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MODULATION OF SYMPATHETIC NERVE ON POLYMODAL NOCICEPTORS IN RATS

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针刺研究 1989年第Z1期 101-102页

作者： Zhu Jun hu sanjue Fan Jinzhi Department of Physiology, the Fourth Military Medical University Xian, China

Single fiber rcording technique and tail flick test of rat were used in thepresent study. The unit discharges evoked by mechanical stimuli and tail flicklatency responsed to noxious heat stimuli as indices of the activity of polymodalnociceptor were examined during and after sympathetic stimulation. Stimula-tion of the peripheral end of the lumbosaeral sympathetic trunk increased thedischarges of polymodal nociceptors at first and then inhibited markedly. Thedepression of the unit discharges lasted for more than ten min. Injection of

关键词： MODULATION OF SYMPATHETIC NERVE ON POLYMODAL NOCICEPTORS IN RATS test

MODULATION OF ACUPUNCTURE AND SYMPATHETIC NERVE ON PERIPHERAL NOCICEPTORS

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针刺研究 1989年第Z1期 98-100页

作者： hu sanjue Chen min Zhu Jun Jiang Shujun Department of Physiology the Fourth Military Medical University, Xian, China

Since the centrifugal inhibitory effect of acupuncture on nociceptors wasfound in 1982, we have systematically studied the regularity of this action andits pathways using dissected technique of nerve fine bundles at nociceptor *** main results and conclusions are as follons: 1. Electrical stimulation of the lateral hypothelamic area could inhibitthe peripheral noxious afferents through the adrenal gland-sympathetic system,indicating that the lateral hypothalamic area is one of the centres originatingthe centrifugal inhibitory effect on nociceptors.

关键词： MODULATION OF ACUPUNCTURE AND SYMPATHETIC NERVE ON PERIPHERAL NOCICEPTORS

STOCHASTIC RESONANCE MEASURED BY THEMUTUAL INFORMATION IN THE NEURONSTHAT TRANSMIT CHAOTIC SPIKE TRAINS

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生物物理学报 1999年第4期15卷 726-732页

作者： Gong Pulin Xu Jianxue hu sanjue(Institution of Nonlinear dynamics, School of Civil Engineering and Mechanics,Xi’an Jiaotong University, Xi’an 710049, China)(Department of Physiology, Fourth Military Medical University, Xi’an, 710032, China)

The spike trains generated by a neuron model are studied by the methods of nonlinear time series analysis. The results show that the spike trains are chaotic. To investigate effect of noise on transmission of chaotic spike trains, this chaotic spike trains are used as a discrete subthreshold input signal to the integrate-and-fire neuronal model and the Fitzhugh-Nagumo(FHN) neuronal model working in noisy environment. The mutual information between the input spike trains and the output spike trains is calculated, the result shows that the transformation of information encoded by the chaotic spike trains is optimized by some level of noise, and stochastic resonance(SR) measured by mutual information is a property available for neurons to transmit chaotic spike trains.

关键词：神经元随机共振传输放电序列

Sex Differences in Scratching Behaviors Induced by Intradermal Injections of Pruritogenic Chemicals in C57BL/6 Mice

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Neuroscience & Medicine 2012年第3期3卷 314-320页

作者： Chunwei Liu Liang Liang Yong Han Ming Zhang Yabin Xie Wenjuan Han sanjue hu hua Zhang hui Xu Department of Neurosurgery Tangdu Hospital Fourth Military Medical University Xi’an China Department of Thoracic Surgery Tangdu Hospital Fourth Military Medical University Xi’an China Institute of Neuroscience Fourth Military Medical University Xi’an China

Pruritus is an individual unpleasant sensation of human sensory nervous system. In the physiological condition it excerts a self-protective mechanism to protect the skin against external harmful agents. Pruritoceptive itch is also a major symptom of skin disease and a common reason for consulting a dermatologist in clinic. It has been well known that both histamine-dependent and histamine-independent pathways mediate acute and chronic itch sensations. Previous studies have showed common neural pathways partially shared by itch and pain sensation, and significant sex differences in pain sensation. However, sex difference in itch sensation has not been given too much attention as the majority of itch studies were done in male mice or rats till now. In the present study, we compared the scratching behaviors induced by pruritogenic agents in male and female C57BL/6 mice. The results showed that both males and females exhibited scratching behaviors in response to the intradermal injection of histamine-dependent and histamine-independent pruritogenic chemicals. Moreover, the number of scratching behaviors in response to compound 4880 and chloroquine were significantly higher in females. These results suggested that sex differences occured in histamine-dependent compound 4880-induced and histamine-independent chloroquine-induced itch sensations, but not in histamine-independent SLIGRL-NH2-induced itch sensation.

关键词： Scratching Pruritus Sex Difference Compound48/80 Chloroquine SLIGRL-NH2

THE FACILITATORY EFFECT OF SYMPATHETIC EFFERENTS ON SUSTAINED DISCHARGES OF POLYMODAL NOCICEPTORS

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针刺研究 1989年第Z1期 100-100页

作者： hu sanjue Zhu Jun Department of Physiology, the Fourth Military Medical University, Xian, China

Injection of a compound algogenic substance into receptive field of the skininduced sustaihed discharges of polymodal nociceptors in rats. The sustaineddischarges were obviously increased by stimulation of the sympathetic nerveinnervating the receptive field. Initial facilitation was followed by the inhibi-tion of discharges in partial units. The sympathetic effeet can be activatedrepeatedly and lasted for a prolonged time. Injection of noreprephrine (5μg/

关键词： THE FACILITATORY EFFECT OF SYMPATHETIC EFFERENTS ON SUSTAINED DISCHARGES OF POLYMODAL NOCICEPTORS

基于Labview的神经电信号采集与实时分析系统

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华中科技大学学报（自然科学版） 2007年第S1期35卷 166-169页

作者：张俊然霍旭阳胡三觉第四军医大学全军神经科学研究所陕西西安710032 第四军医大学生物医学工程系陕西西安710032

从神经电信号实验的实际需求出发,对信号采集系统进行分析,根据这些要求来选择硬件设备,基于Labview来设计信号采集和实时分析系统.对于实验所关注的参数(ISI、潜伏期等),着重探讨采样系统的控制逻辑问题,用软件的方式来实现信号参量的... 详细信息

从神经电信号实验的实际需求出发,对信号采集系统进行分析,根据这些要求来选择硬件设备,基于Labview来设计信号采集和实时分析系统.对于实验所关注的参数(ISI、潜伏期等),着重探讨采样系统的控制逻辑问题,用软件的方式来实现信号参量的实时分析、处理和显示.讨论了设计过程中所遇到的典型问题,提出这些问题的解决途径.

关键词： C类纤维神经电信号采集系统实时分析

外周NMDA受体在慢性痛中的作用及机制研究

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神经解剖学杂志 2011年第3期27卷 340-343页

作者：孔微微胡三觉罗层第四军医大学神经科学研究所西安710032 温州医学院附属第二医院麻醉科温州325027

疼痛是组织损伤或潜在的组织损伤所引起的不愉快的感觉或情感体验（IASP,1994）。在正常生理状况下,疼痛是警示躯体受到威胁的警报信号,是生命不可缺少的一种特殊保护功能。但是,在病理性条件下（如损伤或炎症）,疼痛已经不再是一种警... 详细信息

疼痛是组织损伤或潜在的组织损伤所引起的不愉快的感觉或情感体验（IASP,1994）。在正常生理状况下,疼痛是警示躯体受到威胁的警报信号,是生命不可缺少的一种特殊保护功能。但是,在病理性条件下（如损伤或炎症）,疼痛已经不再是一种警报信号,而是逐渐发生持续慢性化,表现出：

关键词：外周NMDA受体 DRG 慢性痛

Serotonin-2A receptor-activated PKCtheta pathway in mediating longterm facilitation in rats with chronic intermittent hypoxia - the pre-Btzinger complex as a critical site for respiratory plasticity

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Serotonin-2A receptor-activated PKCtheta pathway in mediatin...

利鲁唑对受损背根节A类神经元不同模式自发放电的抑制作用

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yingying LIU,Jinping LIU,Xiaoyan WEI,Caiyun ZHAO,Haojun WANG,Jianhong DUAN,sanjue hu,Gong JU Institute of Neurosciences,The Fourth Military Medical University,Xi''an,710032,China

＜正＞Respiratory behavior expresses diverse forms of plasticity by alterations in breathing *** of respiratory plasticity often leads to diseases,such as sudden infant death syndrome or obstructive sleep ***-term facilitation（LTF） is the most frequently studied model for respiratory *** intermittent hypoxia（AIH）,three to five short-term hypoxia episodes,induces phrenic LTF（pLTF）,whereas chronic intermittent hypoxia（CIH）,lasting for days or weeks’ stimulus episodes,evokes additional neuroplasticity and augmented *** previous studies,however,were mostly concentrated on phrenic neuroplasticity in high-cervical spinal *** pre-B（o|¨）tzinger complex（pre-B（o|¨）tC）,a critical kernel of respiratory rhythmogenesis in the ventrolateral medulla oblongata,has been obscure until *** established a CIH pLTF model through hypobaric hypoxia in adult *** goal was to determine whether the pre-B＆ouml;tC is required for ***-induced CIH rats generated the augmentation of the short-term hypoxic phrenic response and the enhanced pLTF.5-HT2A receptors in the pre-B（o|¨）tC were found localized to sites consistent with active internalization and externalization（re-sensitivity） in the CIH rats and not in ***-protein kinase C（PPKC） theta isoform and P-PKC substrates were highly expressed in the pre-B（o|¨）tC in CIH *** close association of P-PKCtheta with the postsynaptic membrane was especially *** application of ketanserin,a 5-HT2A receptor specific antagonist,abolished pLTF in CIH rats,and PKCtheta-pseudosubstrate,a PKCtheta inhibitor,blocked pLTF in most CIH rats *** particular,a full abolishment of phrenic nerve activity was found in some CIH rats receiving both ketanserin and PKCtheta-pseudosubstrate,indicating a strengthened effect of 5-HT2A receptor and PKCtheta on *** on the neurochemical evidence of highly-activated 5-HT2A receptors and enhanced expressions of P-PKCtheta and

关键词： long-term facilitation chronic intermittent hypoxia 5-HT2A receptor PKCtheta pre-Btzinger complex rat

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神经解剖学杂志 2010年第3期26卷 215-219页

作者：郑大伟徐晖胡三觉第四军医大学神经科学研究所西安710032

目的:研究利鲁唑(riluzole)对受损背根节(DRG)A类神经元的不同模式自发放电的作用,并探讨其可能机制。方法:本实验在大鼠L5椎间孔置入不锈钢柱制备大鼠DRG慢性压迫模型(chronic compression of DRG,CCD)上,利用在体单纤维记录的方法观察... 详细信息

目的:研究利鲁唑(riluzole)对受损背根节(DRG)A类神经元的不同模式自发放电的作用,并探讨其可能机制。方法:本实验在大鼠L5椎间孔置入不锈钢柱制备大鼠DRG慢性压迫模型(chronic compression of DRG,CCD)上,利用在体单纤维记录的方法观察DRG局部浸浴利鲁唑(500μmol/L)对受损DRG神经元自发放电的影响。结果:(1)CCD大鼠手术后表现出明显的损伤侧机械刺激缩足阈值降低(P<0.05);(2)利鲁唑对受损DRG神经元自发放电具有明显抑制作用(n=30,P<0.05);(3)利鲁唑对非周期放电频率的抑制率显著大于对周期放电频率的抑制率(P<0.05)。结论:利鲁唑对慢性压迫DRGA类神经元的自发放电有显著抑制作用,对非周期放电的抑制作用明显大于对周期放电的作用,呈现出"非周期敏感"的特点,提示受损DRG神经元非周期自发放电行为处于更加不稳定的动力学状态。

关键词：利鲁唑背根节自发放电电生理学大鼠