检索结果-南通市图书馆

Superior Ductile and High-barrier Poly(lactic acid)Films by Constructing Oriented Nanocrystals as Efficient Reinforcement of Chain Entanglement Network and Promising Barrier Wall

引用

Chinese Journal of Polymer Science 2022年第10期40卷 1201-1212,I0009页

作者： Lin Zhou Ping-Ping Xu Shi-Hao Ni Ling Xu Hao Lin Gan-Ji Zhong hua-dong huang Zhong-Ming Li Collge of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

It is a daunting task to develop a promising strategy at an industrial scale for simultaneously ameliorating ductility and gas barrier performance of poly(lactic acid)(PLA)films in the application of green *** this work,biaxial stretching and constrained annealing were employed to prepare transparent PLA films with superior ductility and barrier *** oriented nano-sized crystals induced by biaxial stretching were developed into regularαform during constrained annealing,which could not only serve as“nano-barrier wall”to impede the diffusion and dissolution of gas molecules,but also strengthen amorphous chain entanglement network as physical crosslink to enhance *** a result,the as-prepared PLA films exhibited an outstanding comprehensive performance with a low oxygen and water vapor permeability coefficient of 0.733×10^(-14) cm^(3)·cm·cm^(-2)·s^(-1)·Pa^(-1) and 3.82×10^(-14) g·cm·cm^(-2)·s^(-1)·Pa^(-1),respectively,outstanding ductility with elongation at break of 66.0%,high yield strength of 84.2 MPa,and good transparency of more than 80%at 550 *** new insight in the relationship between microscopic amorphous and crystalline structure and macroscopic performance is conducive to alleviating the intrinsic defects of brittle and insufficient barrier PLA films without the aid of any heterogenous modifiers,facilitating their widespread commercialization in the booming sustainable packaging market.

关键词： Poly(lactic acid)films Biaxial stretching Constrained annealing Gas barrier properties Ductility

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydrogen bond producers in powerful protic ionic liquids for enhancing dissolution of natural cellulose

引用

SusMat 2024年第5期4卷 189-201页

作者： Shi-Peng Chen Dan-Yang Zhao Jin-Long Zhu Jing Wang Gan-Ji Zhong hua-dong huang Zhong-Ming Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengduChina

The manipulation of hydrogen bonding within protic ionic liquids is conducive to conquering the robust hydrogen bonding interactions in cellulose for its effective dissolution,but it is a great challenge to establish the delicate bal-ance of hydrogen bonding network between solvent and ***,we proposed the concept of“hydrogen bond producers”for urea molecules in 1,1,3,3-tetramethylguanidinium methoxyacetate acid([TMGH][MAA])to enhance the dissolution of *** optimization of physicochemical properties for[TMGH][MAA]solvent as a function of urea concentration revealed a remark-able increase in cellulose solubility from 13%to 17%(w/w)by adding only 0.25 wt%urea,highlighting the efficiency of[TMGH][MAA]as a power-ful solvent for the dissolution of *** experimental and simulation results verified that the significant improvement on dissolution of cellulose was attributed to the hydrogen bonding interaction of urea molecules with ion pairs and part of free ions,reducing the interference with the active ions bonded to ***,the considerable enhancement on compre-hensive properties of regenerated cellulose films demonstrated the effectiveness of[TMGH][MAA]/urea *** concept of“hydrogen bond producers”presented here opens a new avenue for significantly enhancing the dissolu-tion of natural cellulose,promoting the sustainable development in large-scale processing of cellulose.

关键词： cellulose dissolution hydrogen bond producers protic ionic liquids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

纳米生物条形码方法检测蛋白的关键技术及其发展

引用

中华检验医学杂志 2011年第4期34卷 305-308页

作者：董华凰蒋岩中国疾病预防控制中心性病艾滋病预防控制中心参比实验室北京102206

蛋白生物标志物的检测对了解疾病的发生和发展至关重要,在很多疾病早期,蛋白标志物的浓度通常很低,常用的ELISA法经常无法检出,灵敏度尚不能满足临床的需要.纳米BCA技术是将DNA标记技术与目标蛋白结合起来,将与蛋白识别过程相关的信号... 详细信息

蛋白生物标志物的检测对了解疾病的发生和发展至关重要,在很多疾病早期,蛋白标志物的浓度通常很低,常用的ELISA法经常无法检出,灵敏度尚不能满足临床的需要.纳米BCA技术是将DNA标记技术与目标蛋白结合起来,将与蛋白识别过程相关的信号进行放大,通过标记DNA的鉴定来实现蛋白的检测,为生物标记物的高灵敏度检测打开了新的局面[1],在生物分子检测、传染病监测、肿瘤早期发现和监测等各个方面有着广泛的应用前景.

关键词：蛋白标志物生物标志物分子检测纳米条形码传染病监测疾病早期 ELISA法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phenotypic resistance of resistant strains of HIV type-1 subtype B in China

引用

Chinese Medical Journal 2006年第23期119卷 1972-1977页

作者： LI Jue LU Jun-feng dong hua-huang BAO Zuo-yi LIU Si-yang LI Han-ping Zhuang Dao-min LIU Yong-jian LI Hong WANG Zhe WU Hao LI Jing-yun State Key Laboratory of Pathogen and Biosecurity Institute ofMicrobiology and Epidemiology Academy of Military MedicalSciences Beijing 100071 China Beijing Youan Hospital Capital Medical University Beijing100054 China Henan Center for Disease Control and Prevention Zhengzhou450003 China

Background This study was aim to explore the characteristics of phenotypic resistance of resistant strains of HIV type-1 （HIV-1） subtype B and to compare the concordance between the phenotypic resistance and genotypic resistance. Methods The genotypic resistance assay for the HIV-1 clinical isolates was performed. One isolate without resistance mutation was chosen as a drug-sensitive reference strain and seven subtype B isolates with resistance mutations were phenotypically tested. Fifty percent inhibitory concentrations （IC50） between resistant and sensitive viruses were compared. The resistance extent was determined by the folds of the increased IC50. The concordance between the phenotypic resistance and genotypic resistance was also analyzed. Results IC50 of resistant isolates were 0.0006--0.1300 μmol/L for zidovudine （AZT）, 0.0016--0.0390 μmol/L for lamivudine （3TC）, 0.0104--0.4234 μmol/L for nevirapine （NVP）, and 0.0163--0.1142 μmol/L for indinavir （IDV）, respectively. Genotypic and phenotypic resistance assays indicated that the resistant strains were intermediately and highly resistant to nucleotide analog reverse transcriptase inhibitors and non-nucleotide analog reverse transcriptase inhibitors. The phenotypic assay was consistent with the genotypic assay. For measuring the potential resistance, the genotypic assay was more sensitive than the phenotypic. In evaluating the resistance to protease inhibitors, these two assays were discrepant. Conclusions Both the phenotypic and genotypic assays indicate that the resistant viruses exist in HIV-infected patients in China who have received treatment. Phenotypic and genotypic assays have high concordance, and the genotypic assay could replace the phenotypic assay to predict the HIV- 1 resistance.

关键词： human immunodeficiency virus type-1 phenotype genotype drug resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exploring the performance of large language models on hepatitis B infection-related questions:A comparative study

引用

World Journal of Gastroenterology 2025年第3期31卷 103-112页

作者： Yu Li Chen-Kai huang Yi Hu Xiao-dong Zhou Cong He Jia-Wei Zhong Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina huanKui Academy Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve *** language models(LLMs)can potentially provide medical information for *** To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related *** LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third *** question was run three times using three *** was assessed via the Gunning Fog index and Flesch-Kincaid grade *** Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google *** the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical ***,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal *** Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related *** may be an adjunctive informational tool for patients and physicians to improve ***,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.

关键词： ChatGPT-3.5 ChatGPT-4.0 Google Gemini Hepatitis B infection Accuracy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

附生结晶调控有机高分子半导体材料聚集态结构与性能

引用

高分子学报 2024年第11期55卷 1441-1462页

作者：闫敬越刘玉敏黄华东高灿董焕丽李忠明中国科学院化学研究所北京分子科学国家重点实验室北京100190 四川大学高分子科学与工程学院四川610065 中国科学院大学北京100049

高质量共轭高分子半导体晶体材料的制备对于其基础物性的研究和高性能有机光电器件的构筑具有至关重要的意义.但是高分子材料存在本征分子量大、呈分散性、链间易于缠结等特征,导致其高度有序共轭高分子聚集体的制备面临巨大挑战.本文... 详细信息

高质量共轭高分子半导体晶体材料的制备对于其基础物性的研究和高性能有机光电器件的构筑具有至关重要的意义.但是高分子材料存在本征分子量大、呈分散性、链间易于缠结等特征,导致其高度有序共轭高分子聚集体的制备面临巨大挑战.本文立足于有机高分子半导体材料聚集态结构与性能调控,在传统溶液组装策略的基础上,介绍了新型取向结晶策略,重点探讨了附生结晶的影响因素以及附生结晶在调控有机高分子半导体材料聚集态结构与性能方面的优势,并对目前附生结晶存在的问题进行了总结与展望.

关键词：有机高分子半导体构效关系结构调控附生结晶

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

职业性噪声性听力损失与代谢综合征的关联

引用

环境与职业医学 2020年第12期37卷 1194-1199页

作者：冀芳丁晓文董华凰刘继文李珏北京市化工职业病防治院科研部北京100093 新疆医科大学公共卫生学院新疆乌鲁木齐830001

[背景]职业性噪声性听力损失(ONHL)是一种复杂的疾病,影响着众多劳动者的健康,代谢综合征(MetS)也已成为导致全球疾病负担加重的主要因素,开展ONHL与MetS关联的研究意义重大。[目的]探讨ONHL与Met S的关系,为制定职业性噪声暴露人群的... 详细信息

[背景]职业性噪声性听力损失(ONHL)是一种复杂的疾病,影响着众多劳动者的健康,代谢综合征(MetS)也已成为导致全球疾病负担加重的主要因素,开展ONHL与MetS关联的研究意义重大。[目的]探讨ONHL与Met S的关系,为制定职业性噪声暴露人群的听力损失和MetS的干预措施和防治策略提供科学依据。[方法]采用整群抽样的方法,以某大型机械维修企业1145名男性职业性噪声暴露人群为研究对象。按是否存在高频听力损失,将调查对象分为听力正常组(699人)和听力损失组(446人)。通过问卷调查收集调查对象的一般人口学特征、职业史、家族史、既往史、个人生活行为等资料,通过职业健康检查获得体重指数(BMI)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、血压和空腹血糖(FPG)等数据。使用非条件多因素logistic回归方法分析ONHL与MetS患病之间的关联,计算各危险因素的OR及95%CI。[结果]在1145名职业性噪声接触工人中,听力损失检出率为38.95%,听力损失检出率随接噪工龄的增长而呈增加的趋势(P<0.001)。对临床指标分析发现,听力损失组FPG水平高于听力正常组(P<0.001)。听力损失组人群高TG血症、高血压、高血糖和MetS的检出率均高于听力正常组(P<0.01)。多因素logistic回归分析结果显示,在排除其他混杂因素影响后,MetS是导致ONHL发生的独立危险因素(OR=1.48,95%CI:1.12~1.95,P=0.005),同时接噪工龄长、已婚、文化程度低也是ONHL的危险因素(P<0.01)。[结论]ONHL与MetS的发生有关联,Met S可能是影响ONHL发生发展的独立危险因素,采取MetS预防干预措施可能是降低ONHL发病风险的有效手段。

关键词：职业性噪声性听力损失代谢综合征干预措施

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

摩擦焊机压力控制系统模型辨识与PID参数整定

引用

煤矿机械 2018年第5期39卷 150-152页

作者：周春许翠华董萌萌黄煌兰菲中煤科工集团西安研究院有限公司西安710077

针对摩擦焊机顶锻压力超调和波动造成钻杆焊接质量不稳定的问题,进行了压力闭环系统模型辨识和控制参数优化研究。为精确获得压力系统数学模型,首先采用理论分析确定控制系统阶次,其次使用最小二乘法进行模型辨识获得准确系数,最后采用... 详细信息

针对摩擦焊机顶锻压力超调和波动造成钻杆焊接质量不稳定的问题,进行了压力闭环系统模型辨识和控制参数优化研究。为精确获得压力系统数学模型,首先采用理论分析确定控制系统阶次,其次使用最小二乘法进行模型辨识获得准确系数,最后采用离线优化的方法得到新的控制参数并明确变化趋势。结果表明,采用优化后的控制参数顶锻压力超调量小于2%,响应时间小于1 s,焊接质量稳定可靠。将离线参数优化与在线控制系统相结合,能够减少设备停机时间,缩短系统参数调试周期。

关键词：摩擦焊接压力超调系统辨识最小二乘法 PID整定

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

引用

Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li huang dong-dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

一维半地转浅水模式反演的理论分析和数值试验

引用

水动力学研究与进展（A辑） 2004年第1期19卷 38-45页

作者：杜华栋黄思训石汉青中国人民解放军理工大学气象学院江苏南京211101

　本文利用变分伴随方法,结合正则化思想,对一维半地转浅水模式中各参量的反演进行了理论分析和数值试验。文中首先利用伴随方法导出了进行反演时所需的各参量的泛函梯度,然后就初边值和模式参数的联合反演问题进行了数值试验。试验结... 详细信息

　本文利用变分伴随方法,结合正则化思想,对一维半地转浅水模式中各参量的反演进行了理论分析和数值试验。文中首先利用伴随方法导出了进行反演时所需的各参量的泛函梯度,然后就初边值和模式参数的联合反演问题进行了数值试验。试验结果表明,采用正则化后,模式参数反演的结果明显优于未采用正则化时反演的结果。

关键词：变分伴随正则化模式反演一维半地转浅水模式泛函梯度气象分析定解条件

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：