cells

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World Journal of Gastroenterology 2008年第23期14卷 3754-3758页

作者： rong-hua xu Liang-Yan Zheng Dong-Lei He Jian Tong Li-Ping Zheng Wu-Ping Zheng Jin Meng Li-Ping Xia Cong-Jun Wang Ji-Lin Yi The Affiliated Hospital of Hainan Medical College Haikou 570102 Hainan Province China Department of General Surgery First People's Hospital Affiliated to Shanghai Jiaotong University Shanghai 200080 China Department of General surgery Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM:To evaluate the inhibitory effects of human fragile histidine triad(FHIT) gene on cell proliferation and apoptosis in human hepatocellular carcinoma line Hep3B in vitro. METHODS:A recombinant pcDNA3.1(+) /FHIT including the functional region of FHIT gene was constructed and transferred into human hepatocellular carcinoma cells in vitro. mRNA and protein expression of the FHIT gene in the transfected cells was detected by RT-PCR and Western blot,respectively. The effect of FHIT on proliferation was detected by MTT assay. Changes in cell cycle and apoptosis were assayed by flow cytometry. Five mice received subcutaneous transplantation of Hep3B-FHIT;5 mice received subcutaneous transplantation of normal Hep3B and Hep3B-C as controls. The body weight of nude mice and tumor growth were measured. RESULTS:RT-PCR and Western blot analysis showed that the expression level of FHIT-mRNA and FHIT protein was higher in Hep3B cells after infection withpcDNA3.1(+) /FHIT. The growth of Hep3B cells treated with pcDNA3.1(+) /FHIT was significantly inhibited. The pcDNA3.1(+) /FHIT-transfected Hep3B cells showed a significantly higher cell rate at G0-G1 phase and increased apoptosis in comparison with controls(P < 0.05) . The growth of transplanted tumor was inhibited markedly by FHIT. Tumors arising from the Hep3B-FHIT cells occurred much later than those arising from the Hep3B and Hep3B-C cells. The growth of Hep3B-FHIT cells was slow and the tumor volume was low. CONCLUSION:Transduction of FHIT gene inhibits the growth of human hepatocellular carcinoma cells and induces cell apoptosis in vivo and in vitro.

关键词： Hepatocellular carcinoma Gene therapy Fragile histidine triad gene

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Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin Xing xuyun hua Yuwen Zhang Xin xue Jiajia Wu Mouxiong Zheng He Wang Jianguang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

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