检索结果-南通市图书馆

A new cucurbitane triterpenoid from Momordica charantia

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第7期18卷 843-845页

作者： Qing Yan Li Hong Liang hu biao chen Bin Wang Yu Ying Zhao Department of Natural Medicines School of Pharmaceutical Sciences Peking University Health Science Center Beijing 100083 China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Science Peking University Beijing 100083 China

One new cucurbitane-type triterpenoid saponin, 5β,19-epoxycucurbita-6,23-diene-3β,19,25-triol-3-O-β-D-allopyranoside （1）,named momordicoside P was isolated from the fresh fruits ofMomordica charantia. The structu... 详细信息

关键词： Momordica charantia Cucurbitane triterpenoid Saponin Momordicoside P

Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第12期11卷 3966-3982页

作者： Yancheng Tang Liming Wang Tao Yi Jun Xu Jigang Wang Jiang-Jiang Qin Qilei chen Ka-Man Yip Yihang Pan Peng Hong Yingying Lu Han-Ming Shen hu-biao chen School of Chinese Medicine Hong Kong Baptist UniversityHong Kong SAR 999077China School of Biomedical Sciences Hunan UniversityChangsha 410082China Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Artemisinin Research Center China Academy of Chinese Medical SciencesBeijing 100700China The First Affiliated Hospital of Southern University of Science and Technology the Second Clinical Medical College of Jinan UniversityShenzhen People’s HospitalShenzhen 518020China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China epartment of Medical Research Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China Department of Biomedical Science City University of Hong KongHong Kong SAR 999077China Faculty of Health Sciences University of MacaoMacao SAR 999078China

Mitochondria as a signaling platform play crucial roles in deciding cell *** classic anticancer agents are known to trigger cell death through induction of mitochondrial ***,one selective autophagy,is the key mitochondrial quality control that effectively removes damaged ***,the precise roles of mitophagy in tumorigenesis and anticancer agent treatment remain largely ***,we examined the functional implication of mitophagy in the anticancer properties of magnolol,a natural product isolated from herbal Magnolia ***,we found that magnolol induces mitochondrial depolarization,causes excessive mitochondrial fragmentation,and increases mitochondrial reactive oxygen species(mtROS).Second,magnolol induces PTEN-induced putative kinase protein 1(PINK1)-Parkin-mediated mitophagy through regulating two positive feedforward amplification ***,magnolol triggers cancer cell death and inhibits neuroblastoma tumor growth via the intrinsic apoptosis ***,magnolol prolongs the survival time of tumor-bearing ***,inhibition of mitophagy by PINK1/Parkin knockdown or using inhibitors targeting different autophagy/mitophagy stages significantly promotes magnolol-induced cell death and enhances magnolol's anticancer efficacy,both in vitro and in ***,our study demonstrates that magnolol can induce autophagy/mitophagy and apoptosis,whereas blockage of autophagy/mitophagy remarkably enhances the anticancer efficacy of magnolol,suggesting that targeting mitophagy may be a promising strategy to overcome chemoresistance and improve anticancer therapy.

关键词： PINK1-Parkin-mediated mitophagy Magnolol Combination therapy Apoptosis Tumor suppression

Brusatol Inhibits Proliferation,Migration,and Invasion of Nonsmall Cell Lung Cancer PC-9 Cells

在线全文

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2023年第4期9卷 454-460页

作者： Lu-Ming Yang Wen-Min Zhou Qiao-Ru Guo Xin-Yue Fan Dong-Yu huang Xiao-Fei Sun Jie Yuan hua Yu hu-biao chen Jian-Ye Zhang Key Laboratory of Molecular Target and Clinical Pharmacology and The State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences and The Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhouChina Department of Pharmaceutical Sciences Xinjiang Second Medical CollegeKaramay China Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoMacaoChina School of Chinese Medicine Hong Kong Baptist UniversityHong KongChina

Objective:The purpose of this study was to investigate the inhibitory effect of brusatol,a nigakilactone extracted from Brucea javanica,on lung cancer for development of therapeutic *** explored the effects of brusatol on the proliferation,migration,and invasion of lung cancer PC-9 cells in vitro and analyzed the mechanisms *** and Methods:MTT assay was used to determine the effect of brusatol on the proliferative capacity of PC-9 and H1975 cells in *** half-maximal inhibitory concentrations(IC_(50))were calculated and used as a reference for subsequent *** in the number and size of tumor cell clusters were monitored by the colony formation assay as evidence for the effect of brusatol on cell *** effect of brusatol on the migration and invasion of PC-9 cells was evaluated using wound healing and transwell assays,*** in lung cancer cells was detected using the Annexin V-FITC/propidium iodide *** correlated anticancer mechanism was detected using Western ***:The IC_(50)values of brusatol acting on PC-9 and H1975 cells were 1.58±0.30μM and 31.34±2.72μM,respectively,according to the MTT *** addition,brusatol suppressed PC-9 cell proliferation,migration,and invasion,as well as induced apoptosis,which may be related to the downregulation of epidermal growth factor receptor(EGFR),β-catenin,Akt,and STAT3 ***:Brusatol showed potent anticancer activity against lung cancer PC-9 cells,inhibiting the proliferative capacity and metastatic potential of PC-9 *** anticancer effect may be related to the downregulation of EGFR,β-catenin,Akt,and STAT3.

关键词： Antitumor brusatol lung cancer migration proliferation

在线全文

学校读者我要写书评

暂无评论

爆生裂纹与层理缺陷相互作用的实验研究

振动与冲击 2017年第12期36卷 99-104页

作者：岳中文胡庆文陈彪中国矿业大学(北京)力学与建筑工程学院北京100083

为了研究爆生裂纹与层理缺陷的相互作用机制,采用新型数字激光动态焦散线实验方法对含层理岩体在爆炸载荷下的动态断裂行为进行了实验分析。实验结果表明:在爆炸载荷下,当炮孔切槽方向与层理面存在一定夹角θ时,爆炸使层理岩体裂纹扩展... 详细信息

为了研究爆生裂纹与层理缺陷的相互作用机制,采用新型数字激光动态焦散线实验方法对含层理岩体在爆炸载荷下的动态断裂行为进行了实验分析。实验结果表明:在爆炸载荷下,当炮孔切槽方向与层理面存在一定夹角θ时,爆炸使层理岩体裂纹扩展分为爆生主裂纹、界面裂纹、次生裂纹三个阶段;爆生主裂纹扩展到层理面后,不是直接贯通层理面沿原方向继续扩展,而是产生界面裂纹之后再继续扩展,产生的界面裂纹长度随夹角θ增大而减小;裂纹扩展贯通层理后,次生裂纹继续扩展,随夹角θ的增大,次生裂纹扩展长度逐渐增大;爆生主裂纹扩展过程中,随着爆生主裂纹尖端至层理面距离的减小,爆生主裂纹尖端动态应力强度因子和裂纹扩展速度均逐渐减小,说明层理面对爆生主裂纹的扩展起阻碍作用,且夹角θ越大阻碍作用越明显。实验研究分析了不同角度层理构造缺陷对裂纹扩展规律的影响。

关键词：焦散线层理岩体爆炸荷载动态应力强度因子

在线全文

学校读者我要写书评

暂无评论

肠道菌群与帕金森病的相关性

中华老年医学杂志 2018年第10期37卷 1164-1168页

作者：胡明阳陈彪首都医科大学宣武医院国家老年疾病临床医学研究中心 100053

帕金森病（PD）是第二大神经变性疾病。临床症状和神经病理学证据均提示帕金森病可能起源于肠道，同时肠道内有大量定植菌存在，这些菌群的改变可能与PD的发生发展有着密切关系。为了更好地了解肠道菌群与帕金森病的关系，本文对近10年... 详细信息

帕金森病（PD）是第二大神经变性疾病。临床症状和神经病理学证据均提示帕金森病可能起源于肠道，同时肠道内有大量定植菌存在，这些菌群的改变可能与PD的发生发展有着密切关系。为了更好地了解肠道菌群与帕金森病的关系，本文对近10年肠道菌群与PD相关性研究的文献进行汇总，深入剖析其间可能存在的关系。通过归纳总结，发现PD患者的肠道菌群特征性改变尚未明确，而肠道菌群失调在帕金森病中的作用机制可能包括影响炎症反应及氧化应激、破坏屏障功能、α-突触核蛋白（α—syn）等多种方式，这些作用方式本身并非独立，其间存在着复杂的相互协同的作用，而分子模拟机制可能在这些作用中起着关键作用。肠道菌群与帕金森病存在着一定关系，但具体机制尚不明确，仍需深入研究，为PD的早诊早治提供更多方向。

关键词：帕金森病肠道菌群分子模拟

Integrated Metabolism and Pharmacokinetic Studies of Saussurea laniceps Using UPLC-DAD-QTOF-MS

在线全文

学校读者我要写书评

暂无评论

Integrated Metabolism and Pharmacokinetic Studies of Saussur...

A Novel and Rapid HPGPC-based Strategy for Quality Control of Saccharide-dominant Herbal Materials:Dendrobium Officinale,A Case Study

第十四届全国中药和天然药物学术研讨会

作者： Tao Yi Yi-Na Tang Zhong-Zhen Zhao hu-biao chen Hong Kong Baptist University China Academy of Chinese Medical Sciences

＜正＞Saussurea laniceps Hand.-Mazz.（SL）has long been used under the herbal name Tibetan"Snow Lotus"for the treatment of rheumatoid arthritis,stomachache and dysmenorrhea in Tibetan folk *** herbal medicine（HM）is a synergistical system with multiple components,both of the metabolism and pharmacokinetic studies of HM are interdependent.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

A Novel and Rapid HPGPC-based Strategy for Quality Control o...

A Study on the Mechanism of Bruceine D in the Treatment of Non-small Cell Lung Cancer H1299 Cells

第十四届全国中药和天然药物学术研讨会

作者： Jun Xu Zhong-Zhen Zhao Quan-Bin Han hu-biao chen Hong Kong Baptist University China Academy of Chinese Medical Sciences

＜正＞Qualitative and quantitative characterization of natural saccharides,especially polysaccharides,in herb materials remains a challenge due to their complicated structures and high macro-molecular *** available methods,such as complete structural characterization,total sugar content determination and sugar composition analysis,involve

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2020年第4期6卷 500-507页

作者： Xiao-Yun Shen Chao-Yue Su Yan-Yan Yan Ling-Ling Zhang Qiao-Ru Guo hu-biao chen Shuhela Zhumabieke Yelxat Danabek Jia-Jun Li Yun Liu Bolat Makabel Jian-Ye Zhang Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology School of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhouP.R.China Xinjiang Institute of Materia Medica UrumqiP.R.China Institute of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqiP.R.China Collaborative Innovation Center for Cancer Institute of Respiratory and Occupational DiseasesMedical CollegeShanxi Datong UniversityDatongP.R.China School of Chinese Medicine Hong Kong Baptist UniversityHong KongP.R.China Key Laboratory Ethnomedicine(Minzu University of China) Ministry of EducationBeijingP.R.China

Background:Non-small cell lung cancer(NSCLC)is considered one of the leading causes of cancer-related *** the availability of drugs for the treatment of NSCLC,the need for the development of novel agents with high efficiency and fewer adverse effects remains *** natural compound bruceine D(BD)is widely recognized for its notable anti-inflammatory,antiparasitic,and hypoglycemic ***,it is unclear whether BD can be used as a novel agent for NSCLC *** and Methods:MTT and colony formation assays were used to assess the antiproliferative effect of BD on NSCLC *** healing and transwell assays were performed to determine the effect of BD on the migration and invasion of H1299 cells,*** blotting assay was used to detect the expression levels of ***:We demonstrated that BD significantly inhibited the proliferation of H1299,A549,and H226 cells with respective IC50 values of 6.06±0.52,7.15±0.90,and 7.21±0.75μ*** addition,BD suppressed colony formation of H1299 cells in a dose-dependent *** treatment with BD,the migration and invasive capabilities of H1299 cells were significantly inhibited in a dose-and time-dependent ***,the results of Western blotting demonstrated that BD treatment resulted in the upregulation of the protein expression of E-cadherin and downregulation of the expression of N-cadherin,twist,snail,integrinαv,integrinβ4,matrix metalloproteinase-7,andβ-catenin ***:BD inhibits proliferation,migration,and invasion of NSCLC cells;therefore,BD may be considered for its potential in adjuvant therapy for NSCLC.

关键词： Bruceine D invasion migration non-small cell lung cancer proliferation

Comparative Analysis of Diosgenin in Dioscorea Species and Related Medicinal Plants by UPLC-DAD-MS

在线全文

学校读者我要写书评

暂无评论

Comparative Analysis of Diosgenin in Dioscorea Species and R...