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Study on psychological resilience and associated influencing factors in lung cancer patients with bone metastases

World Journal of Psychiatry 2024年第9期14卷 1326-1334页

作者： Chao-Fan Guo Li-Li Wu Zhong-Zhong Peng hua-long lin Jie-Ni Feng Department of Orthopedics The Third Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325200Zhejiang ProvinceChina Department of Medical Oncology The Third Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325200Zhejiang ProvinceChina Department of Medical Oncology Ningbo Hangzhou Bay HospitalNingbo 315336Zhejiang ProvinceChina

BACKGROUND Evaluating the psychological resilience of lung cancer(LC)patients helps understand their mental state and guides future ***,there is limited research on the psychological resilience of LC patients with bone *** To explore the psychological resilience of LC patients with bone metastases and identify factors that may influence psychological *** LC patients with bone metastases who met the inclusion criteria were screened from those admitted to the Third Affiliated Hospital of Wenzhou Medical *** psychological scores of the enrolled patients were *** were then grouped based on the mean psychological score:Those with scores lower than the mean value were placed in the low-score group and those with scores equal to or greater than the mean value was placed in the high-score *** baseline data(age,gender,education level,marital status,residence,monthly income,and religious beliefs),along with self-efficacy and medical coping mode scores,were *** This study included 142 LC patients with bone metastases admitted to our hospital from June 2022 to December 2023,with an average psychological resilience score of 63.24±9.96 *** grouping,the low-score group consisted of 69 patients,including 42 males and 27 females,with an average age of 67.38±9.55 *** high-score group consisted of 73 patients,including 49 males and 24 females,with a mean age of 61.97±5.00 years.χ2 analysis revealed significant differences between the two groups in education level(χ2=6.604,P=0.037),residence(χ2=12.950,P=0.002),monthly income(χ2=9.375,P=0.009),and medical coping modes(χ2=19.150,P=0.000).Independent sample t-test showed that the high-score group had significantly higher self-efficacy scores(t=3.383,P=0.001)and lower age than the low-score group(t=4.256,P<0.001).Furthermore,multivariate logistic regression hazard analysis confirmed that self-efficacy is an independent protective factor for psy

关键词： Lung cancer Bone metastases Psychological resilience Influencing factors Clinical evaluation

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue lin Gen Wei Jun Ying Fuzhou hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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Efficient Syntheses of Artificial Nucleases Containing di-[12]aneN3 Ligating Units Through Click Reactions

Efficient Syntheses of Artificial Nucleases Containing di-[1...

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大环化学和超分子化学的新发展——当前学科交叉的一个重要桥梁——中国化学会全国第十五届大环化学暨第七届超分子化学学术讨论会

作者： GUO Zhi-Fo SONG Yang CHEN hua-long LU Zhong-lin~* (College of Chemistry,Beijing Normal University,Xinjiekouwai Street 19,Beijing 100875,PR China)

The development of artificial nucleases capable of mimicking the action of nature enzymes is a long-standing goal in bioorganic *** studies will offer many applications,such as in understanding the chemistry of the na... 详细信息

关键词： artificial nucleases click reactions di-aneN3

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Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第01期 297-307页

作者： Bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding Pan Pan Li Bo Peng hua Bai lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng Hu long Yang Zitong Kan Biao Dong Miae Won Hongwei Song lin Xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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Mixed-microencapsulation of Rat Primary Hepatocytes and Sertoli cells Improves the Metabolic Function in a D-galactosamine and Lipopolysaccharide Induced Rat Model of Acute Liver Failure

Mixed-microencapsulation of Rat Primary Hepatocytes and Sert...

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2009香港-北京-杭州内科论坛暨2009年浙江省内科学学术年会

作者： Department of Infection and Liver Diseases,The First Affiliated Hospital of Wenzhou Medical College, Wenzhou,China Ming-hua Zheng Hai-long lin Yong-Ping Chen Department of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical College, Wenzhou,China Jing-Ye Pan

Hepatocyte transplantation is an alternative to the transplantation of the whole *** compared to xenogeneic hepatocytes,primary hepatocytes have some advantages that cannot be replaced,such as a more powerful function,a smaller frequency of rejection caused by the host,et *** microencapsulation prevents the direct access of host cells to the graft,but cannot impede transfer of transplant-derived peptides,which can cross the physical *** cells are central to the immune privilege demonstrated in the testis,and their actions have been utilized to protect cell ***-microencapsulating Sertoli cells with HepG2 cells has proved to be a valuable strategy in hepatocyte ***,mixed microcapsules of primary rat hepatocytes and primary Sertoli cells may improve the metabolic function in the D-galactosamine and lipopolysaccharide induced rat model of acute liver failure.

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SCR系统尿素沉积物内相关组分动力学试验研究

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广西大学学报（自然科学版） 2019年第5期44卷 1363-1370页

作者：黄文君莫春兰龙华林莫益涛邱崇桓广西大学机械工程学院

为完善尿素沉积物生成机理模型,对尿素沉积物进了热解特性试验研究。由TG-DSC曲线表明,尿素沉积物主要分3个阶段进行分解:第一阶段为尿素与缩二脲的分解,第二阶段为未知组分之间的形成与分解,第三阶段为三聚氰酸及其同系物的分解。采用D... 详细信息

为完善尿素沉积物生成机理模型,对尿素沉积物进了热解特性试验研究。由TG-DSC曲线表明,尿素沉积物主要分3个阶段进行分解:第一阶段为尿素与缩二脲的分解,第二阶段为未知组分之间的形成与分解,第三阶段为三聚氰酸及其同系物的分解。采用Doyle积分法分析TG曲线可以得出6个温度区间的拟合曲线,拟合度接近直线,一级动力学反应机理假设合理,并计算出各个区间的活化能和指前因子。研究结果表明,采用Doyle积分法可获得各分解反应的指前因子与活化能近似值,试验与量子化学计算方法分解反应的化学反应速率参数对比,失重阶段中沉积物内部组分分解以及各组分比例表明沉积物的主要组分为三聚氰酸,此方法也可为今后SCR系统尿素沉积物内部组分动力学参数的获取提供试验可行方案。

关键词：尿素沉积物热重分析热解特性动力学参数

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苦杏仁保健营养酸奶的研制

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食品科技 2003年第3期28卷 63-65页

作者：张丽华龙占林锦州师范学院食品科学系锦州121000 锦州康乐食品有限责任公司锦州121000

以苦杏仁和鲜奶为主要原料,配以蔗糖及稳定剂等,通过发酵条件试验、物料配比确定、稳定剂筛选和正交试验的研究,优选出最佳配方,研制出了一种具有营养和保健功能的苦杏仁酸奶。

关键词：苦杏仁营养保健酸奶配方发酵试验质量标准

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Damping of Magnetorheological Elastomers

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Chinese Journal of Chemical Physics 2008年第6期21卷 581-585页

作者： lin Chen Xing-long Gong Wei-hua Li CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Me- chanics University of Science and Technology of China Hefei 230027 China School of Mechanical Materials and Mechatronic Engineering University of Wollongong Wollongong NSW 2522 Australia

The damping property of magnetorheological （MR） elastomers is characterized by a modified dynamic mechanical-magnetic coupled analyzer. The influences of the external magnetic flux density, damping of the matrix, content of iron particles, dynamic strain, and driving frequency on the damping properties of MR elastomers were investigated experimentally. The experimental results indicate that the damping properties of MR elastomers greatly depend on the interfacial slipping between the inner particles and the matrix. Different from general composite materials, the interracial slipping in MR elastomers is affected by the external applied magnetic field.

关键词： Magnetorheological elastomers Damping property Interfacial slipping

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Elastic responses of underground circular arches considering dynamic soil-structure interaction:A theoretical analysis

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Acta Mechanica Sinica 2013年第1期29卷 110-122页

作者： Hai-long Chen Feng-Nian Jin hua-lin Fan PLA University of Science and Technology Key Laboratory of Bridge-structure Engineering Chongqing Jiaotong University Laboratory of Structural Analysis for Defense Engineering and Equipment College of Mechanics and Materials Hohai University Key Laboratory of Road & Bridge and Underground Engineering of Gansu Province Lanzhou Jiaotong University

Due to the wide applications of arches in underground protective structures, dynamic analysis of circular arches including soil-structure interactions is important. In this paper, an exact solution of the forced vibration of circular arches subjected to subsurface denotation forces is obtained. The dynamic soil-structure interaction is considered with the introduction of an interfacial damping between the structure element and the surrounding soil into the equa- tion of motion. By neglecting the influences of shear, rotary inertia and tangential forces and assuming the arch incompressible, the equations of motion of the buried arches were set up. Analytical solutions of the dynamic responses of the protective arches were deduced by means of modal super- position. Arches with different opening angles, acoustic impedances and rise-span ratios were analyzed to discuss their influences on an arch. The theoretical analysis suggests blast loads for elastic designs and predicts the potential failure modes for buried protective arches.

关键词： Underground protective arches - Dynamic soilstructure interaction Dynamic responses Analytical solution

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