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The critical roles of mitophagy in cerebral ischemia

The critical roles of mitophagy in cerebral ischemia

作     者:Yan-Cheng Tang Hong-Xia Tian Tao Yi Hu-Biao Chen 

作者机构:School of Chinese Medicine Hong Kong Baptist University Kowloon Tong Hong Kong China Medical Research Department Guangdong General Hospital and Guangdong Academy of Medical Sciences Guangzhou 510080 China HKBU Institute of Research and Continuing Education Shenzhen 518057 China 

出 版 物:《Protein & Cell》 (蛋白质与细胞(英文版))

年 卷 期:2016年第7卷第10期

页      面:699-713页

核心收录:

学科分类:0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基  金:This work was funded by the Faculty Research Grant of Hong Kong Baptist University (FRG2/15-16/022) and the Guandong Natural Science Foundation (2014A030313766 and 2016A030313008) 

主  题:autophagy mitophagy mitochondria,cerebral ischemia 

摘      要:Mitochondria play a kay role in various cell processes including ATP production, Ca^2+ homeostasis, reactive oxygen species (ROS) generation, and apoptosis. The selective removal of impaired mitochondria by autophagosome is known as mitophagy. Cerebral ischemia is a common form of stroke caused by insuf- ficient blood supply to the brain. Emerging evidence suggests that mitophagy plays important roles in the pathophysiological process of cerebral ischemia. This review focuses on the relationship between ischemic brain injury and mitophagy. Based on the latest research, it describes how the signaling pathways of mitophagy appear to be involved in cerebral ischemia.

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