检索结果-南通市图书馆

Underground Space 2019年第4期4卷 340-347页

作者： Pei-Chen wu Jian-hua Yin Wei-qiang Feng Wen-Bo Chen Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina

Geosynthetics and deep cement mixed(DCM)soil columns have been widely used to improve soft soil grounds in many countries and *** paper presents an experimental study on a geosynthetic-reinforced sand fill over marine clay with or without DCM columns under different *** tests were conducted on the sand fill reinforced with fixed-end and free-end geosynthetics over marine clay under three-stage local loading to investigate the effects of the boundary conditions of geosynthetic reinforcement on reducing *** is observed that the fixed-end geosynthetic sheet is more effective in reducing settlements than the free-end condition under identical local *** test was conducted on the fixed-end geosynthetic-reinforced sand fill over the marine clay improved by DCM columns under single-stage uniform *** vertical stresses on the marine clay and on the DCM columns,as well as the tensile strains of the geosynthetic sheet in the overlying sand fill,were *** results revealed that the stress concentration ratio increases with an increase in consolidation settlements,and the maximum tensile strain of the geosynthetic sheet occurs near the edge rather than at the center of the top surface of the DCM columns.

关键词： Settlement Geosynthetic Reinforcement Deep cement mixed soil columns

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin wu Xiaowu Lin Yiming Qian Jiashu Lian Xin hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

数字赋能乡村教育现代化的实然困境与优化路径

在线全文

学校读者我要写书评

暂无评论

教学与管理 2025年第1期 6-11页

作者：王倩吴家华胡恒钊安徽大学马克思主义学院合肥230601 江西农业大学马克思主义学院南昌330045

以数字赋能为发展契机,推进乡村教育现代化是中国式教育现代化的必然要求,也是乡村全面振兴的重要依托。在教育领域,数字技术蕴含着驱动乡村教育现代化发展的重要价值,能够有效扩大优质教育资源的覆盖范围、变革乡村教育形态、推动乡土... 详细信息

以数字赋能为发展契机,推进乡村教育现代化是中国式教育现代化的必然要求,也是乡村全面振兴的重要依托。在教育领域,数字技术蕴含着驱动乡村教育现代化发展的重要价值,能够有效扩大优质教育资源的覆盖范围、变革乡村教育形态、推动乡土文化的交流传播。但在推动数字赋能乡村教育现代化的实践中,面临着数字教育观念淡薄、数字基础条件不足、师生数字素养薄弱等现实阻碍,迫切需要从重塑价值观念、完善数字设施、培养师生数字素养、加强体制建设入手,为数字赋能乡村教育现代化发展注入新动力,以适应中国式教育现代化发展的新生态。

关键词：数字赋能乡村教育中国式教育现代化乡土文化

Dynamics Analysis of a Parallel Mill-turn Tool Spindle Head Driven by Dual-linear Motors Using Extended Transfer Matrix Method

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2011年第5期24卷 859-869页

作者： wu Wenjing LIU qiang School of Mechanical Engineering and Automation Beihang University Beijing 100191

The hybrid dynamics of multi-rigid-body and multi-flexible-body system becomes the mainstream of multi-body *** there lacks a compact approach to model the hybrid dynamics,especially in modern machine tool application,due to the difficulty of solving the hybrid equations or the limitation of current software when dealing with the hybrid *** extended transfer matrix method（E-TMM）,which extends elements in three-dimensional space with higher matrixes,is proposed to simplify the modeling process of the hybrid *** E-TMM modeling approaches of 3 basic elements including 3D vibrant rigid body,joint and flexible body are studied in details.A parallel mill-turn tool spindle head unit driven by dual-linear motors is chosen as a plant to demonstrate the E-TMM modeling *** using E-TMM,the spindle head unit is simplified as a topological network consisting of the three types of element,i.e.,3D vibrant rigid body,joint and flexible body,including 11 rigid bodies,14 joints and 1 3D-Timoshenko *** the dynamic model of the system can be easily obtained by deducing the element-network by means of state vector *** dynamic characteristics of the spindle head,such as natural frequencies,dynamic flexibility,*** be predicted by solving the obtained *** verification indicates that the E-TMM is valid with enough accuracy in the dynamic analysis of the parallel mill-turn tool spindle *** E-TMM is capable of modeling the dynamics of machine tool structure with no requirements of deducing and solving the sophisticated differential ***,the E-TMM provides a simple and elegant tool for hybrid dynamic analysis in future dynamic design of machine tools.

关键词： NC machine tools dynamics modeling transfer matrix method(TMM)

X-ray pulsar signal detection using photon interarrival time

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2013年第6期24卷 899-905页

作者： qiang Xie Luping Xu hua Zhang School of Electronic Engineering Xidian University

The distribution probability of the photon interarrival time （PIT） without signal initial phases is derived based on the Poisson model of X-ray pulsar signals, and a pulsar signal detection algorithm employing the PIT sequence is put forward. The joint probability of the PIT sequence is regarded as a function of the distribution probability and used to compare a constant radiation intensity model with the nonhomogeneous Poisson model for the signal detection. The relationship between the number of detected photons and the probabilities of false negative and positive is studied, and the success rate and mean detection time are estimated based on the number of the given photons. For the spacecraft velocity data detection, the changes of time of photon arrival （TOPA） and PIT caused by spacecraft motion are presented first, then the influences on detection are analyzed respectively. By using the analytical pulse profile of PSR B0531＋21, the simulation of the Xray pulsar signal detection is implemented. The simulation results verify the effectiveness of the proposed method, and the contrast tests show that the proposed method is suitable for the spacecraft velocity data detection.

关键词： pulsar signal detection photon interarrival time (PIT) Poisson model

A generalized trajectory tracking controller for robot manipulators with bounded inputs

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第10期10卷 1500-1508页

作者： hua-shan LIU Shi-qiang ZHU State Key Lab of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

A generalized controller based on stability theory of singularly perturbed systems is proposed,to deal with the problem of bounded actuator inputs in robot trajectory tracking *** saturation function with error-gain matrix is applied in the torque control law,which ensures the upper bound of torque inputs in any given limited *** appropriately setting the entries of the error-gain matrix,the tracking performance can be ***,a pseudo signal is generated from a linear filter to substitute for the actual velocity error,eliminating the need for velocity ***,to verify the ef-fectiveness of the generalized controller,a new saturated controller with error-gain-contained arc tangent function is *** experiments show that the proposed controller can strictly guarantee the bound of the torque inputs in situations with non-zero initial tracking errors,and gives a better tracking result than other controllers.

关键词： Robot Tracking control Singular perturbation Bounded input

Contrast-enhanced ultrasound of a traumatic neuroma of the extrahepatic bile duct:A case report and review of literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第30期28卷 4211-4220页

作者： Zhi-qiang Yuan hua-Lin Yan Jia-wu Li Yan Luo Department of Medical Ultrasound West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Traumatic neuromas result from nerve injury after trauma or surgery but rarely occur in the bile ***,it is challenging to diagnose traumatic neuromas correctly *** some previous reports have described the imaging features of traumatic neuroma in the bile duct,no features of traumatic neuromas in the bile duct have been identified by using contrast-enhanced ultrasound(CEUS)imaging *** SUMMARY A 55-year-old male patient presented to our hospital with a 3-mo history of abdominal distension and anorexia and history of cholecystectomy 4 years *** ultrasound demonstrated mild to moderate intrahepatic bile duct ***,a hyperechoic nodule was found in the upper extrahepatic bile *** lesion approximately 0.8 cm×0.6 cm with a regular shape and clear *** nodule of the bile duct showed slight hyperenhancement in the arterial phase and isoenhancement in the venous phase on *** tests showed that alanine aminotransferase and aspartate aminotransferase were increased significantly,while the tumor marker carbohydrate antigen 19-9 was increased ***,hilar bile duct resection and end-to-end bile ductal anastomosis were *** histological examination revealed traumatic neuroma of the extrahepatic bile *** patient had an uneventful recovery after *** The current report will help enhance the current knowledge regarding identifying traumatic neuromas by CEUS imaging and review the related literature.

关键词： Traumatic neuroma Bile duct Contrast-enhanced ultrasound Enhancement Cholangiocarcinoma Case report

OsELF3 Is Involved in Circadian Clock Regulation for Promoting Flowering under Long-Day Conditions in Rice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2013年第1期6卷 202-215页

作者： Ying Yang qiang Peng Guo-Xing Chen Xiang-hua Li Chang-Yin wu National Key Laboratory of Crop Genetic Improvement National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan430070 China

Heading date is a critical trait that determines cropping seasons and regional adaptability in rice （Oryza sativa）. Research efforts during the last decade have identified some important photoperiod pathway genes that are conserved between Arabidopsis and rice. In this study, we identified a novel gene, Oryza sativa ELF3 （OsELF3）, which is a putative homolog of the ELF3 gene in Arabidopsis thaliana. OsELF3 was required for the control of heading date under long-day conditions. Its Tos17-tagging mutants exhibited a delayed heading date phenotype only under long-day, but not short-day, conditions. OsELF3 was highly expressed in leaf blades, and the OsELF3 protein was localized in the nucleolus. An obvious diurnal rhythm of OsELF3 transcript level was observed, with a trough in the early day and a peak in the late night in wild-type plants. However, this expression pattern was disrupted in oself3 mutants. Further inves- tigations showed that the expression of OsGI and Ghd7 was up-regulated in the oself3 mutant, indicating that OsELF3 acts as a negative regulator upstream of OsGI and Ghd7 in the flowering-time control under long-day conditions. The rhythmic expression of circadian clock-related genes, including some OsPRR members, was obviously affected in oself3 mutants. Our results indicated that OsELF3 acts as a floral activator in the long-day photoperiodic pathway via its cross- talk with the circadian clock in rice.

关键词： heading date photoperiod pathway circadian clock rice.

Surface molecular imprinting on g-C3N4 photooxidative nanozyme for improved colorimetric biosensing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2019年第12期30卷 2186-2190页

作者： Yuanheng wu qiang Chen Shuang Liu hua Xiao Menglin Zhang Xinfeng Zhang College of Materials and Chemistry&Chemical Engineering Chengdu University of TechnologyChengdu 610059China College of Environment and Ecology Chengdu University of TechnologyChengdu 610059China

Graphitic carbon nitride(g-C3 N4),as a visible-light-active organic semiconductor,has attracted growing attentions in photocatalysis and photoluminescence-based ***,we demonstrated the intrinsic photooxidase activity of g-C3 N4 and then surface molecular imprinting on g-C3 N4 nanozymes was achieved for improved *** blue LED irradiation,the g-C3 N4 exhibited superior enzymatic activity for oxidation of chromogenic substrate like 3,3’,5,5’-tetramethylbenzidine(TMB)without destructive H2 *** oxidation was mainly ascribed to ·O2^-that was generated during light *** surface molecular imprinting on g-C3 N4 can lead to an over 1000-fold alleviation in matrix-interference from serum samples,4-fold improved enzymatic activity as well as enhanced substrate specificity comparing with bare g-C3 N4 during colorimetric ***,the MIP-g-C3 N4 possesses a high affinity to TMB with a Km value of only 22 μmol/L,much lower than other comment nanozymes like AuNPs,Fe3 O4 NPs,*** was successfully applied for detection of cysteine in serum sample with satisfactory recoveries.

关键词： Molecularly imprinted polymer Graphitic carbon nitride Nanoenzyme Colorimetry Biosensing

Exceptional mechanical properties of AZ31 alloy wire by combination of cold drawing and EPT

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2020年第16期47卷 111-118页

作者： Zhaohui Shan Jing Bai Jianfeng Fan Hongfei wu hua Zhang qiang Zhang Yucheng wu Weiguo Li Hongbiao Dong Bingshe Xu Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Southeast UniversityNanjing 211189China Shanxi Key Laboratory of Advanced Magnesium-based Materials Taiyuan 030024China Department of Engineering University of LeicesterLeicester LEI 7RHUK

A 0.66 mm-diameter AZ31 alloy wire with ultimate tensile strength of 400 MPa and elongation of 28.5%was successfully prepared via the combination of cold-drawing and electropulsing treatment processing(EPT).Microstructure observation showed that the grain size of EPTed samples was refined to about 1μm and the basal texture strength with maxima texture index was weakened to *** can significantly accelerate recrystallization by enhancing the mobility of dislocation and atomic diffusion due to the coupling of the thermal and athermal ***,uniform ultrafine-grained structure was obtained in the EPTed samples by static recrystallization completed in a very short time(30 s)at relatively low temperature(433 K).

关键词： AZ31 alloy wire Electropulsing treatment Dislocation Atomic diffusion Microstructure Mechanical properties