检索结果-南通市图书馆

化学教育（中英文） 2024年第9期45卷 118-124页

作者：宋正华郑州外国语学校河南郑州450001

从基本概念、常见反应类型和机理出发,对第37届中国化学奥林匹克(初赛)有机试题进行了解析,以供读者参考。

关键词：化学奥林匹克有机试题反应机理

Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： CAO Ni-da ZHU Xiao-hong MA Fang-qi XU Yan DONG Jia-huan QIN Meng-meng LIU Tian-shu ZHU Chun-chao GUO Wei-jian DING Hong-hua GUO Yuan-biao LIU Li-kun song Jin-jie WU Ji-ping CHENG Yue-lei ZENG Lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China Gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AGC)in China in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AGC patients.Methods This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AGC from 10 hospitals in China between January 1,2000 and July 31,2021.Overall survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for bias.Results A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were enrolled.Among them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received CM.Two-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in first-line.The application of apatinib increased(33.33%)in third-line.The application of checkpoint inhibitors has increased since 2020.COX analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of AGC.After PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(P<0.001).Conclusions In real-world practice for AGC in China,therapy choices consisted with guidelines.Two-drug regimen was the main first-line choice.Standardized CM treatment was an independent prognostic factor and could prolong the OS of C

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine

基于实测数据的半潜式平台贝叶斯模型修正方法研究

在线全文

学校读者我要写书评

暂无评论

船舶力学 2024年第2期28卷 179-190页

作者：李松武文华姚伟岸大连理工大学工业装备结构分析优化与CAE软件全国重点实验室辽宁大连116024 大连理工大学宁波研究院浙江宁波315000

随着半潜式平台的长期海上服役,平台的基本设计参数会发生变化,如仍基于原始设计参数对平台进行分析将影响结果的准确性。本文以半潜式平台服役中易发生变化的基本参数(平台排水量、重心高度和三个自由度回转半径)作为修正参数,以平台... 详细信息

随着半潜式平台的长期海上服役,平台的基本设计参数会发生变化,如仍基于原始设计参数对平台进行分析将影响结果的准确性。本文以半潜式平台服役中易发生变化的基本参数(平台排水量、重心高度和三个自由度回转半径)作为修正参数,以平台横摇、纵摇和垂荡自由度的方差和波频功率谱密度构建目标函数,建立可依据实测数据的半潜式平台贝叶斯参数修正方法。以我国某半潜式平台实测数据为例,开展平台的参数修正研究,并基于修正后的参数对平台多年一遇环境荷载下的响应进行对比评估。

关键词：半潜式平台原型监测贝叶斯参数修正代理模型

Rare earth metals modified Ni-S2O8^2-/ZrO2-Al2O3 catalysts for n-pentane isomerization

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2017年第1期25卷 74-78页

作者： hua song Lele Zhao Na Wang College of Chemistry ＆ Chemical Engineering Northeast Petroleum University Daqing 163318 China Provincial Key Laboratory of Oil ＆ Gas Chemical Technology College of Chemistry ＆ Chemical Engineering Northeast Petroleum University Daqing 163318 China

The effects of adding rare earth(RE) metals,such as Ce,Yb and Pr to Ni-S_2O_8^(2-)/ZrO_2-Al_2O_3(Ni-SZA) on the structure of catalysts as well as their isomerization performance were studied.The prepared catalysts were characterized by XRD,BET,FT-IR,Py-IR,and H_2-TPR,The results showed that the addition of RE metals can increase the strength and amounts of the acid sites,improve the redox properties of catalysts.The Yb-Ni-SZA catalyst showed the best redox properties,which could provide enough metallic sites.In addition,it provided the largest amounts of weak and moderately strong acid sites.Among RE metals modified Ni-SZA catalyst,Yb-Ni-SZA exhibited the highest isopentane yield of 61.7%at 160 °C.The optimum isomerization catalytic performance of the catalysts decreased in the order of Yb-Ni-SZA > Pr-Ni-SZA > Ni-SZA > Ce-Ni-SZA.

关键词：异构化催化剂金属改性稀土金属正戊烷氧化还原性能催化剂结构 FT-IR 催化性能

Asymptomatic recurrence in patients with pulmonary embolism

在线全文

学校读者我要写书评

暂无评论

中华医学杂志(英文版) 2024年第9期137卷 2024 Mar 21页

作者： Hu song Wang Lei Tan Jiangshan Fang Wei Ma Xinghong Guo Tingting Gao Xin Wu Yan Zhou Yuzi Wang Li hua Lu State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Nuclear Medicine National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Key Laboratory of Pulmonary Vascular Medicine Department of Cardiology National Clinical Research Center of Cardiovascular Diseases National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Fuwai Shenzhen Hospital Chinese Academy of Medical Sciences Shenzhen Guangdong China

基于柔性时间窗的地铁货物车厢配置与装载优化

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

交通运输工程学报 2024年第2期24卷 221-231页

作者：石俊刚王松郭军华华东交通大学交通运输工程学院江西南昌330013

为缓解城市道路拥堵,提高城市物流系统周转效率,提出了利用地铁线路在非高峰时段开展货物运输;基于客货共载运输模式,在满足乘客出行需求的前提下,推算了各列车最多可挂载的货物车厢数,在此基础上进行货物车厢配置与装载方案优化;以列... 详细信息

为缓解城市道路拥堵,提高城市物流系统周转效率,提出了利用地铁线路在非高峰时段开展货物运输;基于客货共载运输模式,在满足乘客出行需求的前提下,推算了各列车最多可挂载的货物车厢数,在此基础上进行货物车厢配置与装载方案优化;以列车货物车厢配置计划与货物装载分配方案为决策变量,考虑货物送达柔性时间窗与容量限制的约束条件,以配送服务惩罚和货物车厢挂载成本最低为目标,构建了整数线性规划模型,并利用CPLEX优化软件进行模型求解。试验结果表明:为满足4类不同送达时限货物运输需求,方案共配置货运车厢42节,运营总成本为16970元;随着延迟送达惩罚系数增大,货物延迟送达率呈快速降低趋势,当延迟送达惩罚系数由5元·h^(-1)增加到100元·h^(-1)时,延迟送达率由22.50%降至8.75%,随着提前送达惩罚系数增大,货物提前送达率同样呈现快速降低趋势,当提前送达惩罚系数由0增加到40元·h^(-1)时,提前送达率由37.50%降低至3.75%,说明构建的模型对货物服务时效反应较为灵敏,同时有效满足货物送达服务时限要求;当某类货物惩罚系数增加时,该货物送达的提前率或延迟率会降低,整体表现为货物送达的准点率提高,服务水平得到改善,说明优化模型对不同类型货物的送达惩罚系数反应较为敏感;随着客运满载系数的增大,货物送达的准点率呈现递增趋势,货物送达提前率与延迟率总体上呈下降趋势,方案运营总成本也呈递减趋势,说明适当提高客运满载率阈值可以缓解部分列车运力,进而提高货物送达的准点率。

关键词：铁路运输地铁货运车厢配置装载优化柔性时间窗服务水平

在线全文

学校读者我要写书评

暂无评论

论教学遗憾

教育理论与实践 2024年第8期44卷 43-47页

作者：宋立华湖州师范学院教师教育学院浙江湖州313000

遗憾是教学的必然产物。教学遗憾是指教师在将现实教学结果与设想的更好结果进行比较而产生的“原本可以更好的”“不称心、惋惜”的一种后悔感。教学理想与教学现实之间存在的客观差距、教学的复杂性和教学决策的多元性、教育教学变革... 详细信息

遗憾是教学的必然产物。教学遗憾是指教师在将现实教学结果与设想的更好结果进行比较而产生的“原本可以更好的”“不称心、惋惜”的一种后悔感。教学理想与教学现实之间存在的客观差距、教学的复杂性和教学决策的多元性、教育教学变革的广泛性与深刻性、教师的自责等是教学遗憾产生的主要原因。从促进教师专业成长的角度来看,教学遗憾的价值主要体现在帮助教师更好地反思曾经的负面经验,深入理解自我与教学;促进回避行为的消减和趋近行为的产生;在一定程度上能够维护人际和谐,促进教研共同体的建设。教师可以通过改变对教学遗憾的消极认知、积极进行对话沟通交流、增强教学责任感和洞察力、发挥教学想象力勇于探索和创新等途径来促进其价值的实现。

关键词：教学遗憾教师专业发展教学责任感对话沟通教学想象力

在线全文

学校读者我要写书评

暂无评论

公共卫生治理专家咨询制度的法治探寻

求是学刊 2024年第2期51卷 91-102页

作者：宋华琳郑琛南开大学法学院天津300350

专家咨询制度是公共卫生治理中提升科学理性的重要机制。专家咨询适用于专业性、技术性较强,涉及重大公共利益和具有高度争议性的决策事项。应探究行政任务与专家咨询形式之间的匹配性,在处于科学前沿并兼具高度政策考量的公共卫生治理... 详细信息

专家咨询制度是公共卫生治理中提升科学理性的重要机制。专家咨询适用于专业性、技术性较强,涉及重大公共利益和具有高度争议性的决策事项。应探究行政任务与专家咨询形式之间的匹配性,在处于科学前沿并兼具高度政策考量的公共卫生治理领域,合议制咨询形式更具制度优势。应健全专家遴选机制,从专家个人资质和成员构成两个角度明确遴选标准,完善专家遴选程序。在专家咨询程序方面,应健全专家利益冲突回避制度,完善专家咨询会议制度和会议程序,专家咨询意见对行政机关不具备法律上的拘束力,但具有事实上的影响力。应构建专家咨询制度的监督机制,完善专家咨询公开制度,加强咨询专家的说明理由要求,激活司法审查的监督功能。

关键词：公共卫生治理专家咨询专家遴选专家咨询程序可问责性

数字技术能否缩小区域制造业全要素生产率差距

在线全文

学校读者我要写书评

暂无评论

深圳大学学报（人文社会科学版） 2024年第1期41卷 71-82页

作者：刘富华宋然云南财经大学经济学院云南昆明650221 乡村振兴云南省高校协同创新中心云南昆明650221

缩小制造业全要素生产率差距是推动区域协调发展和区域制造业高质量发展的重要内容。数字技术的研发及应用在为制造业全要素生产率增长提供重要动力的同时,也影响着我国制造业全要素生产率的区域差距。利用我国2014-2022年省级面板数据... 详细信息

缩小制造业全要素生产率差距是推动区域协调发展和区域制造业高质量发展的重要内容。数字技术的研发及应用在为制造业全要素生产率增长提供重要动力的同时,也影响着我国制造业全要素生产率的区域差距。利用我国2014-2022年省级面板数据,以适宜性技术进步和技术扩散理论为核心,系统剖析数字技术空间溢出对区域制造业全要素生产率差距的影响,以及数字经济发展水平和科技资源禀赋两大约束条件对数字技术和区域制造业全要素生产率差距之间关系的影响,结果发现:从整体上看,数字技术发展有利于缩小区域制造业全要素生产率差距,数字技术的空间溢出加速了区域间制造业全要素生产率的趋同;从机制上看,数字技术空间后向溢出对区域制造业全要素生产率差距缩小的贡献效果强于前向溢出的效果。当数字技术水平相对较高时,数字技术通过技术扩散缩小了区域制造业全要素生产率差距;当数字技术水平相对较低时,数字技术通过技术扩散扩大了区域制造业全要素生产率差距;当区域创新要素禀赋相似时,数字技术通过技术扩散对区域制造业全要素生产率差距缩小的贡献程度更强。

关键词：数字技术技术扩散空间溢出区域制造业全要素生产率差距空间条件收敛

Eikenella corrodens isolated from pleural effusion:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第18期12卷 3596-3602页

作者： Zi-Cong Liang Hao Ouyang Xue-Jing song Jian-Xin Liang Wei-hua Zheng Jian-Jun Chen Zheng-Gang Yin Sha-Yan Chen Department of Laboratory Science Binhaiwan Central Hospital of DongguanDongguan 523905Guangdong ProvinceChina Key Laboratory of accurately etiological research on the pathogenesis of inflammation and cancer Dongguan 523905Guangdong ProvinceChina Central Laboratory Binhaiwan Central Hospital of DongguanDongguan 523905Guangdong ProvinceChina

BACKGROUND The bacterium Eikenella,classified as a gram-negative member of the phylum Proteobacteria,is distinguished by its rarity,corrosive nature,facultative anaerobic properties,and conditional pathogenicity.It represents the sole species within its genus-Eikenella corrodens(E.corrodens)-and can be found colonizing both human and animal oral and nasopharyngeal regions.Additionally,it occasionally inhabits the gastrointestinal or urogenital tracts.However,its slow growth rate can be attributed to its high nutritional requirements.However,there is an uneven distribution of construction and diagnostic capacity in China which poses undeniable challenges for the clinical examination and analysis of this case,especially in the basic hospitals.CASE SUMMARY Here we presented a case of empyema associated with E.corrodens infection in a 67-year-old male patient without any previous history of infectious diseases in our primary hospital in Dongguan district of China.The patient was admitted due to recurrent worsening cough,sputum production,and dyspnea for 3 d,which had persisted for over 20 years.Moreover,the patient experienced a onehour episode of unconsciousness.Upon admission,immediate comprehensive examinations were conducted on the patient which subsequently led to his admission to the intensive care unit.Meanwhile,the patient presented with drowsiness and profuse sweating along with bilateral conjunctival edema observed during initiation of non-invasive ventilation,suggesting empyema.A significant amount of coffee-colored malodorous pleural fluid was drained during the procedure above and sent to the laboratory department for inspection.Finally,laboratory culture results confirmed the presence of E.corrodens infection in the pleural fluid sample.The patient received antimicrobial therapy until died on day 22 in the hospital.CONCLUSION In this report,we presented a case of empyema associated with E.corrodens infection.Multiple courses of morphological examination,viable culture analysis,and biochemical identifica

关键词： Eikenella corrodens Pleural fluid Morphology Viable culture Biochemical identification Case report