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Positive association between triglyceride glucose index and central systolic blood pressure among hypertensive adults

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Journal of Geriatric Cardiology 2022年第10期19卷 753-760,I0002页

作者： Li WANG Tian-Yu CAO Jin-Qiao LI Cong-Cong DING Jun-Pei LI hua-bo ying Li-Shun LIU Xiao huaNG Department of Nephrology the Fourth Hospital of Harbin Medical UniversityHarbinChina Biological Anthropo-logy University of California Santa BarbaraCaliforniaUSA Department of Urology Surgery Graduate School of the Fourth Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology the Second Affiliated Hospi-tal of Nanchang UniversityNanchangChina Institute of Biomedicine Anhui Medical UniversityHefeiChina Instit-ute of Biomedical and Health Engineering Graduate School at ShenzhenTsinghua UniversityShenzhenChina Shen-zhen Evergreen Medical Institute ShenzhenChina

BACKGROUND While studies have suggested the association between triglyceride-glucose(TyG)index,a reliable surrogate for insulin resistance and hypertension data are limited to the correlation of TyG and central blood *** study aims to test the hypothesis that a higher TyG index is associated with elevated central systolic blood pressure(cSBP).METHODS A total of 9249 Chinese hypertensive adults from the H-type Hypertension and Stroke Prevention and Control Project were analyzed in this *** was measured noninvasively using an A-Pulse CASPro *** index was calculated as ln[fasting triglycerides(mg/dL)×fasting glucose(mg/dL)/2].Smoothing curve and multivariate linear regression models[beta coefficient(β)with 95%CI]were applied to analyze the association between TyG index and *** analyses were conducted to explore potential modifications to such a *** The overall mean TyG index is 8.8±0.7,and the total mean cSBP is 131.3±12.8 *** index was observed to be independently and positively associated with cSBP among the total population(β=0.92,95%CI:0.53–1.31,P<0.001),and participants who do not use antihypertensive drugs(β=1.03,95%CI:0.46–1.60,P<0.001),which is in accordance with the result of the smoothing *** association between TyG index and cSBP appears robust in all tested *** TyG index is positively and independently associated with cSBP among hypertensive *** study result suggests that TyG index might serve as an effective marker for vascular function.

关键词： hypertensive elevated systolic

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Individual and joint effects of borderline ankle-brachial index and high plasma total homocysteine on all-cause death in hypertensive adults

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Journal of Geriatric Cardiology 2022年第7期19卷 522-530页

作者： Jun-Pei LI Tian-Yu CAO Xiao-Yuan ZHA Yun YU Zi-Heng TAN Zai-hua CHENG hua-bo ying Wei ZHOU Lin-Juan ZHU Tao WANG Li-Shun LIU Hui-Hui BAO Xiao huaNG Xiao-Shu CHENG Department of Cardiology the Second Affiliated Hospital of Nanchang UniversityNanchangChina University of California Santa BarbaraCAUSA Rancheng Community Health Service Center WuyuanChina Center for Prevention and Treatment of Cardiovascular Diseases the Second Affiliated Hospital of Nanchang UniversityNan-changChina Graduate School at Shenzhen Tsinghua UniversityShenzhenChina

BACKGROUND The cardiovascular hazards of total homocysteine(tHcy)are long *** addition,despite the acknow-ledgment on the importance of low ankle-brachial index(ABI)(<0.9),borderline ABI(0.91-0.99)was once commonly **... 详细信息

BACKGROUND The cardiovascular hazards of total homocysteine(tHcy)are long *** addition,despite the acknow-ledgment on the importance of low ankle-brachial index(ABI)(borderline ABI(0.91-0.99)was once commonly *** study aims to explore the independent and joint effect of tHcy level and borderline ABI on all-cause death in hypertensive *** This study included 10,538 participants from China H-type Hypertension Registry *** was described into two groups:normal ABI(1.00-1.40)and borderline *** level was also divided into two groups:borderline ABI and high tHcy level has significantly higher altitude and larger increasing rate over follow-up period compare to other *** those with borderline ABI,participants with high tHcy had higher death risk than those with low tHcy,nevertheless,no significant different between borderline and normal ABI among those with low tHcy *** borderline ABI and tHcy level both have independent predictive value on all-cause *** combined group of borderline ABI and high tHcy has highest risk factor of outcomes,which suggested the mutual additive value of border-line ABI and *** attention should be given to the importance of borderline ABI in hypertensive population,especially with elevated tHcy level.

关键词： hypertensive death ankle

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彩色多普勒超声在人工动静脉内瘘并发症中的临床决策评价

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医学与哲学（B） 2012年第9期33卷 58-59页

作者：薄华颖大连医科大学附属第二医院超声科辽宁大连116027

由于血液透析的广泛应用,尿毒症患者的生存时间显著延长。建立并保持良好的血管通路是长期慢性血液透析的前提条件。彩色多普勒超声作为一种无创性检查方法,在人工动静脉内瘘血管通路的监测中发挥着重要的临床价值。本文评估彩色多普勒... 详细信息

由于血液透析的广泛应用,尿毒症患者的生存时间显著延长。建立并保持良好的血管通路是长期慢性血液透析的前提条件。彩色多普勒超声作为一种无创性检查方法,在人工动静脉内瘘血管通路的监测中发挥着重要的临床价值。本文评估彩色多普勒超声在人工动静脉内瘘并发症临床决策中的重要作用。

关键词：彩色多普勒超声人工动静脉内瘘临床决策

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超声心动图技术在心衰患者心脏再同步化治疗中的应用

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医学与哲学（B） 2012年第10期33卷 49-51页

作者：薄华颖大连医科大学附属第二医院超声科辽宁大连116027

心力衰竭患者普遍存在不同程度的心室内或心室间的不同步化运动。超声心动图可准确评估心脏机械不同步运动的部位、范围及程度。超声心动图在心脏再同步化治疗(CRT)患者筛选、预测和评价CRT疗效,CRT术后随访观察以及房室和室间间期的优... 详细信息

心力衰竭患者普遍存在不同程度的心室内或心室间的不同步化运动。超声心动图可准确评估心脏机械不同步运动的部位、范围及程度。超声心动图在心脏再同步化治疗(CRT)患者筛选、预测和评价CRT疗效,CRT术后随访观察以及房室和室间间期的优化等方面具有重要临床意义。

关键词：超声心动图心力衰竭心脏再同步化治疗

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移植肝硬度及背向散射积分测定的临床诊断价值

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中国医学影像技术 2008年第5期24卷 703-705页

作者：薄华颖夏稻子大连医科大学附属第二院超声科辽宁大连116027

目的应用组织硬度及超声背向散射积分方法对移植肝进行检测,以探讨该技术在肝移植术后的临床诊断价值。方法应用HP Sonos5500型彩超仪对60例健康成年人及60例肝移植患者进行检测,对左肝膈面压缩幅度及背向散射积分值进行定量分析。结果... 详细信息

目的应用组织硬度及超声背向散射积分方法对移植肝进行检测,以探讨该技术在肝移植术后的临床诊断价值。方法应用HP Sonos5500型彩超仪对60例健康成年人及60例肝移植患者进行检测,对左肝膈面压缩幅度及背向散射积分值进行定量分析。结果有术后并发症的肝移植患者移植肝的背向散射积分值高于正常对照组及无术后并发症的肝移植组,其差异有显著性意义(P0.05)。结论肝硬度及超声背向散射积分测定能够较客观、准确地评价移植肝的病理状况。

关键词：超声检查肝硬度超声背向散射积分肝移植

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Achieving further refinement of grain structure and improvement of mechanical properties in Al-12Si-4Cu-2Ni-1Mg alloy by Al-Ti-C-B master alloy addition and deep cryogenic treatment

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China Foundry 2025年第1期22卷 75-82页

作者： Lin-fei Xia Wen-bo Li Zuo-shan Wei Yu-ying Wu Xiang-fa Liu China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China Shandong Key Laboratory of Advanced Aluminum Materials and Technology Binzhou Institute of TechnologyBinzhou 256600ShandongChina

Near-eutectic Al-Si alloys are widely used in automotive manufacturing due to their superior wear resistance and high temperature *** of high Si content,the grain refinement of near-eutectic Al-Si alloy has been a problem for many *** this study,the effect of deep cryogenic treatment(DCT)on the microstructure and mechanical properties of Al-12Si-4Cu-2Ni-Mg alloy with addition of Al-Ti-C-B master alloy was fully *** show that the average grain size of the alloy is greatly reduced from 0.92 mm to 0.50 mm,and the eutectic Si and Al7Cu4Ni precipitates are spheroidized and refined in Al-12Si-4Cu-2Ni-Mg after DCT for 24 h and aging *** these changes of microstructures result in a significant increment of about 22.5%in elongation and a slight enhancement of about 6.8%in tensile ***,the refinement of microstructure also significantly improves the fatigue life of the alloy.

关键词： deep cryogenic treatment near-eutectic Al-Si master alloy microstructure mechanical properties

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Machine learning model using immune indicators to predict outcomes in early liver cancer

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World Journal of Gastroenterology 2025年第5期31卷 43-56页

作者： Yi Zhang Ke Shi ying Feng Xian-bo Wang Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Patients with early-stage hepatocellular carcinoma(HCC)generally have good survival rates following surgical ***,a subset of these patients experience recurrence within five years *** To develop predictive models utilizing machine learning(ML)methods to detect early-stage patients at a high risk of *** Eight hundred and eight patients with HCC at Beijing Ditan Hospital were randomly allocated to training and validation cohorts in a 2:1 *** models were generated using random survival forests and artificial neural networks(ANNs).These ML models were compared with other classic HCC scoring systems.A decision-tree model was established to validate the contri-bution of immune-inflammatory indicators to the long-term outlook of patients with early-stage *** Immune-inflammatory markers,albumin-bilirubin scores,alpha-fetoprotein,tumor size,and International Normalized Ratio were closely associated with the 5-year survival *** various predictive models,the ANN model gene-rated using these indicators through ML algorithms exhibited superior perfor-mance,with a 5-year area under the curve(AUC)of 0.85(95%CI:0.82-0.88).In the validation cohort,the 5-year AUC was 0.82(95%CI:0.74-0.85).According to the ANN model,patients were classified into high-risk and low-risk groups,with an overall survival hazard ratio of 7.98(95%CI:5.85-10.93,P<0.0001)between the two *** Hepatocellular carcinoma(HCC)is one of the six most prevalent cancers[1]and the third leading cause of cancer-related mortality[2].China has some of the highest incidence and mortality rates for liver cancer,accounting for half of global cases[3,4].The Barcelona Clinic Liver Cancer(BCLC)Staging System is the most widely used framework for diagnosing and treating HCC[5].The optimal candidates for surgical treatment are those with early-stage HCC,classified as BCLC stage 0 or *** with early-stage liver cancer typically hav

关键词： Hepatocellular carcinoma Inflammation Machine learning Prognosis Artificial neural networks Immune biomarkers

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Rapid detection of colored and colorless macroand micro-plastics in complex environment via near-infrared spectroscopy and machine learning

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Journal of Environmental Sciences 2025年第1期147卷 512-522页

作者： Hui-huang Zou Pin-Jing He Wei Peng Dong-ying Lan Hao-Yang Xian Fan Lü hua Zhang Institute of Waste Treatment&Reclamation College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

To better understand the migration behavior of plastic fragments in the environment,development of rapid non-destructive methods for in-situ identification and characterization of plastic fragments is ***,most of the studies had focused only on colored plastic fragments,ignoring colorless plastic fragments and the effects of different environmental media(backgrounds),thus underestimating their *** address this issue,the present study used near-infrared spectroscopy to compare the identification of colored and colorless plastic fragments based on partial least squares-discriminant analysis(PLS-DA),extreme gradient boost,support vector machine and random forest *** effects of polymer color,type,thickness,and background on the plastic fragments classification were ***-DA presented the best and most stable outcome,with higher robustness and lower misclassification *** models frequently misinterpreted colorless plastic fragments and its background when the fragment thickness was less than 0.1mm.A two-stage modeling method,which first distinguishes the plastic types and then identifies colorless plastic fragments that had been misclassified as background,was *** method presented an accuracy higher than 99%in different *** summary,this study developed a novel method for rapid and synchronous identification of colored and colorless plastic fragments under complex environmental backgrounds.

关键词： Colorless microplastics Near-infrared hyperspectral imaging Plastic identification Partial least squares discriminant analysis Machine learning

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Tandem asymmetric dearomatized functionalization reaction of phenols with Evans-ynamides enabled by divergent electrophiles

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Science China Chemistry 2025年第2期68卷 649-660页

作者： ying-Qi Zhang Gan-Lu Qian Yun Liu Jia-Hui Li Xin Hong Zhou Xu bo Zhou Long-Wu Ye State Key Laboratory of Physical Chemistry of Solid Surfaces Key Laboratory of Chemical Biology of Fujian Provinceand College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Center of Chemistry for Frontier Technologies Department of ChemistryState Key Laboratory of Clean Energy UtilizationZhejiang UniversityHangzhou 310027China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy School of PharmacyXuzhou Medical UniversityXuzhou 221004China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China State Key Laboratory of Organometallic Chemistry Chinese Academy of SciencesShanghai 200032China

Herein,we disclose a highly regio-/chemoselective tandem asymmetric dearomatized halofunctionalization reaction of phenoltethered ynamides with diverse electrophilic halogenation sources in a catalyst-free manner for the practical and rapid assembly of a series of halogenated spirocyclic ***,the related dearomatized selenation and protonation are also achieved,affording the corresponding selenated and protonated spirocycles in high ***,the enantioselectivities of these products can be perfectly induced by Evans auxiliaries(99%ees).Significantly,this protocol not only represents the first tandem asymmetric halofunctionalization reaction of phenol derivatives,but also constitutes the first asymmetric halogenation/selenation of *** calculations indicate a remote induction model of Evans chiral auxiliary-attached keteniminium.

关键词： alkynes cyclization dearomatization Evans chiral auxiliary spirocycles

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Dual search mode artificial bee colony algorithm based on exploration-exploitation tradeoff and its application

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Kongzhi yu Juece/Control and Decision 2025年第2期40卷 507-516页

作者： Wang, ying-Cong Li, bo Sun, Jun-Wei Wang, Yan-Feng School of Electrical and Information Engineering Zhengzhou University of Light Industry Zhengzhou450002 China

The artificial bee colony algorithm has the advantages of a simple structure and easy implementation. However, due to its strong exploration ability and weak exploitation capability, it also suffers from drawbacks such as low solution accuracy and slow convergence speed. To solve these problems, this paper proposes a dual search mode artificial bee colony algorithm based on exploration-exploitation tradeoff, which includes three core modules: exploration-exploitation control, exploration-exploitation execution, and exploration-exploitation reinforcement. In the control stage, we design an exploration-exploitation indicator based on the population’s evolutionary dynamics, which initially emphasizes exploration and gradually shifts towards exploitation. In the execution stage, we design search equations guided by differential solution information, with a focus on the implementation points of exploration and exploitation. In the enhancement stage, the onlooker bees are instructed to select high-quality food sources for further search, using criteria such as diversity ranking and fitness ranking. Numerical experiments are conducted on traditional test functions and CEC2013 test functions. The results demonstrate that compared with eight high-level artificial bee colony algorithms proposed in recent years, the proposed algorithm exhibits strong competitiveness in terms of solution quality and convergence speed. Finally, the proposed algorithm is applied to optimize the risk prediction model for esophageal cancer, yielding satisfactory results. © 2025 Northeast University. All rights reserved.

关键词： artificial bee colony algorithm esophageal cancer prediction exploration-exploitation tradeoff function optimization

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