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Prognostic value of lymph nodes count on survival of patients with distal cholangiocarcinomas

World Journal of Gastroenterology 2018年第9期24卷 1022-1034页

作者： hua-peng lin Sheng-Wei Li Ye Liu Shi-Ji Zhou Department of Hepatobiliary Surgery The Second Affiliated Hospital of Chongqing Medical University Department of Neonatal Children’s Hospital Chongqing Medical University Department of Gastrointestinal surgery The second Affiliated Hospital of Chongqing Medical University

AIM To evaluate the prognostic value of the number of retrieved lymph nodes(LNs) and other prognostic factors for patients with distal cholangiocarcinomas, and to determine the optimal retrieved LNs cut-off *** The Surveillance, Epidemiology and End Results database was used to screen for patients with distal cholangiocarcinoma. Patients with different numbers of retrieved LNs were divided into three groups by the X-tile program. X-tile from Yale University is a useful tool for outcome-based cut-point optimization. The Kaplan-Meier method and Cox regression analysis were utilized for survival *** A total of 449 patients with distal cholangiocarcinoma met the inclusion criteria. The Kaplan-Meier survival analysis for all patients and for N1 patients revealed no significant differences among patients with different retrieved LN counts in terms of overall and cancerspecific survival. In patients with node-negative distal cholangiocarcinoma, patients with four to nine retrieved LNs had a significantly better overall(P = 0.026) and cancer-specific survival(P = 0.039) than others. In the subsequent multivariate analysis, the number of retrieved LNs was evaluated to be independently associated with survival. Additionally, patients with four to nine retrieved LNs had a significantly lower overall mortality risk [hazard ratio(HR) = 0.39; 95% confidence interval(CI): 0.20-0.74] and cancer causespecific mortality risk(HR = 0.32; 95%CI: 0.15-0.66) than other patients. Additionally, stratified survival analyses showed persistently better overall and cancerspecific survival when retrieving four to nine LNs in patients with any T stage of tumor, a tumor between 20 and 50 mm in diameter, or a poorly differentiated or undifferentiated tumor, and in patients who were ≤ 70-years-old. CONCLUSION The number of retrieved LNs was an important independent prognostic factor for patients with nodenegative distal cholangiocarcinoma. Additionally, patients with four to

关键词： Distal cholangiocarcinomas Lymph node count Survival analysis SEER

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Comparison of biological characteristics of marrow mesenchymal stem cells in hepatitis B patients and normal adults

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World Journal of Gastroenterology 2007年第11期13卷 1743-1746页

作者： Liang peng hua Li lin Gu Xiao-Mou peng Yang-Su huang Zhi-Liang Gao Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou 510630 Guangdong Province China

AIM: To establish a culture system of marrow mesenchymal stem cells (MSCs)from hepatitis B patients and normal adults and to compare their biological characteristics. METHODS: MSCs were isolated from bone marrow in 34 male hepatitis B patients and 15 male normal adults and cultivated in vitro. Their biological characteristics including surface markers, shapes and appearances, growth curves, first passage time and passage generations were compared. RESULTS: Cultivation achievement ratio of hepatitis B patients was lower than that of normal adults, no statistical significance (82.35% vs 100%, P > 0.05). Compared with MSCs of normal adults, MSCs of hepatitis B patients presented a statistical lower growth curve, longer first passage time (13.0 ± 1.6 d vs 11.4 ± 1.5 d, P < 0.05), fewer passaging generation numbers (10.5 ± 1.4 generations vs 12.3 ± 1.7 generations, P < 0.05), though both shared same appearances, shapes and surface markers. MSCs in hepatitis B patients would expand, spread out and age more easily and there were more refractive particles in the cytoplasm. CONCLUSION: MSCs from hepatitis B patients can be cultured in vitro. Although their appearance, shape and surface marker are similar to those of MSCs from normal adults, there are differences in their biological characteristics.

关键词： Marrow mesenchymal stem cells Culture in vitro Biological characters

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明胶纳米颗粒的制备

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精细化工 2017年第7期34卷 774-779页

作者：杨岚王春华李昌朋林炜四川大学皮革化学与工程教育部重点实验室四川成都610065 中国工程物理研究院激光聚变研究中心四川绵阳621000

以B型明胶为原料,戊二醛为交联剂,通过改进的两步去溶剂法制备了较小粒径(约100 nm)的明胶纳米颗粒(Gelatin nanoparticles,GNPs),考察了分散体系浓度、去溶剂化试剂、交联剂用量对GNPs粒径的影响。结果表明:降低明胶在二次分散体系中... 详细信息

以B型明胶为原料,戊二醛为交联剂,通过改进的两步去溶剂法制备了较小粒径(约100 nm)的明胶纳米颗粒(Gelatin nanoparticles,GNPs),考察了分散体系浓度、去溶剂化试剂、交联剂用量对GNPs粒径的影响。结果表明:降低明胶在二次分散体系中的浓度,制得的GNPs的尺寸更小且分布均匀。残留的去溶剂化试剂丙酮需去除,因为它会使GNPs分散性变差。在明胶质量浓度为8 g/L的分散液中,当戊二醛加入量为4.5%(以明胶的质量为基准,下同)时,即可制得稳定的GNPs,其粒径为50~150 nm,PDI约为0.14,Zeta电位绝对值大于30 m V。AFM和TEM测试结果表明:GNPs呈光滑球形,为边缘部分比核心更为疏松的非均质结构。

关键词：明胶纳米颗粒两步去溶剂法去离子水戊二醛功能材料

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***虚拟目录及其配置文件的使用策略

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职大学报 2007年第2期 81-86页

作者：彭华林广州工程技术职业学院广州510075

本文介绍了***应用程序中特定的虚拟目录的作用;***运行于应用程序级别的逻辑代码的架构文件***的使用策略;***的分层式配置设置系统文件***的各种功能配置策略。详细的阐述了***应用程序的两个核心配置文件***和***系统配置及功能,以... 详细信息

本文介绍了***应用程序中特定的虚拟目录的作用;***运行于应用程序级别的逻辑代码的架构文件***的使用策略;***的分层式配置设置系统文件***的各种功能配置策略。详细的阐述了***应用程序的两个核心配置文件***和***系统配置及功能,以便能够轻易将各项设置应用到服务器开发环境与Web应用程序。

关键词： ***应用程序虚拟目录 global.asax web.config

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma peng-peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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基于QiNetix^(TM)的高校网络存储构建

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广东农工商职业技术学院学报 2007年第2期23卷 39-43页

作者：彭华林广州工程技术职业学院广东广州510075

通过网络存储技术,使高校中的各个存储“孤岛”连接成统一的资源,提高系统安全性,提高存储资源的利用效率,从而有力地保障高校的信息资源安全和高效的开展。该文介绍了几种常用的网络存储技术,根据数字化校园信息存储的需求,结合具体系... 详细信息

通过网络存储技术,使高校中的各个存储“孤岛”连接成统一的资源,提高系统安全性,提高存储资源的利用效率,从而有力地保障高校的信息资源安全和高效的开展。该文介绍了几种常用的网络存储技术,根据数字化校园信息存储的需求,结合具体系统设计出一个具有高可用性、可管理性与可扩展性的数字化校园信息存储系统。

关键词：校园网网络存储技术直接连接存储网络附加存储存储区域网

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui peng peng Wu Zong-lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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“互联网+”时代智能产品定制平台应用研究

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教育教学论坛 2018年第46期 243-244页

作者：彭华林广州工程技术职业学院广州510070

互联网科技的发展,让传统的商品从生产到销售渠道都发生了巨大的变化,在这个过程中依托物联网和互联网融合技术而产生的互联网+环境,催生了一大批的定制产品出现,本文就结合实际情况对互联网+时代智能产品定制平台应用进行简析。

关键词：互联网+ 智能产品定制平台

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Economics Analysis for Information Flow of the Leader Dynamic Management in Virtual Enterprise

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厦门大学学报（自然科学版） 2002年第S1期41卷 234-页

作者： huaNG Rui-hua, peng Xiao-chun, lin Jian (School of Management, Xi’an Jiaotong University, Xi’an 710049, China)

The virtual enterprise will play a more and more im po rtant role in economy development. The virtual enterprise leader raises market a daptability and group cooperation ability through its dynamic management. Thus t he validity and efficiency of leader’s dynamic management determines the efficie ncy of the virtual enterprise operation, and the validity of the information flo w is one of the main factors. In this paper, the validity of the information flo w in the course of the leader’s dynamic management in the virtual enterprise is analyzed by using the economic searching theory and the information theory, and the possible ways to improve the validity and efficiency of leader’s dynamic man agement are indicated. Firstly, the basic concepts such as leader’s dynamic management, virtual enterpr ise, and its leader are defined. The dynamic management procedure for the virtua l enterprise leader is analyzed with the dynamic theory raised by Mowshowitz. Secondly, the model for the dynamic management of the virtual enterprise leader is constructed using multi-goal selection. The information flow validity for th e leader during the stages of the identification and the establishment is analyz ed with the economic searching theory and the information theory. Meanwhile, the value of the dynamic management policy is discussed with the information va lue theory. Finally, two ways to improve the validity of the information flow are obtained. The first way is to process the various kinds of information of the existing mem bers in the virtual enterprise for the future cooperative usage and to extend th e selective objects for the leader, and to make the detailed and clear mechanism of the object evaluation and selection (the market chance and the cooperative partner). The other way is to build the system of the effective transfer and process of the feedback information flow during the operation of the virtual ent erprise based on the information technology.

关键词： virtual enterprise leader dynamic management i nformation flow validity and efficiency

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意愿、资源、能力约束下精准创业扶贫模式运行机制的实证研究

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长安大学学报（社会科学版） 2018年第3期20卷 85-96页

作者：彭华涛林琳武汉理工大学管理学院湖北武汉430070

中国情境下的创业扶贫工作受到创业意愿不强、创业资源不足、创业能力不高的约束,必须将创业扶贫与精准扶贫相结合才能从根本上实现精准脱贫。聚焦于意愿、资源、能力约束下精准创业扶贫模式运行机制及政策设计,以陕西省礼泉县栖霞镇袁... 详细信息

中国情境下的创业扶贫工作受到创业意愿不强、创业资源不足、创业能力不高的约束,必须将创业扶贫与精准扶贫相结合才能从根本上实现精准脱贫。聚焦于意愿、资源、能力约束下精准创业扶贫模式运行机制及政策设计,以陕西省礼泉县栖霞镇袁家村创业扶贫为案例,运用探索性案例研究方法,旨在有效构建意愿、资源和能力约束破解与精准创业扶贫模式的内在逻辑。研究表明:意愿、资源和能力约束下创业扶贫的"输血""活血""造血""换血"等典型模式需赋予其"精准"内涵;精准创业扶贫模式可通过自助、互助和他助机制实现;精准创业扶贫政策需从系统性、整体性、时效性、层次性等角度予以优化。根据研究结果,提出了如下结论与启示:当前中国贫困县中开展的"互联网+""科技特派员""经济共享发展""农业科技示范园"等典型创业扶贫模式需从意愿、资源和能力约束破解视角予以完善;不同的精准创业扶贫模式适用于不同的意愿、资源、能力约束条件,且在运行中必须将多种扶助机制融会贯通;针对具体的精准创业扶贫模式,相关政策仍需从意愿瓶颈突破效应、资源缺口补偿效应以及能力差距缩小效应等角度予以评价,并建立基于以上效应动态监控的精准创业扶贫政策优化方案。

关键词：精准创业扶贫创业意愿创业资源创业能力扶贫开发

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