检索结果-南通市图书馆

Primary Systemic Amyloidosis Presenting as Skin Vegetations:A Case Report

在线全文

学校读者我要写书评

暂无评论

International Journal of Dermatology and Venereology 2022年第3期5卷 178-180页

作者： Meng-hua li li-ming Wu Department of Dermatology Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China

Introduction:Primary systemic amyloidosis is characterized by clonal plasma cell disorder,and its signs and symptoms are various and complex,damage to the skin and mucous membrane is often more likely to attract attention.Here we reported a case of a 61-year-old male patient who presented with topical mucocutaneous lesion,as well unusual skin vegetations.Case presentation:A 61-year-old man was hospitalized due to repeated burning sensation on his back,multiple ecchymosis,and skin vegetations.Through a series of examinations(mainly including skin histopathology,bone marrow cytology,bone marrow flow cytometry,immunofixation electrophoresis),Primary systemic amyloidosis was diagnosed,but multiple myeloma could not be diagnosed.Subsequently,he received chemotherapy.In the half-year follow-up,there was no significant change in his symptoms and signs.Discussion:In this case,in addition to the typical skin damage of primary amyloidosis,the multiple skin vegetations in the buttocks,abdomen,and arms are particularly noteworthy.According to the histopathology and Immunohistochemistry of the skin vegetation,we infer that the formation mechanism of these skin vegetation is lymphatic obstruction caused by amyloid,which leads to lymphatic dilatation,lymph leakage,and dermal edema.Conclusion:Primary systemic amyloidosis is a rare disease,which is often difficult to diagnose.We should be alert to those atypical skin features so as not to delay diagnosis.

关键词： primary systemic amyloidosis skin vegetations case report

Numerical simulation of dynamic large deformation and fracture damage for solid armature in electromagnetic railgun

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2020年第2期16卷 348-353页

作者： Qing-hua lin Bao-ming li National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyP.O.Box210094NanjingPR China

The design of solid armature of railgun should take full account of its operating conditions and material properties because the armature is subjected to dynamic loading conditions and experiences a complicated electrical,thermal and mechanical process in the interior ballistic cycle.In this paper present,we first introduced a multi-physical field model of railgun,followed by several examples to investigate the launching process.Especially,we used the explicit finite element method,in which material nonlinearity and geometric nonlinearity were accounted,to investigate the deform behaviors of solid armature.The results show that the dynamic mechanical process of armature is dependent on the armature geometry,material and exciting electric current.By the numerical simulation,the understanding of the fracture mechanism of solid armature was deepened.

关键词： Electromagnetic railgun Solid armature Fracture Explicit finite element Numerical simulation

The Immune Responses Induced by licensed Flavivirus Vaccines against Zika Virus

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2022年第8期35卷 750-754页

作者： WANG ling liU Jing Jing FANG En Yue li ming liU ming Lei li Yu hua State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041SichuanChina National Institutes for Food and Drug Control Beijing 102629China

Zika virus(ZIKV) is a mosquito-borne virus of the Spondweni group that belongs to the Flaviviridae family and genus Flavivirus. Microcephaly(small head size, decreased brain size, and poor neurocognitive development) was linked to ZIKV infection in Brazil in 2015. Outbreaks and indications of transmission have spread quickly over the Americas, Africa, and other parts of the globe.Over 80 nations and territories have documented symptoms of Zika infection spread by mosquitoes,including microcephaly and Guillain-Barre syndrome(GBS).

关键词： infection Immune belongs

Active phase morphology engineering of NiMo/Al2O3 through La introduction for boosting hydrodesulfurization of 4,6-DMDBT

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2023年第2期20卷 1231-1237页

作者： Ji-Xing liu Xiang-Qi liu Ri-Xin Yan ling-Feng Ji Hui-Fang Cheng Hui liu Yan huang ming-Qing hua Hua-Ming Li Wen-Shuai Zhu School of Chemistry and Chemical Engineering and Institute for Energy Research Jiangsu UniversityZhenjiangJiangsu 212013China State Key Laboratory of Heavy Oil Processing and Beijing Key Lab of Oil&Gas Pollution Control China University of PetroleumBeijing 102249China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalianLiaoning 116024China

Herein,we designed and constructed a mesoporous LaAlOx via a solvent evaporation induced self-assembly protocol.The structure and physicochemical property of the corresponding NiMo supported catalyst was analyzed by a set of characterizations,and its catalytic activity was investigated for hydrodesulfurization(HDS)of 4,6-dimethyldibenzothiophene.It has confirmed that the incorporation of La profoundly facilitate the generation of“Type II”NiMoS phase by weakening the interaction of Mo–O–Al leakage and promoting the sulfidation of both Ni and Mo oxides as well as changing the morphology of Ni promoted MoS2 slabs,thereafter boosting the HDS performance substantially.The finding here may contribute to the fundamental understanding of structure-activity in ultra-deep desulfurization and inspire the advancement of highly-efficient HDS catalyst in future.

关键词： NiMo supported Catalyst LaAlOx composites Hydrodesulfurization Morphology Reaction kinetics

Analysis and discussion on launching mechanism and tactical electromagnetic railgun technology

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2018年第5期14卷 484-495页

作者： Bao-ming li Qing-hua lin National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyP.O.Box210094NanjingPR China China Academy of Ordnance P.O.Box100089BeijingPR China

This paper begins with a discussion on the significance of multi-physical fields in the research of railgun launching mechanism, followed by an introduction of research work about dynamic measurements and numerical simulations. The application of some measurement methods including the atomic emission spectrum, fiber-optic strain, optical level, pulsed X-ray, and high-speed video in observing the launching process was introduced. The models about the electromechanical dynamic processes and multi-physical fields in a railgun were developed. The mechanisms of the grooving, arc transition, and gouging were analyzed. These work provided a deeper understanding of launching mechanism of electromagnetic railgun. Some issues about the tactical railgun, such as the fiber composite overwrapped barrel, recoil,loading modes and eddy current loss were also discussed. Taking a medium-caliber launcher as an example, the basic process of design and analysis was introduced.

关键词： Railgun Launching mechanism Dynamic measurement Numerical simulation

Experimental Study on Interference Effect of Three Risers Arranged in Tandem with Variable Spacing Ratios

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2023年第3期37卷 408-419页

作者： ZHANG Peng liU li-hua liU ming REN Xiao-hui WANG Yu School of Civil Engineering Qingdao University of TechnologyQingdao 266520China College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China Shandong Provincial Key Laboratory of Civil Engineering Disaster Prevention and Mitigation Qingdao 266590China School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580China

Taking the three-riser group arranged in tandem as the research subject,an experimental study was carried out on the risers arranged in tandem.The purpose is to explore the sensitivity of the dynamic response of each riser to spacing ratio and reveal the physical mechanism of riser groups under the interference effect.The spacing ratios of the adj acent risers are 4.0,5.0,6.0,and 8.0.At the spacing between the risers of 4.0D,the strong feedback effect increases the cross-flow(CF) displacement amplitude of the upstream riser.The shielding effect is the key factor affecting the interference effect on the midstream and downstream risers.At low reduced velocities,the shielding area initially appears,the displacement amplitude of the midstream and downstream risers varies greatly,the vibration of the two risers is still dominated by the first-order mode,and the transition between adjacent vibration modes is restrained.The multi-frequency superposition phenomenon is very significant at high reduced velocities.The most sensitive interference spacing under the test conditions is obtained.Due to the separation of the incoming flow and the double shielding effect of the upstream and midstream risers,the regular vortex-induced vibration in the wake area of the downstream riser is broken,and the vibration in the two directions is weakened.In general,the interference effect is more significant for the CF vibration of the three-riser groups than the in-line(IL) vibration.

关键词： three-riser group tandem arrangement vortex-induced vibration wake interference variable spacing ratios

2-Connected Factor-critical Graphs G with Exactly ｜E(G)｜＋ 1 Maximum Matchings

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2017年第4期33卷 1001-1014页

作者： ming-hua li Yan liU School of Mathematical Sciences South China Normal University Guangzhou 510631 China

A connected graph G is said to be a factor-critical graph if G - v has a perfect matching for every vertex v of G. In this paper, the 2-connected factor-critical graph G which has exactly ｜E（G）｜＋ 1 maximum matchi... 详细信息

关键词： maximum matching factor-critical graph 2-connected graph

Synaptic development of layer V pyramidal neurons in the prenatal human prefrontal neocortex: a Neurolucida-aided Golgi study

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第8期15卷 1490-1495页

作者： li-Xin He lily Wan Wei Xiang Jian-ming li An-hua Pan Da-hua Lu Xiangtan Medicine and Health Vocational College XiangtanHunan ProvinceChina Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Changde Vocational Technical College ChangdeHunan ProvinceChina Department of Anatomy Changsha Medical UniversityChangshaHunan ProvinceChina Department of Anatomy and Neurobiology Xiangya School of MedicineCentral South UniversityChangshaHunan ProvinceChina

The prefrontal neocortex is involved in many high cognitive functions in humans.Deficits in neuronal and neurocircuitry development in this part of the cerebrum have been associated with various neuropsychiatric disorders in adolescents and adults.There are currently little available data regarding prenatal dendrite and spine formation on projecting neurons in the human prefrontal neocortex.Previous studies have demonstrated that Golgi silver staining can identify neurons in the frontal lobe and visual cortex in human embryos.In the present study,five fetal brains,at 19,20,26,35,and 38 gestational weeks,were obtained via the body donation program at Xiangya School of Medicine,Central South University,China.Golgi-stained pyramidal neurons in layer V of Brodmann area 46 in fetuses were quantitatively analyzed using the Neurolucida morphometry system.Results revealed that somal size,total dendritic length,and branching points of these neurons increased from 26 to 38 gestational weeks.There was also a large increase in dendritic spines from 35 to 38 gestational weeks.These findings indicate that,in the human prefrontal neocortex,dendritic growth in layer V pyramidal neurons occurs rapidly during the third trimester of gestation.The use of human fetal brain tissue was approved by the Animal Ethics Committee of Xiangya School of Medicine,Central South University,China(approval No.2011-045)on April 5,2011.

关键词： Golgi staining human brain banking neurodevelopment Neurolucida neuropsychiatric disorders prefrontal cortex synaptogenesis three-dimensional reconstruction

Potential contribution of the gut microbiota to hypoglycemia after gastric bypass surgery

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2020年第15期133卷 1834-1843页

作者： li-Yuan Zhou ming-Qun Deng Xin-hua Xiao Key Laboratory of Endocrinology Translational Medicine CenterMinistry of HealthDepartment of EndocrinologyPeking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

Obesity has become a global health problem. lifestyle modification and medical treatment only appear to yield short-term weight loss. Roux-en-Y gastric bypass (RYGB) is the most popular bariatric procedure, and it sustains weight reduction and results in the remission of obesity-associated comorbidities for obese individuals. However, patients who undergo this surgery may develop hypoglycemia. To date, the diagnosis is challenging and the prevalence of post-RYGB hypoglycemia (PRH) is unclear. RYGB alters the anatomy of the upper gastrointestinal tract and has a combined effect of caloric intake restriction and nutrient malabsorption. Nevertheless, the physiologic changes after RYGB are complex. Although hyperinsulinemia, incretin effects, dysfunction of β-cells and α-cells, and some other factors have been widely investigated and are reported to be possible mediators of PRH, the pathogenesis is still not completely understood. In light of the important role of the gut microbiome in metabolism, we hypothesized that the gut microbiome might also be a critical link between RYGB and hypoglycemia. In this review, we mainly highlight the current possible factors predisposing individuals to PRH, particularly related to the gut microbiota, which may yield significant insights into the intestinal regulation of glucose metabolic homeostasis and provide novel clues to improve the treatment of type 2 diabetes mellitus.

关键词： Roux-en-Y gastric bypass surgery Hypoglycemia Gut microbiota Obesity