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Advanced primary peritoneal carcinoma:clinicopathological and prognostic factor analyses

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 435-440页

作者： Chao ZHANG Xiao-ping li Heng CUI Dan-hua SHEN li-hui WEI Gynecological Oncology Center Peking University People＇s Hospital Beijing 100044 China

Objective: To investigate the factors favoring a positive prognosis for advanced primary peritoneal carcinoma (PPC). Methods: Twenty-four cases meeting the criteria for PPC were analyzed retrospectively for the clinicopathologic profiles. Im- munohistochemistry was used to determine the expressions of p53, Top2α, Ki-67 and Her-2/neu. Then all these clinicopa- thological factors and molecular markers were correlated with the prognosis. Results: There were 15 cases of primary peritoneal serous papillary carcinoma (PPSPC), 6 cases of mixed epithelial carcinoma (MEC) and 3 cases of malignant mixed Mullerian tumor (MMMT). All patients underwent cytoreductive surgery with optimal debulking achieved in 3 cases. Among those re- ceiving first-line chemotherapy, 13 patients received the TP regimen (paclitaxel-cisplatin or carboplatin) and 7 patients received the PAC regimen (cisplatin-doxorubicin-cyclophosphamide). The median overall survival of all patients was 42 months, while the breakdown for survival time for patients with PPSPC, MMT and MEC was 44, 13 and 19 months, respectively. The expressions of p53, Top2α and Ki-67 were all demonstrated in 11 cases respectively. None showed the expression of Her-2/neu. There were significant differences in the median survival between patients with PPSPC and those with MMMT (44 months vs 13 months, P<0.05), also between patients receiving TP combination and those receiving the PAC regimen (75 months vs 28 months, P<0.05). Another significant difference in the median progression-free survival (PFS) was identified between patients with positive p53 immunostaining and those with negative p53 immunostaining (15 months vs 47 months, P<0.05), whereas age, menopausal status, residual tumor size and the other molecular factors did not significantly impact survival. Conclusion: Patients with PPC should be treated with a comprehensive management plan including appropriate cytoreductive surgery and responsive chemotherapy. Overestimating an opt

关键词： Primary peritoneal carcinoma (PPC) Cytoreductive surgery Chemotherapy Immunohistochemistry Prognosis

Activity Enhancement of Pt/Ba/Al_(2)O_(3) Mixed with Mn/Ba/Al_(2)O_(3) for NO_(x) Storage-reduction by Hydrogen

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Chinese Chemical Letters 2006年第10期17卷 1357-1360页

作者： Jian hua XIAO Xue hui li Sha DENG Fu Rong WANG Le Fu WANG School of Chemical and Energy Engineering South China University of Technology Guangzhou 510640

Abstract： Mn/Ba/Al2O3 catalyst for NO oxidation-storage and Pt/Ba/Al2O3 catalyst mixed with Mn/Ba/Al2O3 for NOx storage-reduction by hydrogen were investigated. The results showed that Mn/Ba/Al2O3 had large nitrogen oxides storage capacity （397.9 μmolg^-1） under lean burn condition. When Pt/Ba/Al2O3 catalyst was mixed with Mn/Ba/Al2O3 in equal weight proportion, the NOx conversion increased between 250 ℃ and 500 ℃ under the dynamic lean-rich burn conditions, and the maximum NOx conversion increased from 95.4% to 98.2%. Mn/Ba/Al2O3 has promoted NOx storing in the lean stage and improved NOx reduction efficiency in the rich stage, these might result in higher NOx conversion over the low Pt loading content catalyst.

关键词： Nitrogen oxides storage-reduction lean burn Pt/Ba/Al2O3 Mn/Ba/Al2O3

EFFECTS OF GLUCAGON ON ISLET β CELL FUNCTION IN PATIENTS WITH DIABETES MELliTUS

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Chinese Medical Sciences Journal 2008年第2期23卷 117-120页

作者： Tong Wang Xin-hua Xiao Wen-hui li Heng Wang Qi Sun Tao Yuan Guo-hua Yang Key Laboratory of Endocrinology Peking Union Medical CollegePeking Unionof Ministry of Health Department of EndocrinologyHospital Chinese Academy of Medical Sciences ＆Medical College Beijing 100730

Objective To evaluate islet β cell response to intravenous glucagon （ a non-glucose secretagogue） stimulation in diabetes mellitus. Methods Nineteen patients with type 1 diabetes （T1 D） and 131 patients with type 2 diabetes （T2D） were recruited in this study. T2D patients were divided into two groups according to therapy： 36 cases treated with insulin and 95 cases treated with diet or oral therapy. The serum C-peptide levels were determined at fasting and six minutes after intra- venous injection of 1 mg of ghicagon. Results Both fasting and 6-minute post-ghicagon-stimulated C-peptide levels in T1D patients were significantly lower than those of T2D patients （0. 76±0. 36 ng/mL vs. 1.81±0. 78 ng/mL, P 〈 0.05 ; 0.88±0.42 ng/mL vs. 3.68±0. 98 ng/mL, P 〈 0. 05 ）. In T1D patients, the C-peptide level after injection of ghicagon was similar to the fasting level. In T2D, patients treated with diet or oral drug had a significantly greater fasting and stimulated C-peptide level than those patients received insulin therapy （2.45±0. 93 ng/mL vs. 1.61±0. 68 ng/mL, P 〈 0.05 ; 5.26±1.24 ng/mL vs. 2.15±0.76 ng/mL, P 〈 0.05 ）. The serum C-peptide level after ghicagon stimulation was positively correlated with C-peptide levels at fasting in all three groups （ r = 0.76, P 〈 0.05 ）. Conclusions The 6-minute ghicagon test is valuable in assessing the function of islet β cell in patients with diabetes mellitus. It is helpful for diagnosis and treatment of diabetes mellitus.

关键词： glucagon diabetes mellitus C-peptide islet β cell function

Biomedical Image Processing Using FCM Algorithm Based on the Wavelet Transform

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Journal of Wuhan University of Technology(Materials Science) 2004年第3期19卷 18-20页

作者：闫玉华 Wuhan University of Technology

An effective processing method for biomedical images and the Fuzzy C-mean (FCM) algorithm based on the wavelet transform are *** using hierarchical wavelet decomposition, an original image could be decomposed into one lower image and several detail images. The segmentation started at the lowest resolution with the FCM clustering algorithm and the texture feature extracted from various sub-bands. With the improvement of the FCM algorithm, FCM alternation frequency was decreased and the accuracy of segmentation was advanced.

关键词： biomedical image processing FCM algorithm wavelet transform texture feature

Spaceflight alters the gene expression profile of cervical cancer cells

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Chinese Journal of Cancer 2011年第12期30卷 842-852页

作者： Zhi-Jie Zhang Yong-Qing Tong Jia-Jia Wang Cheng Yang Guo-hua Zhou Yue-hui li Ping-li Xie Jin-Yue Hu Guan-Cheng li Cancer Research Inst tute Xiangya Schoo of Med c neCentral South University Changsha Hunan 410078 P. R. China

Our previous study revealed that spaceflight induced biological changes in human cervical carcinoma Caski cells. Here, we report that 48A9 cells, which were subcloned from Caski cells, experienced significant growth suppression and exhibited low tumorigenic ability after spaceflight. To further understand the potential mechanism at the transcriptional level, we compared gene expression between 48A9 cells and ground control Caski cells with suppression subtractive hybridization (SSH) and reverse Northern blotting methods, and analyzed the relative gene network and molecular functions with the Ingenuity Pathways Analysis (IPA) program. We found 5 genes, SUB1, SGEF, MALAT-1, MYL6, and MT-CO2, to be up-regulated and identified 3 new cDNAs, termed B4, B5, and C4, in 48A9 cells. In addition, we also identified the two most significant gene networks to indicate the function of these genes using the IPA program. To our knowledge, our results show for the first time that spaceflight can reduce the growth of tumor cells, and we also provide a new model for oncogenesis study.

关键词：基因表达谱航天飞行癌细胞宫颈癌 Northern 抑制性消减杂交生长抑制基因网络

β-decay studies of the neutron-rich ^(18,21)N isotopes

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Science China(Physics,Mechanics & Astronomy) 2011年第S1期54卷 53-60页

作者： hua hui, li Zhihuan, YE Yanlin, JIANG DongXing, LOU Jianling, li XiangQing & XU FuRong School of Physics and State Key Laboratory of Nuclear Physics and Technology, Peking University, Beijing 100871, China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing China

The β-decay studies of neutron-rich 18,21N isotopes have been performed using β-n, β-γ, and β-n-γ coincidence methods. The 18,21N ions were produced by the fragmentation of the 22Ne and 26Mg beams, respectively, on a thick beryllium target. The time of flight of the emitted neutrons following the β-decay of 18,21N was measured by a neutron detector system with wide energy detection range and low-energy detection threshold. In addition, several clover germanium detectors were used to detect the β-delayed γ-rays. The half-lives of the β-decays of 18N and 21N were determined to be (619±2) ms and (82.9±7.5) ms, respec tively. Several new β-delayed neutron groups were observed with a total branching ratio of (6.98±1.46)% and (90.5±4.2)% for 18N and 21N, respectively. The level schemes of 18O and 21O were deduced. The experimental Gamow-Teller β-decay strengths of 18N and 21N to these levels were compared with the shell model calculations.

关键词： β-delayed neutron decay 18 21N neutron detector system branching ratio Gamow-Teller strength

Delayed right-sided diaphragmatic hernia with severe ：raniocerebral trauma

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Chinese Medical Journal 2010年第7期123卷 974-976页

作者： TANG hua WU li-hui li Jian-qiu XU Zhi-fei Department of Thoracic and Cardiovascular Surgery Shanghai Changzheng Hospital Second Military Medical University Shanghai 200003 China

Diaphragmatic hernia （DH） is an uncommon result of trauma, but presents a severe problem in patients With multiple injuries. Right-sided DH is rare, owing to the protection of the liver and strength of the right hem... 详细信息

关键词： trauma diaphragmatic hernia craniocerebral trauma

Nonverbal language in cross-cultural communication

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Sino-US English Teaching 2007年第10期4卷 66-70页

作者： WANG De-hua li hui School of Foreign Languages Ningbo Institute of Technology Zhejiang University Ningbo 315100 China

All cultures make use of nonverbal communication but the meanings of nonverbal communication vary across cultures. Nonverbal communication may be as important to understand as words are, for it can cause misunderstandings between people from different cultures if they misinterpret nonverbal symbols. Nonverbal communication is largely beyond our conscious, and the system we learn is not determined by the genetic heritage but by the socio-cultural environment. The differences across cultures in nonverbal signals have been studied widely, because of the importance and necessity in communication .The paper mainly focuses on the differences related to body language, body space, body touch and paralanguage.

关键词： body language body space paralanguage cross-cultural communication

Epigallocatechin-3-gallate Modulates MicroRNA Expression Profiles in Human Nasopharyngeal Carcinoma CNE2 Cells

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Chinese Medical Journal 2017年第1期130卷 93-99页

作者： Bin-Bin li Guo-liang huang hua-hui li Xia Kong Zhi-Wei He Department of Pathophysiology Guangdong Medical University Dongguan Guangdong 523808 China Sino-American Cancer Research Institute Key Laboratory for Medical Diagnostics of Guangdong Province Guangdong Medical University Dongguan Guangdong 523808 China

Background： Epigallocatechin-3-gallate （EGCG） has exhibited antitumor properties in several types of cancers, including nasopharyngeal carcinoma （NPC）, but the molecular mechanisms underlying this function remain incompletely understood. The aim of the present study was to characterize the global impact of EGCG on the expression of microRNAs （miRNAs） in NPC cells. Methods： Using microarray analysis, the alterations of miRNA expression profiles were investigated in EGCG-treated CNE2 cells. Furthermore, the target genes and signaling pathways regulated by EGCG-specific miRNAs were identified using target prediction program and gene ontology analysis. Results： A total of 14 miRNAs exhibited 〉2-fold expression changes in a dose-dependent manner after treatment with 20 μmol/L and 40 μmol/L EGCG. Totally 43, 49, and 52 target genes from these differentially expressed miRNAs were associated with the apoptosis, cell cycle regulation, and cell proliferation, respectively. A total of 66 signaling pathways, primarily involved in cancer development and lipid and glucose metabolism, were shown to be regulated by EGCG-specific miRNAs. Conclusion： EGCG induces considerable alterations of miRNA expression profiles in CNE2 cells, which provides mechanistic insights into cellular responses and antitumor activity mediated by EGCG.

关键词： Antitumor Agents Epigallocatechin-3-gallate MicroRNAs Nasopharyngeal Carcinoma